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    Amendment: SEC Form 20-F/A filed by Cellectis S.A.

    3/14/25 4:56:48 PM ET
    $CLLS
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $CLLS alert in real time by email
    20-F/A
    trueFY0001627281true 0001627281 2024-01-01 2024-12-31 0001627281 2023-01-01 2023-12-31 0001627281 dei:AdrMember 2024-01-01 2024-12-31 0001627281 dei:BusinessContactMember 2024-01-01 2024-12-31 0001627281 ifrs-full:OrdinarySharesMember 2024-12-31 0001627281 clls:ClassAConvertiblePreferredSharesMember 2024-12-31 0001627281 clls:ClassBConvertiblePreferredSharesMember 2024-12-31 xbrli:shares
     
     
    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
     
     
    FORM
    20-F/A
    (Amendment No. 1)
     
     
    (Mark One)
    ☐
    REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) or (g) OF THE SECURITIES EXCHANGE ACT OF 1934
    OR
     
    ☒
    ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    For the fiscal year ended December 31, 2024
    OR
     
    ☐
    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    OR
     
    ☐
    SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    Date of event requiring this shell company report      
    For the transition period from
     
     
      
     
    to
     
     
      
     
    Commission file number
    001-36891
     
     
    CELLECTIS S.A.
    (Exact name of Registrant as specified in its charter)
     
     
     
    (Translation of Registrant’s name into English)
    France
    (Jurisdiction of incorporation or organization)
    Cellectis S.A.
    8, rue de la Croix Jarry
    75013 Paris, France
    (Address of principal executive office)
    Marie-Bleuenn Terrier General Counsel Cellectis S.A.
    8, rue de la Croix Jarry
    75013 Paris, France
    Tel: +33 (0)1 81 69 16 00, Fax: +33 (0)1 81 69 16 06
    (Name, Telephone,
    E-mail
    and/or Facsimile number and Address of Company Contact Person)
    Securities registered pursuant to Section 12(b) of the Act.
     
    Title of each class
     
    Trading
    Symbol
     
    Name of each exchange
    on which registered
    American Depositary Shares, each representing one
     
    “CLLS”
     
    Nasdaq Global Market
    American Depositary Shares, each representing one
       
    Ordinary shares, nominal value €0.05 per share*
       
    Nasdaq Global Market*
     
    *
    No
    t for trading, but only in connection with the registration of the American Depositary Shares.
    Securities registered pursuant to Section 12(g) of the Act.
    None
     
     
    Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act.
    None
     
     
    Indicate the number of outstanding shares of the issuer’s classes of capital stock as of the close of the period covered by the annual report.
    Outstanding capital stock as of December 31, 2024: 100,093,873 shares, nominal value €0.05 per share, comprising 72,093,873 ordinary shares, 10,000,000 class A convertible preferred shares (with voting rights) and 18,000,000 class B convertible preferred shares (with no voting rights).
     
     
    Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒
    If this report is an annual or transition report, indicate by check mark, if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. Yes ☐ No ☒
    Note – Checking the box above will not relieve any registrant required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 from their obligations under those Sections.
    Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
    Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation
    S-T
    during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
    Indicate by check mark whether the registrant is a large accelerated filer, accelerated filer, a
    non-accelerated
    filer, or an emerging growth company. See definition of “large accelerated filer”, “accelerated filer” and “emerging growth company” in Rule
    12b-2
    of the Exchange Act.
     
    Large accelerated filer   ☐    Accelerated filer   ☒
    Non-accelerated file   ☐    Emerging Growth Company   ☐
    If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided pursuant to Section 13(a) of the Exchange Act. ☐
    † The term “new or revised financial accounting standard” refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5, 2012.
    Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☒
    If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included on the filing reflect the correction of an error to previously issued financial statements ☐
    Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to
    §240.10D-1(b). ☐
    Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:
     
    U.S. GAAP ☐   
    International Financial Reporting Standards as issued
    by the International Accounting Standards Board ☒
       Other ☐
    If “Other” has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow: Item 17 ☐ Item 18 ☐
    If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule
    12b-2
    of the Exchange Act). Yes ☐ No ☒
    (APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PAST FIVE YEARS)
    Indicate by check mark whether the registrant has filed all documents and reports required to be filed by Sections 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a court. ☐ Yes ☐ No
     
    Auditor Firm Id: 1253    Auditor Name: KPMG SA    Auditor Location: Paris-La Defense, France
    Auditor Firm Id: 1704    Auditor Name: Ernst & Young et Autres    Auditor Location: Courbevoie, France
     
     
     

