NARI - SEC Form 4 insider transactions

Director Warner Robert Keith closing all direct ownership in the company (SEC Form 4)

Chief Medical Officer Tu Thomas was granted 7,406 shares, closing all direct ownership in the company (SEC Form 4)

Director Szyman Catherine M. closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Strange Kevin T closing all direct ownership in the company (SEC Form 4)

Principal Accounting Officer Silva Karen closing all direct ownership in the company (SEC Form 4)

Director Root Jonathan D closing all direct ownership in the company (SEC Form 4)

Director Milder Donald B closing all direct ownership in the company (SEC Form 4)

Director Mead Dana G Jr. closing all direct ownership in the company (SEC Form 4)

Director Lucchese Cynthia L closing all direct ownership in the company (SEC Form 4)

President and CEO Hykes Andrew was granted 20,393 shares, closing all direct ownership in the company (SEC Form 4)

Director Hoffman William closing all direct ownership in the company (SEC Form 4)

Director Chambers Rebecca closing all direct ownership in the company (SEC Form 4)

President and CEO Hykes Andrew exercised 194,538 shares at a strike of $0.95, increasing direct ownership by 39% to 697,244 units (SEC Form 4)

Chief Medical Officer Tu Thomas exercised 148,004 shares at a strike of $0.80, increasing direct ownership by 46% to 471,361 units (SEC Form 4)

President and CEO Hykes Andrew was granted 67,282 shares, increasing direct ownership by 15% to 502,706 units (SEC Form 4)

Chief Financial Officer Strange Kevin T was granted 21,102 shares, increasing direct ownership by 45% to 67,502 units (SEC Form 4)

Chief Medical Officer Tu Thomas was granted 21,102 shares, increasing direct ownership by 7% to 323,357 units (SEC Form 4)

Principal Accounting Officer Silva Karen was granted 5,504 shares, increasing direct ownership by 60% to 14,719 units (SEC Form 4)

Director Hoffman William sold $12,093,174 worth of shares (200,000 units at $60.47), decreasing direct ownership by 46% to 238,987 units (SEC Form 4)

President and CEO Hykes Andrew covered exercise/tax liability with 4,409 shares, decreasing direct ownership by 1% to 434,901 units (SEC Form 4)

Chief Financial Officer Strange Kevin T covered exercise/tax liability with 1,037 shares, decreasing direct ownership by 2% to 46,318 units (SEC Form 4)

Chief Medical Officer Tu Thomas covered exercise/tax liability with 2,303 shares, decreasing direct ownership by 0.76% to 301,733 units (SEC Form 4)

Director Hoffman William covered exercise/tax liability with 2,246 shares, decreasing direct ownership by 0.51% to 438,987 units (SEC Form 4)

President and CEO Hykes Andrew sold $165,870 worth of shares (3,000 units at $55.29), decreasing direct ownership by 0.68% to 439,310 units (SEC Form 4)

Director Hoffman William sold $3,339,704 worth of shares (60,000 units at $55.66), decreasing direct ownership by 12% to 441,233 units (SEC Form 4)

Chief Medical Officer Tu Thomas sold $220,000 worth of shares (4,000 units at $55.00), decreasing direct ownership by 1% to 304,036 units (SEC Form 4)

Principal Accounting Officer Silva Karen was granted 9,215 shares (SEC Form 4)

President and CEO Hykes Andrew sold $152,490 worth of shares (3,000 units at $50.83), decreasing direct ownership by 0.67% to 442,310 units (SEC Form 4)

Director Hoffman William sold $3,069,521 worth of shares (60,000 units at $51.16), decreasing direct ownership by 11% to 501,233 units (SEC Form 4)

President and CEO Hykes Andrew sold $150,000 worth of shares (3,000 units at $50.00), decreasing direct ownership by 0.67% to 445,310 units (SEC Form 4)

Director Hoffman William sold $2,002,000 worth of shares (40,000 units at $50.05), decreasing direct ownership by 7% to 561,233 units (SEC Form 4)

Director Hoffman William sold $1,800,835 worth of shares (40,000 units at $45.02), decreasing direct ownership by 6% to 601,233 units (SEC Form 4)

Chief Financial Officer Strange Kevin T was granted 5,695 shares and covered exercise/tax liability with 1,041 shares, increasing direct ownership by 11% to 47,355 units (SEC Form 4)

