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    Amendment: SEC Form 10-K/A filed by UroGen Pharma Ltd.

    4/30/25 4:00:34 PM ET
    $URGN
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $URGN alert in real time by email
    urgn20231231_10ka.htm
    0001668243 true FY 2024 00016682432024-01-012024-12-31 iso4217:USD 00016682432024-06-28 xbrli:shares 00016682432025-04-23
     

    --12-31FY2023

     

     



     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549


     

    Form 10-K/A

     

    (Amendment No. 1)

     


     

     

    (Mark One)

    ☑ 

    ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

     

     

    For the fiscal year ended December 31, 2024

     

     

     

    OR

     

     

    ☐ 

    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

     

     

    For the transition period from_____________ to ________________

     

    Commission file number: 001-38079

     


     

    UROGEN PHARMA LTD.

     

    (Exact name of registrant as specified in its charter)

     


     

    Israel

     

    98-1460746

    (State or other jurisdiction of

    incorporation or organization)

     

    (I.R.S. Employer

    Identification Number)

    400 Alexander Park, Princeton, NJ

     

    08540

    (Address of principal executive offices)

     

    (Zip Code)

     

     

     

    Registrant’s telephone number, including area code:

     

    (646) 768-9780

     

    Securities registered pursuant to Section 12(b) of the Act:

     

     

    Title of each class

    Trading Symbol

    Name of exchange on which registered

    Ordinary Shares, par value NIS 0.01 per share

    URGN

    The Nasdaq Stock Market LLC

     

    Securities registered pursuant to Section 12(g) of the Act: None

     

     


     

    Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☑

     

    Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ☐ No ☑

     

    Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☑ No ☐

     

    Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☑ No ☐

     

    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

     

    Large accelerated filer

    ☐

     

    Accelerated filer

    ☐

    Non-accelerated filer

    ☑

     

    Smaller reporting company

    ☑

       

    Emerging growth company

    ☐

     

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

     

    Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

     

    If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

     

    Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

     

    Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☑

     

    The aggregate market value of the ordinary shares held by non-affiliates of the registrant as of June 28, 2024 totaled approximately $675.1 million based on the closing price for the registrant’s ordinary shares on that day as reported by the Nasdaq Stock Market LLC. Such value excludes ordinary shares held by executive officers, directors and certain entities affiliated with directors as of June 28, 2024.

     

    As of April 23, 2025, there were 46,107,451 of the registrant’s ordinary shares outstanding.

     

     

     

     

    Auditor Firm ID: 238

    Auditor Name: PricewaterhouseCoopers LLP

    Auditor Location: Florham Park, New Jersey

     

     

     

     

    EXPLANATORY NOTE

     

    UroGen Pharma Ltd. (the “Company,” “our,” “us” or “we”) is filing this Amendment No. 1 on Form 10‑K/A (this “Amendment No. 1”) to our Annual Report on Form 10-K for the fiscal year ended December 31, 2024 (the “Form 10-K”), which was filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 10, 2025, to provide the information required by Part III of Form 10-K. This Amendment No. 1 amends and restates in their entirety Items 10, 11, 12, 13 and 14 of Part III of the Form 10-K.

     

    In addition, as required by Section 302 of the Sarbanes-Oxley Act of 2002 and Rule 12b-15 of the Securities Exchange Act of 1934 (the “Exchange Act”), as amended, updated certifications of the Company’s principal executive officer and principal financial officer are included as Exhibits 31.3 and 31.4 hereto. Because no financial statements have been included in this Amendment No. 1 and this Amendment No. 1 does not contain or amend any disclosure with respect to Items 307 and 308 of Regulation S-K, paragraphs 3, 4, and 5 of the certifications have been omitted. We are also not including the certifications under Section 906 of the Sarbanes-Oxley Act of 2002 as no financial statements are being filed with this Amendment No. 1. This Amendment No. 1 also amends Item 15 of Part IV to add the foregoing certifications.

     

    No other changes have been made to the Form 10-K other than those described above. This Amendment No. 1 does not reflect subsequent events occurring after the original filing date of the Form 10-K or modify or update in any way the financial statements, consents or any other items or disclosures made in the Form 10-K in any way other than as required to reflect the amendments discussed above. Accordingly, this Amendment No. 1 should be read in conjunction with the Form 10-K and the Company’s other filings with the SEC subsequent to the filing of the Form 10-K.

     

     

     

     

    Table of Contents

     

     

     

    Table of Contents

     

           

    Page

    PART III.

       

    Item 10.

     

    Directors, Executive Officers and Corporate Governance.

     

    1

    Item 11.

     

    Executive Compensation.

     

    6

    Item 12.

     

    Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.

     

    22

    Item 13.

     

    Certain Relationships and Related Transactions and Director Independence.

     

    25

    Item 14.

     

    Principal Accountant Fees and Services.

     

    27

             

    PART IV.

           

    Item 15.

     

    Exhibits, Financial Statement Schedules.

     

    28

     

     

     

     

    PART III

     

    Item 10. Directors, Executive Officers and Corporate Governance.

     

     

    Information Concerning Our Directors

     

    Our Board currently consists of seven directors. The brief biographies below include information, as of the date of this Amendment No. 1, regarding the specific and particular experience, qualifications, attributes or skills of each director that qualify such director to serve on our Board.

     

     

    Name 

     

    Age

     

    Position Held With the Company

    Arie Belldegrun, M.D., FACS

     

    75

     

    Chair of the Board

    Elizabeth Barrett

     

    62

     

    President, Chief Executive Officer and Director

    Cynthia M. Butitta

     

    70

     

    Director

    Stuart Holden, M.D.

     

    82

     

    Director

    James A. Robinson, Jr

     

    55

     

    Director

    Leana Wen, M.D., M.SC.

     

    42

     

    Director

    Daniel G. Wildman

     

    68

     

    Director

     

    Arie Belldegrun, M.D., FACS has served as our Chair of the Board since December 2012. Dr. Belldegrun is a co-founder of Allogene Therapeutics, a public biopharmaceutical company, and has served as Executive Chairman of its board of directors since November 2017. From March 2014 until October 2017 Dr. Belldegrun served as the President and Chief Executive Officer of Kite Pharma, Inc. and as a member of its board of directors from June 2009 until October 2017. He was also a Director of Gingko Bioworks (from September 2021 to November 2024). Dr. Belldegrun currently serves as Chairman of Bellco Capital LLC (since 2004); Chairman and Partner of Two River (since June 2009); Co-chairman of Breakthrough Properties LLC and Breakthrough Services, L.L.C. (since April 2019); Chairman of Kronos Bio (since November 2017); Co-chairman of Symbiotic Capital (since June 2023); and Director of ByHeart, Inc. (since October 2019). Dr. Belldegrun is also Senior Managing Director of Vida Ventures, LLC (since November 2017). Dr. Belldegrun is a Research Professor, holds the Roy and Carol Doumani Chair in Urologic Oncology, and is Founder and Director of the UCLA Institute of Urologic Oncology at the David Geffen School of Medicine at UCLA. Prior to joining UCLA, Dr. Belldegrun was at the National Cancer Institute/NIH as a research fellow in surgical oncology and immunotherapy under Dr. Steven A. Rosenberg. He completed his M.D. at the Hebrew University Hadassah Medical School in Jerusalem, his post-graduate studies in Immunology at the Weizmann Institute of Science, and his residency in urologic surgery at Harvard Medical School. He has authored several books on oncology and more than 500 scientific and medical papers related to urological cancers, immunotherapy, gene therapy and cancer vaccines. He is certified by the American Board of Urology and the American Association of Genitourinary Surgeons. Our Board believes Dr. Belldegrun’s business and medical knowledge and experience qualify him to serve on our Board.

     

    Elizabeth Barrett has served as our President and Chief Executive Officer and as a director since January 2019. Prior to joining UroGen, Ms. Barrett served as the Chief Executive Officer of Novartis Oncology and a member of the Novartis Executive Committee since February 2018. Prior to Novartis, Ms. Barrett served at Pfizer Inc. in various leadership capacities, most recently as the Global President of Oncology and, before that, as President of Global Innovative Pharma for Europe, President of the Specialty Care Business Unit for North America, and Regional President of United States Oncology. Prior to Pfizer, Ms. Barrett was Vice President and General Manager of the Oncology Business Unit at Cephalon Inc. Ms. Barrett received an M.B.A. degree in Business Administration-Marketing from Saint Joseph’s University and a B.S. from the University of Louisiana. Ms. Barrett also currently serves on the boards of directors of Sage Therapeutics, Inc. (since 2019) and Allogene Therapeutics, Inc. (since 2021). Our Board believes Ms. Barrett’s service as our Chief Executive Officer and her leadership of both large organizations and growing businesses qualify her to serve on our Board.

     

    Cynthia M. Butitta has served as our director since October 2017. Ms. Butitta served as Chief Financial Officer of Kite Pharma, Inc. from January 2014 to May 2016 and as Chief Operating Officer from March 2014 to September 2017. From May 2011 to December 2012, she was Senior Vice President and Chief Financial Officer at NextWave Pharmaceuticals Inc., a specialty pharmaceutical company. Prior to that, Ms. Butitta served as Chief Operating Officer of Telik, Inc., a biopharmaceutical company, from March 2001 to December 2010 and as its Chief Financial Officer from August 1998 to December 2010. Ms. Butitta also served as Principal Accounting Officer of Telik, Inc. until December 2010. She has served as a Director of Autolus, Ltd., a biotechnology company, since March 2018; a board member of Olema Oncology since August 2020 and Century Therapeutics, Inc. since February 2021. Ms. Butitta received her B.S. degree with honors in Business and Accounting from Edgewood College in Madison, Wisconsin and her M.B.A. degree in Finance from the University of Wisconsin-Madison. Our Board believes Ms. Butitta’s financial knowledge and experience qualify her to serve on our Board.

     

    Stuart Holden, M.D. has served as our director since December 2015. Dr. Holden has been the Chair of ProQuest Investments’ Scientific Advisory Board since it was founded in 1998. Since May 2014, Dr. Holden has served as a member of the UCLA faculty as a Health Sciences Clinical Professor of Urology, Spielberg Family Chair in Urologic Oncology, in the Department of Urology at the UCLA David Geffen School of Medicine and Associate Director of the UCLA Institute of Urologic Oncology. Dr. Holden has worked in the field of prostate cancer for more than 36 years. Dr. Holden also serves as Medical Director of the Prostate Cancer Foundation since the foundation’s inception in 1993. Dr. Holden was the director of the Louis Warschaw Prostate Cancer Center at Cedars-Sinai Medical Center and the first holder of the Warschaw, Robertson, Law Families Chair in Prostate Cancer. Dr. Holden has served as a member of the board of directors of Telormedix SA from 2008 to 2017 and served as a member of the board of directors of Acurian, Inc. from 1999 through 2014. Dr. Holden also served on the Board of the American College of Medical Informatics from 1999 through 2006 and is currently on the board of Clarus Therapeutics, Inc. In addition, he was a founding partner at Tower Urology in Los Angeles. Dr. Holden received a B.S. degree from the University of Wisconsin-Madison and completed his medical degree and received his surgical training at Weill Cornell Medical College and the New York Hospital-Cornell University Medical College. He completed his urology residency at Emory University School of Medicine and fellowships in urology and developmental genetics at Memorial Sloan-Kettering Cancer Center. He also was awarded a clinical fellowship from the American Cancer Society. Our Board believes Dr. Holden’s medical knowledge and experience qualify him to serve on our Board.

     

    James A. Robinson, Jr. has served as our director since July 2023. Mr. Robinson currently serves as the President, Chief Executive Officer and member of the board directors of A2 Biotherapeutics, Inc. Prior to this role, he served as the Chief Executive Officer of Urovant Sciences, Inc. from March 2020 through June 2023 and has served as a member of Urovant’s board of directors from March 2019 through June 2023. Prior to Urovant Sciences, Mr. Robinson held the position of President and Chief Operating Officer at Paragon Biosciences where he oversaw Paragon’s operations from April 2019 to March 2020. Previously, Mr. Robinson served as the President and Chief Operating Officer of Alkermes, where he was responsible for global commercial, new product planning, corporate planning, manufacturing, quality, human resources and business development functions. Prior to Alkermes, Mr. Robinson spent over twelve years at Astellas U.S., most recently as President, Americas Operations, where his responsibilities included all aspects of operations for North and South America. Prior to that, he was President of Astellas Pharma US, where he was responsible for leading the U.S. commercial organization. Prior to Astellas, Mr. Robinson spent thirteen years at Schering-Plough Pharmaceuticals, where his last role was Vice President, Hepatitis Sales and Managed Care. Mr. Robinson currently serves as an advisor to BridgeBio Pharma, Inc. and on the board of directors of Eledon Pharmaceuticals, Inc., a public biotechnology company, and Petauri Health, a private healthcare service company. Previously, Mr. Robinson served on the board of directors of Neos Therapeutics, Inc. prior to its acquisition by Aytu Biopharma, Inc. as well as the board of directors of Applied Genetic Technologies Corporation until its acquisition by Syncona LTD in November 2022. He also previously served on the board of directors of the Pharmaceutical Research and Manufacturers of America ("PhRMA") and served as Chairman of PhRMA’s State Committee. He is a founding member of MATTER. Mr. Robinson received a Bachelor of Science degree from DePaul University. Our Board believes Mr. Robinson’s broad business leadership experience, including his experience as an executive of commercial organizations, qualifies him to serve on our Board.