    Table of Contents
    EXPLANATORY NOTE
    Cellectis S.A. (the “Company”) is filing this Amendment No. 1 (“Amendment No. 1”) on Form
    20-F/A
    to amend its Annual Report on Form 20-F for the fiscal year ended December 31, 2024 (the “Original Form
    20-F”),
    which was originally filed with the Securities and Exchange Commission (“SEC”) on March 14, 2025.
    This Amendment No. 1 is being filed solely to provide (i) an updated Exhibit 15.1 (Consent of KPMG SA) to correct an administrative error in such Exhibit 15.1 in the Original Form
    20-F,
    where the conformed signature of KPMG SA was inadvertently omitted and (ii) an updated Exhibit 15.2 (Consent of Ernst & Young et Autres) to correct an administrative error in such Exhibit 15.2 in the Original Form
    20-F,
    where the incorrect date of the consent was inadvertently included. The updated consents are included with this Amendment No. 1.
    This Amendment No. 1 speaks as of the date of the Original Form
    20-F.
    Except as described above, the Company has not modified or updated disclosures made in the Original Form
    20-F
    in this Amendment No. 1. Accordingly, this Amendment No. 1 does not reflect events occurring after the filing of the Original Form
    20-F
    or modify or update any disclosures affected by subsequent events.
    This Amendment No. 1 consists of a cover page, this explanatory note, the signature page, Exhibits 12.1 and 12.2 (new certifications by the Company’s principal executive officer and principal financial officer as required by Rule
    12b-15
    under the Securities Exchange Act of 1934, as amended) and the updated Exhibits 15.1 and 15.2.


    ITEM 19. EXHIBITS

    Exhibit Index

    The following exhibits are filed as part of this Annual Report:

     

    Exhibit
    Number

      

    Description of Exhibit

       Schedule/
    Form
         File Number      Exhibit      File Date  

     1.1#

       By-laws (Statuts) of the registrant      20-F        001-36891        1.1        March 14, 2025  

     2.1#

       Form of Deposit Agreement      F-1        333-202205        4.1        March 10, 2015  

     2.2#

       Form of American Depositary Receipt (included in Exhibit 2.1)      F-1        333-202205        Included in 4.1        March 10, 2015  

     2.3#

       Description of Securities registered under Section 12 of the Exchange Act      20-F        001-36891        2.3        March 14, 2025  

     4.1#*

       Exclusive Patent License Agreement between Regents of the University of Minnesota and Cellectis S.A., dated January 10, 2011      F-1        333-202205        10.6        March 12, 2015  

     4.1.1#*

      

    First Amendment to the Exclusive Patent License Agreement between

    Regents of the University of Minnesota and Cellectis S.A., dated

    May 24, 2012

         F-1        333-202205        10.6.1        March 12, 2015  

     4.1.2#*

       Second Amendment to the Exclusive Patent License Agreement between Regents of the University of Minnesota and Cellectis S.A., dated April 1, 2014      F-1        333-202205        10.6.2        March 12, 2015  

     4.1.3#*

       Third Amendment to the Exclusive Patent License Agreement between Regents of the University of Minnesota and Cellectis S.A., dated December 16, 2015      20-F        001-36891        4.6.3        March 13, 2018  

     4.1.4#**

       Fourth Amendment to the Exclusive Patent License Agreement between Regents of the University of Minnesota and Cellectis S.A., dated November 4, 2022      20-F        001-36891        4.1.4        March 14, 2023  

     4.2#

       Patent & Technology License Agreement between Ohio State Innovation Foundation and Cellectis S.A., dated October 23, 2014      20-F        001-36891        4.7        March 12, 2019  

     4.3#

       Form Change in Control Agreement      20-F        001-36891        4.3        March 14, 2023  

     4.4#

       2024 Employees Change of Control Plan, dated May 27, 2024      20-F        001-36891        4.4        March 14, 2025  

     4.5†#

       2012 Free Share Plan      F-1        333-202205        10.13        March 10, 2015  

     4.6†#

       2013 Free Share Plan      F-1        333-202205        10.14        March 10, 2015  

     4.7†#

       2014 Free Share Plan      F-1        333-202205        10.15        March 10, 2015  

     4.8†#

       2015 Free Share Plan      20-F        001-36891        4.16        March 10, 2015  

     4.9†#

       2015 Stock Option Plan      20-F        001-36891        4.17        March 10, 2015  

     4.10†#

       2016 Stock Option Plan      S-8        333-214884        99.1        December 2, 2016  

     4.11†#

       2017 Stock Option Plan      S-8        333-222482        99.1        January 9, 2018  

     4.12†#

       Free Share 2018 Plan      S-8 POS        333-222482        99.3        April 13, 2018  

     4.13†#

       2018 Stock Option Plan      S-8        333-227717        99.1        October 5, 2018  

     4.14†#

       Summary of BSA Plan      S-8        333-227717        99.2        October 5, 2018  

     4.15†#

       Second Free Share 2018 Plan      S-8 POS        333-227717        99.3        March 4, 2021  

