ITOS insider transactions

Chief Operating Officer Call Matthew closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Detheux Michel closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Director Lee David K

Chief Medical Officer Feltquate David closing all direct ownership in the company (SEC Form 4)

Chief Scientific Officer Mcgrath Yvonne closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Gall Matthew closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Director Hallal David

SEC Form 4 filed by Director Rhoads Ann D

Chief Executive Officer Detheux Michel exercised 216,592 shares at a strike of $4.30 and sold $1,048,264 worth of shares (104,565 units at $10.02), increasing direct ownership by 13% to 153,903 units (SEC Form 4)

Chief Executive Officer Detheux Michel exercised 156,847 shares at a strike of $4.30 and sold $1,592,520 worth of shares (156,847 units at $10.15) (SEC Form 4)

Director Hallal David exercised 114,682 shares at a strike of $4.30 and sold $1,164,405 worth of shares (114,682 units at $10.15) (SEC Form 4)

Large owner Ecor1 Capital, Llc bought $38,685,562 worth of shares (4,958,978 units at $7.80) (SEC Form 4)

Former 10% Owner Gadicke Ansbert sold $8,317,364 worth of shares (1,031,931 units at $8.06) (SEC Form 4)

Former 10% Owner Mpm Bioventures 2018, L.P. sold $5,079,339 worth of shares (630,191 units at $8.06) (SEC Form 4)

Former 10% Owner Mpm Bioventures 2014, L.P. sold $5,079,339 worth of shares (630,191 units at $8.06) (SEC Form 4)

Director Van Hauwermeiren Timothy exercised 22,346 shares at a strike of $4.30 (SEC Form 4)

New insider Ecor1 Capital, Llc claimed ownership of 5,730,000 shares (SEC Form 3)

Chief Financial Officer Gall Matthew was granted 24,000 shares, increasing direct ownership by 37% to 89,429 units (SEC Form 4)

Chief Scientific Officer Mcgrath Yvonne was granted 15,300 shares, increasing direct ownership by 49% to 46,300 units (SEC Form 4)

Chief Executive Officer Detheux Michel was granted 77,000 shares, increasing direct ownership by 131% to 135,903 units (SEC Form 4)

Chief Operating Officer Call Matthew was granted 24,000 shares, increasing direct ownership by 17% to 161,898 units (SEC Form 4)

Chief Medical Officer Feltquate David was granted 47,000 shares (SEC Form 4)

Chief Financial Officer Gall Matthew bought $38,635 worth of shares (5,000 units at $7.73), increasing direct ownership by 8% to 65,429 units (SEC Form 4)

SEC Form 4 filed by Chief Executive Officer Detheux Michel

SEC Form 4 filed by Chief Medical Officer Feltquate David

SEC Form 3 filed by new insider Feltquate David

SEC Form 4 filed by Director Ho Tony W

SEC Form 4 filed by Director Lee David K

SEC Form 4 filed by Director Van Hauwermeiren Timothy

SEC Form 4 filed by Director Davis Aaron I.

SEC Form 4 filed by Director Hallal David

SEC Form 4 filed by Director Desimone Jill

SEC Form 4 filed by Director Iannone Robert

SEC Form 4 filed by Director Rhoads Ann D

Boxer Capital, Llc was granted 1,142,857 shares (SEC Form 4)

Ra Capital Management, L.P. disposed of 900,000 shares (SEC Form 4)

SEC Form 4 filed by Gall Matthew

SEC Form 4 filed by Call Matthew

SEC Form 4 filed by Mcgrath Yvonne

SEC Form 4 filed by Detheux Michel

SEC Form 4 filed by Desimone Jill

SEC Form 3 filed by new insider Desimone Jill

Mcgrath Yvonne was granted 31,000 shares (SEC Form 4)

Call Matthew was granted 44,000 shares, increasing direct ownership by 47% to 137,898 units (SEC Form 4)

Gall Matthew was granted 41,000 shares, increasing direct ownership by 211% to 60,429 units (SEC Form 4)

Detheux Michel was granted 30,000 shares, increasing direct ownership by 104% to 58,903 units (SEC Form 4)

SEC Form 4 filed by Lee David K

SEC Form 3 filed by new insider Lee David K

Gall Matthew bought $41,850 worth of shares (5,000 units at $8.37), increasing direct ownership by 35% to 19,429 units (SEC Form 4)

SEC Form 4: Boxer Capital, Llc sold $5,692,673 worth of shares (350,000 units at $16.26)

SEC Form 4 filed by Van Hauwermeiren Timothy

SEC Form 4 filed by Rhoads Ann D

SEC Form 4 filed by Iannone Robert

SEC Form 4 filed by Ho Tony W

SEC Form 4 filed by Hallal David

SEC Form 4 filed by Dirocco Derek

SEC Form 4 filed by Davis Aaron I.

SEC Form 4 filed by Call Matthew

SEC Form 4 filed by Mcgrath Yvonne

SEC Form 4 filed by Lager Joanne Jenkins