ONC insider transactions

Director Yi Qingqing sold $65,596 worth of American Depositary Shares (235 units at $279.13), closing all direct ownership in the company (SEC Form 4) (for withholding tax)

Director Riva Alessandro sold $65,617 worth of American Depositary Shares (212 units at $309.51), closing all direct ownership in the company (SEC Form 4) (tax liability)

Director Dugan Margaret sold $65,636 worth of American Depositary Shares (212 units at $309.60), closing all direct ownership in the company (SEC Form 4) to cover taxes

Director Sanders Corazon (Corsee) D. sold $65,633 worth of American Depositary Shares (212 units at $309.59), closing all direct ownership in the company (SEC Form 4) to cover taxes

Director Baker Bros. Advisors Lp sold $261,981 worth of Ordinary Shares (10,998 units at $23.82) (SEC Form 4) to satisfy withholding tax

Amendment: New insider Sharp Shalini claimed ownership of 9 units of American Depositary Shares (SEC Form 3)

SVP, General Counsel Lee Chan Henry exercised 332 units of American Depositary Shares at a strike of $191.56 and sold $103,159 worth of American Depositary Shares (332 units at $310.72) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Lee Chan Henry

SVP, General Counsel Lee Chan Henry sold $102,300 worth of American Depositary Shares (341 units at $300.00) and exercised 341 units of American Depositary Shares at a strike of $191.64 (SEC Form 4)

Chief Executive Officer Oyler John was granted 444,912 units of Ordinary Shares, increasing direct ownership by 9% to 5,609,275 units (SEC Form 4)

President, Global Head of R&D Wang Lai was granted 167,635 units of Ordinary Shares, increasing direct ownership by 12% to 1,619,059 units (SEC Form 4)

President and COO Wu Xiaobin was granted 247,546 units of Ordinary Shares, increasing direct ownership by 26% to 1,216,524 units (SEC Form 4)

Chief Financial Officer Rosenberg Aaron was granted 119,587 units of Ordinary Shares, increasing direct ownership by 56% to 334,919 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry was granted 95,264 units of Ordinary Shares, increasing direct ownership by 43% to 318,370 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $580,197 worth of American Depositary Shares (1,660 units at $349.52) and exercised 1,660 units of American Depositary Shares at a strike of $191.40 (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 664 units of American Depositary Shares at a strike of $191.56 and sold $220,289 worth of American Depositary Shares (664 units at $331.76) (SEC Form 4)

President, Global Head of R&D Wang Lai was granted 427,895 units of Ordinary Shares, increasing direct ownership by 42% to 1,451,424 units (SEC Form 4)

Chief Executive Officer Oyler John sold $30,659,419 worth of American Depositary Shares (100,000 units at $306.59), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 664 units of American Depositary Shares at a strike of $191.56 and sold $213,569 worth of American Depositary Shares (664 units at $321.64) (SEC Form 4)

Director Sanders Corazon (Corsee) D. exercised 2,627 units of American Depositary Shares at a strike of $159.03 and sold $895,534 worth of American Depositary Shares (2,627 units at $340.90) (SEC Form 4)

President and COO Wu Xiaobin sold $1,518,303 worth of American Depositary Shares (3,991 units at $380.43), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin sold $5,846,820 worth of American Depositary Shares (16,009 units at $365.22), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 996 units of American Depositary Shares at a strike of $191.47 and sold $347,770 worth of American Depositary Shares (996 units at $349.17) (SEC Form 4)

Chief Executive Officer Oyler John gifted 1,009,853 units of Ordinary Shares, decreasing direct ownership by 14% to 6,441,041 units (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong gifted 424,073 units of Ordinary Shares, decreasing direct ownership by 8% to 4,582,601 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,739,108 worth of American Depositary Shares (10,671 units at $350.40) and exercised 9,559 units of American Depositary Shares at a strike of $211.04, closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $9,055,694 worth of American Depositary Shares (27,803 units at $325.71), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,257,289 worth of American Depositary Shares (10,006 units at $325.53) and exercised 8,894 units of American Depositary Shares at a strike of $197.10, closing all direct ownership in the company (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong gifted 148,096 units of Ordinary Shares, decreasing direct ownership by 3% to 5,006,674 units (SEC Form 4)