     4.16†#

       2021 Stock Option Plan      S-8        333-258514        99.1        August 5, 2021  

     4.17†#

       2021 Free Shares Plan      S-8        333-258514        99.2        August 5, 2021  

     4.18†#

       2022 Stock Option Plan      S-8        333-267760        99.1        October 6, 2022  

     4.19†#

       2022 Free Shares Plan      S-8        333-267760        99.2        October 6, 2022  

     4.20†#

       2023 Stock Option Plan      S-8        333-273777        99.1        August 7, 2023  

     4.21†#

       2023 Free Shares Plan      S-8        333-273777        99.2        August 7, 2023  

     

    2


     4.22#**

       License Agreement between Allogene Therapeutics, Inc. and Cellectis S.A. dated March 8, 2019      20-F/A        001-36891        4.25        April 25, 2019  

     4.23#**

       License, Development and Commercialization Agreement between Les Laboratoires Servier and Cellectis S.A. dated March 6, 2019      20-F/A        001-36891        4.26        April 25, 2019  

     4.24#**

       Amendment No. 1 to License, Development and Commercialization Agreement between Les Laboratoires Servier and Cellectis S.A. dated March 4, 2020      20-F        001-36891        4.26.1        March 5, 2020  

     4.25†#

       2024 Stock Options Plan      S-8        333-284301        99.1        January 15, 2025  

     4.26†#

       2024 Free Shares Plan      S-8        333-284301        99.1        January 15, 2025  

     4.27

       [Reserved.]            

     4.28

       [Reserved.]            

     4.29#

       Sales Agreement, dated as of March 29, 2021, by and between Cellectis S.A. and Jefferies LLC      6-K        001-36891        1.1        March 29, 2021  

     4.29.1#

       Amendment No. 1 to the Sales Agreement between Jefferies LLC and Cellectis S.A., dated January 4, 2023      6-K        001-36891        1.2        January 4, 2023  

     4.30#**

       Credit Facility Agreement between the European Investment Bank and Cellectis S.A., dated December 28, 2022      20-F        001-36891        4.26        March 14, 2023  

     4.31#**

       Joint Research and Collaboration Agreement dated November 1, 2023 between Cellectis S.A. and AstraZeneca Ireland Limited      6-K        001-36891        99.1        November 9, 2023  

     4.32#**

       Initial Investment Agreement dated November 1, 2023 between AstraZeneca Holdings B.V. and Cellectis S.A.      6-K        001-36891        99.2        November 9, 2023  

     4.33#**

       Subsequent Investment Agreement dated November 14, 2023 between AstraZeneca Holdings B.V. and Cellectis S.A      6-K        001-36891        99.3        November 9, 2023  

     4.34#**

       Subscription Agreement for Warrants to be issued by Cellectis S.A. dated March 30, 2023      20-F        001-36891        4.34        March 14, 2025  

     8.1#

       List of subsidiaries of the registrant      20-F        001-36891        8.1        March 14, 2025  

    11.1#

       Insider Trading Policy      20-F        001-36891        11.1        March 14, 2025  

    12.1

       Certificate of Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002               Filed herewith  

    12.2

       Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002               Filed herewith  

    13.1#

       Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002      20-F        001-36891        13.1        March 14, 2025  

    13.2#

       Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002      20-F        001-36891        13.2        March 14, 2025  

    15.1

       Consent of KPMG SA (PCAOB #1253)               Filed herewith  

    15.2

       Consent of Ernst & Young et Autres (PCAOB # 1704)               Filed herewith  

    97.1#

       Compensation Recoupment Policy of Cellectis      20-F        001-36891        97.1        March 14, 2025  


    101

       The following materials from Cellectis S.A.’s Report on Form 20.F formatted in iXBRL (Inline eXtensible Business Reporting Language): (i) the Statements of Consolidated Financial Position, (ii) the Statements of Consolidated Operations, (iii) the Statements of Consolidated Comprehensive Income (Loss), (iv) the Statements of Consolidated Cash Flows, (v) the Statements of Changes in Consolidated Shareholders’ Equity, and (vi) Notes to the Consolidated Financial Statements.            

    104.1

       Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)            

     

    †

    Indicates a management contract or any compensatory plan, contract or arrangement.

    #

    Indicates a document previously filed with the Commission.

    *

    Portions of this exhibit (indicated by asterisks) have been omitted pursuant to a request for confidential treatment.

    **

    Portions of this exhibit (indicated by asterisks) have been omitted because they are not material and would likely cause competitive harm if disclosed.

     

    4


    SIGNATURES

    The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F/A and that it has duly caused and authorized the undersigned to sign this Amendment No. 1 to the Annual Report on its behalf.

