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    Amendment: SEC Form SC 13D/A filed by Instil Bio Inc.

    10/22/24 6:21:56 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $TIL alert in real time by email
    SC 13D/A 1 d890198dsc13da.htm SC 13D/A SC 13D/A

     

     

    SECURITIES AND EXCHANGE COMMISSION

    WASHINGTON, D.C. 20549

     

     

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 1)*

     

     

    Instil Bio, Inc.

    (Name of Issuer)

    Common Stock, par value $0.000001

    (Title of Class of Securities)

    4578C101

    (CUSIP NUMBER)

    Curative Ventures V LLC

    3963 Maple Avenue Suite 390

    Dallas, Texas 75219

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    August 6, 2022

    (Date of event which requires filing of this statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g) check the following box ☐.

     

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

     

     

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (the “Act”), or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

     

     

     


    CUSIP No. 45783C101    13D

     

     1   

     NAMES OF REPORTING PERSONS

     

     Curative Ventures V LLC

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     WC

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     Delaware

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

     0

        8  

     SHARED VOTING POWER

     

     1,899,003

        9  

     SOLE DISPOSITIVE POWER

     

     0

       10  

     SHARED DISPOSITIVE POWER

     

     1,899,003

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     1,899,003

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     29.2%

    14  

     TYPE OF REPORTING PERSON*

     

     OO

     

    *

    SEE INSTRUCTIONS BEFORE FILLING OUT


    CUSIP No. 45783C101

       13D

     

     1   

     NAMES OF REPORTING PERSONS

     

     CV-Immetacyte Manager LP

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     AF

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     Delaware

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

     0

        8  

     SHARED VOTING POWER

     

     1,899,003

        9  

     SOLE DISPOSITIVE POWER

     

     0

       10  

     SHARED DISPOSITIVE POWER

     

     1,899,003

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     1,899,003

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     29.2%

    14  

     TYPE OF REPORTING PERSON*

     

     OO

     

    *

    SEE INSTRUCTIONS BEFORE FILLING OUT


    CUSIP No. 45783C101    13D

     

     1   

     NAMES OF REPORTING PERSONS

     

     CV-Immetacyte Ultimate Manager LLC

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     AF

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     Delaware

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

     0

        8  

     SHARED VOTING POWER

     

     1,899,003

        9  

     SOLE DISPOSITIVE POWER

     

     0

       10  

     SHARED DISPOSITIVE POWER

     

     1,899,003

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     1,899,003

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     29.2%

    14  

     TYPE OF REPORTING PERSON*

     

     OO

     

    *

    SEE INSTRUCTIONS BEFORE FILLING OUT


    CUSIP No. 45783C101    13D

     

     1   

     NAMES OF REPORTING PERSONS

     

     SB2A LP

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     AF

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     Delaware

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

        8  

     SHARED VOTING POWER

     

     2,019,002

        9  

     SOLE DISPOSITIVE POWER

     

       10  

     SHARED DISPOSITIVE POWER

     

     2,019,002

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     2,019,002

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     31.0%

    14  

     TYPE OF REPORTING PERSON*

     

     PN


    CUSIP No. 45783C101    13D

     

     1   

     NAMES OF REPORTING PERSONS

     

     SB2A Management LLC

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     AF

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     Delaware

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

        8  

     SHARED VOTING POWER

     

     2,019,002

        9  

     SOLE DISPOSITIVE POWER

     

       10  

     SHARED DISPOSITIVE POWER

     

     2,019,002

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     2,019,002

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     31.0%

    14  

     TYPE OF REPORTING PERSON*

     

     OO


     1   

     NAMES OF REPORTING PERSONS

     

     Bronson Crouch

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) ☐  (b) ☒

     

     3  

     SEC USE ONLY

     

     4  

     SOURCE OF FUNDS*

     

     PF/AF

     5  

     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

     

     ☐

     6  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     United States

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

        7   

     SOLE VOTING POWER

     

     518,496

        8  

     SHARED VOTING POWER

     

     2,019,002

        9  

     SOLE DISPOSITIVE POWER

     

     518,496

       10  

     SHARED DISPOSITIVE POWER

     

     2,019,002

    11   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     2,537,498

    12  

     CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

     

     ☐

    13  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

     36.80%

    14  

     TYPE OF REPORTING PERSON*

     

     HC, IN

     

    *

    SEE INSTRUCTIONS BEFORE FILLING OUT


    SCHEDULE 13D

    Explanatory Note

    This Amendment No. 1 (this “Amendment”) reflects changes to the information in the Schedule 13D relating to the Common Stock, par value $0.000001 (the “Shares”) of Instil Bio, Inc. (the “Issuer” or the “Company”) filed on March 23, 2021 by the Reporting Persons (as amended, the “Schedule 13D”).

    Unless otherwise indicated, each capitalized term used but not defined in this Amendment shall have the meaning assigned to such term in the Schedule 13D. With the exception of the changes indicated below, the Schedule 13D is unchanged.

     

    Item 3.

