Amendment: SEC Form SCHEDULE 13D/A filed by Cellectis S.A.

Item 3 of the Schedule 13D is hereby amended and supplemented to add the following: "On May 7, 2024, AstraZeneca announced the successful completion of the Additional Investment pursuant to which AZ Holdings BV received 10,000,000 series A convertible preferred shares of the Issuer and 18,000,000 series B convertible shares of the Issuer, each at a price of $5.00 per convertible preferred share, as contemplated and described in more detail elsewhere in the Schedule 13D. The source of the total subscription price for the convertible preferred shares of $140,000,000 was working capital."

Item 4 of the Schedule 13D is hereby amended and supplemented to add the following: "On May 7, 2024, AstraZeneca announced the successful completion of the Additional Investment pursuant to which AZ Holdings BV received 10,000,000 series A convertible preferred shares of the Issuer and 18,000,000 series B convertible shares of the Issuer, each at a price of $5.00 per convertible preferred share, as contemplated and described in more detail elsewhere in the Schedule 13D. On January 15, 2025, the Issuer filed a Registration Statement on Form F-3 (File No. 333-284302) (the "Registration Statement"), which was declared effective by the Securities and Exchange Commission on January 23, 2025, to register the resale of Ordinary Shares (including in the form of American Depositary Shares) issuable upon conversion of the series A convertible preferred shares and the series B convertible preferred shares. The effectiveness of the Registration Statement permits AstraZeneca and AZ Holdings BV to publicly resell Ordinary Shares (including in the form of American Depositary Shares). AstraZeneca intends to continue to review its investment in the Issuer on an ongoing basis and, depending on various factors, including, without limitation, the Issuer's financial position, the price of the Ordinary Shares and the American Depositary Shares representing Ordinary Shares, conditions in the securities markets and general economic and industry conditions, AstraZeneca may, in the future, take such actions with respect to the Ordinary Shares as they deem appropriate, including, without limitation: purchasing additional Ordinary Shares; selling Ordinary Shares; taking any other action with respect to the Issuer or any of its securities in any manner permitted by law or changing their intention with respect to any and all matters referred to in paragraphs (a) through (j) in Item 4 of the Schedule 13D."

Item 5(a) of the Schedule 13D is hereby amended and replaced in its entirety with the following: "As at the date of this Amendment No. 2, each of AstraZeneca and AZ Holdings BV may be deemed to beneficially own 44,000,000 Ordinary Shares, representing approximately 44.0% of the Ordinary Shares outstanding. These figures assume the conversion of all series A convertible preferred shares and series B convertible preferred shares (one series A convertible preferred share shall convert into one Ordinary Share, and one series B convertible preferred share shall convert into one Ordinary Share). Without giving effect to any conversion of the series A convertible preferred shares or series B convertible preferred shares, AstraZeneca and AZ Holdings BV hold 16,000,000 Ordinary Shares (representing 22.2% of the Issuer's outstanding Ordinary Shares) and 26,000,000 voting rights (representing 29.3% of the Issuer's outstanding voting rights). This response is based on 72,093,873 Ordinary Shares outstanding as of December 31, 2024 and 78,660,539 voting rights associated with the Issuer's Ordinary Shares outstanding as of December 31, 2024, in each case according to the Form F-3 filed by the Issuer on January 15, 2025 (File No. 333-284302). To the knowledge of AstraZeneca and AZ Holdings BV, no other Reporting Person beneficially owns any Ordinary Shares."

Item 5(b) of the Schedule 13D is hereby amended and replaced in its entirety with the following: "As at the date of this Amendment No. 2, each of AstraZeneca and AZ Holdings BV may be deemed to have sole voting and dispositive power over 16,000,000 Ordinary Shares, 10,000,000 series A convertible preferred shares and 18,000,000 series B convertible preferred shares. Neither AstraZeneca nor AZ Holdings BV has shared voting or dispositive power over any Ordinary Shares, series A convertible preferred shares or series B convertible preferred shares. To the knowledge of AstraZeneca and AZ Holdings BV, no other Reporting Person has any voting or dispositive power over any Ordinary Shares."