     

    CELLECTIS S.A.
    /s/ André Choulika
    By: André Choulika
    Title: Chief Executive Officer

    Date: March 14, 2025

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      EMERYVILLE, Calif., Jan. 28, 2025 (GLOBE NEWSWIRE) -- Totus Medicines, a company revolutionizing small molecule drug discovery and development using covalent DNA-encoded libraries and AI tools, today announced the appointment of Simon Harnest, MSc, BSc, as Chief Financial Officer. This key addition comes at a pivotal moment for Totus as the company prepares to advance its clinical-stage program following encouraging results from its Phase 1 study of TOS-358, a covalent PI3Kα inhibitor. "The addition of Simon, with over 15 years' experience in private capital markets strategy and IPO processes, comes at the right time for Totus as we advance our clinical-stage and discovery programs," said

      1/28/25 8:00:00 AM ET
      $CBUS
      $CLLS
      $MGX
      $CLXT
      Agricultural Chemicals
      Industrials
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cellectis Provides Business Updates and Financial Results for Third Quarter 2024

      UCART22 and UCART20x22: enrollment ongoing, Phase 1 dataset and late-stage development strategy to be presented in 2025AstraZeneca partnership: R&D activities are ongoing on three programs – one allogeneic CAR T for hematological malignancies, one allogeneic CAR T for solid tumors, and one in vivo gene therapy for a genetic disorderAppointed Adrian Kilcoyne, M.D., MPH, MBA, an industry leader in the advancement of cell therapy treatment, as Chief Medical OfficerCash position of $264 million as of September 30, 20241; cash runway projection into 2027Conference call scheduled for 8:00 am ET / 2:00 pm CET on November 5, 2024 NEW YORK, Nov. 04, 2024 (GLOBE NEWSWIRE) -- Cellectis (the "Company

      11/4/24 4:30:00 PM ET
      $CLLS
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cellectis Appoints Dr. Adrian Kilcoyne as Chief Medical Officer

      NEW YORK, Aug. 07, 2024 (GLOBE NEWSWIRE) -- Cellectis (the "Company") (NASDAQ:CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, announced today the appointment of Dr. Adrian Kilcoyne, M.D., MPH, MBA as its Chief Medical Officer, effective immediately. "We're thrilled to welcome Dr. Kilcoyne to Cellectis. He is a strategic, forward-thinking drug developer who is passionate about delivering life-saving therapies to patients. His clinical vision and proven leadership, as well as his extensive experience, will strengthen our clinical development efforts as we advance our product pipeline of next-generation

      8/7/24 2:00:00 AM ET
      $CLLS
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cellectis to Report First Quarter Financial Results on May 12, 2025

      NEW YORK, May 06, 2025 (GLOBE NEWSWIRE) -- Cellectis (the "Company") (NASDAQ:CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, today announced that it will report financial results for the first quarter 2025 ending March 31, 2025 on Monday, May 12, 2025 after the close of the US market. The press release will be available in the Investors section of Cellectis' website: https://www.cellectis.com/en/investors/press-releases/ Cellectis will not host a conference call to discuss these results. Our investors relations team remains available for questions at [email protected]      About Cellectis  Ce

      5/6/25 4:30:00 PM ET
      $CLLS
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cellectis Reports Financial Results for the Fourth Quarter and Full Year 2024 and Provides a Business Update

      ○ UCART22 Phase 1 dataset and late-stage development strategy expected in the third quarter of 2025; Orphan Drug Designation (ODD) and Rare Pediatric Disease Designation (RPDD) granted by FDA and ODD granted by the European Commission to UCART22 for the treatment of ALL. ○ UCART20x22 Phase 1 study in relapsed or refractory B-cell non-Hodgkin lymphoma (r/r NHL) ongoing with readout expected in late 2025. ○ AstraZeneca partnership: R&D activities ongoing on three programs – one allogeneic CAR T for hematological malignancies, one allogeneic CAR T for solid tumors, and one in vivo gene therapy for a genetic disorder. ○ Cash position of $264 million as of December 31, 20241 provides runway in

      3/13/25 6:07:50 PM ET
      $CLLS
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cellectis to Report Fourth Quarter and Full Year 2024 Financial Results on March 13, 2025

      NEW YORK, March 07, 2025 (GLOBE NEWSWIRE) -- Cellectis (the "Company") (NASDAQ:CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, today announced that it will report financial results for the fourth quarter and full year 2024 ending December 31, 2024 on Thursday, March 13, 2025 after the close of the US market. The publication will be followed by an investor conference call and webcast on Friday, March 14, 2025, at 8:00 AM ET / 1:00 PM CET. The call will include the Company's fourth quarter and full year 2024 results and an update on business activities. Details for the call are as follows: Di

      3/7/25 4:30:00 PM ET
      $CLLS
      Biotechnology: Pharmaceutical Preparations
      Health Care