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    Amendment: SEC Form SCHEDULE 13D/A filed by Omega Therapeutics Inc.

    12/31/24 5:37:22 PM ET
    $OMGA
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $OMGA alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)*


    OMEGA THERAPEUTICS, INC.

    (Name of Issuer)


    Common Stock, $0.001 par value per share

    (Title of Class of Securities)


    68217N105

    (CUSIP Number)


    Noubar B. Afeyan, Ph.D.
    55 Cambridge Parkway, Suite 800E,
    Cambridge, MA, 02142
    Flagship Pioneering

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    12/29/2024

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship V VentureLabs Rx Fund, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,470.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,470.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,470.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Ventures Fund V, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    5,896,386.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    5,896,386.00
    11Aggregate amount beneficially owned by each reporting person

    5,896,386.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    10.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Ventures Fund V General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    6,984,856.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    6,984,856.00
    11Aggregate amount beneficially owned by each reporting person

    6,984,856.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    12.6 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Fund VI, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    8,617,413.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    8,617,413.00
    11Aggregate amount beneficially owned by each reporting person

    8,617,413.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    15.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Fund VI General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    8,617,413.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    8,617,413.00
    11Aggregate amount beneficially owned by each reporting person

    8,617,413.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    1.8 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Nutritional Health LTP Fund, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    970,588.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    970,588.00
    11Aggregate amount beneficially owned by each reporting person

    970,588.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    1.8 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Nutritional Health LTP Fund General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    970,588.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    970,588.00
    11Aggregate amount beneficially owned by each reporting person

    970,588.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    1.8 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Special Opportunities Fund II, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,508,693.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,508,693.00
    11Aggregate amount beneficially owned by each reporting person

    7,508,693.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    13.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Special Opportunities Fund II General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,508,693.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,508,693.00
    11Aggregate amount beneficially owned by each reporting person

    7,508,693.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    13.6 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    FPN, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    ONTARIO, CANADA
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,617,646.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,617,646.00
    11Aggregate amount beneficially owned by each reporting person

    1,617,646.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.9 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    FPN General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,617,646.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,617,646.00
    11Aggregate amount beneficially owned by each reporting person

    1,617,646.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.9 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship VentureLabs V, LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,197,059.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,197,059.00
    11Aggregate amount beneficially owned by each reporting person

    2,197,059.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship VentureLabs V Manager LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,197,059.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,197,059.00
    11Aggregate amount beneficially owned by each reporting person

    2,197,059.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Fund VII, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,329,324.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,329,324.00
    11Aggregate amount beneficially owned by each reporting person

    1,329,324.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering Fund VII General Partner LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,329,324.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,329,324.00
    11Aggregate amount beneficially owned by each reporting person

    1,329,324.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Flagship Pioneering, Inc.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    22,240,723.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    22,240,723.00
    11Aggregate amount beneficially owned by each reporting person

    22,240,723.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    40.2 %
    14Type of Reporting Person (See Instructions)

    CO



    SCHEDULE 13D

    CUSIP No.
    68217N105


    1 Name of reporting person

    Noubar Afeyan
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    29,225,579.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    29,225,579.00
    11Aggregate amount beneficially owned by each reporting person

    29,225,579.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    52.8 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, $0.001 par value per share
    (b)Name of Issuer:

    OMEGA THERAPEUTICS, INC.
    (c)Address of Issuer's Principal Executive Offices:

