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Compare · MRK vs SYRE

MRK vs SYRE

Side-by-side comparison of Merck & Company Inc. (MRK) and Spyre Therapeutics Inc. (SYRE): market cap, price performance, sector, and recent activity on the wire.

Summary

  • Both MRK and SYRE operate in Biotechnology: Pharmaceutical Preparations (Health Care), so they compete in similar markets.
  • MRK is the larger of the two at $276.54B, about 42.8x SYRE ($6.46B).
  • Over the past year, MRK is up 34.4% and SYRE is up 375.3% - SYRE leads by 340.8 points.
  • SYRE has been more active in the news (13 items in the past 4 weeks vs 9 for MRK).
  • MRK has more recent analyst coverage (25 ratings vs 10 for SYRE).
PerformanceMRK+34.42%SYRE+375.26%
2025-04-28+0.00%2026-04-24
MetricMRKSYRE
Company
Merck & Company Inc.
Spyre Therapeutics Inc.
Price
$111.84-2.43%
$69.72+0.66%
Market cap
$276.54B
$6.46B
1M return
-6.32%
+52.74%
1Y return
+34.42%
+375.26%
Industry
Biotechnology: Pharmaceutical Preparations
Biotechnology: Pharmaceutical Preparations
Exchange
NYSE
NASDAQ
IPO
2016
News (4w)
9
13
Recent ratings
25
10
MRK

Merck & Company Inc.

Merck & Co., Inc. operates as a healthcare company worldwide. It operates through two segments, Pharmaceutical and Animal Health segments. The Pharmaceutical segment offers human health pharmaceutical products in the areas of oncology, hospital acute care, immunology, neuroscience, virology, cardiovascular, diabetes, and women's health, as well as vaccine products. The Animal Health segment provides discovers, develops, manufactures, and markets a range of veterinary pharmaceuticals, vaccines, and health management solutions and services, as well as a suite of digitally connected identification, traceability, and monitoring products. The company has collaborations with AstraZeneca PLC; Bayer AG; Eisai Co., Ltd.; and Ridgeback Biotherapeutics. It serves drug wholesalers and retailers, hospitals, and government agencies; managed health care providers, such as health maintenance organizations, pharmacy benefit managers, and other institutions; and physicians and physician distributors, veterinarians, and animal producers. The company has collaboration agreement with Gilead Sciences, Inc. to co-develop and co-commercialize long-acting investigational treatment combinations of Lenacapavir and Islatravir in HIV; Amathus Therapeutics to develop treatments for neurodegenerative diseases; and Linnaeus Therapeutics, Inc. to evaluate LNS8801 in combination with KEYTRUDA for patients with advanced cancer. It also has a collaboration with Biomed X Gmbh for building on ongoing research projects in the fields of oncology (DNA damage response and RNA splicing) and autoimmunity (intestinal epithelial barrier in autoimmune diseases); and a collaboration agreement with NGM Biopharmaceuticals, Inc. to focus primarily on the development of novel medicines for unmet patient needs in retinal and CVM diseases, including heart failure. Merck & Co., Inc. was founded in 1891 and is headquartered in Kenilworth, New Jersey.

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