     

    Leana S. Wen, M.D., M.Sc. has served as our director since August 2022. Dr. Wen is an emergency physician and has served as a faculty member at the George Washington University since September 2019. She has been a contributing columnist for The Washington Post since June 2020, writing on health policy and public health, and a health and medical expert for CNN since August 2020. From January 2015 to October 2018, she was the health commissioner for the city of Baltimore, where she led the nation’s oldest continuously operating health department to combat the opioid epidemic and improve maternal and child health. From 2013 to 2015, Dr. Wen served as director of patient-centered care research in the department of emergency medicine at George Washington University, and authored a critically-acclaimed book on patient advocacy. She is currently on the board of the Bipartisan Policy Center and the Baltimore Community Foundation, and chairs the advisory board of the Behavioral Health Group. She has also been a global health fellow at the World Health Organization, a consultant with the China Medical Board, and a nonresident senior fellow at the Brookings Institution. Dr. Wen also served as the President of Planned Parenthood from 2018 through 2019. She has been a member of more than ten nonprofit boards, including serving as the chair of Behavioral Health System Baltimore. Dr. Wen has also served on the board of directors of Glaukos Corporation since March 2021 and also serves on its audit committee. Dr. Wen’s work has been recognized by numerous professional organizations, including as one of Modern Healthcare’s Top 50 Physician-Executives and a member of the Council on Foreign Relationships. In 2019, she was named one of TIME magazine’s 100 Most Influential People and in 2022 as one of Modern Healthcare’s 100 Most Influential People in Healthcare. She holds a B.S. from California State University, Los Angeles, an M.D. from Washington University School of Medicine and two M.Sc.s from the University of Oxford, where she was a Rhodes Scholar. She completed her residency training at Brigham & Women’s Hospital and Massachusetts General Hospital, where she was a clinical fellow at Harvard Medical School. Our Board believes Dr. Wen’s experience as a practicing physician, combined with her extensive experience working in governmental sectors, with innovative health companies, and serving on a public company board and audit committee and on nonprofit boards and foundations qualify her to serve on our Board.

     

    Daniel G. Wildman has served as our director since November 2022. Mr. Wildman is Chairman of the Board of Progenerative Medical, Inc., a pre-commercial company translating clinically proven reduced pressure technology into medical treatments for orthopedic surgeries. He also serves on the board of directors for Nyxoah S.A., Progenerative Medical, Inc. and PanTher Therapeutics, Inc. At Johnson & Johnson, Mr. Wildman led the Digital Surgery Strategy initiative where he was tasked with developing an integrated strategy for robotic surgery for the company. This strategy directly led to the 2019 acquisition of Auris Health, Inc. Prior to Digital Surgery, Mr. Wildman led Depuy Synthes Spine. In this role, he had overall responsibility for the second-largest spine surgery business in the world ($1.8B). He served in this capacity from August of 2015 to September of 2017, and during this period developed and implemented an integrated turn-around plan for the company. Previously, Mr. Wildman served as Worldwide President of Ethicon Biosurgery, a division of Ethicon, Inc. From 2003-2015 he led this global business dedicated to delivering innovative and life-saving solutions to surgeons via development and commercialization of biomaterial, biologic and combination products that changed the standard of care for intraoperative hemostasis. In this role, Mr. Wildman transitioned the company from Advanced Wound Care to Biosurgery through a combination of acquisitions, divestitures, and internal capability development, all focused on development and commercialization of meaningful innovations. The Biosurgery business at Ethicon continues to be one of the fastest growing companies in Johnson & Johnson's portfolio. Prior to Johnson & Johnson, Mr. Wildman spent 10 years with Boston Scientific Corporation in a variety of sales, marketing, operations and strategic planning roles of increasing responsibility. Mr. Wildman is an accomplished global leader. Throughout his career, he has earned a solid reputation for his strategic vision, motivational leadership, innovative technologies, ability to execute and his commitment to people development. Mr. Wildman received a Bachelor of Arts degree in Economics from St. Lawrence University in New York. Our Board believes Mr. Wildman’s business and executive experience qualify him to serve on our Board.

     

     

    Information Concerning Our Executive Officers

     

    The following table sets forth information concerning our executive officers, including their ages.

     

    Name of Executive Officer

     

    Age

     

    Position(s)

    Elizabeth Barrett

     

    62

     

    Chief Executive Officer and Director

    Chris Degnan

     

    45

     

    Chief Financial Officer

    Mark P. Schoenberg, M.D.

     

    67

     

    Chief Medical Officer

    Jason Smith

     

    53

     

    General Counsel and Chief Compliance Officer

     

    The biography of Ms. Barrett is set forth under the heading “Information Concerning Our Directors” above.

     

    Chris Degnan has served as our Chief Financial Officer since October 2024. Prior to joining UroGen, Mr. Degnan served as the Chief Financial Officer of Galera Therapeutics, Inc., a public, late-stage biopharmaceutical company focused on oncology, from October 2019 to August 2024. Prior to Galera, Mr. Degnan served as the Chief Financial Officer of Verrica Pharmaceuticals Inc., a public, biotechnology company focused on medical dermatology, from March 2018 to October 2019. Prior to Verrica, Mr. Degnan held roles of increasing responsibility at Endo International plc, a generics and specialty branded pharmaceutical company, beginning in November 2014. At Endo, Mr. Degnan most recently served as the Vice President of Finance, Corporate FP&A and International Pharmaceuticals Segment Chief Financial Officer from December 2016 to March 2018. Prior to that, he served as the Vice President of Finance, Chief Financial Officer for Endo’s U.S. Branded Pharmaceuticals segment from March 2016 to December 2016, and as the Senior Finance Director, U.S. Branded Pharmaceuticals from November 2014 to March 2016. Prior to joining Endo, Mr. Degnan held roles of increasing responsibility at AstraZeneca plc, a global biopharmaceutical company, beginning in 2004. At AstraZeneca, Mr. Degnan most recently served as Senior Finance Director, U.S. Commercial Finance from July 2013 to November 2014. Mr. Degnan is a Certified Public Accountant in the State of Pennsylvania (voluntary inactive status) and holds a B.B.A. degree in Accountancy from the University of Notre Dame.

     

    Mark P. Schoenberg, M.D. has served as our Chief Medical Officer since December 2017 and, prior to that, served as our Medical Director since February 2016. Dr. Schoenberg has over 20 years of experience in clinical practice and research focused on the care of patients with all forms of bladder cancer. Since April 2014, Dr. Schoenberg has been University Professor and Chair of the Urology Department at The Montefiore Medical Center for The Albert Einstein College of Medicine of Yeshiva University. Prior to joining Montefiore, from 2005 to 2014, Dr. Schoenberg served as Director of Urologic Oncology and Bernard L. Schwartz Distinguished Professor of Urologic Oncology at Johns Hopkins Hospital. Dr. Schoenberg is also the past chair of the Medical Advisory Board of the Bladder Cancer Advocacy Network, the author of The Guide to Living with Bladder Cancer, co-editor of The Textbook of Bladder Cancer, a contributor to Campbell’s Urology and a past Senior Editor of the journal Seminars in Urologic Oncology. Dr. Schoenberg received his M.D. (Alpha Omega Alpha) from the University of Texas Health Sciences Center and completed his residency in General Surgery and Urology at the Hospital of The University of Pennsylvania, where he served as chief resident and urology instructor, before completing basic research and clinical urologic oncology fellowships at Johns Hopkins under the auspices of The American Cancer Society. Dr. Schoenberg is a fellow of the American College of Surgeons, as well as a member of the American Association of Cancer Research, the Society of Urologic Oncology and the American Urological Association.

     

    Jason Smith has served as our General Counsel, Chief Compliance Officer and Corporate Secretary since August 2020. Mr. Smith is responsible for leading our legal, intellectual property, and corporate compliance functions. Mr. Smith joined us from Pfizer Inc., where he served as Chief Counsel, Oncology from August 2016 to August 2020. Prior to Pfizer, Mr. Smith worked in the legal department at Wyeth in a variety of roles including as antitrust counsel, Global Product Counsel and Chief Counsel, U.S. Pharmaceuticals, leading a team of lawyers supporting the prescription pharmaceuticals businesses. Before joining Wyeth, Mr. Smith was an associate at Howrey, Simon, Arnold & White in Washington, DC, in the antitrust and commercial litigation groups. Mr. Smith received his bachelor's degree in Economics, cum laude from Binghamton University and his juris doctor degree, with high honors, from George Washington University.

     

    Family Relationships

     

    There are no family relationships among any of our directors or executive officers.

     

    Delinquent Section 16(a) Reports

     

    Section 16(a) of the Exchange Act requires the Company’s directors and executive officers, and persons who own more than ten percent of a registered class of the Company’s equity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of ordinary shares and other equity securities of the Company. Officers, directors and greater than ten percent shareholders are required by SEC regulation to furnish the Company with copies of all Section 16(a) forms they file.

     

    During the year ended December 31, 2024, Mr. Kim, Dr. Schoenberg, and Mr. Smith each filed a Form 4 on September 12, 2024 for transactions that occurred September 9, 2024.

     

    Conduct and Ethics

     

    We have adopted a Corporate Code of Ethics and Conduct (the “Code of Conduct”) applicable to all of our employees, executive officers and directors. The Code of Conduct is available on our website at www.urogen.com. Our Audit Committee is responsible for monitoring the implementation of the Code of Conduct and must approve any material changes to or waivers of the Code of Conduct regarding our directors or executive officers, and disclosures made in the Company’s annual report in such regard. In addition, we intend to post on our website all disclosures that are required by law or the listing standards of the applicable stock exchange concerning any amendments to, or waivers from, any provision of the Code of Conduct.

     

    Audit Committee

     

    Our Board of Directors has a standing Audit Committee established in accordance with Section 3(a)(58)(A) of the Exchange Act. Our Audit Committee consists of Ms. Butitta, Dr. Holden and Dr. Wen. Ms. Butitta serves as Chair of the Audit Committee. All members of our Audit Committee meet the requirements for financial literacy under the applicable rules and regulations of the SEC and Nasdaq. Our Board has determined that Ms. Butitta is an “audit committee financial expert” as such term is defined in the applicable SEC rules and has the requisite financial experience as defined by the Nasdaq listing standards. Each of the members of our Audit Committee is “independent” as such term is defined in Rule 10A-3(b)(1) under the Exchange Act and satisfies the independent director requirements under the Nasdaq listing standards.

     

     

    Insider Trading Policy; Hedging and Pledging Policy 

     

    We have adopted an insider trading policy (“Insider Trading Policy”) governing the purchase, sale, and/or other dispositions of the Company’s securities by directors, officers, and other employees of the Company that is designed to promote compliance with insider trading laws, rules and regulations, as well as procedures designed to further the foregoing purposes. A copy of our Insider Trading Policy is filed as an exhibit to the Form 10-K for our fiscal year ended December 31, 2024. In addition, it is the Company’s intent to comply with applicable laws and regulations relating to insider trading.

     

    Our Insider Trading Policy also prohibits our directors, officers and employees, and generally any entities or family members of such individuals whose trading activities are controlled or influenced by any such persons, from engaging in short sales, transactions in put or call options, hedging transactions, margin accounts or other inherently speculative transactions with respect to our equity securities, which protects against short-term decision making.

     

    Item 11. Executive Compensation.

     

     

    EXECUTIVE COMPENSATION

     

    We are a “smaller reporting company” under Item 10 of Regulation S-K promulgated under the Exchange Act and the following compensation disclosure is intended to comply with the requirements applicable to smaller reporting companies. Although the rules allow us to provide less detail about our executive compensation program than companies that are not smaller reporting companies, our Compensation Committee is committed to providing the information necessary to help shareholders understand its executive compensation-related decisions. Accordingly, this section includes supplemental narratives that describe our 2024 compensation program for our named executive officers.

     

    Overview

     

    Our fundamental objective is to advance patient care while creating consistent long-term value for our shareholders. To accomplish this objective, we have established an overall compensation program intended to attract and retain highly qualified executives, incentivize achievement of our key performance goals in order to align our executives’ interests with those of our shareholders and link pay to company performance. We take a holistic approach to assessing Company performance, and identify corporate objectives that align with our short- and long-term strategic priorities, and build towards creation of long-term, sustainable shareholder value.

