IONS insider transactions

EVP, Chief Business Officer Baroldi Joseph sold $116,727 worth of shares (1,626 units at $71.79) as part of a pre-agreed trading plan, decreasing direct ownership by 3% to 44,909 units (SEC Form 4)

SEC Form 4 filed by Jenne Kyle

SEC Form 4 filed by Parshall B Lynne

SEC Form 4 filed by Birchler Brian

SEC Form 4 filed by Baroldi Joseph

SEC Form 4 filed by Klein Joseph Iii

SEC Form 4 filed by Devers Shannon L.

SEC Form 4 filed by Schneider Eugene

SEC Form 4 filed by Ionis Pharmaceuticals Inc.

Chief Executive Officer Monia Brett P sold $12,114,155 worth of shares (160,773 units at $75.35) and exercised 148,454 shares at a strike of $60.89, decreasing direct ownership by 5% to 242,662 units (SEC Form 4)

SEC Form 4 filed by Ionis Pharmaceuticals Inc.

SEC Form 4 filed by Ionis Pharmaceuticals Inc.

Director Klein Joseph Iii exercised 16,000 shares at a strike of $40.76 and sold $1,696,181 worth of shares (21,332 units at $79.51), decreasing direct ownership by 33% to 11,014 units (SEC Form 4)

Director Loscalzo Joseph exercised 1,032 shares at a strike of $38.06 and sold $82,833 worth of shares (1,032 units at $80.26) (SEC Form 4)

Director Diaz Allene M. exercised 40,321 shares at a strike of $39.72 and sold $4,354,428 worth of shares (54,878 units at $79.35), decreasing direct ownership by 79% to 3,811 units (SEC Form 4)

EVP, Chief Human Resources Ofc Devers Shannon L. exercised 20,106 shares at a strike of $35.97 and sold $1,596,433 worth of shares (20,106 units at $79.40) (SEC Form 4)

EVP, Chief Scientific Officer Bennett C Frank exercised 65,089 shares at a strike of $53.73 and sold $6,741,669 worth of shares (85,089 units at $79.23), decreasing direct ownership by 20% to 80,554 units (SEC Form 4)

EVP, Chief Business Officer Baroldi Joseph sold $530,987 worth of shares (6,659 units at $79.74) and exercised 2,138 shares at a strike of $44.57, decreasing direct ownership by 9% to 41,317 units (SEC Form 4)

EVP Research Swayze Eric acquired $12,510 worth of shares (256 units at $48.87), increasing direct ownership by 0.80% to 32,361 units (SEC Form 4)

EVP CLO & General Counsel O'Neil Patrick R. acquired $18,374 worth of shares (376 units at $48.87), increasing direct ownership by 0.52% to 72,359 units (SEC Form 4)

Chief Executive Officer Monia Brett P acquired $23,651 worth of shares (484 units at $48.87), increasing direct ownership by 0.19% to 254,981 units (SEC Form 4)

EVP, Corp and Development Ops Birchler Brian acquired $17,152 worth of shares (351 units at $48.87), increasing direct ownership by 0.53% to 66,598 units (SEC Form 4)

EVP, Chief Scientific Officer Bennett C Frank acquired $12,754 worth of shares (261 units at $48.87), increasing direct ownership by 0.26% to 100,554 units (SEC Form 4)

Amendment: EVP, Chief Scientific Officer Bennett C Frank disposed of 0 shares (SEC Form 4)

EVP Research Swayze Eric sold $1,278,914 worth of shares (15,642 units at $81.76), decreasing direct ownership by 33% to 32,105 units (SEC Form 4)

Director Parshall B Lynne sold $413,588 worth of shares (5,000 units at $82.72), decreasing direct ownership by 8% to 56,344 units (SEC Form 4)

Chief Executive Officer Monia Brett P sold $2,524,820 worth of shares (29,430 units at $85.79), decreasing direct ownership by 10% to 254,497 units (SEC Form 4)

EVP, Chief Scientific Officer Bennett C Frank sold $7,056,216 worth of shares (85,089 units at $82.93) and exercised 65,089 shares at a strike of $53.73, decreasing direct ownership by 20% to 80,293 units (SEC Form 4)

EVP Research Swayze Eric was granted 11,991 shares and sold $512,446 worth of shares (6,179 units at $82.93), increasing direct ownership by 14% to 47,747 units (SEC Form 4)

EVP CLO & General Counsel O'Neil Patrick R. was granted 11,991 shares and sold $516,153 worth of shares (6,179 units at $83.53), increasing direct ownership by 9% to 71,983 units (SEC Form 4)

EVP, Chf Clinical Develop Ofcr Schneider Eugene was granted 11,991 shares and sold $515,630 worth of shares (6,179 units at $83.45), increasing direct ownership by 9% to 69,702 units (SEC Form 4)

Chief Executive Officer Monia Brett P was granted 122,214 shares and sold $5,208,979 worth of shares (62,970 units at $82.72), increasing direct ownership by 26% to 283,927 units (SEC Form 4)