Global Head of R&D Wang Lai sold $1,750,312 worth of American Depositary Shares (5,000 units at $350.06) (SEC Form 4)

Director Sanders Corazon (Corsee) D. exercised 2,665 units of American Depositary Shares at a strike of $155.68 and sold $898,105 worth of American Depositary Shares (2,665 units at $337.00) (SEC Form 4)

Principal Accounting Officer Ball Titus B. sold $39,865 worth of American Depositary Shares (122 units at $326.76), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin exercised 89,794 units of American Depositary Shares at a strike of $160.78 and sold $27,347,635 worth of American Depositary Shares (89,794 units at $304.56) (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,308,877 worth of American Depositary Shares (11,013 units at $300.45) and exercised 8,230 units of American Depositary Shares at a strike of $177.90, closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Rosenberg Aaron sold $345,659 worth of American Depositary Shares (1,190 units at $290.47), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $1,301,375 worth of American Depositary Shares (4,300 units at $302.65) (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $280,233 worth of American Depositary Shares (920 units at $304.60), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $210,000 worth of American Depositary Shares (700 units at $300.00) (SEC Form 4)

Chief Executive Officer Oyler John sold $7,044,591 worth of American Depositary Shares (27,802 units at $253.38), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $267,280 worth of American Depositary Shares (1,028 units at $260.00), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin sold $354,380 worth of American Depositary Shares (1,363 units at $260.00), closing all direct ownership in the company (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong sold $532,867 worth of American Depositary Shares (2,007 units at $265.50), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $830,360 worth of American Depositary Shares (3,174 units at $261.61), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $112,463 worth of American Depositary Shares (422 units at $266.50), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $431,699 worth of American Depositary Shares (1,647 units at $262.11), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin sold $567,742 worth of American Depositary Shares (2,173 units at $261.27), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $1,353,520 worth of American Depositary Shares (5,140 units at $263.33), closing all direct ownership in the company (SEC Form 4)

Principal Accounting Officer Ball Titus B. was granted 29,601 units of Ordinary Shares and sold $34,620 worth of American Depositary Shares (134 units at $258.36), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry was granted 46,878 units of Ordinary Shares, increasing direct ownership by 20% to 283,920 units (SEC Form 4)

Chief Financial Officer Rosenberg Aaron was granted 63,674 units of Ordinary Shares, increasing direct ownership by 38% to 230,802 units (SEC Form 4)

Global Head of R&D Wang Lai was granted 86,359 units of Ordinary Shares, increasing direct ownership by 9% to 1,058,304 units (SEC Form 4)

President and COO Wu Xiaobin was granted 123,370 units of Ordinary Shares, increasing direct ownership by 11% to 1,274,296 units (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong was granted 98,696 units of Ordinary Shares, exercised 41,760 units of American Depositary Shares at a strike of $6.50 and sold $10,975,316 worth of American Depositary Shares (41,760 units at $262.82), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John was granted 185,055 units of Ordinary Shares, increasing direct ownership by 2% to 8,281,841 units (SEC Form 4)

Director Yi Qingqing disposed of 29,614 units of Ordinary Shares, decreasing direct ownership by 52% to 27,326 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $179,280 worth of American Depositary Shares (700 units at $256.11), closing all direct ownership in the company (SEC Form 4)

Global Head of R&D Wang Lai sold $353,853 worth of American Depositary Shares (1,402 units at $252.39), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin sold $489,591 worth of American Depositary Shares (1,934 units at $253.15), closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $1,295,946 worth of American Depositary Shares (5,127 units at $252.77), closing all direct ownership in the company (SEC Form 4)

Director Yi Qingqing was granted 10,985 units of Ordinary Shares, increasing direct ownership by 24% to 56,940 units (SEC Form 4)