Insider purchases

Officer Frangou Angeliki bought $251,999 worth of Common Unit (3,597 units at $70.06) (SEC Form 4)

Director Thawley Michael was granted 1,436 shares and bought $48,352 worth of shares (665 units at $72.71), increasing direct ownership by 21% to 12,154 units (SEC Form 4)

Director Elsztain Alejandro Gustavo bought $200,170 worth of American Depositary Shares (17,833 units at $11.22), increasing direct ownership by 1% to 1,207,564 units (SEC Form 4)

Chief Executive Officer Panagiotidis Petros Panagiotis bought $14,254,646 worth of shares (2,315,971 units at $6.15) (SEC Form 4)

Large owner Strome Mark E bought $200,000 worth of shares (100,000 units at $2.00) (SEC Form 4)

Chief Clinical Officer Neman-Ebrahim Yousha bought $2,440 worth of shares (500 units at $4.88), increasing direct ownership by 0.37% to 134,760 units (SEC Form 4)

CFO Garnett Keithly bought $1,614 worth of shares (300 units at $5.38), increasing direct ownership by 0.12% to 241,200 units (SEC Form 4)

Director Gorman Jeremi converted options into 100,000 shares and bought $50,082 worth of shares (65,897 units at $0.76) (SEC Form 4)

Director Magzanyan Anahit bought 1,450 shares, increasing direct ownership by 51% to 4,290 units (SEC Form 4)

CFO Joachimczyk Paul bought $399,998 worth of shares (8,058 units at $49.64), increasing direct ownership by 39% to 28,558 units (SEC Form 4)

Portfolio Manager Caraher Scott C. bought $102,570 worth of shares (14,000 units at $7.33), increasing direct ownership by 31% to 59,440 units (SEC Form 4)

Portfolio Manager Caraher Scott C. bought $95,131 worth of shares (20,000 units at $4.76), increasing direct ownership by 333% to 26,000 units (SEC Form 4)

Chief Executive Officer Patel Paresh bought $33,240 worth of shares (2,000 units at $16.62), increasing direct ownership by 0.12% to 1,626,013 units (SEC Form 4)

Director Leonard Kathie Merrill bought $70,000 worth of shares (5,000 units at $14.00) (SEC Form 4)

Director Anania Kimberly Monzeglio bought $98,000 worth of shares (7,000 units at $14.00) (SEC Form 4)

Amendment: Director Ferrari Richard bought $46,000 worth of shares (57,500 units at $0.80), increasing direct ownership by 25% to 286,636 units (SEC Form 4)

Director Butler Ronald Jr bought $24,999 worth of shares (17,730 units at $1.41) (SEC Form 4)

Director Pascucci Hope bought $389,281 worth of shares (20,000 units at $19.46), increasing direct ownership by 16% to 142,402 units (SEC Form 4)

Director Reasner Amy L bought $8,835 worth of shares (100 units at $88.35), increasing direct ownership by 8% to 1,411 units (SEC Form 4)

Director Altman Louis Michael bought $101,160 worth of shares (3,000 units at $33.72), increasing direct ownership by 10% to 33,164 units (SEC Form 4)

Director Burdman Lee J. bought $100,800 worth of shares (3,000 units at $33.60), increasing direct ownership by 7% to 46,772 units (SEC Form 4)

Amendment: Large owner Goldman Sachs Group Inc bought $5,503 worth of Series A Common Stock (10,006 units at $0.55) and sold $5,082 worth of Series A Common Stock (9,964 units at $0.51) (SEC Form 4)

Large owner Horizon Kinetics Asset Management Llc bought $437 worth of shares (1 units at $436.73), increasing direct ownership by 0.00% to 3,435,503 units (SEC Form 4)

Director Kilts James M bought $991,480 worth of shares (80,000 units at $12.39), increasing direct ownership by 86% to 172,854 units (SEC Form 4)

Chief Medical Officer Yu Jeffrey was granted 219,429 shares and bought $750,000 worth of shares (903,614 units at $0.83), increasing direct ownership by 15% to 8,449,266 units (SEC Form 4)

Director Kosasa Thomas bought $749,999 worth of shares (876,136 units at $0.86), increasing direct ownership by 6% to 16,661,327 units (SEC Form 4)

CEO and President Xu John bought $2,958 worth of shares (23,400 units at $0.13), increasing direct ownership by 0.20% to 11,827,400 units (SEC Form 4)

President Heshmatpour Amir F bought $49,000 worth of shares (10,000 units at $4.90), increasing direct ownership by 0.33% to 3,052,000 units (SEC Form 4)

Director Kirwin Patrick D. bought $45,320 worth of shares (4,000 units at $11.33) (SEC Form 4)

Director Bonita David P bought $12,499,999 worth of shares (2,815,315 units at $4.44) (SEC Form 4)

Director Orbimed Advisors Llc bought $12,499,999 worth of shares (2,815,315 units at $4.44) (SEC Form 4)

