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    SEC Form 3: Lp Advisors Bros. Baker claimed ownership of 3,410,106 units of Common Stock

    2/25/21 7:30:48 PM ET
    $AGLE
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $AGLE alert in real time by email
    SEC FORM 3 SEC Form 3
    FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0104
    Estimated average burden
    hours per response: 0.5
    1. Name and Address of Reporting Person*
    BAKER BROS. ADVISORS LP

    (Last) (First) (Middle)
    860 WASHINGTON STREET
    3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    2. Date of Event Requiring Statement (Month/Day/Year)
    02/23/2021
    3. Issuer Name and Ticker or Trading Symbol
    Aeglea BioTherapeutics, Inc. [ AGLE ]
    4. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    X Director 10% Owner
    Officer (give title below) Other (specify below)
    5. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    Form filed by One Reporting Person
    X Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Beneficially Owned
    1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
    Common Stock 315,516 I See Footnotes(1)(3)(4)
    Common Stock 3,094,590 I See Footnotes(2)(3)(4)
    Table II - Derivative Securities Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
    Date Exercisable Expiration Date Title Amount or Number of Shares
    Warrants to purchase Common Stock (5) (5) Common Stock 1,311,405 0.0001(5) I See Footnotes(3)(4)(6)
    Warrants to purchase Common Stock (5) (5) Common Stock 14,298,923 0.0001(5) I See Footnotes(3)(4)(7)
    1. Name and Address of Reporting Person*
    BAKER BROS. ADVISORS LP

    (Last) (First) (Middle)
    860 WASHINGTON STREET
    3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    1. Name and Address of Reporting Person*
    667, L.P.

    (Last) (First) (Middle)
    860 WASHINGTON STREET, 3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    1. Name and Address of Reporting Person*
    Baker Bros. Advisors (GP) LLC

    (Last) (First) (Middle)
    860 WASHINGTON STREET
    3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    1. Name and Address of Reporting Person*
    Baker Brothers Life Sciences LP

    (Last) (First) (Middle)
    860 WASHINGTON STREET
    3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    1. Name and Address of Reporting Person*
    BAKER FELIX

    (Last) (First) (Middle)
    860 WASHINGTON STREET
    3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    1. Name and Address of Reporting Person*
    BAKER JULIAN

    (Last) (First) (Middle)
    860 WASHINGTON STREET, 3RD FLOOR

    (Street)
    NEW YORK NY 10014

    (City) (State) (Zip)
    Explanation of Responses:
    1. As a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, L.P. ("667"), Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") reported in column 2 of Table I directly held by 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.
    2. As a result of their ownership interest in (i) Baker Brothers Life Sciences Capital L.P. and (ii) Baker Brothers Life Sciences, L.P. ("Life Sciences" and together with 667, the "Funds"), Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in Common Stock reported in column 2 of Table I directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.
    3. Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds.
    4. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.
    5. These securities consist of warrants exercisable at $0.0001 per share into Common Stock on a 1-for-1 basis at any time at the option of the holder (the "Pre-Funded Warrants") subject to a 9.9% beneficial ownership limitation described below. The Prefunded Warrants are only exercisable to the extent that the holders thereof together with their affiliates and any persons who are members of a Section 13(d) group with the holders or their affiliates would beneficially own in the aggregate, for purposes of Rule 13d-3 under the Exchange Act of 1934, as amended, no more than 9.9% of the outstanding Common Stock after exercise (the "Maximum Percentage"). By written notice to the Issuer, the Funds may from time to time increase or decrease the Maximum Percentage applicable to that Fund to any other percentage. Any such increase will not be effective until the 61st day after such notice is delivered to the Issuer. The Pre-Funded Warrants have no expiration date.
    6. As a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities reported in column 3 of Table II directly held by 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP),LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.
    7. As a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported in column 3 of Table II directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.
    Remarks:
    Sara Brownstein, a full-time employee of Baker Bros. Advisors LP, was appointed as a director on the Board of Directors (the "Board") of Aeglea BioTherapeutics, Inc. (the "Issuer") on February 23, 2021. By virtue of their representation on the Board, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, the reporting persons are deemed directors by deputization of the Issuer.
    By: Baker Bros. Advisors LP, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing 02/25/2021
    Baker Bros. Advisors LP, Mgmt. Co. and Inv. Adviser to 667, L.P., pursuant to authority granted by Baker Biotech Capital, L.P., GP to 667, L.P. Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing 02/25/2021
    By: Baker Bros. Advisors (GP) LLC, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing 02/25/2021
    Baker Bros. Advisors LP, Mgmt. Co. and Inv. Adviser to BAKER BROTHERS LIFE SCIENCES, L.P., pursuant to authority granted by Baker Brothers Life Sciences Capital, L.P., GP to Baker Brothers Life Sciences, L.P., Name: Scott L. Lessing, Title: President /s/ 02/25/2021
    /s/ Felix J. Baker 02/25/2021
    /s/ Julian C. Baker 02/25/2021
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
    Get the next $AGLE alert in real time by email

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