NAMS insider transactions

Chief Accounting Officer Kooij Louise Frederika exercised 65,000 units of Ordinary Shares at a strike of $10.07 and sold $2,319,850 worth of Ordinary Shares (65,000 units at $35.69) as part of a pre-agreed trading plan (SEC Form 4)

Director Lange Louis G sold $1,357,230 worth of Ordinary Shares (44,619 units at $30.42), decreasing direct ownership by 81% to 10,360 units (SEC Form 4)

Director Lange Louis G sold $828,950 worth of Ordinary Shares (28,186 units at $29.41) and exercised 44,619 in-the-money units of Ordinary Shares at a strike of $11.50, increasing direct ownership by 431% to 54,979 units (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter converted options into 300,000 units of Ordinary Shares and sold $9,090,868 worth of Ordinary Shares (300,000 units at $30.30) (SEC Form 4)

Chief Executive Officer Davidson Michael H. converted options into 443,707 units of Ordinary Shares and sold $14,753,258 worth of Ordinary Shares (443,707 units at $33.25) (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter sold $1,605,998 worth of Ordinary Shares (45,481 units at $35.31), decreasing direct ownership by 46% to 53,500 units (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika exercised 72,428 units of Ordinary Shares at a strike of $10.90 and sold $2,335,860 worth of Ordinary Shares (72,428 units at $32.25) (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika sold $2,415,843 worth of Ordinary Shares (72,572 units at $33.29) and exercised 72,572 units of Ordinary Shares at a strike of $10.90 (SEC Form 4)

Chief Financial Officer Somaiya Mayur Ian exercised 100,000 units of Ordinary Shares at a strike of $9.26 and sold $3,260,618 worth of Ordinary Shares (100,000 units at $32.61) (SEC Form 4)

Director Van Der Kamp Hilde Johanna was granted 3,400 units of Ordinary Shares, increasing direct ownership by 49% to 10,360 units (SEC Form 4)

Director Gulfo Adele M. was granted 3,400 units of Ordinary Shares, increasing direct ownership by 31% to 14,260 units (SEC Form 4)

Chief Executive Officer Davidson Michael H. sold 11,582 units of Ordinary Shares and was granted 81,000 units of Ordinary Shares, increasing direct ownership by 18% to 459,859 units (SEC Form 4)

Director Lewis William was granted 3,400 units of Ordinary Shares, increasing direct ownership by 49% to 10,360 units (SEC Form 4)

Director Smither John W was granted 3,400 units of Ordinary Shares, increasing direct ownership by 49% to 10,360 units (SEC Form 4)

Director Mckenna Mark C. was granted 3,400 units of Ordinary Shares, increasing direct ownership by 49% to 10,360 units (SEC Form 4)

Director Lange Louis G was granted 3,400 units of Ordinary Shares, increasing direct ownership by 49% to 10,360 units (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter sold $199,500 worth of Ordinary Shares (6,000 units at $33.25) and was granted 25,500 units of Ordinary Shares, increasing direct ownership by 25% to 98,981 units (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika was granted 12,000 units of Ordinary Shares and sold $88,013 worth of Ordinary Shares (2,647 units at $33.25), increasing direct ownership by 62% to 24,353 units (SEC Form 4)

Chief Financial Officer Somaiya Mayur Ian sold $170,174 worth of Ordinary Shares (5,118 units at $33.25) and was granted 25,500 units of Ordinary Shares, increasing direct ownership by 54% to 58,382 units (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika exercised 145,000 units of Ordinary Shares at a strike of $10.03 and sold $5,196,741 worth of Ordinary Shares (145,000 units at $35.84) (SEC Form 4)

Director Topper James N bought $15,639 worth of Ordinary Shares (660 units at $23.70) (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika exercised 150,000 units of Ordinary Shares at a strike of $10.00 and sold $3,874,017 worth of Ordinary Shares (150,000 units at $25.83) (SEC Form 4)

Director Topper James N bought $31,487 worth of Ordinary Shares (1,260 units at $24.99) (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika sold $453,452 worth of Ordinary Shares (18,073 units at $25.09), decreasing direct ownership by 55% to 15,000 units (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika converted options into 18,073 units of Ordinary Shares, increasing direct ownership by 120% to 33,073 units (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika sold $205,567 worth of Ordinary Shares (8,269 units at $24.86), decreasing direct ownership by 36% to 15,000 units (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter sold $2,471,640 worth of Ordinary Shares (100,000 units at $24.72) (SEC Form 4)

