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    Amendment: SEC Form SC 13D/A filed by Monte Rosa Therapeutics Inc.

    8/12/24 5:07:57 PM ET
    $GLUE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $GLUE alert in real time by email
    SC 13D/A 1 d882488dsc13da.htm SC 13D/A SC 13D/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D

    (Rule 13d-102)

    INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

    TO RULE 13d-l(a) AND AMENDMENTS THERE TO FILED PURSUANT

    TO RULE 13d-2(a)

    (Amendment No. 2)*

     

     

    Monte Rosa Therapeutics, Inc.

    (Name of Issuer)

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

    61225M102

    (CUSIP Number)

    Versant Venture Capital VI, L.P.

    Max Eisenberg

    One Sansome Street, Suite 1650

    San Francisco, CA 94104

    415-801-8100

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    August 8, 2024

    (Date of Event Which Requires Filing of this Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

     

     

     


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Venture Capital VI, L.P.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     WC

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     6,799,115 shares of common stock (1)

        8.   

     Shared Voting Power

     

     0

        9.   

     Sole Dispositive Power

     

     6,799,115 shares of common stock (1)

       10.   

     Shared Dispositive Power

     

     0

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     6,799,115 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     11.1% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     PN

     

    (1)

    These shares are held by Versant VI (as defined in Item 2(a) of the Original Schedule 13D). Versant Ventures VI GP-GP (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of Versant Ventures VI GP (as defined in Item 2(a) of the Original Schedule 13D), which is the general partner of Versant VI. Each of Versant Ventures VI GP-GP and Versant Ventures VI GP may be deemed to share voting, investment and dispositive power with respect to the shares held by Versant VI.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock (as defined in Item 1 of the Original Schedule 13D) outstanding as of August 5, 2024, as set forth in the Issuer’s quarterly report on Form 10-Q for the quarter ended June 30, 2024, filed with the United States Securities and Exchange Commission (the “Commission”) on August 8, 2024 (the “Form 10-Q”)


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Ventures VI GP, L.P.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     6,799,115 shares of common stock (1)

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     6,799,115 shares of common stock (1)

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     6,799,115 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     11.1% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     PN

     

    (1)

    These shares are held by Versant VI. Versant Ventures VI GP-GP is the general partner of Versant Ventures VI GP, which is the general partner of Versant VI. Each of Versant Ventures VI GP-GP and Versant Ventures VI GP may be deemed to share voting, investment and dispositive power with respect to the shares held by Versant VI.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as set forth in the Form 10-Q.


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Ventures VI GP-GP, LLC

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     6,799,115 shares of common stock (1)

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     6,799,115 shares of common stock (1)

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     6,799,115 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     11.1% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     OO

     

    (1)

    These shares are held by Versant VI. Versant Ventures VI GP-GP is the general partner of Versant Ventures VI GP, which is the general partner of Versant VI. Each of Versant Ventures VI GP-GP and Versant Ventures VI GP may be deemed to share voting, investment and dispositive power with respect to the shares held by Versant VI.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as set forth in the Form 10-Q.


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Vantage I, L.P.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     WC

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     2,097,938 shares of common stock (1)

        8.   

     Shared Voting Power

     

     0

        9.   

     Sole Dispositive Power

     

     2,097,938 shares of common stock (1)

       10.   

     Shared Dispositive Power

     

     0

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     2,097,938 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     3.4% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     PN

     

    (1)

    These shares are held by Versant Vantage I (as defined in item 2(a) of the Original Schedule 13D). Versant Vantage I GP (as defined in item 2(a) of the Original Schedule 13D) is the general partner of Versant Vantage I, and Versant Vantage I GP-GP (as defined in item 2(a) of the Original Schedule 13D) is the general partner of Versant Vantage I GP. Each of Versant Vantage I GP and Versant Vantage I GP-GP share voting, investment and dispositive power over the shares held by Versant Vantage I.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as set forth in the Form 10-Q.


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Vantage I GP, L.P.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     2,097,938 shares of common stock (1)

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     2,097,938 shares of common stock (1)

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     2,097,938 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     3.4% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     PN

     

    (1)

    These shares are held by Versant Vantage I. Versant Vantage I GP is the general partner of Versant Vantage I, and Versant Vantage I GP-GP is the general partner of Versant Vantage I GP. Each of Versant Vantage I GP and Versant Vantage I GP-GP share voting, investment and dispositive power over the shares held by Versant Vantage I.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as set forth in the Form 10-Q.


    CUSIP No. 61225M102   13D

     

     1.    

     Name of Reporting Persons

     

     Versant Vantage I GP-GP, LLC

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     2,097,938 shares of common stock (1)

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     2,097,938 shares of common stock (1)

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     2,097,938 shares of common stock (1)

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row 11

     

     3.4% (2)

    14.  

     Type of Reporting Person (See Instructions)

     

     OO

     

    (1)

    These shares are held by Versant Vantage I. Versant Vantage I GP is the general partner of Versant Vantage I, and Versant Vantage I GP-GP is the general partner of Versant Vantage I GP. Each of Versant Vantage I GP and Versant Vantage I GP-GP share voting, investment and dispositive power over the shares held by Versant Vantage I.

    (2)

    Based upon 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as set forth in the Form 10-Q.


    CUSIP No. 61225M102   13D

     

    Explanatory Note:

    This Amendment No. 2 (this “Amendment”) amends and supplements the Schedule 13D originally filed by the Reporting Persons with the Commission on July 8, 2021, as amended by Amendment No. 1 (“Amendment No. 1”) filed with the Commission on November 9, 2023 (together, the “Original Schedule 13D”). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13D.

