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    Amendment: SEC Form SC 13G/A filed by Ionis Pharmaceuticals Inc.

    11/14/24 8:34:57 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care
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    SC 13G/A 1 d877529dsc13ga.htm SC 13G/A SC 13G/A

     

     

    United States

    SECURITIES AND EXCHANGE COMMISSION

    WASHINGTON, D.C. 20549

     

     

    SCHEDULE 13G

    Under the Securities Exchange Act of 1934

    (Amendment No. 14)*

     

     

    Ionis Pharmaceuticals, Inc.

    (Name of Issuer)

    Common Stock

    (Title of Class of Securities)

    462222100

    (CUSIP Number)

    September 30, 2024

    (Date of Event Which Requires Filing This Statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

    ☐ Rule 13d-1(b)

    ☒ Rule 13d-1(c)

    ☐ Rule 13d-1(d)

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 462222100

     

     1.   

     Names of Reporting Persons

     

     BB Biotech AG

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☒  (b) ☐

     

     3.  

     SEC Use Only

     

      

     4.  

     Citizenship or Place of Organization

     

     Switzerland

    Number of

    Shares  Beneficially 

    Owned by

    Each

    Reporting

    Person

    with:

       5.   

     Sole Voting Power

     

     0

       6.  

     Shared Voting Power

     

     7,850,000

       7.  

     Sole Dispositive Power

     

     0

       8.  

     Shared Dispositive Power

     

     7,850,000

     9.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     7,850,000

    10.  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     ☐

    11.  

     Percent of Class Represented by amount in Row (9)

     

     5.0%

    12.  

     Type of Reporting Person (See Instructions)

     

     HC, CO

     

    2 of 7


    CUSIP No. 462222100

     

     1.   

     Names of Reporting Persons

     

     Biotech Invest N.V.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☒  (b) ☐

     

     3.  

     SEC Use Only

     

      

     4.  

     Citizenship or Place of Organization

     

     Curaçao

    Number of

    Shares  Beneficially 

    Owned by

    Each

    Reporting

    Person

    with:

       5.   

     Sole Voting Power

     

     0

       6.  

     Shared Voting Power

     

     7,850,000

       7.  

     Sole Dispositive Power

     

     0

       8.  

     Shared Dispositive Power

     

     7,850,000

     9.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     7,850,000

    10.  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     ☐

    11.  

     Percent of Class Represented by amount in Row (9)

     

     5.0%

    12.  

     Type of Reporting Person (See Instructions)

     

     CO

     

    3 of 7


    Item 1

    1(a) Name of Issuer: Ionis Pharmaceuticals, Inc.

    1(b) Address of Issuer’s Principal Executive Offices:

    2855 Gazelle Court, Carlsbad, California 92010

    Item 2

    2(a) Name of Person Filing: BB Biotech AG (“BB Biotech”) on behalf of its wholly-owned subsidiary, Biotech Invest N.V. (“Biotech Invest”)

    2(b) Address of Principal Business Office or, if none, Residence:

    BB Biotech AG: Schwertstrasse 6, CH-8200 Schaffhausen, Switzerland

    Biotech Invest N.V.: Ara Hill Top Building, Unit A-5, Pletterijweg Oost 1, Curaçao

    2(c) Citizenship: BB Biotech AG: Switzerland

     Biotech Invest N.V.: Curaçao

    2(d) Title of Class of Securities: Common Stock, $0.001 Par Value

    2(e) CUSIP Number: 462222100

    Item 4. Ownership

    Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

     

      (a)

    Amount beneficially owned: 7,850,000

     

      (b)

    Percent of class: 5.0%

     

      (c)

    Number of shares as to which the person has:

     

      (i)

    Sole power to vote or to direct the vote 0

     

      (ii)

    Shared power to vote or to direct the vote 7,850,000

     

      (iii)

    Sole power to dispose or to direct the disposition of 0

     

      (iv)

    Shared power to dispose or to direct the disposition of 7,850,000

    Item 5. Ownership of Five Percent or Less of a Class

    If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ☒

     

    4 of 7


    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

    This statement is filed jointly by BB Biotech and Biotech Invest. Biotech Invest is a wholly-owned subsidiary of BB Biotech.

    Item 10. Certification

    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

     

    5 of 7


    SIGNATURES

    After reasonable inquiry and the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    BB Biotech AG      
    Date: November 14, 2024     By:   /s/ Martin Gubler
          Signatory Authority
        Name:   Martin Gubler
        Title:   Signatory Authority
    Date: November 14, 2024     By:   /s/ Ivo Betschart
          Signatory Authority
        Name:   Ivo Betschart
        Title:   Signatory Authority
    Biotech Invest N.V.      
    Date: November 14, 2024     By:   /s/ Jan Bootsma
          Signatory Authority
        Name:   Jan Bootsma
        Title:   Signatory Authority
    Date: November 14, 2024     By:   /s/ Hugo van Neutegem
          Signatory Authority
        Name:   Hugo van Neutegem
            Title:   Signatory Authority

     

    6 of 7


    Exhibit Index

    Exhibit A: Agreement by and between BB Biotech AG and Biotech Invest N.V. with respect to the filing of this disclosure statement.*

     

    *

    Previously filed as an exhibit to BB Biotech AG and Biotech Invest N.V.’s Schedule 13G filed with the Securities and Exchange Commission on February 13, 2020.

     

    7 of 7

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