     

    Our 2024 corporate performance highlights include the following:

     

     

    ●

    Our UGN-102 Pivotal ENVISION trial demonstrated a 12-month duration of response of 82.3% (95% CI, 75.9%, 87.1%), by Kaplan-Meier estimate, for patients who achieved a complete response at three months after the first instillation of UGN-102.

     

     

    ●

    Our new drug application (NDA) for UGN-102 was accepted in October 2024 and is under review by the FDA, with a Prescription Drug User Fee Act (PDUFA) target action date set for June 13, 2025.

     

     

    ●

    We secured an exclusive license from medac GmbH to develop a next-generation novel mitomycin-based formulation for urothelial cancers.

     

     

    ●

    We received a new U.S. patent that covers the use of our UGN-103 and UGN-104 development programs in the treatment of low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) and low-grade upper tract urothelial cancer (LG-UTUC), respectively. The U.S. patent has an expiration date in December 2041. UGN-103 and UGN-104 combine our proprietary RTGel technology with medac GmbH’s licensed proprietary lyophilized mitomycin formulation.

     

     

    ●

    We entered into multiple strategic research collaborations to explore the potential of our proprietary RTGel technology to enhance clinical effectiveness of multiple immunotherapies in support of long-term growth strategy.

     

     

    ●

    We restructured our loan agreement with Pharmakon Advisors providing UroGen with additional funding of up to $100 million.

     

     

    ●

    We completed an underwritten public offering of ordinary shares for aggregate gross proceeds of $123.6 million, before deducting underwriting discounts and commissions and offering expenses.

     

     

    ●

    JELMYTO® achieved net product revenue of $90.4 million in 2024, compared with $82.7 million in 2023, driven by underlying demand revenue growth of 12% for 2024.

     

    The following discussion describes our executive compensation process and policies. It provides qualitative information on the factors relevant to these decisions and the manner in which compensation is awarded to our named executive officers for the fiscal year ended December 31, 2024, which consisted of our principal executive officer, our current principal financial officer, our general counsel and chief compliance officer, and our former principal financial officer. These named executive officers were as follows:

     

    Name

    Position(s)

    Elizabeth Barrett 

    President and Chief Executive Officer

    Chris Degnan

    Chief Financial Officer

    Jason Smith

    General Counsel and Chief Compliance Officer

    Don Kim Former Chief Financial Officer

     

     

    Objectives, Philosophy and Elements of Executive Compensation

     

    Our compensation program aims to achieve the following main objectives:

     

     

    ●

    attract, retain and reward highly qualified executives;

     

    ●

    provide incentives that motivate executives to achieve our key performance goals that create shareholder value;

     

    ●

    align our executives’ interests with those of our shareholders; and

     

    ●

    link pay to company performance.

     

    The Company’s executive compensation program is overseen by the Compensation Committee with the advice and support of an independent third-party compensation consultant. The following are key characteristics of the Company’s executive compensation program:

     

     

    ●

    A substantial portion of executive pay is tied to performance. We structure a significant portion of our named executive officers’ compensation to be variable. Annual cash performance bonuses and long-term equity compensation are dependent on achievement of corporate performance objectives and determined by the Compensation Committee.

     

     

    ●

    Our executive bonuses are dependent on the Company and the officer achieving annually determined objectives. As a smaller reporting company with significant development-stage activities, we take a holistic approach to evaluating the Company's performance. We measure performance against challenging objectives established at the beginning of each performance cycle. We establish a broad set of measurable performance objectives that align with our long-term strategic priorities and build towards lasting long-term value. Our annual performance-based bonus opportunities for all our named executive officers are determined by the Compensation Committee, and ultimately the Board, based upon the Company’s and the officer’s achievement of objectives determined on an annual basis by the Company.

     

     

    ●

    We emphasize long-term equity incentives. Equity awards are an integral part of our executive compensation program and comprise the primary “at-risk” portion of our named executive officer compensation package. During 2024, we granted our executive officers options to purchase our ordinary shares, restricted stock units and performance stock units. These awards strongly align our executive officers’ interests with those of our shareholders by providing a continuing financial incentive to maximize value for our shareholders and by encouraging our executive officers to remain in our long-term employ. Options and restricted stock units granted to our named executive officers in 2024 vest in equal annual installments over three years from the vesting commencement date. Performance stock units granted to our executive officers in 2024 will vest upon the first sale of our product candidate UGN-102, directly tying a substantial component of our executive officers' total compensation to performance against one of the primary drivers of long-term value.

     

     

    ●

    Our Compensation Committee has retained Compensia as an independent third-party compensation consultant for guidance in making compensation decisions. The compensation consultant advises the Compensation Committee on market practices, including identifying a peer group of companies and their compensation practices, so that our Compensation Committee can regularly assess the Company’s individual and total compensation programs against these peer companies, the general marketplace and other industry data points.

     

     

    ●

    We do not provide our executive officers with any excise tax gross ups.

     

     

    ●

    We have not repriced options.

     

     

    ●

    We do not provide executive fringe benefits or perquisites to our executives.

     

    Our executive compensation program generally consists of, and is intended to strike a balance among, the following three principal components: base salary, annual performance-based bonuses and long-term incentive compensation. We provided signing bonuses to our executive officers when they joined the Company. We also provide our executive officers with benefits available to all our employees, including participation in employee benefit plans. The following chart summarizes the three main elements of compensation, their objectives and key features.

     

    Element of
    Compensation

     

    Objectives

     

    Key Features

    Base Salary
    (fixed cash)  

     

    Provides financial stability and security through a fixed amount of cash for performing job responsibilities.

     

    Generally reviewed annually and determined based on a number of factors, including in part, market data provided by our independent compensation consultant.

             

    Performance Bonus
    (at-risk cash) 

     

    Motivates and rewards for attaining key annual Company and executive officer performance objectives.

     

    Target bonus amounts are generally reviewed annually and determined based upon positions that have similar impact on the organization and competitive bonus opportunities in our market. Bonus opportunities are dependent upon achievement of specific corporate performance objectives consistent with our strategic plan and individual performance objectives that relate to the officer’s role and expected contribution toward reaching our corporate goals, determined by the Board and communicated at the beginning of the year. Actual bonus amounts earned are determined at the end of the year, taking into account corporate and individual performance objectives.

             

    Long-Term Incentive
    (at-risk equity) 

     

    Motivates and rewards for long-term Company performance; aligns executives’ interests with shareholder interests and changes in shareholder value.

     

    Attracts highly qualified executives and encourages their continued employment over the long-term.

     

    Equity opportunities are generally reviewed annually and may be granted during the first half of the year or as appropriate during the year for new hires, promotions, or other special circumstances, such as to encourage retention, or as a reward for significant achievement. Individual awards are determined based on a number of factors, including current corporate and individual performance and market data provided by our independent compensation consultant.

             

     

     

    We focus on providing a competitive compensation package to our executive officers which provides short- and long-term incentives for the achievement of measurable Company and executive officer objectives. We believe that this approach provides an appropriate blend of short-term and long-term incentives to maximize shareholder value. We generally do not have any formal policies for allocating compensation among salary, performance bonus awards and equity grants, short-term and long-term compensation or among cash and non-cash compensation, although total annual cash bonus compensation to any individual is capped at 150% of such individual’s salary pursuant to our Officers Compensation Policy. Our Compensation Committee uses its judgment to establish a total compensation program for each named executive officer that is a mix of current, short-term and long-term incentive compensation, and cash and non-cash compensation, that it believes is appropriate to achieve the goals of our executive compensation program and our corporate objectives. In 2024 our Actual CEO compensation was as follows:

     

    ceocompensation.jpg

     

     

    To ensure the alignment of our executive officer incentives with shareholder interests, we have historically structured a significant portion of the named executive officers’ total target compensation with performance-based bonus opportunities and long-term incentive equity awards. Additionally, in 2024, half of the value of our CEO’s long-term incentive equity awards were in the form of performance stock units which vest upon the first sale of our lead product candidate UGN-102, directly tying a substantial component of our CEO’s total compensation to performance against one of the primary drivers of long-term value creation. Our CEO's total direct compensation for 2024 was positioned at approximately the 20th percentile of our compensation peer group. Our non-CEO executives' total direct compensation for 2024 was positioned at approximately the 15th percentile of our compensation peer group (see section titled "Use of Competitive Market Compensation Data" below for more detail on the selection of our compensation peer group).

     

    2024 Say-on-Pay Results

     

    At our 2024 annual meeting of shareholders, we held a shareholder advisory vote on executive compensation, commonly referred to as a “say-on-pay” vote, which resulted in over 87% of the total votes cast being in favor of the advisory proposal, representing a significant increase over the prior year’s approval percentage.

     

    We continue to assess and enhance our approach to executive compensation by seeking feedback from shareholders and reviewing the analyses of the Institutional Shareholder Services and Glass Lewis published reports. Our approach to aligning pay and performance focuses on maintaining a significant portion of executive’s annual total compensation based on evaluation of individual executives' performance against our corporate objectives. We take a holistic approach to assessing Company performance, undertake a robust goal-setting process to determine corporate objectives that align with our short- and long-term strategic priorities, and build towards creation of shareholder value.

     

    We continually endeavor to align our executives' interests with those of our shareholders, and link pay to company performance. We have identified receipt of U.S. regulatory approval for our lead product candidate UGN-102 as critical short and long-term strategic objectives. In 2024 and 2025, we have included performance stock units as part of our officers’ long-term incentive compensation, with vesting of these performance stock units upon the first commercial sale of UGN-102 and upon achievement of a net product sales target for UGN-102, respectively, directly tying a substantial component of our officers’ total compensation to the primary drivers of long-term value.

     

    Our next “say-on-pay” vote will be held at our 2025 annual meeting of shareholders.

     

    Our Compensation Governance Structure 

     

    Role of our Compensation Committee, Management and the Board

     

    The Compensation Committee is appointed by the Board and has responsibilities related to the compensation of the Company’s directors, officers, and employees and the development and administration of the Company’s compensation plans. For details on the Compensation Committee’s oversight of the executive compensation program, see the section above titled “Compensation Committee”. Our Compensation Committee consists solely of independent members of the Board.

     

    The Compensation Committee reviews all compensation paid to our executive officers, including our named executive officers. The Chief Executive Officer evaluates and provides to the Compensation Committee performance assessments and compensation recommendations. While the Chief Executive Officer discusses her recommendations with the Compensation Committee, she does not participate in the deliberations concerning her own compensation. More specifically, the Compensation Committee discusses and makes final recommendations to the Board with respect to executive compensation matters without the Chief Executive Officer present during discussions of the Chief Executive Officer’s compensation. From time to time, various other members of management and other employees as well as outside advisors or consultants may be invited by the Compensation Committee to make presentations, provide financial or other background information or advice or otherwise participate in the Compensation Committee meetings.

     

    The Compensation Committee meets periodically throughout the year to manage and evaluate our executive compensation program, and generally determines the principal components of compensation (base salary, performance bonus and equity awards) for our executive officers on an annual basis; however, decisions may occur at other times for new hires, promotions or other special circumstances as our Compensation Committee determines appropriate. The Compensation Committee does not delegate authority to approve executive officer compensation. The Compensation Committee does not maintain a formal policy regarding the timing of equity awards to our executive officers. The Compensation Committee will continue to monitor and evaluate our executive compensation program in light of our shareholders’ views, before making any adjustments, and continue to consider the outcome of our say-on-pay votes and our shareholders’ views when making future compensation decisions for our named executive officers.

     

    Role of Compensation Consultant

     

    The Compensation Committee has the sole authority to retain compensation consultants to assist in its evaluation of executive compensation, including the authority to approve the consultant’s reasonable fees and other retention terms. The Compensation Committee has retained Compensia, Inc. (“Compensia”), a management consulting firm that provides executive compensation and advisory services to compensation committees of life sciences companies, as its compensation consultant. A representative of Compensia attends meetings of the Compensation Committee at the invitation of the Committee. In addition, Compensia supported the selection of companies included in our compensation peer group, provided competitive market assessments of the compensation of our executive officers and non-employee director compensation programs, and provided support on other matters as requested by the Compensation Committee.

     

    The Compensation Committee has analyzed whether the work of Compensia as compensation consultant raises any conflict of interest, taking into account relevant factors in accordance with SEC guidelines. Based on its analysis, our Compensation Committee determined that the work of Compensia and the individual compensation advisors employed by Compensia does not create any conflict of interest pursuant to the SEC rules and Nasdaq listing standards.

     

    Use of Competitive Market Compensation Data

     

    The Compensation Committee believes that it is important when making its compensation decisions to be informed as to the current practices of comparable public companies with which we compete for top talent.