    Item 5. Interest in Securities of the Issuer

    This information reported below is based on a total of 61,372,824 shares of the Issuer’s Common Stock outstanding as of August 5, 2024, as reported on the Issuer’s Form 10-Q filed with the Commission on August 8, 2024. This Amendment is being filed to update the aggregate percentage of the Issuer’s Common Stock owned by the Reporting Persons due to dilution caused by the Issuer’s sales of additional shares of its Common Stock from time to time since the date of the filing of Amendment No. 1. Such transactions resulted in a decrease of over one percent (1%) in the aggregate percentage ownership reported by the Reporting Persons in the Original Schedule 13D.

    (a) and (b) See Items 7-11 and 13 of the cover pages of this Statement for each Reporting Person and Item 2 above.


    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    August 12, 2024
    Versant Venture Capital VI, L.P.
    By:   Versant Ventures VI GP, L.P.
    Its:   General Partner
    By:   Versant Ventures VI GP-GP, LLC
    Its:   General Partner
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

    Versant Ventures VI GP, L.P.
    By:   Versant Ventures VI GP-GP, LLC
    Its:   General Partner
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

    Versant Ventures VI GP-GP, LLC
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

    Versant Vantage I, L.P.
    By:   Versant Vantage I GP, L.P.
    Its:   General Partner
    By:   Versant Vantage I GP-GP, LLC
    Its:   General Partner
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

    Versant Vantage I GP, L.P.
    By:   Versant Vantage I GP-GP, LLC
    Its:   General Partner
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

    Versant Vantage I GP-GP, LLC
    By:  

    /s/ Max Eisenberg, Chief Operating Officer

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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $GLUE
    Insider Trading

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    • Director Leo Chandra P. bought $58,383 worth of shares (10,000 units at $5.84) (SEC Form 4)

      4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

      3/25/25 6:32:00 PM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Chief Business & Legal Officer Nickson Philip was granted 36,000 shares (SEC Form 4)

      4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

      1/6/25 4:15:17 PM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Principal Accounting Officer Dunn Edmund was granted 11,850 shares, increasing direct ownership by 85% to 25,794 units (SEC Form 4)

      4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

      1/6/25 4:15:13 PM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $GLUE
    Press Releases

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    • Monte Rosa Therapeutics Announces First Quarter 2025 Financial Results and Business Updates

      VAV1-directed MRT-6160 program advancing toward multiple Phase 2 studies, enabled by Phase 1 SAD/MAD study data supporting broad potential application in immune-mediated diseases MRT-2359 Phase 1/2 study data demonstrate encouraging signals of clinical response in heavily pretreated castration-resistant prostate cancer patients resistant to AR therapy; additional results expected in H2 2025 MRT-8102, a NEK7-directed molecular glue degrader targeting diseases driven by IL-1β and the NLRP3 inflammasome, on track for IND filing in H1 2025 Cyclin E1 (CCNE1) and CDK2-directed MGD programs for the treatment of CCNE1-driven solid tumors and ER+ breast cancer advancing toward the clin

      5/8/25 7:00:00 AM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Monte Rosa Therapeutics Presents Preclinical Data at American Association for Cancer Research (AACR) Annual Meeting 2025 on the Potential of its CDK2-directed Molecular Glue Degrader to Treat HR-positive/HER2-negative Breast Cancer

      CDK2 molecular glue degrader (MGD) in combination with CDK4/6 inhibition and anti-estrogen therapy achieved superior tumor regression in vivo compared to standard of care CDK4/6 inhibition and anti-estrogen therapy CDK2 MGD delayed resistance to CDK4/6 inhibition in vitro and displayed superior selectivity versus clinical-stage CDK2 inhibitors BOSTON, April 28, 2025 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical-stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced the company will present preclinical data on the potential of its highly selective cyclin-dependent kinase 2 (CDK2)-directed molecular glue

      4/28/25 7:00:00 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Monte Rosa Therapeutics Announces Fourth Quarter 2024 Financial Results and Provides Corporate Update Including New Clinical Results from MRT-6160 and MRT-2359 Programs

      Results of the MRT-6160 Phase 1 SAD/MAD study demonstrate deep VAV1 degradation of greater than 90%, significant T and B cell functional inhibition as well as significant inhibition of cytokine release from T and B cells following ex-vivo stimulation, and favorable safety/tolerability profile; data support clear path to Phase 2 studies and broad potential applications in immune-mediated diseases Phase 1/2 study of MRT-2359 demonstrates encouraging signals of clinical response in castration-resistant prostate cancer (CRPC) patients resistant to AR therapy, including confirmed RECIST response; CRPC cohort will be focus moving forward with additional Phase 1/2 results expected in H2 2025; depr

      3/20/25 7:00:00 AM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

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    SEC Filings

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    • SEC Form 10-Q filed by Monte Rosa Therapeutics Inc.

      10-Q - Monte Rosa Therapeutics, Inc. (0001826457) (Filer)

      5/8/25 7:14:15 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Monte Rosa Therapeutics Inc. filed SEC Form 8-K: Results of Operations and Financial Condition, Regulation FD Disclosure, Financial Statements and Exhibits

      8-K - Monte Rosa Therapeutics, Inc. (0001826457) (Filer)

      5/8/25 7:11:22 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form DEFA14A filed by Monte Rosa Therapeutics Inc.

      DEFA14A - Monte Rosa Therapeutics, Inc. (0001826457) (Filer)

      4/25/25 4:02:35 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

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    Insider Purchases

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    • Director Leo Chandra P. bought $58,383 worth of shares (10,000 units at $5.84) (SEC Form 4)

      4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

      3/25/25 6:32:00 PM ET
      $GLUE
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care