    Source and Amount of Funds or Other Considerations

    Solely as a result of the periodic vesting of options held directly by Bronson Crouch, the Chief Executive Officer of the Issuer, Mr. Crouch was deemed to beneficially own additional shares of Common Stock as follows:

     

      •  

    On August 6, 2022, Mr. Crouch’s vesting of options caused the number of shares to be 46,220,773 resulting in the Reporting Persons’ having aggregate beneficial ownership of 34.60%.

     

      •  

    On August 6, 2023, Mr. Crouch’s vesting of options caused the number of shares to be 48,301,188 resulting in the Reporting Persons’ having aggregate beneficial ownership of 35.60%.

     

      •  

    On August 10, 2024, Mr. Crouch’s vesting of options caused the number of shares to be 2,518,124 (which would have been equal to 50,362,470 on a pre-split basis**) resulting in the Reporting Persons’ having aggregate beneficial ownership of 36.60%.

     

    **

    On December 7, 2023, the Issuer effected a 1-for-20 reverse stock split of its common stock. As a result, the number of Shares held by the Reporting Persons, as well as all other common stockholders, was proportionately reduced on such date.

    All changes were solely the result of the periodic vesting of options held by Mr. Crouch. Mr. Crouch did not exercise any such options during this period, and no other Reporting Person acquired any Common Stock during this period. Additionally, Mr. Crouch reports his beneficial ownership in accordance with the filing requirements of Section 16(a) of the Act.

     

    Item 5.

    Interest in Securities of the Issuer

     

      (a)

    As of the date hereof, (i) Curative Ventures V LLC (“CVV”) may be deemed to beneficially own 1,899,003 shares of Common Stock, which represents approximately 29.2% of the outstanding Common Stock; (ii) CV-Immetacyte Manager LP (“CV-Immetacyte Manager”) may be deemed to beneficially own 1,899,003 shares of Common Stock, which represents approximately 29.2% of the outstanding Common Stock; (iii) CV-Immetacyte Ultimate Manager LLC (“Ultimate Manager”) may be deemed to beneficially own 1,899,003 shares of Common Stock, which represents approximately 29.2% of the outstanding Common Stock; (iv) SB2A LP (“SB2A”) may be deemed to beneficially own 2,019,002 shares of Common


      Stock, which represents approximately 31.0% of the Outstanding Common Stock; (v) SB2A Management LLC (“SB2A Manager”) may be deemed to beneficially own 2,019,002 shares of Common Stock, which represents approximately 31.0% of the Outstanding Common Stock; and (vi) Mr. Crouch may be deemed to beneficially own 2,537,498 shares of Common Stock (this amount includes 391,603 shares of Common Stock that are obtainable upon exercise of options within the next 60 days), which represents approximately 36.80% of the outstanding Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or his pecuniary interest therein.
      (b)

    As of August 6, 2022:

     

    Name of Reporting Person

       Sole Voting
    Power
         Shared Voting
    Power
         Sole Dispositive
    Power
         Shared Dispositive
    Power
     

    CVV

         0        37,980,073        0        37,980,073  

    CV-Immetacyte Manager

         0        37,980,073        0        37,980,073  

    Ultimate Manager

         0        37,980,073        0        37,980,073  

    SB2A

         0        40,380,072        0        40,380,072  

    SB2A Manager

         0        40,380,072        0        40,380,072  

    Bronson Crouch

         5,840,701        40,380,072        5,840,701        40,380,072  

    As of August 6, 2023:

     

    Name of Reporting Person

       Sole Voting
    Power
         Shared Voting
    Power
         Sole Dispositive
    Power
         Shared Dispositive
    Power
     

    CVV

         0        37,980,073        0        37,980,073  

    CV-Immetacyte Manager

         0        37,980,073        0        37,980,073  

    Ultimate Manager

         0        37,980,073        0        37,980,073  

    SB2A

         0        40,380,072        0        40,380,072  

    SB2A Manager

         0        40,380,072        0        40,380,072  

    Bronson Crouch

         7,921,116        40,380,072        7,921,116        40,380,072  

    Following Reverse Stock Split

    As of August 10, 2024:

     

    Name of Reporting Person

       Sole Voting
    Power
         Shared Voting
    Power
         Sole Dispositive
    Power
         Shared Dispositive
    Power
     

    CVV

         0        1,899,003        0        1,899,003  

    CV-Immetacyte Manager

         0        1,899,003        0        1,899,003  

    Ultimate Manager

         0        1,899,003        0        1,899,003  

    SB2A

         0        2,019,002        0        2,019,002  

    SB2A Manager

         0        2,019,002        0        2,019,002  

    Bronson Crouch

         499,122        2,019,002        499,122        2,019,002  

    As of the date hereof:

     

    Name of Reporting Person   

    Sole Voting

    Power

        

    Shared Voting

    Power

        

    Sole Dispositive

    Power

        

    Shared Dispositive

    Power

     

    CVV

         0        1,899,003        0        1,899,003  

    CV-Immetacyte Manager

         0        1,899,003        0        1,899,003  

    Ultimate Manager

         0        1,899,003        0        1,899,003  

    SB2A

         0        2,019,002        0        2,019,002  

    SB2A Manager

         0        2,019,002        0        2,019,002  

    Bronson Crouch

         518,496        2,019,002        518,496        2,019,002  

     

    Item 7.