     

    Working with Compensia, the Compensation Committee approved a group of companies that were identified as peers based on alignment with our Company’s industry, stage of drug development, headcount, and market capitalization. The peer group that was identified and used in research that informed executive compensation for 2024 included the following companies: 2seventy bio, Arcus Biosciences, Day One Biopharmaceuticals, Deciphera Pharmaceuticals, Eagle Pharmaceuticals, Erasca, IDEAYA Biosciences, Inhibrx, iTeos Therapeutics, Karyopharm Therapeutics, Kura Oncology, RAPT Therapeutics, Rigel Pharmaceuticals, Syndax Pharmaceuticals, Tango Therapeutics, Verastem, Xencor and Y-mAbs Therapeutics. 

     

    Compensia completed a benchmarking assessment of our historical executive compensation at the end of 2023 to inform the Compensation Committee’s determinations regarding executive compensation for 2024 using data compiled from the aforementioned peer group. Identification of peers included consideration of comparable market capitalization, revenues, investigational and/or in-line portfolio, number of employees as well as stage and maturity of the peer company. Compensia prepared and the Compensation Committee reviewed, a range of market data reference points with respect to base salary, performance bonuses, target total cash compensation (base salary and the annual target performance bonus), equity compensation, and total direct compensation (target total cash compensation and equity compensation) with respect to each of the named executive officers.

     

    Additionally, Compensia performed benchmarking analysis of actual 2024 executive compensation awarded as compared to the following peers: Acrivon Therapeutics, Arcus Biosciences, Arvinas, Aura Biosciences, C4 Therapeutics, Day One Biopharmaceuticals, Erasca, IDEAYA Biosciences, iTeos Therapeutics, Kura Oncology, Olema Pharmaceuticals, Rigel Pharmaceuticals, Sutro Biopharma, Syndax Pharmaceuticals, Tango Therapeutics, Tyra Biosciences, Xencor and Y-mAbs Therapeutics. Changes in the peer group were driven by consideration of comparable market capitalization, as well the acquisition of several companies in the prior peer group. This benchmarking analysis found that overall target total direct compensation awarded in 2024 was at approximately the 15th percentile for our executive officers excluding the CEO and the 20th percentile for the CEO. This analysis of 2024 compensation and other research performed by Compensia is then used to inform the Compensation Committee’s determinations regarding executive compensation for 2025.

     

    Factors Used in Determining Executive Compensation

     

    Our Compensation Committee sets the compensation of our executive officers at levels they determine to be competitive and appropriate for each named executive officer, using their professional experience and judgment. Pay decisions are not made by use of a formulaic approach or benchmark; the Compensation Committee believes that executive pay decisions require consideration of a multitude of relevant factors which may vary from year to year. In making executive compensation decisions, the Compensation Committee generally takes into consideration the factors listed below.

     

     

    ●

    Company performance and existing business needs

     

    ●

    Each named executive officer’s individual performance, scope of job function and the critical skill set of the named executive officer to the Company’s future performance

     

    ●

    The need to attract new talent to our executive team and retain existing talent in a highly competitive industry

     

    ●

    A range of market data reference points, as described above under “Use of Competitive Market Compensation Data” 

     

    ●

    Recommendations from consultants on compensation policy determinations for the executive officer group

     

    2024 Executive Compensation Summary

     

    Base Salary

     

    The base salaries of our executive officers are designed to compensate them for day-to-day services rendered during the fiscal year. Appropriate base salaries are used to recognize the experience, skills, knowledge and responsibilities required of each executive officer and to allow us to attract and retain individuals capable of leading us to achieve our business goals in competitive market conditions.

     

    The base salaries of our executive officers are reviewed at least annually by our Compensation Committee and adjustments are made to reflect Company and individual performance, as well as competitive market practices. Our Compensation Committee also takes into account subjective performance criteria, such as an executive officer’s ability to lead, organize and motivate others, develop the skills necessary to mature with us, set realistic goals to be achieved in his or her respective area, and recognize and pursue new business opportunities that enhance our growth and success. Our Compensation Committee does not apply specific formulas to determine increases, but instead makes an evaluation of each executive officer’s contribution to our long-term success. Annual adjustments to base salaries are effective as of March 1 of each year, with mid-year adjustments to base salaries made under special circumstances, such as promotions or increased responsibilities, or to align certain base salaries with those of individuals in comparable positions at the companies in our compensation peer group.

     

    The 2024 base salaries for our named executive officers were as follows:

     

     

    Executive

     

    Base
    Salary

       

    Percentage
    Increase
    in Base
    Salary from
    December 2023

     

    Elizabeth Barrett

       

     $831,342

         

    4.00%

     

    Chris Degnan

       

     $500,000

         

    *

     

    Jason Smith

       

     $478,067

         

    4.00%

     
    Don Kim      $435,120       12.00%  

     

    * Mr. Degnan commenced employment with us in October 2024.

     

    Annual Performance Bonus

     

    Our named executive officers are eligible to receive performance-based cash bonuses, which are designed to provide appropriate incentives to our executive officers to achieve defined annual corporate goals and to reward them for individual performance towards these goals. The annual performance-based bonus that each named executive officer is eligible to receive is generally based on the extent to which we achieve the corporate objectives that the Board establishes each year. At the end of the year, the Board and Compensation Committee review the Company’s performance and approve the extent to which we achieved each of these corporate goals. Generally, the Board and Compensation Committee will assess each named executive officer’s individual contributions towards reaching our annual corporate goals and objectives but does not typically establish specific individual goals for our named executive officers.

     

    The table below sets forth the targets for our named executive officers for 2024, as provided for in their respective employment agreements. The target percentage is paid as a percentage of such executive officer’s base salary. For example, if 100% of the Company’s performance goals are achieved, this would yield our Chief Executive Officer, Elizabeth Barrett, a cash incentive award of 75% of her base salary.

     

     

    Executive Officer

     

    Target
    Percentage of
    Base Salary

     

    Elizabeth Barrett

       

    75%

     

    Chris Degnan

       

    50%

     

    Jason Smith

       

    50%

     
    Don Kim     50%  

     

    In late 2023, the Compensation Committee finalized the corporate goals for the 2024 performance year as described below. Our objective corporate goals were designed to be challenging to achieve and are directly aligned with our specific strategic goals, including advancing our development programs, our research function, our clinical activities, commercialization activities and certain corporate and financial goals, which we believe will create value for shareholders. The maximum possible corporate achievement for 2024 was 150% of our 2024 corporate goals (up to 100% for the core goals and 50% for the stretch goals), regardless of whether the maximum weighting of 60% for the stretch goals were achieved. In December 2024, the Compensation Committee and the Board evaluated the accomplishments and performance of the Company against such corporate goals, including progress towards the goal in making their recommendations for the ultimate funding levels, and the Board made the following determinations regarding corporate performance achieved against the pre-established performance goals.

     

    Corporate Goal – Core

     

    Weighting

     

    Corporate
    Achievement

    FDA acceptance of UGN-102 application by Oct 31st 2024    

    65%

     

    Achieved

    Achieve $100 million in revenue    

    35%

     

    Not Achieved

     

    Corporate Goal – Stretch

     

    Weighting

     

    Corporate
    Achievement

    Exceed $100 million revenue target by 10%, 20%, 30%

     

    5%, 10%, 15% (max 15%)

     

    Not Achieved

    Accelerated FDA acceptance of UGN-102 by 30, 60, 90 days ahead of Oct 31st, 2024   10%, 15% 25% (max 25%)  

    Not Achieved

    Execute a Strategic Partnership/Business Development Deal (1)  

    20%

     

    Achieved

     

    (1) Entered into multiple strategic research collaborations to explore the potential of our proprietary RTGel technology to enhance clinical effectiveness of multiple immunotherapies in support of long-term growth strategy. 

     

    In January 2025, the Board reviewed and approved corporate cash incentives as set forth in the table below. The Compensation Committee or Board may, in its sole discretion, eliminate any individual cash incentive or reduce or increase the amount of compensation payable with respect to any individual cash incentive.

     

       

    2024 Target Annual Cash
    Incentive

       

    2024 Actual Annual Cash
    Incentive Paid

     

    Named Executive Officer

     

    % of Base Salary

       

    $

       

    % of Target Annual Cash Incentive

       

    $

     

    Elizabeth Barrett

       

    75%

       

    $

     623,507

         

    85%

       

    $

    529,981

     

    Chris Degnan

       

    50%

       

    $

     250,000

         

    92%

       

    $

    53,125 (1)

     

    Jason Smith

       

    50%

       

    $

     239,034

         

    85%

       

    $

    203,179

     
    Don Kim (2)     50%     $ 217,560        —        —  

     

    (1)

    The actual annual cash incentive paid to Mr. Degnan has been prorated for the period from the date of hire, October 8, 2024, to year-end, December 31, 2024.  

    (2) Mr. Kim resigned from his positions as the Company’s Chief Financial Officer, Principal Financial Officer, and Principal Accounting Officer, effective October 8, 2024. As a result, his annual cash incentive is included under "All Other Compensation" in the Summary Compensation Table, as part of his separation agreement.

     

     

    Equity Awards

     

    In 2024, the Compensation Committee approved the following grants of options to purchase our ordinary shares, restricted stock units and performance stock units to our named executive officers.

     

     

     

    Executive

     

    Share Option Grant
    (# shares)

       

    Restricted
    Stock units

    (# shares)

       

    Performance Stock units

    (# shares)

    Elizabeth Barrett

       

    -

         

    87,615

       

    87,615

    Chris Degnan (1)

       

    74,142

         

    13,450

       

    -

    Jason Smith

       

    -

         

    16,500

       

    16,500

    Don Kim     -       12,000     12,000

     

    (1)

    Grants to Mr. Degnan reflect new hire grants. Since Mr. Degnan commenced employment with us in October 2024, he did not receive a performance stock unit.  

     

    All options and restricted stock units granted to our named executive officers above vest in equal annual installments over three years from the vesting commencement date, subject to the continued service of the named executive officer through each vesting date. Performance stock units vest based on the first commercial sale of our lead product candidate UGN-102, subject to the continued service of the named executive officer through the vesting date. The annual equity grants to our named executive officers are evaluated and approved by the Compensation Committee in the context of each named executive officer’s total compensation and take into account the market data provided by compensation consultants in addition to the individual officer’s responsibilities and performance. New hire equity grants to our named executive officers are evaluated and approved by the Compensation Committee and the Board based on competitive market data provided by compensation consultants as well as such officer’s experience and expected contributions. The Compensation Committee also takes into account the recommendations of the Chief Executive Officer with respect to appropriate grants and any particular individual circumstances, other than with respect her own grants.

     

    Other Features of Our Executive Compensation Program

     

    Agreements with Our Named Executive Officers

     

    We have entered into written employment agreements with each of our executive officers. Each of these employment agreements provides for “at will” employment and set forth the initial compensation arrangements for the executive officer, including an initial base salary, an annual cash opportunity, and an equity award recommendation. These agreements and the proprietary information and invention assignment agreements each executive officer executes upon commencing employment at the Company also set forth the rights and responsibilities of each party and include, among other rights and responsibilities, the prohibition on the executive officer from engaging directly or indirectly in competition with us, soliciting any of our employees, or disclosing our confidential information.

     

    Below are descriptions of our employment agreements with our named executive officers. For a discussion of the severance payments and other benefits to be provided in connection with an involuntary termination of employment, including in connection with a change in control of the Company under the arrangements with our executive officers, please see “Severance and Change in Control Benefits” below.

     

    Elizabeth Barrett. On January 3, 2019, we entered into an employment agreement with Ms. Barrett, which was amended in January 2021 to provide certain change in control benefits, as described in more detail below under “Severance and Change in Control Benefits”. Pursuant to her employment agreement, Ms. Barrett (i) received a signing bonus of $300,000 (subject to full repayment if she resigned without good reason, or the Company terminated her employment for cause, before January 3, 2020); (ii) received an initial annual base salary of $700,000; (iii) was eligible to receive an annual discretionary bonus for 2019 of up to 100% of her base salary, with 50% guaranteed; and (iv) is eligible to receive annual discretionary bonuses for years following 2020, with an annual target bonus of 50% of her base salary. In December 2023, the Board approved an increase in the annual bonus target from 50% to 75% to be effective starting with the 2024 performance year.

     

    Pursuant to her employment agreement, Ms. Barrett was also initially granted a restricted stock unit covering 317,065 of our ordinary shares and an option to purchase 277,432 ordinary shares. Under the terms of an omnibus amendment of Ms. Barrett’s prior equity award agreements, executed in January 2021, the remainder of the unvested shares underlying both of these equity awards vested in full in January 2022, in lieu of the prior monthly vesting.

     

    Chris Degnan. On October 7, 2024, we entered into an employment agreement with Mr. Degnan. Pursuant to the terms of the agreement, Mr. Degnan receives an annual base salary of $500,000 and is eligible for a target annual cash bonus equal to 50% of his base salary (pro-rated in the case of a partial year). Mr. Degnan was granted an initial new hire option to purchase 74,142 ordinary shares and 13,450 restricted stock units.

