TECX insider transactions

Chief Medical Officer Ruddy Marcella K. sold $31,950 worth of shares (1,065 units at $30.00) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 67,682 units (SEC Form 4)

SEC Form 4 filed by Ruddy Marcella K.

SEC Form 4 filed by Nader Francois

SEC Form 3 filed by new insider Nader Francois

Chief Medical Officer Ruddy Marcella K. sold $300,000 worth of shares (10,000 units at $30.00), decreasing direct ownership by 13% to 69,747 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter sold $188,935 worth of shares (6,262 units at $30.17) and exercised 2,715 shares at a strike of $3.36, decreasing direct ownership by 6% to 55,285 units (SEC Form 4)

Chief Executive Officer Reicin Alise was granted 76,500 shares, increasing direct ownership by 33% to 311,547 units (SEC Form 4)

Chief Business Officer Schwabish Marc was granted 19,500 shares, increasing direct ownership by 76% to 45,314 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter sold $77,627 worth of shares (3,299 units at $23.53) and was granted 23,000 shares, increasing direct ownership by 50% to 58,832 units (SEC Form 4)

Chief Financial Officer Lochner Daniel was granted 26,500 shares, increasing direct ownership by 83% to 58,544 units (SEC Form 4)

Chief Medical Officer Ruddy Marcella K. was granted 26,500 shares, increasing direct ownership by 50% to 79,747 units (SEC Form 4)

Amendment: Chief Executive Officer Reicin Alise bought $52,750 worth of shares (2,500 units at $21.10) (SEC Form 4)

Chief Executive Officer Reicin Alise bought $52,750 worth of shares (2,500 units at $21.10), increasing direct ownership by 1% to 237,547 units (SEC Form 4)

Chief Business Officer Schwabish Marc exercised 4,500 shares at a strike of $2.38, increasing direct ownership by 21% to 25,814 units (SEC Form 4)

Chief Financial Officer Lochner Daniel bought $129,660 worth of shares (6,000 units at $21.61), increasing direct ownership by 23% to 32,044 units (SEC Form 4)

Chief Business Officer Schwabish Marc covered exercise/tax liability with 1,619 shares, decreasing direct ownership by 7% to 21,314 units (SEC Form 4)

Chief Medical Officer Ruddy Marcella K. covered exercise/tax liability with 2,064 shares, decreasing direct ownership by 4% to 53,247 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter covered exercise/tax liability with 1,748 shares, decreasing direct ownership by 4% to 39,131 units (SEC Form 4)

Chief Executive Officer Reicin Alise covered exercise/tax liability with 4,104 shares, decreasing direct ownership by 2% to 235,047 units (SEC Form 4)

Chief Financial Officer Lochner Daniel covered exercise/tax liability with 2,077 shares, decreasing direct ownership by 7% to 26,044 units (SEC Form 4)

Chief Executive Officer Reicin Alise exercised 10,966 shares at a strike of $2.38, increasing direct ownership by 5% to 239,151 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter exercised 7,000 shares at a strike of $2.98, increasing direct ownership by 21% to 40,879 units (SEC Form 4)

Chief Business Officer Schwabish Marc was granted 4,210 shares, increasing direct ownership by 22% to 22,933 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter was granted 4,550 shares, increasing direct ownership by 16% to 33,879 units (SEC Form 4)

Chief Medical Officer Ruddy Marcella K. was granted 5,370 shares, increasing direct ownership by 11% to 55,311 units (SEC Form 4)

Chief Executive Officer Reicin Alise was granted 14,700 shares, increasing direct ownership by 7% to 228,185 units (SEC Form 4)

Chief Financial Officer Lochner Daniel was granted 5,430 shares, increasing direct ownership by 24% to 28,121 units (SEC Form 4)

Chief Executive Officer Reicin Alise covered exercise/tax liability with 859 shares, decreasing direct ownership by 0.40% to 213,485 units (SEC Form 4)

SEC Form 4 filed by Director Vitorovic Stefan

SEC Form 4 filed by Director Donenberg Phillip B.

SEC Form 4 filed by Director Springer Timothy A

SEC Form 4 filed by Director Mcguire Terrance

SEC Form 4 filed by Director Tipirneni Praveen P.

Director Springer Timothy A bought $2,299,015 worth of shares (141,923 units at $16.20), increasing direct ownership by 0.49% to 4,334,846 units (SEC Form 4)

Director Springer Timothy A bought $8,550,000 worth of shares (500,000 units at $17.10), increasing direct ownership by 2% to 4,313,558 units (SEC Form 4)

Director Mcguire Terrance sold $8,550,000 worth of shares (500,000 units at $17.10) (SEC Form 4)

Director Springer Timothy A bought $39,999,977 worth of shares (789,294 units at $50.68), increasing direct ownership by 3% to 4,226,058 units (SEC Form 4)

Chief Financial Officer Lochner Daniel bought $249,964 worth of shares (4,617 units at $54.14) (SEC Form 4)

Chief Business Officer Schwabish Marc was granted 14,023 shares, increasing direct ownership by 298% to 18,723 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter was granted 15,141 shares, increasing direct ownership by 107% to 29,329 units (SEC Form 4)

Chief Medical Officer Ruddy Marcella K. was granted 17,876 shares, increasing direct ownership by 56% to 49,941 units (SEC Form 4)

Chief Executive Officer Reicin Alise was granted 36,047 shares, increasing direct ownership by 20% to 214,344 units (SEC Form 4)

Chief Financial Officer Lochner Daniel was granted 18,074 shares (SEC Form 4)

Chief Business Officer Schwabish Marc exercised 2,700 shares at a strike of $2.38, increasing direct ownership by 135% to 4,700 units (SEC Form 4)

Chief Business Officer Schwabish Marc exercised 2,000 shares at a strike of $2.38 (SEC Form 4)

Chief Executive Officer Reicin Alise was granted 11,717 shares, increasing direct ownership by 7% to 178,297 units (SEC Form 4)

Chief Scientific Officer Mcnamara Peter exercised 3,500 shares at a strike of $2.38, increasing direct ownership by 33% to 14,188 units (SEC Form 4)

Director Springer Timothy A bought $10,077,000 worth of shares (300,000 units at $33.59), increasing direct ownership by 8% to 4,096,764 units (SEC Form 4)

Director Springer Timothy A disposed of 1,240,893 shares, acquired 1,240,893 shares and bought $1,440,829 worth of shares (50,000 units at $28.82), increasing direct ownership by 41% to 3,796,764 units (SEC Form 4)