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    Amendment: SEC Form SCHEDULE 13D/A filed by LAVA Therapeutics N.V.

    10/17/25 6:01:02 PM ET
    $LVTX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $LVTX alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)


    LAVA THERAPEUTICS N.V.

    (Name of Issuer)


    Common shares, Euro 0.12 nominal value per share

    (Title of Class of Securities)


    N51517105

    (CUSIP Number)


    Edwin de Graaf
    Cooperatieve Gilde Healthcare IV U.A., Stadsplateau 36
    Utrecht P7, P7, 3521 AZ
    31 30 219 2565

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    10/15/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    N51517105


    1 Name of reporting person

    Cooperatieve Gilde Healthcare IV U.A.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,947,781.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,947,781.00
    11Aggregate amount beneficially owned by each reporting person

    2,947,781.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    11.2 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    N51517105


    1 Name of reporting person

    Gilde Healthcare IV Management B.V.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,947,781.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,947,781.00
    11Aggregate amount beneficially owned by each reporting person

    2,947,781.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    11.2 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    N51517105


    1 Name of reporting person

    Gilde Healthcare Holding B.V.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,947,781.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,947,781.00
    11Aggregate amount beneficially owned by each reporting person

    2,947,781.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    11.2 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    N51517105


    1 Name of reporting person

    Manapouri B.V.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,947,781.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,947,781.00
    11Aggregate amount beneficially owned by each reporting person

    2,947,781.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    11.2 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    N51517105


    1 Name of reporting person

    Martemanshurk B.V.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,947,781.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,947,781.00
    11Aggregate amount beneficially owned by each reporting person

    2,947,781.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    11.2 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common shares, Euro 0.12 nominal value per share
    (b)Name of Issuer:

    LAVA THERAPEUTICS N.V.
    (c)Address of Issuer's Principal Executive Offices:

    Yalelaan 62, Utrecht, NETHERLANDS , 3584 CM.
    Item 1 Comment:
    This Amendment No. 2 ("Amendment No. 2") to Schedule 13D amends the initial Statement on Schedule 13D filed on March 21, 2021, as amended by Amendment No. 1 filed on October 14, 2025 (as so amended, the "Schedule 13D"), relating to the common shares, nominal value Euro 0.12 per share ("Common Shares"), of LAVA Therapeutics N.V., a Netherlands corporation (the "Issuer"). This Amendment No. 2 reflects, among other things, the sales of Common Shares by Cooperatieve Gilde Healthcare IV U.A. ("Gilde Healthcare"). Only those items that are hereby reported are amended; all other items reported in the Schedule 13D remain unchanged. Capitalized terms used but not defined in this Amendment No. 2 shall have the same meanings ascribed to them in the Schedule 13D.
    Item 4.Purpose of Transaction
     
    Item 4 of the Schedule 13D is hereby amended and supplemented by adding the following: Between October 14, 2025 and October 17, 2025, Gilde Healthcare sold an aggregate of 2,298,711 Common Shares of the Issuer in open market transactions.
    Item 5.Interest in Securities of the Issuer
    (a)
    According to the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission ("SEC") on August 13, 2025, there were 26,305,295 Common Shares outstanding as of August 8, 2025. Gilde Healthcare is the record holder of an aggregate of 2,947,781 Common Shares, which represents beneficial ownership of approximately 11.2% of the outstanding Common Shares as of August 8, 2025. GHCIVM, as the manager of Gilde Healthcare, has the power to vote and dispose of securities held by Gilde Healthcare and may be deemed to beneficially own the securities held of record by Gilde Healthcare. As a result, each of the Reporting Persons may beneficially own 2,947,781 Common Shares, or approximately 11.2% of the outstanding Common Shares.
    (b)
    Each Reporting Person has shared power to vote and dispose of 2,947,781 Common Shares.
    (c)
    On October 14, 2025, Gilde Healthcare sold 227,341 Common Shares at a weighted average price per share of $1.5092 for aggregate proceeds of approximately $343,103.04. On October 15, 2025, Gilde Healthcare sold 200,000 Common Shares at a weighted average price per share of $1.5070 for aggregate proceeds of approximately $301,400.89. On October 16, 2025, Gilde Healthcare sold 690,239 Common Shares at a weighted average price per share of $1.4936 for aggregate proceeds of approximately $1,030,940.97. On October 17, 2025, Gilde Healthcare sold 1,181,131 Common Shares at a weighted average price per share of $1.4743 for aggregate proceeds of approximately $1,741,341.43.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Cooperatieve Gilde Healthcare IV U.A.
     
    Signature:/s/ Edwin de Graaf
    Name/Title:Edwin de Graaf/Managing Director of Gilde Healthcare IV Management B.V., as Manager of Cooperatieve Gilde Healthcare IV U.A.
    Date:10/17/2025
     
    Gilde Healthcare IV Management B.V.
     
    Signature:/s/ Edwin de Graaf
    Name/Title:Edwin de Graaf/Managing Director
    Date:10/17/2025
     
    Gilde Healthcare Holding B.V.
     
    Signature:/s/ Edwin de Graaf
    Name/Title:Edwin de Graaf/Managing Director
    Date:10/17/2025
     
    Manapouri B.V.
     
    Signature:/s/ Edwin de Graaf
    Name/Title:Edwin de Graaf/Managing Director
    Date:10/17/2025
     
    Martemanshurk B.V.
     
    Signature:/s/ Pieter van der Meer
    Name/Title:Pieter van der Meer/Managing Director
    Date:10/17/2025
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