     

    Jason Smith. On August 12, 2020, we entered into an employment agreement with Mr. Smith, which was amended in January 2021 to provide certain change in control benefits, as described in more detail below under “Severance and Change in Control Benefits”. Pursuant to the terms of the agreement, Mr. Smith (i) received a signing bonus of $100,000 (which was subject to full repayment if his employment with the Company had terminated for any reason before August 31, 2021), (ii) received an initial annual base salary of $425,000 and (iii) was eligible for a target annual cash bonus equal to 50% of his base salary. Mr. Smith was granted an initial new hire option to purchase 60,000 ordinary shares and 25,000 restricted stock units.

     

    Don Kim. On March 20, 2022, we entered into an employment agreement with Mr. Kim. Pursuant to the terms of the agreement, Mr. Kim (i) received an initial annual base salary of $370,000 and (ii) is eligible for a target annual cash bonus equal to 50% of his base salary. Mr. Kim was granted an initial option to purchase 20,000 ordinary shares. On October 8, 2024, Mr. Kim resigned as the Company's Chief Financial Officer.

     

    On October 7, 2024, we entered into a separation and consulting agreement with Mr. Kim, pursuant to which Mr. Kim resigned from his positions as the Company’s Chief Financial Officer, effective October 8, 2024, and agreed to provide consulting services to us on a part-time basis through April 28, 2025 in exchange for a cash payment of $36,260. The consulting agreement was subsequently extended to September 30, 2025. Mr. Kim’s outstanding equity awards as of October 8, 2024 remain eligible for continued vesting through September 30, 2025. In addition, pursuant to the separation agreement, we have paid or will pay Mr. Kim: (i) the equivalent of nine months of his base salary in effect as of October 8, 2024, paid as salary continuation over nine months, (ii) a lump sum payment equal to $217,590, which was equal to Mr. Kim’s target performance bonus for 2024, and (iii) reimbursement for COBRA premiums for up to nine months following October 8, 2024.

     

    Severance and Change in Control Benefits

     

    Our employment agreements with Ms. Barrett, Mr. Degnan, Mr. Smith, and Mr. Kim (prior to his resignation) provide that they are eligible for severance benefits upon certain involuntary terminations of employment, including in connection with a change in control, as described below.

     

    Pursuant to their respective employment agreements (or amended employment agreements in the case of Ms. Barrett and Mr. Smith), if the named executive officer is terminated by the Company without cause, by the named executive officer for good reason, or due to the named executive officer’s death or disability, then the named executive officer will be entitled to the following severance benefits: (i) continuing base salary payments for 6 months (or 12 months in the case of Ms. Barrett); (ii) a prorated target annual bonus for the year of termination (to the extent earned based on Company performance and with any individual performance component deemed achieved); (iii) any unpaid annual bonus earned with respect to the year preceding termination; (iv) the accelerated vesting of restricted shares and options held by the named executive officer at the time of such termination (in the case of Ms. Barrett, the portion of the award otherwise scheduled to vest within the 12 month period following termination; and in the case of Mr. Degnan, Mr. Smith and Mr. Kim, vesting will be accelerated by 1/12th, such that 8.33% of the total restricted shares and options subject to the awards will be deemed immediately vested and exercisable); and (v) COBRA payment reimbursement for up to 6 months for Mr. Degnan, Mr. Smith and Mr. Kim, and 12 months in the case of Ms. Barrett following such termination.

     

    If there is a change in control and the named executive officer is terminated without cause or resigns for good reason, in either case within three months prior to, or 24 months following the effective date of the change in control, all four named executive officers will be entitled to 100% vesting and exercisability of all of his or her Company equity awards or other equity interests that are outstanding and unvested as of the termination or resignation date as well as the following severance benefits, in lieu of the corresponding severance benefits described above: (i) a lump sum payment equal to the sum of (1) 12 months (18 months in the case of Ms. Barrett) of his or her then-current annual base salary and (2) 100% of his or her current target annual bonus; and (ii) the amount of any COBRA premium payments made by the named executive officer during the 12 months (or 18 months in the case of Ms. Barrett) following such termination.

     

    Payment of the severance benefits described in the preceding paragraphs is subject to the named executive officer signing and not revoking a separation agreement and release of claims in a form satisfactory to us.

     

    Other Benefits

     

    Our named executive officers are eligible to participate in our employee benefit plans, including our medical, dental, vision, group life, disability and accidental death and dismemberment insurance plans, in each case on the same basis as all of our other employees. We provided a 401(k) plan to all of our U.S. employees, including our named executive officers. We do not generally provide perquisites or personal benefits to our named executive officers. We do, however, pay the premiums for term life insurance and disability insurance for all of our employees, including our named executive officers.

     

    Tax and Accounting Implications

     

    Under Financial Accounting Standard Board ASC Topic 718 (“ASC Topic 718”), we are required to estimate and record an expense for each award of equity compensation over the vesting period of the award. We record share-based compensation expense on an ongoing basis according to ASC Topic 718.

     

    Under Section 162(m) of the Code, compensation paid to each of our “covered employees” that exceeds $1 million per taxable year is generally non-deductible. Although the Compensation Committee will continue to consider tax implications as one factor in determining executive compensation, it also looks at other factors in making its decisions and retains the flexibility to provide compensation for our named executive officers in a manner consistent with the goals of our executive compensation program and our best interests, and the best interests of our shareholders, which may include providing for compensation that is not deductible by us due to the deduction limit under Section 162(m) of the Code.

     

    Clawbacks

     

    As a public company, if we are required to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws, including any required accounting restatement to correct an error in previously issued financial statements that is material to the previously issued financial statements, or that would result in a material misstatement if the error were corrected in the current period or left uncorrected in the current period, certain covered officers, including the Chief Executive Officer and Chief Financial Officer, may be legally required to reimburse our Company for any cash bonus or other incentive-based or equity-based compensation they receive in accordance with the provisions of section 304 of the Sarbanes-Oxley Act of 2002. Additionally, we have adopted an incentive compensation recoupment policy to comply with Section 10D of the Exchange Act, Rule 10D-1 promulgated thereunder and Nasdaq Listing Rule 5608.

     

    Risk Analysis of Our Compensation Policies and Practices

     

    The Compensation Committee has reviewed the Company’s compensation policies and practices, in consultation with Compensia and outside Company counsel, to assess whether they encourage employees to take inappropriate risks. After reviewing and assessing the Company’s compensation philosophy, terms and practices, including the mix of fixed and variable, short and long-term incentives and overall pay, incentive plan structures, and the checks and balances built into, and oversight of, each plan and practice, the Compensation Committee determined that any risks arising from our compensation policies and practices for our employees are not reasonably likely to have a material adverse effect on our Company as a whole. The Compensation Committee believes that the mix and design of the elements of executive compensation do not encourage management to assume excessive risks; the mix of short-term compensation (in the form of salary and annual bonus, if any, which is based on a variety of performance factors), and long-term compensation (in the form of options to purchase our ordinary shares and restricted stock units) prevents undue focus on short-term results and helps align the interests of the Company’s executive officers with the interests of our shareholders.

     

    2024 Summary Compensation Table

     

    The following table sets forth all of the compensation awarded to, earned by or paid to our named executive officers during the years indicated.

     

     

    Name and Principal Position

     

    Year

     

    Salary
    ($)

       

    Bonus
    ($) (1)

       

    Stock
    Awards
    ($) (2)

       

    Option
    Awards
    ($) (3)

       

    Non-Equity
    Incentive

    Plan
    Compensation
    ($) (4)

       

    All Other
    Compensation
    ($) (5)

       

    Total ($)

     

    Elizabeth Barrett

     

    2024

       

    826,013

         

    —

         

    2,751,111

         

    —

         

    529,981

         

    42,753

         

    4,149,858

     

    Chief Executive Officer

     

    2023

       

    794,243

         

    19,984

         

    2,464,250

         

    836,533

         

    479,620

         

    44,959

         

    4,639,589

     

    Chris Degnan (6)

     

    2024

       

    115,530

         

    —

         

    176,330

         

    695,294

         

    53,125

         

    13,510

         

    1,053,789

     

    Chief Financial Officer

     

    2023

       

    —

         

    —

         

    —

         

    —

         

    —

         

    —

         

    —

     

    Jason Smith

     

    2024

       

    475,003

          —      

    518,100

         

    —

         

    203,179

         

    79,182

         

    1,275,464

     

    General Counsel and Chief Compliance Officer

     

    2023

       

    456,733

          47,984      

    376,300

         

    267,691

         

    275,808

         

    83,663

         

    1,508,179

     
    Don Kim (7)   2024     363,694       —       376,800       —       —       623,728       1,364,222  
    Former Chief Financial Officer   2023     —       —       —       —       —       —       —  

     

     

      (1)

    Represents discretionary bonuses paid to the named executive officer for the applicable year. Discretionary bonuses earned in 2023 were approved by the Board based on assessment of overall achievements in the business and individual performance, including the accomplishments noted in our 2023 corporate performance highlights, above.

     

     

    (2)

    Represents the aggregate grant-date fair value of the restricted stock units and, except for Mr. Degnan, performance stock units awarded to the named executive officer for the applicable year, calculated in accordance with ASC Topic 718 and does not take into account estimated forfeitures, which value is based on the closing market price of our ordinary shares on the date of grant. The grant date fair value of the restricted stock units is based on the closing market price of the Company’s ordinary shares on the date of the grant. The grant date fair value and the maximum potential value of the performance stock units are the same and are based on the closing market price of our ordinary shares on the date of grant. 

     

     

    (3)

    Represents the aggregate grant-date fair value of the stock options awarded to the named executive officer for the applicable year, calculated in accordance with ASC Topic 718, and does not take into account estimated forfeitures related to service-based conditions. The assumptions used in the calculation of these amounts are included in Note 16 of the Form 10-K for the year ended December 31, 2024, filed with the SEC on March 10, 2025.

     

     

    (4)

    For more information, see “Annual Performance Bonus” above.

     

     

    (5)

    The amounts reported in this column represent the value of Company-paid life insurance, Company contributions to 401(k) plans, other Company paid health, dental, disability and insurance premiums, and/or amounts paid or accrued under a plan or arrangement in connection with a termination, severance, or change of control (in the case of Mr. Kim).

     

     

    (6)

    Mr. Degnan commenced employment with us in October 2024.

     

     

    (7)

    Mr. Kim resigned from his positions as the Company’s Chief Financial Officer, Principal Financial Officer, and Principal Accounting Officer, effective October 8, 2024. As a result, Mr. Kim's "All Other Compensation" included amounts paid or accrued under a plan or arrangement in connection with his termination of $585,182, which included his severance, annual cash incentive, a post-separation consulting arrangement, and COBRA payment reimbursement. Mr. Kim was not a named executive officer in 2023.

     

    2024 Outstanding Equity Awards at Fiscal Year End Table

     

    The following table shows for the fiscal year ended December 31, 2024, certain information regarding outstanding equity awards at fiscal year-end for our named executive officers.

     

     

     

     

     

     

     

     

          Option Awards         Stock Awards    

    Name 

    Grant Date

    Number of

    Number of

         

    Number

    Market

    Equity Equity
       

    Securities

    Securities

         

    of Shares

    Value of

    Incentive Incentive
       

    Underlying

    Underlying

     Option

     Option

     

    of Stock

    Shares of

    Plan Plan
       

    Unexercised

    Unexercised

     Exercise

     Expiration

     

    that have

    Stock that

    Awards: Awards:
       

    Options (#)

    Options (#)

     Price ($)

     Date

     

    not

    have not

    Number of Market or
       

    Exercisable

    Unexercisable

    (2)    

    Vested (#)

    Vested ($)

    Unearned Payout
        (1)           (3) Shares, units or other rights that have not Vested (#) Value of Unearned Shares, Units or Other Rights that have not Vested ($)(4)

    Elizabeth Barrett

    1/3/2019

      277,432

      — 

    47.57

    1/3/2029

     

     — 

      — 

       
     

    1/31/2020

      45,000

      — 

    29.41

    1/31/2030

     

     — 

      — 

       
     

    1/31/2021

             

      13,334

      142,007

       
     

    1/31/2021

      150,000

      — 

    22.07

    1/31/2031

     

     — 

      —

       
     

    1/31/2022

      100,000

      50,000

    7.72

    1/31/2032

     

     — 

    532,500

       
     

    1/31/2023

             

    75,000

    798,750

       
     

    1/31/2023

    41,666

    83,334

    10.39

    1/31/2033

     

    —

    887,507

       
     

    9/7/2023

                  100,000 1,065,000

     

    1/31/2024

     

     

     

     

     

    87,615

    933,100

       
     

    1/31/2024

     

     

     

     

     

     

     

    87,615 933,100
    Chris Degnan

    10/8/2024 (5)

     

     

     

     

     

    13,450

    143,243    
     

    10/8/2024 (5)

    —

    74,142

    13.11

    10/8/2034

     

    —

    789,612

       
    Jason Smith

    10/1/2020 (5)

      60,000  — 19.66 10/1/2030  

    —

    —

       
     

    1/31/2021

      8,000  — 22.07 1/31/2031  

    —

    —

       

     

    6/5/2021

      15,000

      —

    17.98

    6/5/2031

     

      — 

      — 

       
     

    1/31/2022

     

     

     

     

     

     2,500 

      26,625

       
     

    1/31/2022

      20,000

      10,000

    7.72

    1/31/2032

     

     — 

      106,500

       
     

    1/31/2023

             

      13,334

      142,007

       
     

    1/31/2023

      13,333

      26,667

    10.39

    1/31/2033

     

     — 

      284,004

       
     

    9/7/2023

             

    6,667

      71,004

       
     

    1/31/2024

     

     

     

     

     

    16,500

    175,725

       
     

    1/31/2024

             

     

     

    16,500 175,725
    Don Kim 12/1/2021 10,000 — 11.92 12/1/2031   — —    
      1/31/2022           3,334 35,507    
      3/25/2022 13,333 6,667 8.61 3/25/2032   — 71,004    
      1/31/2023           6,667 71,004    
      1/31/2023 12,666 25,334 10.39 1/31/2033   — 269,807    
      9/7/2023           5,000 53,250    
      1/31/2024           12,000 127,800    
      1/31/2024               12,000 127,800

     

      (1)

    Options granted to Ms. Barrett, Mr. Degnan, Mr. Smith, and Mr. Kim vest in equal annual installments over three years from the vesting commencement date.