    Material to be Filed as Exhibits

    Exhibit A: Joint Filing Agreement

    Exhibit B: Second Amended and Restated Investors’ Rights Agreement (incorporated by reference to Exhibit 4.1 to the registration statement on Form S-1 filed by the Company as File Number 333-253620)


    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: October 22, 2024

     

    CURATIVE VENTURES V LLC

    By:

     

    By:

     

    CV-Immetacyte Manager LP, its manager

     

    CV-Immetacyte Ultimate Manager LLC, its general partner

    By:  

    /S/ Bronson Crouch

      Name:   Bronson Crouch
      Title:   Manager
    CV-IMMETACYTE MANAGER LP
    By:   CV-Immetacyte Ultimate Manager LLC, its general partner
    By:  

    /S/ Bronson Crouch

      Name:   Bronson Crouch
      Title:   Manager

     

    CV-IMMETACYTE ULTIMATE MANAGER LLC
    By:  

    /S/ Bronson Crouch

      Name: Bronson Crouch
      Title: Manager
    SB2A LP
    By:   SB2A Management LLC, its general partner
    By:  

    /S/ Bronson Crouch

     

    Name: Bronson Crouch

    Title: Managing Member


    SB2A MANAGEMENT LLC
    By:  

    /S/ Bronson Crouch

    Name: Bronson Crouch
    Title: Managing Member
    BRONSON CROUCH

    /S/ Bronson Crouch

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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Instil Bio and ImmuneOnco Announced the Phase 2 Trial in First-line NSCLC of IMM2510/AXN-2510 ('2510), a PD-L1xVEGF Bispecific Antibody, in Combination with Chemotherapy in China is on Track to Complete Enrollment in Q3 2025; Initial Results Anticipated in 2H 2025

      Phase 3 trial of ‘2510 in combination with chemotherapy in first-line NSCLC anticipated to start in mid-2026 in China, subject to regulatory discussions Monotherapy US dose optimization Phase 1b/2 trial of ‘2510 in relapsed/refractory solid tumors, intended to bridge the doses to the ongoing China trials, replaces the previously planned US trial DALLAS and SHANGHAI, May 22, 2025 (GLOBE NEWSWIRE) -- Instil Bio, Inc. (NASDAQ:TIL, ", Instil", )) and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. (HKEX Code: 1541.HK, "ImmuneOnco"), today announced clinical trial updates of ‘2510 and NSCLC clinical development strategy. "We are delighted with the significant clinical advancements by our colla

      5/22/25 6:00:00 AM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TIL
    SEC Filings

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    • Instil Bio Inc. filed SEC Form 8-K: Submission of Matters to a Vote of Security Holders

      8-K - Instil Bio, Inc. (0001789769) (Filer)

      5/28/25 5:16:42 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Instil Bio Inc. filed SEC Form 8-K: Regulation FD Disclosure, Other Events, Financial Statements and Exhibits

      8-K - Instil Bio, Inc. (0001789769) (Filer)

      5/27/25 5:03:44 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Instil Bio Inc. filed SEC Form 8-K: Regulation FD Disclosure, Financial Statements and Exhibits

      8-K - Instil Bio, Inc. (0001789769) (Filer)

      5/22/25 6:02:42 AM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TIL
    Leadership Updates

    Live Leadership Updates

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    • Instil Bio Reports Third Quarter 2022 Financial Results and Provides Corporate Update

      Manufacturing update on voluntary pause of DELTA-1 trial of ITIL-168 in advanced melanoma expected in Q1'23 Reprioritization of resources with enrollment deferred in DELTA-2 trial of ITIL-168 First patient with non-small cell lung cancer dosed with ITIL-306, the first engineered TIL therapy using CoStAR Platform, with plans to share clinical data in 2023 Appointment of cell therapy pioneer Dr. Robert Hawkins as Head of Research and Development, and resignation of Chief Medical Officer, Dr. Zachary Roberts Company confirms cash runway into 2025 with anticipated sale-leaseback transaction of its Tarzana manufacturing facility DALLAS, Nov. 14, 2022 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("

      11/14/22 4:07:40 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Instil Bio Announces Appointment of Tim Moore as Chief Operating Officer

      DALLAS, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("Instil") (NASDAQ:TIL), a clinical-stage biopharmaceutical company focused on developing tumor infiltrating lymphocyte, or TIL, therapies for the treatment of patients with cancer, today announced the appointment of Tim Moore to the role of Chief Operating Officer. Tim Moore has more than three decades of leadership experience in biopharmaceutical manufacturing and operations, including at Genentech, Kite and most recently PACT Pharma. From 2016 to 2019, Mr. Moore was Executive Vice President, Technical Operations at Kite Pharma, where he was responsible for technical operations and successfully launched Yescarta®, one of the fi

      9/6/22 7:00:00 AM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TIL
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

      SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

      11/14/24 6:59:16 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

      SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

      11/14/24 5:48:56 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

      SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

      10/25/24 9:42:03 PM ET
      $TIL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care