TECH - SEC Form 4 insider transactions

President - Diag & Spatial Bi Crouse Steven C. converted options into 600 shares and covered exercise/tax liability with 216 shares, increasing direct ownership by 6% to 6,761 units (SEC Form 4)

Director Herr Amy E. sold $320,386 worth of shares (6,636 units at $48.28) and exercised 6,636 shares at a strike of $47.60 (SEC Form 4)

CFO Hippel James covered exercise/tax liability with 56,955 shares and exercised 62,000 shares at a strike of $47.60, increasing direct ownership by 3% to 153,670 units (SEC Form 4)

SVP - General Counsel Bohnen Shane exercised 8,400 shares at a strike of $47.60 and covered exercise/tax liability with 7,055 shares, increasing direct ownership by 23% to 7,249 units (SEC Form 4)

Chief Executive Officer Kelderman Kim exercised 26,692 shares at a strike of $47.60 and covered exercise/tax liability with 23,951 shares, increasing direct ownership by 4% to 65,799 units (SEC Form 4)

President - Diag & Spatial Bi Crouse Steven C. converted options into 794 shares and covered exercise/tax liability with 311 shares, increasing direct ownership by 8% to 6,337 units (SEC Form 4)

Chief Executive Officer Kelderman Kim converted options into 11,344 shares and covered exercise/tax liability with 1,363 shares, increasing direct ownership by 19% to 63,058 units (SEC Form 4)

CFO Hippel James covered exercise/tax liability with 56,097 shares and converted options into 62,000 shares, increasing direct ownership by 4% to 148,625 units (SEC Form 4)

SEC Form 4 filed by Kelderman Kim

SEC Form 4 filed by Bohnen Shane

SEC Form 4 filed by President - Diag & Spatial Bi Crouse Steven C.

Director Herr Amy E. sold $116,791 worth of shares (1,976 units at $59.10) (SEC Form 4)

Director Herr Amy E. covered exercise/tax liability with 16 shares and converted options into 38 shares (SEC Form 4)

President - Diag & Spatial Bio Mcmanus Matthew converted options into 4,621 shares and covered exercise/tax liability with 1,665 shares, increasing direct ownership by 62% to 7,691 units (SEC Form 4)

Chief Executive Officer Kelderman Kim covered exercise/tax liability with 2,303 shares, decreasing direct ownership by 5% to 48,665 units (SEC Form 4)

CFO Hippel James converted options into 24,704 shares and covered exercise/tax liability with 11,865 shares, increasing direct ownership by 10% to 142,722 units (SEC Form 4)

PRESIDENT, PROTEIN SCIENCES Geist William converted options into 9,911 shares and covered exercise/tax liability with 4,520 shares, increasing direct ownership by 36% to 20,503 units (SEC Form 4)

Director Bushman Julie L was granted 1,640 shares, increasing direct ownership by 23% to 8,775 units (SEC Form 4)

Director Keegan Joseph D was granted 1,640 shares, increasing direct ownership by 12% to 15,411 units (SEC Form 4)

Director Higgins John L was granted 1,640 shares, increasing direct ownership by 3% to 66,876 units (SEC Form 4)

Director Seth Alpna was granted 1,640 shares, increasing direct ownership by 12% to 15,411 units (SEC Form 4)

Director Herr Amy E. was granted 1,640 shares, increasing direct ownership by 158% to 2,680 units (SEC Form 4)

Director Klimovsky Judith V. was granted 1,640 shares, increasing direct ownership by 77% to 3,782 units (SEC Form 4)

Director Vessey Rupert was granted 1,640 shares, increasing direct ownership by 18% to 10,987 units (SEC Form 4)

Director Baumgartner Robert V was granted 1,640 shares, increasing direct ownership by 4% to 46,503 units (SEC Form 4)

Director Nusse Roeland exercised 17,040 shares at a strike of $21.84 and sold $960,388 worth of shares (17,040 units at $56.36) (SEC Form 4)

Director Baumgartner Robert V exercised 17,040 shares at a strike of $21.84 and sold $957,818 worth of shares (17,040 units at $56.21) (SEC Form 4)

CFO Hippel James converted options into 4,010 shares and covered exercise/tax liability with 1,926 shares, increasing direct ownership by 2% to 129,883 units (SEC Form 4)

Director Herr Amy E. converted options into 279 shares and covered exercise/tax liability with 101 shares (SEC Form 4)

Chief Executive Officer Kelderman Kim converted options into 8,543 shares and covered exercise/tax liability with 4,305 shares, increasing direct ownership by 9% to 50,968 units (SEC Form 4)