Large owner Jobson Charles E bought $4,367 worth of Common (509 units at $8.58), increasing direct ownership by 0.03% to 1,645,803 units (SEC Form 4)

Director Wondeh Inez bought $3,281 worth of shares (61 units at $53.78), increasing direct ownership by 6% to 1,007 units (SEC Form 4)

Chief Executive Officer Wagner Daniel Maurice bought $3,251,824 worth of Ordinary Shares (812,956 units at $4.00) (SEC Form 4)

Director Sprang Todd A. bought $62,532 worth of shares (450 units at $138.96), increasing direct ownership by 29% to 2,015 units (SEC Form 4)

Director Stayer-Suprick Michael S bought $31,509 worth of shares (225 units at $140.04), increasing direct ownership by 5% to 4,597 units (SEC Form 4)

Chief Executive Officer Patel Paresh bought $32,920 worth of shares (2,000 units at $16.46), increasing direct ownership by 0.12% to 1,624,013 units (SEC Form 4)

EVP-N.A. Muncipal Utility Wrocklage Robert bought $122,350 worth of shares (1,000 units at $122.35), increasing direct ownership by 4% to 23,321 units (SEC Form 4)

Large owner Hrt Financial Lp bought $24,061 worth of Class A Shares (72,912 units at $0.33) and sold $3,595 worth of Class A Shares (11,982 units at $0.30), increasing direct ownership by 100% to 121,592 units (SEC Form 4)

Chief Financial Officer Hoag Erik D bought $65,670 worth of shares (1,000 units at $65.67) (SEC Form 4)

Officer Gross Michael S bought $493,104 worth of shares (35,452 units at $13.91) and was granted 354,511 shares (SEC Form 4)

Large owner Coliseum Capital Management, Llc bought $3,068,690 worth of shares (228,920 units at $13.41) (SEC Form 4)

Director Volpe John Paul bought $7,180 worth of shares (1,000 units at $7.18) (SEC Form 4)

Large owner Glenbrook Capital Management bought $330,182 worth of shares (171,034 units at $1.93) (SEC Form 4)

Large owner Chernett Jorey bought $1,225,101 worth of shares (398,985 units at $3.07), increasing direct ownership by 4% to 10,251,929 units (SEC Form 4)

Director Estes Ronald E. bought $11,328 worth of shares (800 units at $14.16), increasing direct ownership by 2% to 40,443 units (SEC Form 4)

CEO, President and CIO Brown Kyle Steven covered exercise/tax liability with 16,187 shares, was granted 256,588 shares and bought $50,018 worth of shares (3,532 units at $14.16), increasing direct ownership by 65% to 620,709 units (SEC Form 4)

Director Farrell Sarah E bought $1,388,730 worth of shares (10,500 units at $132.26) (SEC Form 4)

Senior Vice President & CFO Lakhia Brad S. bought $331,719 worth of shares (12,775 units at $25.97), increasing direct ownership by 9% to 148,480 units (SEC Form 4)

Chief Executive Officer Duke John D bought $25,050 worth of shares (5,000 units at $5.01), increasing direct ownership by 5% to 105,000 units (SEC Form 4)

Director Ragatz Erik D. bought $702,618 worth of shares (116,003 units at $6.06) (SEC Form 4)

Director Ford Joe T bought $253,000 worth of shares (55,000 units at $4.60), increasing direct ownership by 11% to 533,916 units (SEC Form 4)

SVP, Regulatory Affairs Bedoya-Toro Munera Maria E bought $1,270 worth of shares (1,000 units at $1.27), increasing direct ownership by 8,333% to 1,012 units (SEC Form 4)

Chief Financial Officer Points Jeffrey S. exercised 13,264 shares at a strike of $2.48 and bought $30,000 worth of shares (2,000 units at $15.00), increasing direct ownership by 27% to 70,785 units (SEC Form 4)

Director Dunn Timothy S bought $119,275 worth of shares (2,500 units at $47.71), increasing direct ownership by 86% to 5,403 units (SEC Form 4)

Director Getz Heather C bought $13,972 worth of shares (20,000 units at $0.70), increasing direct ownership by 18% to 131,754 units (SEC Form 4)

Director Buchholz Richard bought $14,840 worth of shares (1,000 units at $14.84), increasing direct ownership by 8% to 13,666 units (SEC Form 4)

Director Lopes Robert A. Jr. bought $24,600 worth of shares (30,000 units at $0.82), increasing direct ownership by 34% to 117,219 units (SEC Form 4)

CEO & Executive Chairman Ball Robert Joseph bought $33,392 worth of shares (2,200 units at $15.18), increasing direct ownership by 0.80% to 278,866 units (SEC Form 4)

Chief Financial Officer Traverse David K bought $5,175 worth of shares (4,500 units at $1.15), increasing direct ownership by 8% to 60,984 units (SEC Form 4)