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    Amendment: SEC Form SCHEDULE 13D/A filed by Apogee Therapeutics Inc.

    1/22/26 8:00:19 PM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $APGE alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 4)


    Apogee Therapeutics, Inc.

    (Name of Issuer)


    Common Stock, $0.00001 par value

    (Title of Class of Securities)


    03770N101

    (CUSIP Number)


    Ms. Erin O'Connor
    Fairmount Funds Management LLC, 200 Barr Harbor Drive, Suite 400
    West Conshohocken, PA, 19428
    (267) 262-5300

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    01/22/2026

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    03770N101


    1 Name of reporting person

    Fairmount Funds Management LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    5,948,385.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    5,948,385.00
    11Aggregate amount beneficially owned by each reporting person

    5,948,385.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.82 %
    14Type of Reporting Person (See Instructions)

    IA

    Comment for Type of Reporting Person:
    The securities include (i) 298,647 shares of common stock, $0.00001 par value per share (the "Common Stock") and (ii) 5,649,738 shares of Common Stock issuable upon conversion of 5,649,738 shares of Non-Voting Common Stock, par value $0.00001 per share (the "Non-Voting Common Stock"), the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock, both directly held by Fairmount Healthcare Fund II L.P., a Delaware limited partnership ("Fund II"). The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock held by Fund II in excess of the beneficial ownership limitation. Row 13 is based on 60,567,741 shares of Common Stock outstanding as of January 22, 2026, consisting of (i) 54,833,587 shares of Common Stock outstanding as of November 3, 2025, as reported in the Company's Form 10-Q filed on November 10, 2025, (ii) 84,416 shares underlying vested stock options owned by the Reporting Persons and (iii) 5,649,738 shares of Common Stock underlying the 5,649,738 shares of Non-Voting Common Stock owned by Fund II, applying the beneficial ownership limitation.


    SCHEDULE 13D

    CUSIP No.
    03770N101


    1 Name of reporting person

    Fairmount Healthcare Fund II L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    5,948,385.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    5,948,385.00
    11Aggregate amount beneficially owned by each reporting person

    5,948,385.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.82 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The securities include (i) 298,647 shares of Common Stock and (ii) 5,649,738 shares of Common Stock issuable upon conversion of 5,649,738 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock, both directly held by Fund II. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock held by Fund II in excess of the beneficial ownership limitation. Row 13 is based on 60,567,741 shares of Common Stock outstanding as of January 22, 2026, consisting of (i) 54,833,587 shares of Common Stock outstanding as of November 3, 2025, as reported in the Company's Form 10-Q filed on November 10, 2025, (ii) 84,416 shares underlying vested stock options owned by the Reporting Persons and (iii) 5,649,738 shares of Common Stock underlying the 5,649,738 shares of Non-Voting Common Stock owned by Fund II, applying the beneficial ownership limitation.


    SCHEDULE 13D

    CUSIP No.
    03770N101


    1 Name of reporting person

    Peter Evan Harwin
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    93,374.00
    8Shared Voting Power

    5,953,653.00
    9Sole Dispositive Power

    93,374.00
    10Shared Dispositive Power

    5,953,653.00
    11Aggregate amount beneficially owned by each reporting person

    6,047,027.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.99 %
    14Type of Reporting Person (See Instructions)

    IN, HC

    Comment for Type of Reporting Person:
    The securities include (a) 51,166 shares of Common Stock held directly by Mr. Harwin, (b) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin* and (c) Fund II's direct holdings of (i) 298,647 shares of Common Stock and (ii) 5,655,066 shares of Common Stock issuable upon conversion of 5,655,066 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock in excess of the beneficial ownership limitation. Row 13 is based on 60,530,801 shares of Common Stock outstanding as of January 22, 2026, consisting of (i) 54,833,587 shares of Common Stock outstanding as of November 3, 2025, as reported in the Company's Form 10-Q filed on November 10, 2025, (ii) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin and (iii) 5,655,006 shares of Common Stock underlying the 5,655,006 shares of Non-Voting Common Stock owned by Fund II, subject to the beneficial ownership limitation. * Under Mr. Harwin's arrangement with Fairmount, Mr. Harwin holds the options for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Harwin is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Harwin therefore disclaims beneficial ownership of the option and underlying common stock.