Director Topper James N bought $11,294 worth of Ordinary Shares (471 units at $23.98) (SEC Form 4)

Chief Operating Officer Kling Douglas F exercised 98,612 units of Ordinary Shares at a strike of $10.90 and sold $2,096,655 worth of Ordinary Shares (98,612 units at $21.26) (SEC Form 4)

Director Topper James N bought $69,466 worth of Ordinary Shares (3,780 units at $18.38) (SEC Form 4)

Chief Operating Officer Kling Douglas F exercised 100,000 units of Ordinary Shares at a strike of $10.20 and sold $1,929,141 worth of Ordinary Shares (100,000 units at $19.29) (SEC Form 4)

Director Topper James N bought $167,381 worth of Ordinary Shares (8,584 units at $19.50) (SEC Form 4)

Officer Marino Michael F Iii was granted 55,000 units of Ordinary Shares (SEC Form 4)

Director Lange Louis G converted options into 68 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Marino Michael F Iii

Chief Operating Officer Kling Douglas F exercised 100,000 units of Ordinary Shares at a strike of $10.00 and sold 100,000 units of Ordinary Shares (SEC Form 4)

SEC Form 4 filed by Officer Audet Juliette Berangere

Director Lange Louis G converted options into 69 units of Ordinary Shares (SEC Form 4)

Director Lange Louis G converted options into 69 units of Ordinary Shares (SEC Form 4)

Chief Operating Officer Kling Douglas F exercised 100,000 units of Ordinary Shares at a strike of $10.00 and sold 100,000 units of Ordinary Shares (SEC Form 4)

Director Gulfo Adele M. was granted 10,860 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Gulfo Adele M.

Director Topper James N bought $25,521 worth of Ordinary Shares (1,135 units at $22.49) (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika converted options into 8,269 units of Ordinary Shares, increasing direct ownership by 55% to 23,269 units (SEC Form 4)

Director Lange Louis G converted options into 3,102 units of Ordinary Shares, increasing direct ownership by 45% to 10,062 units (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter was granted 19,302 units of Ordinary Shares and converted options into 45,481 units of Ordinary Shares, increasing direct ownership by 134% to 79,481 units (SEC Form 4)

Chief Operating Officer Kling Douglas F sold 16,539 units of Ordinary Shares and converted options into 16,539 units of Ordinary Shares (SEC Form 4)

Chief Executive Officer Davidson Michael H. was granted 30,992 units of Ordinary Shares, converted options into 38,394 units of Ordinary Shares and sold 12,258 units of Ordinary Shares, increasing direct ownership by 17% to 390,441 units (SEC Form 4)

Chief Scientific Officer Kastelein Johannes Jacob Pieter converted options into 150,000 units of Ordinary Shares (SEC Form 4)

Chief Operating Officer Kling Douglas F exercised 100,000 units of Ordinary Shares at a strike of $1.19 and sold 100,000 units of Ordinary Shares (SEC Form 4)

Director Topper James N bought $84,203 worth of Ordinary Shares (4,005 units at $21.02) (SEC Form 4)

Chief Accounting Officer Kooij Louise Frederika sold $3,055,500 worth of Ordinary Shares (150,000 units at $20.37) and converted options into 150,000 units of Ordinary Shares, decreasing direct ownership by 91% to 15,000 units (SEC Form 4)

Chief Operating Officer Kling Douglas F converted options into 100,000 units of Ordinary Shares and sold 100,000 units of Ordinary Shares (SEC Form 4)

Chief Operating Officer Kling Douglas F converted options into 70,441 units of Ordinary Shares and sold 70,441 units of Ordinary Shares (SEC Form 4)

Chief Financial Officer Somaiya Mayur Ian exercised 61,883 units of Ordinary Shares at a strike of $9.26 and sold 61,883 units of Ordinary Shares (SEC Form 4)

Chief Operating Officer Kling Douglas F converted options into 129,559 units of Ordinary Shares and sold 129,559 units of Ordinary Shares (SEC Form 4)

Director Smither John W was granted 6,960 units of Ordinary Shares (SEC Form 4)

Director Mckenna Mark C. was granted 6,960 units of Ordinary Shares (SEC Form 4)

Director Lewis William was granted 6,960 units of Ordinary Shares (SEC Form 4)

Director Van Der Kamp Hilde Johanna was granted 6,960 units of Ordinary Shares (SEC Form 4)