     

      (2)

    Options to purchase our ordinary shares were granted with a per share exercise price equal to the fair market value of one ordinary share on the date of grant, as determined in good faith by our Board.

     

      (3)

    RSU and option grants with amounts that have not yet vested vest in equal annual installments over three years from the grant date. Market value is based on the Company's share price as of December 31, 2024.

     

      (4)

    Represents performance stock units which vest upon the earlier of the receipt of U.S. regulatory approval for our lead product candidate UGN-102 in the three years following the grant or the occurrence of a change in control, or for certain other awards, the achievement of the first commercial sale of UGN-102 in the United States following UGN-102's receipt of regulatory approval. Market value is based on the Company's share price as of December 31, 2024.

     

      (5)

    Awards granted to Mr. Smith and Mr. Degnan in 2020 and 2024, respectively, were granted as inducement awards under equity compensation plans not approved by security holders. All other equity awards were granted under our 2017 Plan.

     

    Compensation Committee Interlocks and Insider Participation

     

    None of our directors who serve as a member of our Compensation Committee is, or has at any time during the past year been, one of our officers or employees. None of our executive officers currently serves, or in the past year has served, as a member of the board of directors or compensation committee of any other entity that has one or more executive officers serving on our Board or Compensation Committee.

     

    Policies and Practices Related to the Grant of Certain Equity Awards Close in Time to the Release of Material Nonpublic Information

     

    From time to time, the Company grants stock options to its employees, including the named executive officers. Historically, the Company has generally granted new-hire option awards to our executive officers on or shortly following the executive’s employment start date. For other new hires, new-hire option awards are generally granted in the first week of the month following the new hire’s employment start date. Promotion option grants are generally granted in the month following the promotion date. The Company’s typical practice is to grant annual employee equity awards on January 31st of each year, which includes stock options for certain employees, including the named executive officers. These grants are recommended by the Compensation Committee at a regularly scheduled meeting in December of the preceding year. Our non-employee directors receive automatic grants of initial and annual stock option awards, at the time of a director’s initial appointment or election to the Board and at the time of each annual meeting of the Company’s shareholders, respectively, pursuant to the Non-Employee Director Compensation Policy, as further described under the heading, “Director Compensation—Non-Employee Director Compensation Policy,” below. The Company does not otherwise maintain any written policies on the timing of awards of stock options, stock appreciation rights, or similar instruments with option-like features. Because we have a practice of generally granting new-hire, promotion and annual refresh options at specified times, as described above, the Board and the Compensation Committee generally do not take material non-public information (“MNPI”) into account when determining the timing or terms of awards, and they do not seek to time the award of stock options in relation to the Company’s public disclosure of MNPI. The Company has not timed the release of MNPI for the purpose of affecting the value of executive compensation.

     

    The following table is provided pursuant to Item 402(x) of Regulation S-K:

     

     

    Name

    Grant Date

    Number of Securities Underlying the Award

     

    Exercise Price of the Award ($/Share)

     

    Grant Date Fair Value of the Award

    Percentage Change in the Closing Market Price of the Securities Underlying the Award Between the Trading Day Immediately Prior to the Disclosure of Material Nonpublic Information and the Trading Day Beginning Immediately Following Disclosure of Material Nonpublic Information

    Chris Degnan(1)

    10/8/2024

    74,142

     

    13.11

     

    $695,294

    (9.3%)

     

    (1)

    On October 9, 2024, the Company filed a Current Report on Form 8-K reporting the departure of its former Chief Financial Officer and the appointment of Mr. Degnan as the Company’s new Chief Financial Officer.

     

     

    DIRECTOR COMPENSATION

     

    Non-Employee Director Compensation

     

    The following table sets forth in summary form information concerning the compensation that we paid or was earned or awarded during the year ended December 31, 2024 to each of our non-employee directors:

     

     

    Name

     

    Fees Earned or
    Paid in Cash
    ($)

       

    Option
    Awards
    ($) (1)

       

    Total
    ($)

     

    Arie Belldegrun, M.D., FACS (2)

       

    200,000

         

    131,911

         

    331,911

     

    Cynthia M. Butitta (3)

       

    62,011

          131,911      

    193,922

     

    Stuart Holden, M.D. (4)

       

    54,511

          131,911      

    186,422

     

    Leana Wen, M.D., M.SC. (5)

       

    64,510

          131,911      

    196,421

     

    Daniel G. Wildman (Wildman Ventures LLC) (6)

       

    62,391

          131,911      

    194,302

     

    James A. Robinson, Jr. (7)

       

    52,011

          131,911      

    183,922

     
    Fred E. Cohen, M.D., D.Phil(8)     39,076       131,911       170,987  

     


     

     

    (1)

    The amounts reported in this column do not reflect the amounts that may actually be received by our non-employee directors. Instead, these amounts reflect the aggregate grant date fair value of options to purchase our ordinary shares granted to our non-employee directors during the fiscal year ended December 31, 2024, as computed in accordance with ASC Topic 718. Assumptions used in the calculation of these amounts are included in Note 16 in the Form 10-K for the year ended December 31, 2024, filed with the SEC on March 10, 2025. As required by SEC rules, the amounts reported exclude the impact of estimated forfeitures related to service-based vesting conditions. Our non-employee directors who have received shares will only realize compensation with regard to these options to the extent the market price of our ordinary shares is greater than the exercise price of such options.

     

    (2)

    Aggregate number of option awards outstanding held by Dr. Belldegrun at December 31, 2024 was 82,500.

     

    (3)

    Aggregate number of option awards outstanding held by Ms. Butitta at December 31, 2024 was 112,500.

     

    (4)

    Aggregate number of option awards outstanding held by Dr. Holden at December 31, 2024 was 72,500.

     

    (5)

    Aggregate number of option awards outstanding held by Dr. Wen at December 31, 2024 was 27,500.

     

    (6)

    Aggregate number of option awards outstanding beneficially owned by Mr. Wildman at December 31, 2024 was 25,833.

     

    (7)

    Aggregate number of option awards outstanding held by Mr. Robinson at December 31, 2024 was 20,833.

     

    (8)

    Dr. Cohen resigned from our Board effective on September 12, 2024. Dr. Cohen did not hold any outstanding options at December 31, 2024.

     

    The cash fees paid to or earned by our directors in 2024, as reflected in the table above, were paid pursuant to our director compensation policy. In August 2024, our shareholders approved an increase of the annual cash compensation for non-employee directors from $40,000 to $45,000 for their service on the Board, except for our Chair, Dr. Belldegrun, who received $195,000 for his service as Chair of our Board. Members of the Compensation Committee, Nominating and Corporate Governance Committee, and the Compliance Committee, received an additional $5,000 per year, or $15,000 in the case of the committee Chair. Members of the Audit Committee received an additional $7,500 per year, or $20,000 in the case of the committee Chair.

     

     

     

     

     

     

     

     

     

     

     

     

    Non-Employee Director Compensation Policy

     

    Our Board adopted a Director Compensation Policy pursuant to which each of our directors who is not an employee of our company, which is currently all directors other than Ms. Barrett, is eligible to receive compensation for service on our Board and committees of our Board. Under the Director Compensation Policy, each non-employee member of our Board is entitled to receive a cash retainer in the following amounts for service in each specified role:

     

    Annual Board Service Retainer:

     

    ●

    Chair of the Board: $195,000

     

    ●

    All other eligible directors: $45,000 (which amount was increased from $40,000 upon shareholder approval in August 2024)

    Annual Committee Member Service Retainer (in addition to Board Service Retainer):

     

    ●

    Member of the Audit Committee: $7,500

     

    ●

    Member of the Compensation Committee: $5,000

      ● Member of the Nominating and Corporate Governance Committee: $5,000
     

    ●

    Member of the Compliance Committee: $5,000

    Annual Committee Chair Service Retainer (in addition to Committee Member Service Retainer):

     

    ●

    Chair of the Audit Committee: $20,000

     

    ●

    Chair of the Compensation Committee: $15,000

      ● Chair of the Nominating and Corporate Governance Committee: $15,000
     

    ●

    Chair of the Compliance Committee: $15,000

     

    Each non-employee director is also entitled to receive an initial option grant to purchase 20,000 of our ordinary shares, and an annual option grant to purchase 10,000 of our ordinary shares on the date of each annual shareholders meeting of the Company, contingent upon their continued service as a non-employee member of the Board. If a director joins the Board between annual meetings, the annual grant awarded at his/her first annual meeting will be pro-rated based on the duration of service leading up to the meeting date: (i) for service between 0 (zero) and 90 (ninety) days – no grant; (ii) for service between 91 (ninety-one) and 180 (one hundred eighty) days – 5,000 (five thousand) options; and (iii) for service of at least 181 (one hundred eighty-one) days – 10,000 (ten thousand) options. The exercise price per share of each stock option granted under the non-employee director compensation policy will be equal to 100% of the fair market value of the underlying ordinary share on the date of grant. The initial option grants vest in equal quarterly installments over a period of three years. The annual option grants vest in equal quarterly installments over a period of one year.

     

    Additionally, a grant in excess of the 20,000 ordinary share initial option grant may be applied as an inducement for eligible or prospective non-employee directors.

     

    Our non-employee directors also received reimbursement of their actual out-of-pocket costs and expenses incurred in connection with attending Board meetings.

     

    Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.

     

    Securities Authorized for Issuance Under Equity Compensation Plans

     

    The following table summarizes our compensation plans under which our equity securities are authorized for issuance at December 31, 2024:

     

    Plan category

     

    Number of securities
    to be issued upon
    exercise of
    outstanding options,
    warrants and rights

       

    Weighted-average exercise
    price of outstanding options,
    warrants and rights(3)

       

    Number of securities remaining
    available for
    future issuance under equity
    compensation plans
    (excluding securities
    reflected in column (a))

     
       

    (a)

       

    (b)

       

    (c)

     

    Equity compensation plans approved by security holders

       

    2,323,729

         

    $25.82

         

    1,223,963

     

    Equity compensation plans not approved by security holders(1)

       

    288,114(2)

         

    $10.69

         

    430,729

     

    Total

       

    2,611,843

         

    $24.15

         

    1,654,692

     

     

     

     

    1.

    In May 2019, we adopted the UroGen Pharma Ltd. 2019 Inducement Plan (the “Inducement Plan”) without the approval of our security holders. Under the Inducement Plan, the Company is authorized to issue up to 900,000 ordinary shares pursuant to awards issued under the Inducement Plan. In December 2021, the Board approved a 300,000 increase in the share reserve of the Inducement plan. In June 2024, the Board approved a 600,000 increase in the share reserve of the Inducement plan. Our Inducement Plan provides for the grant of nonstatutory stock options, restricted stock unit awards, and other awards. The only persons eligible to receive awards under our Inducement Plan are individuals who satisfy the standards for inducement grants under Nasdaq Marketplace Rule 5635(c)(4) or 5635(c)(3) and the related guidance under Nasdaq IM 5635-1, including individuals who were not previously an employee or director of the Company or are following a bona fide period of non-employment, in each case as an inducement material to such individual’s agreement to enter into employment with the Company. In addition, awards granted under our Inducement Plan must be approved by either a majority of the Company’s “independent directors” (as such term is defined in Nasdaq Marketplace Rule 5605(a)(2)) or the Compensation Committee, provided such committee comprises solely independent directors. The terms of our Inducement Plan are otherwise substantially similar to our Amended 2017 Plan (including with respect to the treatment of awards upon corporate transactions involving us or certain changes in our capitalization).