    SCHEDULE 13D

    CUSIP No.
    03770N101


    1 Name of reporting person

    Tomas Kiselak
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    SLOVAKIA
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    93,374.00
    8Shared Voting Power

    5,953,653.00
    9Sole Dispositive Power

    93,374.00
    10Shared Dispositive Power

    5,953,653.00
    11Aggregate amount beneficially owned by each reporting person

    6,047,027.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.99 %
    14Type of Reporting Person (See Instructions)

    IN, HC

    Comment for Type of Reporting Person:
    The securities include (a) 51,166 shares of Common Stock held directly by Mr. Kiselak, (b) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak* and (c) Fund II's direct holdings of (i) 298,647 shares of Common Stock and (ii) 5,655,066 shares of Common Stock issuable upon conversion of 5,655,066 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock in excess of the beneficial ownership limitation. Row 13 is based on 60,530,801 shares of Common Stock outstanding as of January 22, 2026, consisting of (i) 54,833,587 shares of Common Stock outstanding as of November 3, 2025, as reported in the Company's Form 10-Q filed on November 10, 2025, (ii) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak and (iii) 5,655,006 shares of Common Stock underlying the 5,655,006 shares of Non-Voting Common Stock owned by Fund II, subject to the beneficial ownership limitation. * Under Mr. Kiselak's arrangement with Fairmount, Mr. Kiselak holds the options for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Kiselak is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Kiselak therefore disclaims beneficial ownership of the option and underlying common stock.


    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, $0.00001 par value
    (b)Name of Issuer:

    Apogee Therapeutics, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    221 Crescent Street, Building 17, Suite 102b, Waltham, MASSACHUSETTS , 02453.
    Item 1 Comment:
    This Amendment No. 4 amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on July 21, 2023, Amendment No. 1 filed on January 31, 2024, Amendment No. 2 filed on April 1, 2024, and Amendment No. 3 filed on October 14, 2025 (as amended, the "Statement" or the "Schedule 13D") by the Reporting Persons with respect to the Common Stock of the Company. Unless otherwise defined herein, capitalized terms used in this Amendment No. 4 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged.
    Item 5.Interest in Securities of the Issuer
    (a)
    The information in rows 11 and 13 of each of the cover pages (including the explanatory note in the "Comments") of this Amendment No. 4 is incorporated by reference herein.
    (b)
    The information in rows 7 through 10 of each of the cover pages of this Amendment No. 4 is incorporated by reference herein. In the aggregate, the Reporting Persons have voting and dispositive power over 6,031,979 shares of Common Stock, which is comprised of the following: (i) 298,647 shares of Common Stock held by Fund II; (ii) 5,546,584 shares of Common Stock issuable upon conversion of 5,546,584 shares of Non-Voting Common Stock, held by Fund II, reflecting the beneficial ownership limitation of 9.99% of the outstanding Common Stock; (iii) 51,166 shares of Common Stock held by Mr. Harwin; (iv) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin; (v) 51,166 shares of Common Stock held by Mr. Kiselak; and (vi) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak. In total, the Fund II currently owns 6,743,321 shares of Non-Voting Common Stock.
    (c)
    Item 5(c) of the Schedule 13D is hereby amended and supplemented as follows: On January 22, 2026, Fund II sold in a block trade a total of 1,750,000 shares of Common Stock at a price of $76.30 per share.
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    Company Stock Options On June 17, 2025, in their respective capacities as members of the Company's board of directors, Mr. Harwin and Mr. Kiselak were each granted stock options by the Company representing the right to purchase 14,461 shares of Common Stock. The options will vest on the one-year anniversary of the grant date, subject to Mr. Harwin and Mr. Kiselak's continued service to the Company on such vesting date. Under Mr. Harwin's and Mr. Kiselak's respective arrangements with Fairmount Funds Management, Mr. Harwin and Mr. Kiselak hold the options for one or more Fairmount Funds and are obligated to turn over to Fairmount Funds Management any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Harwin and Mr. Kiselak therefore each disclaim beneficial ownership of their respective options and underlying common stock.
    Item 7.Material to be Filed as Exhibits.
     
    99.1 Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Schedule 13D filed with the SEC on October 14, 2025)

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Fairmount Funds Management LLC
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin, Managing Member
    Date:01/22/2026
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak, Managing Member
    Date:01/22/2026
     
    Fairmount Healthcare Fund II L.P.
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin, Managing Member
    Date:01/22/2026
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak, Managing Member
    Date:01/22/2026
     
    Peter Evan Harwin
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin
    Date:01/22/2026
     
    Tomas Kiselak
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak
    Date:01/22/2026
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    APEX Part A met all primary and key secondary endpoints and exceeded trial objectives, including 71.0% decrease from baseline in EASI at Week 16 APG777 demonstrated EASI-75 of 66.9% (42.5% placebo-adjusted) at Week 16, the highest topline and placebo-adjusted efficacy of any biologic in a global study Exposure-response relationship observed across multiple key endpoints; APEX Part B is testing higher exposures with readout accelerated and now anticipated mid-2026, enabling planned Phase 3 initiation in 2026 APEX Part A testing potentially best in class 3- or 6-month maintenance dosing with 52-week readout anticipated 1H 2026 APG777 was well tolerated with a favorable safety profi

    7/7/25 6:00:00 AM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

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    Large Ownership Changes

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    Amendment: SEC Form SC 13G/A filed by Apogee Therapeutics Inc.

    SC 13G/A - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 5:46:11 PM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form SC 13G filed by Apogee Therapeutics Inc.

    SC 13G - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 11:16:12 AM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Apogee Therapeutics Inc.

    SC 13G/A - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 10:18:32 AM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care