BGNE insider transactions

Chief Executive Officer Oyler John exercised 1,300,000 units of Ordinary Shares at a strike of $0.50, increasing direct ownership by 77% to 2,978,833 units (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong sold $7,805,106 worth of American Depositary Shares (41,760 units at $186.90) and exercised 41,760 units of American Depositary Shares at a strike of $6.50 (SEC Form 4)

Director Baker Bros. Advisors Lp sold $194,200,043 worth of American Depositary Shares (1,037,017 units at $187.27) (SEC Form 4)

President, COO & GM China Wu Xiaobin sold 0 units of RMB Shares (SEC Form 4)

Large owner Hhlr Advisors, Ltd. sold $3,568,500,000 worth of Ordinary Shares (17,842,500 units at $200.00) (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong exercised 38,461 units of American Depositary Shares at a strike of $6.50 and sold $9,190,570 worth of American Depositary Shares (48,351 units at $190.08), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $3,756,092 worth of American Depositary Shares (16,175 units at $232.22), closing all direct ownership in the company (SEC Form 4)

Director Sharp Shalini was granted 8,151 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Sharp Shalini

SVP, General Counsel Lee Chan Henry sold $284,994 worth of American Depositary Shares (1,202 units at $237.10), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $1,101,774 worth of American Depositary Shares (5,000 units at $220.35) (SEC Form 4)

President, COO & GM China Wu Xiaobin sold $1,000,615 worth of American Depositary Shares (5,000 units at $200.12), closing all direct ownership in the company (SEC Form 4)

President, COO & GM China Wu Xiaobin sold $1,053,677 worth of American Depositary Shares (5,556 units at $189.65), closing all direct ownership in the company (SEC Form 4)

Principal Accounting Officer Ball Titus B. sold $26,022 worth of American Depositary Shares (137 units at $189.94), closing all direct ownership in the company (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong gifted 301,457 units of Ordinary Shares, decreasing direct ownership by 5% to 5,266,973 units (SEC Form 4)

Chief Financial Officer Rosenberg Aaron was granted 118,547 units of Ordinary Shares (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $133,915 worth of American Depositary Shares (834 units at $160.57), closing all direct ownership in the company (SEC Form 4)

SEC Form 3 filed by new insider Rosenberg Aaron

Chief Financial Officer Wang Julia Aijun sold $67,919 worth of American Depositary Shares (472 units at $143.90), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $170,030 worth of American Depositary Shares (1,064 units at $159.80), closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Wang Julia Aijun sold $139,938 worth of American Depositary Shares (899 units at $155.66), closing all direct ownership in the company (SEC Form 4)

President, COO & GM China Wu Xiaobin sold $233,133 worth of American Depositary Shares (1,459 units at $159.79), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $445,070 worth of American Depositary Shares (2,789 units at $159.58), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $204,125 worth of American Depositary Shares (1,281 units at $159.35), closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Wang Julia Aijun sold $145,678 worth of American Depositary Shares (916 units at $159.04), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $368,162 worth of American Depositary Shares (2,341 units at $157.27), closing all direct ownership in the company (SEC Form 4)

President, COO & GM China Wu Xiaobin sold $505,208 worth of American Depositary Shares (3,254 units at $155.26), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $69,955 worth of American Depositary Shares (439 units at $159.35), closing all direct ownership in the company (SEC Form 4)

Ball Titus B. was granted 24,427 units of Ordinary Shares, increasing direct ownership by 104% to 47,905 units (SEC Form 4)

Wu Xiaobin was granted 253,409 units of Ordinary Shares, increasing direct ownership by 25% to 1,268,849 units (SEC Form 4)

Wang Lai was granted 168,935 units of Ordinary Shares, increasing direct ownership by 11% to 1,768,962 units (SEC Form 4)

Lee Chan Henry was granted 98,085 units of Ordinary Shares, increasing direct ownership by 57% to 269,399 units (SEC Form 4)

Dugan Margaret was granted 16,341 units of Ordinary Shares, increasing direct ownership by 55% to 45,955 units (SEC Form 4)

Brandicourt Olivier was granted 16,341 units of Ordinary Shares (SEC Form 4)

Hooper Anthony C was granted 16,341 units of Ordinary Shares, increasing direct ownership by 44% to 53,755 units (SEC Form 4)

Oyler John was granted 490,464 units of Ordinary Shares, increasing direct ownership by 37% to 1,812,018 units (SEC Form 4)

Glazer Donald W. was granted 16,341 units of Ordinary Shares, increasing direct ownership by 0.60% to 2,718,464 units (SEC Form 4)

Riva Alessandro was granted 16,341 units of Ordinary Shares, increasing direct ownership by 55% to 45,955 units (SEC Form 4)

Wang Xiaodong was granted 108,992 units of Ordinary Shares, increasing direct ownership by 2% to 5,568,430 units (SEC Form 4)

Sanders Corazon (Corsee) D. was granted 16,341 units of Ordinary Shares, increasing direct ownership by 55% to 46,241 units (SEC Form 4)

Wang Julia Aijun was granted 136,240 units of Ordinary Shares, increasing direct ownership by 43% to 456,326 units (SEC Form 4)

Yi Qingqing was granted 16,341 units of Ordinary Shares, increasing direct ownership by 55% to 45,955 units (SEC Form 4)

Baker Bros. Advisors Lp was granted 65,364 units of Ordinary Shares (SEC Form 4)

Oyler John sold $7,475,024 worth of American Depositary Shares (50,000 units at $149.50) (SEC Form 4)

New insider Ball Titus B. claimed ownership of 23,478 units of Ordinary Shares (SEC Form 3)

Oyler John sold $8,368,017 worth of American Depositary Shares (50,000 units at $167.36), closing all direct ownership in the company (SEC Form 4)

Glazer Donald W. gifted 82,020 units of Ordinary Shares, decreasing direct ownership by 3% to 2,702,123 units (SEC Form 4)

SEC Form 4 filed by Brandicourt Olivier

SEC Form 3 filed by new insider Brandicourt Olivier

Wang Xiaodong gifted 71,890 units of Ordinary Shares and disposed of 172,372 units of Ordinary Shares, decreasing direct ownership by 1% to 5,459,438 units (SEC Form 4)

Baker Bros. Advisors Lp sold $198,550,000 worth of American Depositary Shares (1,100,000 units at $180.50) (SEC Form 4)

SEC Form 4: Lee Chan Henry sold $171,059 worth of American Depositary Shares (791 units at $216.26), closing all direct ownership in the company

SEC Form 4 filed by Wang Julia Aijun

SEC Form 4 filed by Wang Lai

SEC Form 4 filed by Wang Julia Aijun

SEC Form 4 filed by Sanders Corazon (Corsee) D.

SEC Form 4 filed by Wu Xiaobin

SEC Form 4 filed by Wang Xiaodong

SEC Form 4 filed by Oyler John

SEC Form 4 filed by Wang Julia Aijun