     

     

    2.

    As of December 31, 2024, options to purchase 288,114 ordinary shares and restricted stock units covering 410,610 shares were outstanding under the Inducement Plan. All options granted under the Inducement Plan have a maximum term of ten years. The Inducement Plan, and awards thereunder, may be amended by the Board at any time or from time to time in accordance with the terms of the Inducement Plan and applicable law.

     

     

    3.

    The weighted-average exercise price does not take into account the shares subject to outstanding restricted stock units which have no exercise price.

     

     

     

    SECURITY OWNERSHIP OF
    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     

    The following table sets forth certain information relating to the beneficial ownership of our ordinary shares as of March 31, 2025, by:

     

     

    ●

    each person, or group of affiliated persons, known by us to beneficially own more than 5% of our outstanding ordinary shares;

     

    ●

    each of our directors and each nominee for director;

     

    ●

    each of our named executive officers; and

     

    ●

    all of our current directors and executive officers as a group.

     

    Beneficial ownership is based upon 46,101,785 ordinary shares issued and outstanding as of March 31, 2025 and determined in accordance with the rules of the SEC and generally includes any shares over which a person exercises sole or shared voting or investment power. Unless otherwise indicated, we believe that the persons or entities identified in this table have sole voting and investment power with respect to all shares shown beneficially owned by them, subject to applicable community property laws. Ordinary shares issuable upon vesting of outstanding equity awards that are exercisable or subject to vesting within 60 days after March 31, 2025 are deemed beneficially owned and such shares are used in computing the percentage ownership of the person holding the awards but are not deemed outstanding for the purpose of computing the percentage ownership of any other person. The information contained in the following table is not necessarily indicative of beneficial ownership for any other purpose, and the inclusion of any shares in the table does not constitute an admission of beneficial ownership of those shares.

     

    Unless otherwise noted below, the address of each shareholder, director and executive officer is c/o UroGen Pharma Ltd., 400 Alexander Park Drive, 4th Floor, Princeton, New Jersey 08540.

     

    Name of Beneficial Owner

     

    Number

       

    Percent

     

    Greater than 5% Shareholders

                   
    RTW Investments, LP (1)     3,787,347       8.2 %
    RA Capital Management, L.P. (2)     3,206,271       7.0 %

    Adage Capital Management, L.P. (3)

       

    2,928,086

         

    6.4

    %

    BlackRock, Inc. (4)

       

    2,497,943

         

    5.4

    %

    Directors and Named Executive Officers

                   

    Elizabeth Barrett (5)

       

    1,032,456

         

    2.2

    %

    Chris Degnan

       

    —

         

    *

     

    Jason Smith (6)

       

    172,180

         

    *

     
    Don Kim (7)     100,420       *  

    Arie Belldegrun M.D., FACS (8)

       

    496,193

         

    1.1

    %

    Cynthia M. Butitta (9)

       

    117,500

         

    *

     

    Stuart Holden, M.D. (10)

       

    77,500

         

    *

     

    Leana Wen, M.D., M.SC. (11)

       

    34,166

         

    *

     

    Daniel G. Wildman (12)

       

    34,166

         

    *

     

    James A. Robinson Jr. (13)

       

    29,166

         

    *

     

    All current directors and executive officers as a group (10 persons) (14)

       

    2,232,431

         

    4.7

    %


    *         Indicates beneficial ownership of less than 1% of the total ordinary shares outstanding.

     

     

    1)

    Represents ordinary shares beneficially owned as of September 30, 2024, based on a Schedule 13G/A filed on November 14, 2024, by RTW Investments, LP. In such filing, RTW Investments LP lists its address as 40 10th Avenue, Floor 7, New York, New York 10014, and indicates that it has shared voting power with respect to 4,930,204 ordinary shares, including 1,142,857 ordinary shares issuable upon exercise of warrants, and shared dispositive power with respect to 4,930,204 ordinary shares, including 1,142,857 ordinary shares issuable upon exercise of warrants.

     

     

    2)

    Represents ordinary shares beneficially owned as of September 30, 2024, based on a Schedule 13G/A filed on November 14, 2024, by RA Capital Management, L.P. In such filing, RA Capital Management, L.P. lists its address as RA Capital Management, L.P., 200 Berkeley Street, 18th Floor, Boston MA 02116, and indicates that it has shared voting power with respect to 3,206,271 ordinary shares and shared dispositive power with respect to 3,206,271 ordinary shares.

     

     

    3)

    Represents ordinary shares beneficially owned as of December 31, 2024, based on a Schedule 13G/A filed on February 12, 2025, by Adage Capital Management, L.P. In such filing, Adage Capital Management, L.P. lists its address as 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116, and indicates that it has shared voting power with respect to 2,928,086 ordinary shares and shared dispositive power with respect to 2,928,086 ordinary shares.

     

     

    4)

    Represents ordinary shares beneficially owned as of September 30, 2024, based on a Schedule 13G filed on November 8, 2024, by BlackRock, Inc. In such filing, BlackRock, Inc. lists its address as BlackRock, Inc., 50 Hudson Yards, New York, NY 10001, and indicates that it has shared voting power with respect to 2,453,286 ordinary shares and shared dispositive power with respect to 2,497,943 ordinary shares.

     

     

    5)

    Consists of 326,691 ordinary shares and 705,765 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    6)

    Consists of 32,514 ordinary shares and 139,666 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    7)

    Consists of 45,087 ordinary shares (based on Mr. Kim's Form 4 filed on September 12, 2024 and subsequent vesting of his restricted shares) and 55,333 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    8)

    Consists of 408,693 ordinary shares and 87,500 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    9)

    Consists of 117,500 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    10)

    Consists of 77,500 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2024.

     

     

    11)

    Consists of 34,166 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    12)

    Consists of 34,166 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    13)

    Consists of 29,166 ordinary shares issuable upon exercise of options or upon settlement of restricted stock units within 60 days following March 31, 2025.

     

     

    14)

    Includes the shares described in notes (5), (6) and (8) through (13) and 239,104 ordinary shares (which includes 90,564 ordinary shares issuable upon the exercise of options or upon settlement of restricted stock units within 60 days of March 31, 2025) beneficially owned by an additional executive officer who is not named in the table above.

     

     

    Item 13. Certain Relationships and Related Transactions, and Director Independence.

     

    TRANSACTIONS WITH RELATED PERSONS

     

    Certain Related-Person Transactions

     

    Described below are all transactions occurring since January 1, 2023 to which we were a party and in which (i) the amounts involved exceeded or will exceed the lesser of $120,000 or 1% of the average of our total assets at year-end for the last two completed fiscal years, and (ii) a director, executive officer, holder of more than 5% of our outstanding ordinary shares, or any member of such person’s immediate family had or will have a direct or indirect material interest, other than the equity and other compensation agreements that are described under “Executive Compensation” and “Director Compensation” or that are not required to be described under this item pursuant to the instructions to Item 404(a) of Regulation S-K. We believe the terms obtained or consideration that we paid or received, as applicable, in connection with the transactions described below were comparable to terms available or the amounts that would be paid or received, as applicable, in arm’s-length transactions with unrelated third parties.

     

    On July 26, 2023, we entered into a securities purchase agreement with certain institutional and other accredited investors (the “Purchasers”), pursuant to which the Company agreed to sell and issue to the Purchasers 12,579,156 ordinary shares of the Company (“Shares”) (or in lieu of Shares, pre-funded warrants to purchase ordinary shares of the Company) at a purchase price of $9.54 per Share (or $9.539 for each ordinary share underlying a pre-funded warrant), in a private placement transaction (the “Private Placement”).

     

    Monograph Capital Partners I, L.P. (“Monograph”), a life sciences venture firm that is affiliated with Dr. Cohen, a former director of the Company, purchased 1,572,327 Shares in the Private Placement, for an aggregate purchase price of $15.0 million. Dr. Cohen is the Chair and Chief Investment Officer of Monograph.

     

    On February 14, 2025, the Company entered into an Asset Purchase Agreement (the “Agreement”) with IconOVir Bio, Inc. (“IconOVir”), pursuant to which the Company purchased and acquired certain assets of IconOVir, including the product candidate ICVB-1042 and certain contracts, intellectual property rights, regulatory applications, submissions and registrations, and data and other rights related thereto, and assumed certain liabilities and obligations of IconOVir arising under certain contracts of IconOVir acquired by the Company. As consideration for the acquired assets, the Company (i) issued 374,843 ordinary shares of the Company (the “Company Shares”) to IconOVir, which represents a purchase price of $4.0 million divided by the volume-weighted average closing price of the Company Shares on The Nasdaq Stock Market over the 30 consecutive trading days ending on (and including) the trading day immediately prior to the closing of the acquisition, (ii) agreed to pay IconOVir a one-time payment of $15.0 million in cash upon the achievement of a cumulative aggregate worldwide net sales milestone for all products, including combination products, that incorporate or comprise ICVB-1042 (“ICVB Products”), (iii) agreed to pay IconOVir a low, single-digit percentage royalty, on an ICVB Product-by-ICVB Product basis, on the annual, worldwide net sales of such ICVB Product during the royalty term, subject to certain reductions as set forth in the Agreement, and (iv) agreed to assume certain immaterial liabilities arising under certain acquired contracts ((i), (ii), (iii), and (iv) collectively, the “Purchase Price”).

     

    Entities affiliated with Arie Belldegrun, M.D., the Chair of the Board of Directors of the Company, held certain promissory notes of IconOVir that may entitle such entities to receive, in the aggregate, approximately 28.3% of the Purchase Price.

     

    Indemnification agreements

     

    Our articles of association permit us to exculpate, indemnify and insure each of our directors and executive officers to the fullest extent permitted by the Israeli Companies Law. We have entered into indemnification agreements with each of our directors and executive officers, undertaking to indemnify them to the fullest extent permitted by Israeli law, to the extent that these liabilities are not covered by insurance. We have also obtained Directors and Officers insurance for each of our executive officers and directors.

     

    Employment Agreements

     

    We have entered into an employment agreement with our named executive officers. For more information regarding these agreements, see “Executive Compensation”.

     

    Equity Award Grants to Executive Officers and Directors

     

    We have granted options to purchase our ordinary shares and restricted stock units to our directors and named executive officers as more fully described in the sections titled “Director Compensation” and “Executive Compensation,” respectively.

     

    Policies and Procedures for Transactions with Related Persons

     

    We adopted a related person transaction policy that sets forth our procedures for the identification, review, consideration and approval or ratification of related person transactions. For purposes of our policy only, a “related person transaction” is a transaction, arrangement or relationship, or any series of similar transactions, arrangements or relationships, in which we and any related person are, were or will be participants in which the amount involved exceeds $120,000. Transactions involving compensation for services provided to us as an employee or director are not covered by this policy. A “related person” is any executive officer, director or beneficial owner of more than 5% of any class of our voting securities, including any of their immediate family members and any entity owned or controlled by such persons.

     

    Under the policy, if a transaction has been identified as a related person transaction, including any transaction that was not a related person transaction when originally consummated or any transaction that was not initially identified as a related person transaction prior to consummation, our management must present information regarding the related person transaction to our Audit Committee or, if Audit Committee approval would be inappropriate, to another independent body of our Board, for review, consideration and approval or ratification. The presentation must include a description of, among other things, the material facts, interests, direct and indirect, of the related persons, benefits to us of the transaction and whether the transaction is on terms that are comparable to the terms available to or from, as the case may be, an unrelated third party or to or from employees generally. Under the policy, we will collect information that we deem reasonably necessary from each director, executive officer and, to the extent feasible, significant shareholder to enable us to identify any existing or potential related-person transactions and to effectuate the terms of the policy. In addition, under our Code of Conduct, our employees and directors have an affirmative responsibility to disclose any transaction or relationship that reasonably could be expected to give rise to a conflict of interest. In considering related person transactions, our Audit Committee, or other independent body of our Board, is required to take into account the relevant available facts and circumstances including, but not limited to:

     

     

    ●

    the risks, costs and benefits to us;

     

    ●

    the impact on a director’s independence in the event that the related person is a director, immediate family member of a director or an entity with which a director is affiliated;

     

    ●

    the availability of other sources for comparable services or products; and

     

    ●

    the terms available to or from, as the case may be, unrelated third parties or to or from employees generally.

     

    The policy requires that, in determining whether to approve, ratify or reject a related person transaction, our Audit Committee, or other independent body of our Board, must consider, in light of known circumstances, whether the transaction is in, or is not inconsistent with, our best interests and those of our shareholders, as our Audit Committee, or other independent body of our Board, determines in the good faith exercise of its discretion.