Chief Medical Officer Tu Thomas covered exercise/tax liability with 2,120 shares, decreasing direct ownership by 0.68% to 308,036 units (SEC Form 4)

President and CEO Hykes Andrew covered exercise/tax liability with 4,222 shares, decreasing direct ownership by 0.93% to 448,310 units (SEC Form 4)

Director Hoffman William covered exercise/tax liability with 2,063 shares, decreasing direct ownership by 0.32% to 641,233 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. covered exercise/tax liability with 2,067 shares, decreasing direct ownership by 1% to 177,533 units (SEC Form 4)

Director Hoffman William sold $1,833,188 worth of shares (40,000 units at $45.83), decreasing direct ownership by 6% to 643,296 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. exercised 3,000 shares at a strike of $0.46 and sold $135,385 worth of shares (3,000 units at $45.13) (SEC Form 4)

President and CEO Hykes Andrew sold $150,000 worth of shares (3,000 units at $50.00), decreasing direct ownership by 0.66% to 452,532 units (SEC Form 4)

Director Hoffman William sold $2,961,751 worth of shares (60,000 units at $49.36), decreasing direct ownership by 8% to 683,296 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. exercised 5,000 shares at a strike of $0.46 and sold $239,964 worth of shares (5,000 units at $47.99) (SEC Form 4)

President and CEO Hykes Andrew sold $165,690 worth of shares (3,000 units at $55.23), decreasing direct ownership by 0.65% to 455,252 units (SEC Form 4)

Director Hoffman William sold $3,404,646 worth of shares (60,000 units at $56.74), decreasing direct ownership by 7% to 743,296 units (SEC Form 4)

Chief Medical Officer Tu Thomas sold $191,957 worth of shares (3,480 units at $55.16), decreasing direct ownership by 1% to 309,777 units (SEC Form 4)

Chief Medical Officer Tu Thomas sold $910,087 worth of shares (16,520 units at $55.09), decreasing direct ownership by 5% to 313,257 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. exercised 5,000 shares at a strike of $0.46 and sold $269,759 worth of shares (5,000 units at $53.95) (SEC Form 4)

Director Hoffman William sold $1,003,000 worth of shares (20,000 units at $50.15) and covered exercise/tax liability with 2,063 shares, decreasing direct ownership by 3% to 803,296 units (SEC Form 4)

President and CEO Hykes Andrew sold $150,240 worth of shares (3,000 units at $50.08) and covered exercise/tax liability with 4,222 shares, decreasing direct ownership by 2% to 458,252 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. covered exercise/tax liability with 2,067 shares, decreasing direct ownership by 1% to 179,227 units (SEC Form 4)

Chief Medical Officer Tu Thomas covered exercise/tax liability with 2,120 shares, decreasing direct ownership by 0.64% to 329,777 units (SEC Form 4)

Director Chambers Rebecca sold $11,957 worth of shares (260 units at $45.99), decreasing direct ownership by 3% to 9,684 units (SEC Form 4)

Director Hoffman William sold $1,741,579 worth of shares (40,000 units at $43.54), decreasing direct ownership by 5% to 825,359 units (SEC Form 4)

Chief Financial Officer Hill, Mitch C. exercised 5,000 shares at a strike of $0.46 and sold $237,977 worth of shares (5,000 units at $47.60) (SEC Form 4)

Warner Robert Keith was granted 4,126 shares, increasing direct ownership by 51% to 12,149 units (SEC Form 4) (Amendment)

Szyman Catherine M. was granted 4,126 shares, increasing direct ownership by 23% to 22,429 units (SEC Form 4) (Amendment)

Root Jonathan D was granted 4,126 shares, increasing direct ownership by 0.77% to 541,149 units (SEC Form 4) (Amendment)

Mead Dana G Jr. was granted 4,126 shares, increasing direct ownership by 59% to 11,148 units (SEC Form 4) (Amendment)

Lucchese Cynthia L was granted 4,126 shares, increasing direct ownership by 12% to 38,429 units (SEC Form 4) (Amendment)

Hykes Andrew sold $150,000 worth of shares (3,000 units at $50.00), decreasing direct ownership by 0.64% to 465,474 units (SEC Form 4)