EVP, Finance & CFO Hougen Elizabeth L was granted 13,562 shares and sold $581,702 worth of shares (6,988 units at $83.24), increasing direct ownership by 5% to 132,881 units (SEC Form 4)

EVP, Corp and Development Ops Birchler Brian was granted 11,991 shares and sold $513,048 worth of shares (6,179 units at $83.03), increasing direct ownership by 10% to 66,247 units (SEC Form 4)

EVP, Chief Scientific Officer Bennett C Frank was granted 11,421 shares and sold $488,141 worth of shares (5,885 units at $82.95), increasing direct ownership by 6% to 100,293 units (SEC Form 4)

EVP, Chief Business Officer Baroldi Joseph was granted 10,278 shares and sold $439,364 worth of shares (5,296 units at $82.96), increasing direct ownership by 12% to 45,413 units (SEC Form 4)

EVP, Chief Human Resources Ofc Devers Shannon L. sold $323,490 worth of shares (3,977 units at $81.34), decreasing direct ownership by 15% to 22,541 units (SEC Form 4)

Director Yang Michael J. converted options into 1,930 shares, increasing direct ownership by 32% to 7,940 units (SEC Form 4)

EVP Research Swayze Eric converted options into 21,477 shares and sold $748,383 worth of shares (9,933 units at $75.34), increasing direct ownership by 38% to 41,935 units (SEC Form 4)

EVP, Chf Clinical Develop Ofcr Schneider Eugene converted options into 21,685 shares and sold $703,138 worth of shares (9,302 units at $75.59), increasing direct ownership by 24% to 63,890 units (SEC Form 4)

EVP CLO & General Counsel O'Neil Patrick R. converted options into 21,473 shares and sold $697,045 worth of shares (9,191 units at $75.84), increasing direct ownership by 23% to 66,171 units (SEC Form 4)

Chief Executive Officer Monia Brett P converted options into 89,145 shares and sold $3,294,624 worth of shares (44,034 units at $74.82), increasing direct ownership by 25% to 224,683 units (SEC Form 4)

Amendment: SEC Form 4 filed by EVP, Chief Development Officer Kordasiewicz Holly B.

EVP, Chf GL Pdt Str Ofcr Jenne Kyle sold $138,475 worth of shares (1,823 units at $75.96) and converted options into 7,013 shares, increasing direct ownership by 46% to 16,389 units (SEC Form 4)

EVP, Chief Development Officer Kordasiewicz Holly B. converted options into 11,119 shares and sold $313,308 worth of shares (4,141 units at $75.66), increasing direct ownership by 90% to 14,718 units (SEC Form 4)

EVP, Finance & CFO Hougen Elizabeth L converted options into 28,729 shares and sold $971,993 worth of shares (12,922 units at $75.22), increasing direct ownership by 14% to 126,307 units (SEC Form 4)

EVP, Chief Human Resources Ofc Devers Shannon L. sold $634,410 worth of shares (8,353 units at $75.95) and converted options into 17,377 shares, increasing direct ownership by 52% to 26,518 units (SEC Form 4)

EVP, Corp and Development Ops Birchler Brian sold $636,933 worth of shares (8,480 units at $75.11) and converted options into 20,089 shares, increasing direct ownership by 24% to 60,435 units (SEC Form 4)

EVP, Chief Scientific Officer Bennett C Frank converted options into 21,055 shares and sold $674,622 worth of shares (8,977 units at $75.15), increasing direct ownership by 15% to 94,757 units (SEC Form 4)

EVP, Chief Business Officer Baroldi Joseph converted options into 19,887 shares and sold $610,276 worth of shares (8,056 units at $75.75), increasing direct ownership by 33% to 40,431 units (SEC Form 4)

EVP, Chief Human Resources Ofc Devers Shannon L. exercised 44,199 shares at a strike of $51.25 and sold $3,760,577 worth of shares (44,199 units at $85.08) (SEC Form 4)

SEC Form 4 filed by EVP, Chf GL Pdt Str Ofcr Jenne Kyle

SEC Form 4 filed by EVP, Chf Clinical Develop Ofcr Schneider Eugene

EVP Research Swayze Eric exercised 23,463 shares at a strike of $60.89 and sold $1,856,325 worth of shares (23,463 units at $79.12) (SEC Form 4)

SEC Form 4 filed by EVP CLO & General Counsel O'Neil Patrick R.

SEC Form 4 filed by EVP, Chief Development Officer Kordasiewicz Holly B.

SEC Form 4 filed by Chief Executive Officer Monia Brett P

New insider Kordasiewicz Holly B. claimed ownership of 7,740 shares (SEC Form 3)

SEC Form 4 filed by EVP, Finance & CFO Hougen Elizabeth L

SEC Form 4 filed by EVP, Chief Human Resources Ofc Devers Shannon L.