     

    Independence of the Board of Directors

     

    Applicable Nasdaq rules require a majority of a listed company’s directors to be comprised of independent directors within one year of listing. In addition, Nasdaq rules require that, subject to specified exceptions, each member of a listed company’s Audit, Compensation and Nominating and Corporate Governance Committees be independent and that Audit Committee members also satisfy independence criteria set forth in Rule 10A-3 under the Exchange Act. The Board consults with the Company’s counsel to ensure that the Board’s independence determinations are consistent with relevant securities and other laws and regulations regarding the definition of “independent,” including those set forth in the pertinent listing standards of Nasdaq, as in effect from time to time.

     

    Consistent with these considerations, the Board has determined that all of our directors, except Ms. Barrett, are independent directors, as defined under applicable Nasdaq listing standards. In making such determination, our Board considered the relationships that each such non-employee director has with the Company and all other facts and circumstances that our Board deemed relevant in determining his or her independence, including the beneficial ownership of our capital stock by each non-employee director.

     

    Item 14. Principal Accountant Fees and Services.

     

    Principal Accountant Fees and Services

     

    The following table represents aggregate fees billed to us for the years ended December 31, 2024 and 2023, by PwC.

     

       

    Year Ended December 31,

     
       

    2024

       

    2023

     
       

    (in thousands)

     

    Audit Fees(1)

     

    $

    1,384

       

    $

    1,195

     

    Tax Fees(2)

       

    —

         

    80

     

    All Other Fees(3)

       

    2

         

    1

     
       

    $

    1,386

       

    $

    1,276

     

     

     

    1)

    For the years ended December 31, 2024 and 2023, the aggregate audit fees were for professional services rendered for audits, quarterly reviews of our consolidated financial statements, statutory financial statements, registration statements and preparation of comfort letters.

     

     

    2)

    For the years ended December 31, 2023, tax fees were tax transfer pricing services and tax consulting services.

     

     

    3)

    For the years ended December 31, 2024 and 2023, all other fees were for accounting research subscription services.

     

    All fees described above were pre-approved by the Audit Committee.

     

    Pre-Approval Policies and Procedures

     

    The Audit Committee must pre-approve all audit, audit-related and all permitted non-audit services, and related fees and terms, to be provided to the Company by the independent auditor under applicable law and regulations. Pre-approval may be given as part of the Audit Committee’s approval of the scope of the engagement of the independent auditor or on an individual, explicit, case-by-case basis before the independent auditor is engaged to provide each service. The pre-approval of services may be delegated to the Audit Committee’s Chairperson, but the decision must be reported to the full Audit Committee at its next scheduled meeting.

     

    The Audit Committee has determined that the rendering of services other than audit services by PwC US is compatible with maintaining the principal accountant’s independence.

     

    PART IV

     

    Item 15.    Exhibits, Financial Statement Schedules.

     

    (a)(1) Financial Statements.

     

    The response to this portion of Item 15 is set forth under Part II, Item 8 of the Form 10-K.

     

    (a)(2) Financial Statement Schedules.

     

    All schedules have been omitted because they are not required or because the required information is given in the Financial Statements or Notes thereto set forth under Part II, Item 8 of the Form 10-K.

     

    (a)(3) Exhibits.  

     

    Exhibit

    Number

     

    Exhibit Description

         

    3.1

     

    Articles of Association of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Report on Form 6-K, filed with the SEC on May 18, 2017).

         

    4.1

     

    Reference is made to Exhibit 3.1.

         

    4.2

     

    Description of the Registrant’s Ordinary Shares (previously filed as Exhibit 4.2 to the Form 10-K).

         

    4.3

     

    Form of July 2023 Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on July 27, 2023).

         

    4.4

     

    Form of June 2024 Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on June 18, 2024).

         

    10.1*

     

    Form of Officer Indemnity and Exculpation Agreement (incorporated by reference to Exhibit 99.2 to the Registrant’s Report Form 6-K, filed with the SEC on July 13, 2018).

         

    10.2*

     

    Amended and Restated 2010 Israeli Share Option Plan (incorporated by reference to Exhibit 4.2 to the Registrant’s Annual Report on Form 20-F, filed with the SEC on March 15, 2018).

         

    10.3*

     

    2017 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K, filed with the SEC on August 8, 2024).

         

    10.4*

     

    2017 Israeli Equity Incentive Sub Plan to the 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.7 to the Registrant’s Registration Statement on Form F-1, filed with the SEC on April 7, 2017).

         

    10.5

     

    Form of Performance Stock Award Grant Notice and Performance Stock Award Agreement under the UroGen Pharma Ltd. Israeli Sub-Plan to 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2024).

         

    10.6

     

    Form of Stock Option Grant Notice and Stock Option Agreement under the UroGen Pharma Ltd. 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 14, 2023).

         

    10.7

     

    Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement under the UroGen Pharma Ltd. 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.4 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 14, 2023).

         

    10.8

     

    Amendment to Form of Restricted Stock Unit Grant Notice under the UroGen Pharma Ltd. 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.7 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024)

         

    10.9

     

    Form of Performance-Based Restricted Stock Unit Grant Notice and Performance-Based Restricted Stock Unit Award Agreement under the UroGen Pharma Ltd. 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.5 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 14, 2023).

         

    10.10

     

    Amendment to Form of Performance-Based Restricted Stock Unit Grant Notice under the UroGen Pharma Ltd. 2017 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2024).

         

    10.11*

     

    UroGen Pharma Ltd. 2019 Inducement Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q, filed with the SEC on August 13, 2024).

         

    10.12

     

    Form of Stock Option Grant Notice and Stock Option Agreement under the UroGen Pharma Ltd. 2019 Inducement Plan (incorporated by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K, filed with the SEC on May 28, 2019).

         

    10.13

     

    Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement under the UroGen Pharma Ltd. 2019 Inducement Plan (incorporated by reference to Exhibit 10.3 to the Registrant’s Current Report on Form 8-K, filed with the SEC on May 28, 2019).

         

    10.14

     

    Amendment to Form of Restricted Stock Unit Grant Notice under the UroGen Pharma Ltd. 2019 Inducement Plan (incorporated by reference to Exhibit 10.12 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).

         

    10.15*

     

    UroGen Pharma Ltd. 2024 Non-Employee Director and Officer Compensation Policy (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on August 8, 2024).

         

    10.16*

     

    Employment Agreement by and between the Registrant and Elizabeth Barrett, dated as of January 3, 2019 (incorporated by reference to Exhibit 10.9 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on February 28, 2019).

         
    10.17*   Amendment 1 to Employment Agreement by and between the Registrant and Elizabeth Barrett, dated as of January 26, 2021 (incorporated by reference to Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2021).
         
    10.18*   Omnibus Amendment to Equity Awards by and between the Registrant and Elizabeth Barrett, dated as of January 19, 2021 (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2021).
         
    10.19*   Performance-Based Restricted Stock Unit Grant Notice by and between the Registrant and Elizabeth Barrett, dated as of November 13, 2023 (incorporated by reference to Exhibit 10.6 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 14, 2023).
         
    10.20*   Amended Restricted Stock Unit Grant Notice by and between the Registrant and Elizabeth Barrett, dated as of December 20, 2023 (incorporated by reference to Exhibit 10.18 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).
         
    10.21*   Employment Agreement by and between the Registrant and Mark Schoenberg, dated as of December 5, 2017 (incorporated by reference to Exhibit 10.12 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on February 28, 2019).
         
    10.22*   Amendment 1 to Employment Agreement by and between the Registrant and Mark Schoenberg, dated as of January 26, 2021 (incorporated by reference to Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2021).
         
    10.23*   Amendment 2 to Employment Agreement by and between the Registrant and Mark Schoenberg, dated as of March 15, 2021 (incorporated by reference to Exhibit 10.5 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2021).
         
    10.24*   Employment Agreement between the Registrant and Jason Smith, dated August 12, 2020 (incorporated by reference to Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 9, 2020).
         
    10.25*   Amendment 1 to Employment Agreement between the Registrant and Jason Smith, dated January 26, 2021 (incorporated by reference to Exhibit 10.4 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2021).
         
    10.26*   Employment Agreement between the Company and Chris Degnan, dated October 7, 2024 (incorporated by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K, filed with the SEC on October 9, 2024).
         
    10.27*   Separation Agreement between the Company and Don Kim, dated October 7, 2024 (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on October 9, 2024).
         
    10.28†   License Agreement, dated November 8, 2019, by and between the Registrant and Agenus Inc. (incorporated by reference to Exhibit 10.14 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 2, 2020).
         
    10.29   Lease Agreement, dated November 4, 2019, by and between the Registrant and Witman Properties, L.L.C. and Alexander Road at Davanne, L.L.C. (incorporated by reference to Exhibit 10.15 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 2, 2020).
         
    10.30   Amendment to Lease Agreement, dated June 8, 2022, by and between the Registrant and Witman Properties, L.L.C. and Alexander Road at Davanne, L.L.C. (incorporated by reference to Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on August 11, 2022).
         
    10.31†**   Manufacturing and Supply Agreement, dated May 26, 2020, by and between the Registrant and Isotopia Molecular Imaging Ltd. (the “Isotopia Agreement”) and the extension to the Isotopia Agreement, dated August 25, 2022, by and between the Registrant and Isotopia Molecular Imaging Ltd. (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 10, 2022).
         
    10.32†**   Manufacturing and Supply Agreement - Amendment No. 2, dated May 19, 2023, by and between the Registrant and Isotopia Molecular Imaging Ltd. (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on August 10, 2023).
         
    10.33†**   Manufacturing & Supply Agreement, dated as of April 24, 2020 and amended as of March 2, 2022, by and between UroGen Pharma Ltd. and Cenexi-Laboratoires Thissen s.a. (incorporated by reference to Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on May 10, 2022).
         
    10.34†**   Amendment 2 to Manufacturing & Supply Agreement, dated as of December 28, 2023 by and between UroGen Pharma Ltd. and Cenexi-Laboratoires Thissen s.a. (incorporated by reference to Exhibit 10.31 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).
         
    10.35†**   License and Supply Agreement, dated as of January 16, 2024, by and between UroGen Pharma Ltd. and Medac Gesellschaft für klinische Spezialpräparate m.b.H. (incorporated by reference to Exhibit 10.32 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).
         
    10.36   Amended and Restated Loan Agreement, dated as of March 13, 2024, by and among UroGen Pharma, Inc., as the borrower, and a credit party, UroGen Pharma Ltd. as Parent, and a Credit Party, the other guarantors signatory hereto or otherwise party hereto from time to time as additional Credit Parties, BioPharma Credit PLC as collateral agent, BPCR Limited Partnership as a lender and BioPharma Credit Investments V (Master) LP as a lender (incorporated by reference to Exhibit 10.35 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).
         
    10.37†**   Pre-Paid Forward Contract by and among the Registrant and RTW Investments ICAV for and on behalf of RTW Fund 2, dated as of March 18, 2021, as amended April 30, 2021 and August 14, 2024 (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on November 6, 2024).
         
    19.1   UroGen Pharma Ltd. Insider Trading Policy (previously filed as Exhibit 19.1 to the Form 10-K).
         

    21.1

      Subsidiary of the Registrant (incorporated by reference to Exhibit 21.1 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 24, 2023).
         
    23.1   Consent of PricewaterhouseCoopers LLP, an independent registered public accounting firm (previously filed as Exhibit 23.1 to the Form 10-K).
         
    24.1   Power of Attorney (previously filed within the signature page of the Form 10-K).
         
    31.1   Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 31.1 to the Form 10-K).
         
    31.2   Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (previously field as Exhibit 31.2 to the Form 10-K).
         
    31.3   Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934.
         
    31.4   Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934.
         
    32.1   Certification of Principal Executive and Financial Officers Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 32.1 to the Form 10-K).
         
    97   UroGen Pharma Ltd. Incentive Compensation Recoupment Policy (incorporated by reference to Exhibit 97 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 14, 2024).
         
    101   The following financial information from the Annual Report on Form 10-K of UroGen Pharma Ltd. for the year ended December 31, 2024, formatted in Inline XBRL (extensible Business Reporting Language): (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Operations, (iii) Consolidated Statements of Changes in Shareholders Equity, (iv) Consolidated Statements of Cash Flows, and (v) the Notes to Consolidated Financial Statements (previously filed as Exhibit 101.SCH, 101.CAL, 101.DEF, 101.LAB and 101.PRE to the Form 10-K).
         
    104   The cover page to this Annual Report on Form 10-K/A has been formatted in Inline XBRL

     

     

    *

    Management contract or compensatory plan.

     

    †

    Certain information in this exhibit has been redacted pursuant to Item 601(b)(10)(iv) of Regulation S-K because it is both not material and is the type of information that the registrant treats as private or confidential.

    **

    Schedules and exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K.

     

     

     

     

     

     

     

    SIGNATURES

     

    Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Amendment No. 1 to be signed on its behalf by the undersigned, thereunto duly authorized.

     

     

    UROGEN PHARMA LTD.

       

    April 30, 2025

     

    By:

    /s/ Elizabeth Barrett

       

    Elizabeth Barrett

       

    President and Chief Executive Officer

     

     

     
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