SVP - General Counsel Bohnen Shane converted options into 1,718 shares and covered exercise/tax liability with 527 shares, increasing direct ownership by 37% to 4,385 units (SEC Form 4)

President - Diag & Spatial Bio Mcmanus Matthew converted options into 2,637 shares and covered exercise/tax liability with 880 shares, increasing direct ownership by 59% to 4,735 units (SEC Form 4)

PRESIDENT, PROTEIN SCIENCES Geist William converted options into 2,623 shares and covered exercise/tax liability with 803 shares, increasing direct ownership by 14% to 15,112 units (SEC Form 4)

Director Higgins John L exercised 5,040 shares at a strike of $21.84, increasing direct ownership by 8% to 65,236 units (SEC Form 4)

CFO Hippel James covered exercise/tax liability with 147,431 shares and exercised 168,620 shares at a strike of $44.33, increasing direct ownership by 20% to 127,799 units (SEC Form 4)

Chief Executive Officer Kelderman Kim covered exercise/tax liability with 43,649 shares and exercised 48,176 shares at a strike of $44.33, increasing direct ownership by 11% to 46,730 units (SEC Form 4)

Chief Executive Officer Kelderman Kim exercised 36,132 shares at a strike of $44.33 and covered exercise/tax liability with 32,933 shares, increasing direct ownership by 8% to 42,203 units (SEC Form 4)

Director Herr Amy E. exercised 1,280 shares at a strike of $44.33 and sold $63,705 worth of shares (1,280 units at $49.77) (SEC Form 4)

Director Higgins John L exercised 12,000 shares at a strike of $21.84, increasing direct ownership by 25% to 60,196 units (SEC Form 4)

SVP - General Counsel Bohnen Shane converted options into 2,260 shares and covered exercise/tax liability with 747 shares, increasing direct ownership by 90% to 3,194 units (SEC Form 4)

Director Herr Amy E. exercised 1,976 shares at a strike of $44.33 and sold $122,691 worth of shares (1,860 units at $65.96) (SEC Form 4)

Director Herr Amy E. was granted 1,040 shares (SEC Form 4)

President - DGS Mcmanus Matthew converted options into 4,620 shares and covered exercise/tax liability with 1,642 shares (SEC Form 4)

PRESIDENT, PROTEIN SCIENCES Geist William converted options into 3,320 shares and covered exercise/tax liability with 1,109 shares, increasing direct ownership by 20% to 13,292 units (SEC Form 4)

Amendment: SEC Form 4 filed by President - DGS Mcmanus Matthew

Chief Executive Officer Kelderman Kim exercised 13,392 shares at a strike of $37.70 and sold $1,035,013 worth of shares (13,392 units at $77.29) (SEC Form 4)

PRESIDENT, PROTEIN SCIENCES Geist William converted options into 9,912 shares and covered exercise/tax liability with 3,270 shares, increasing direct ownership by 150% to 11,081 units (SEC Form 4)

Chief Executive Officer Kelderman Kim covered exercise/tax liability with 2,430 shares, decreasing direct ownership by 6% to 39,004 units (SEC Form 4)

CFO Hippel James converted options into 13,159 shares and covered exercise/tax liability with 6,475 shares, increasing direct ownership by 7% to 106,610 units (SEC Form 4)

Director Keegan Joseph D was granted 1,462 shares, increasing direct ownership by 12% to 13,771 units (SEC Form 4)

Director Vessey Rupert was granted 1,462 shares, increasing direct ownership by 19% to 9,347 units (SEC Form 4)

Director Bushman Julie L was granted 1,462 shares, increasing direct ownership by 26% to 7,135 units (SEC Form 4)

Director Higgins John L was granted 1,462 shares, increasing direct ownership by 3% to 48,196 units (SEC Form 4)

Director Nusse Roeland was granted 1,462 shares, increasing direct ownership by 3% to 44,559 units (SEC Form 4)

Director Seth Alpna was granted 1,462 shares, increasing direct ownership by 12% to 13,771 units (SEC Form 4)

Director Klimovsky Judith V was granted 1,462 shares, increasing direct ownership by 215% to 2,142 units (SEC Form 4)

Director Baumgartner Robert V was granted 1,462 shares, increasing direct ownership by 3% to 44,863 units (SEC Form 4)

Director Higgins John L exercised 6,000 shares at a strike of $22.95 and covered exercise/tax liability with 1,874 shares, increasing direct ownership by 10% to 46,734 units (SEC Form 4)

Chief Executive Officer Kelderman Kim exercised 1,492 shares at a strike of $66.97, increasing direct ownership by 4% to 41,434 units (SEC Form 4)

SEC Form 4 filed by CFO Hippel James