    140 First Street, Suite 501, Cambridge, MASSACHUSETTS , 02141.
    Item 4.Purpose of Transaction
     
    Item 4 of the Schedule 13D is hereby amended to include the following: On December 29, 2024, Mirai Bio, Inc. ("Mirai"), an affiliate of Flagship Pioneering Fund VII, L.P. sent a proposal (the "Proposal") to a special committee of independent directors of the Company (the "Special Committee"), which described a proposed modification to the terms of that certain Research Collaboration Agreement filed as Exhibit 10.33 to Omega's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with SEC on March 28, 2024 (the "Collaboration"). The end result of such modification would be the acquisition by Mirai (or its designee) of Omega's rights and obligations under the Collaboration and a non-exclusive, sublicensable (through multiple tiers), worldwide, royalty-free, fully paid-up, perpetual and irrevocable license to the entirety of Omega's platform for discovering and developing epigenetic/epigenomic controllers (the "OEC Platform") in exchange for the assumption of $8,000,000 of Omega's indebtedness under that certain Loan and Security Agreement filed as Exhibit 10.11 to Amendment No. 1 to Omega's Registration Statement on Form S-1, filed with the SEC on July 26, 2021, as subsequently amended (the "Term Loan"), such amendment to the Term Loan subject to the lender's approval. The modifications to the Collaboration include Mirai (or its designee) entering into an amendment of the agreements related to the Collaboration, with any required consents, to provide for Mirai (or its designees) to assume all of the Company's existing rights and obligations under the Collaboration agreements, including all of the Company's obligations to perform research and development activities and the Company's rights to receive payments under the Collaboration. The Proposal is subject to the non-waivable approval by the Special Committee. On December 30, 2024, Michelle C. Werner, CEO-Partner at Flagship Pioneering, resigned from Omega's Board of Directors, effective immediately. The Proposal may result in one or more of the transactions, events or actions specified in subparagraphs (a) through (j) of Item 4 of Schedule 13D, including without limitation, an extraordinary corporate transaction involving the Company and other material changes to the Company's business or corporate structure. There can be no assurance that the foregoing, or anything related to the Proposal, will result in any definitive agreement, transaction or any other strategic alternative and or whether or when any of the foregoing may happen. Notwithstanding anything contained herein, the Reporting Persons and Mirai reserve the right to modify or withdraw the Proposal at any time. The Reporting Persons and Mirai reserve the right to formulate other plans or make other proposals which could result in one or more of the transactions, events or actions specified in subparagraphs (a) through (j) of Item 4 of Schedule 13D, and to modify or withdraw any such plan or proposal at any time. The Reporting Persons and Mirai do not intend to update additional disclosures regarding the Proposal until a definitive agreement has been reached, or unless disclosure is otherwise required under applicable U.S. securities laws. The Reporting Persons and Mirai intend to engage in discussions with the Special Committee regarding the terms of the Proposal. The Reporting Persons and Mirai may change the terms of the Proposal, determine to accelerate or terminate discussions with the Special Committee with respect to the Proposal, withdraw the Proposal, take any action to facilitate or increase the likelihood of consummation of the Proposal, or change their intentions with respect to any such matters, in each case at any time and without prior notice. The Reporting Persons and Mirai and their affiliates will, directly or indirectly, continue to take and take such additional steps as they may deem appropriate to further the Proposal or otherwise to support their investment in the Company, including, without limitation: (i) engaging in discussions with advisors and other relevant parties and (ii) entering into confidentiality arrangements and other agreements, arrangements and understandings in connection with the Proposal. Neither the Proposal nor this Schedule 13D is meant to be, nor should be construed as, an offer to buy or the solicitation of an offer to sell any of the Company's securities.
    Item 5.Interest in Securities of the Issuer
    (a)
    Item 5(a)-(c) of the Schedule 13D is hereby amended and restated as follows: (a)-(b) The information set forth in rows 7 through 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 55,366,213 shares of Common Stock outstanding, as disclosed in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 14, 2024. Flagship V VentureLabs Rx Fund, L.P. ("Flagship Fund V Rx") directly holds 1,088,470 shares of Common Stock. Flagship Ventures Fund V, L.P. ("Flagship Fund V") directly holds 5,896,386 shares of Common Stock. Flagship Ventures Fund V General Partner LLC ("Flagship Fund V GP"), as the general partner of each of Flagship Fund V Rx and Flagship Fund V, may be deemed to beneficially own the shares directly held by Flagship Fund V Rx and Flagship Fund V. Flagship Pioneering Fund VI, L.P. ("Flagship Fund VI") directly holds 8,617,413 shares of Common Stock. Flagship Pioneering Fund VI General Partner LLC ("Flagship Fund VI GP"), as general partner of Flagship Fund VI, may be deemed to beneficially own the shares directly held by Flagship Fund VI. Nutritional Health LTP Fund, L.P. ("Nutritional LTP") directly holds 970,588 shares of Common Stock. Nutritional Health LTP Fund General Partner LLC ("Nutritional LTP GP"), as general partner of Nutritional LTP, may be deemed to beneficially own the shares directly held by Nutritional LTP. Flagship Pioneering Special Opportunities Fund II, L.P. ("Flagship Opportunities Fund II") directly holds 7,508,693 shares of Common Stock. Flagship Pioneering Special Opportunities Fund II General Partner LLC ("Flagship Opportunities Fund II GP"), as general partner of Flagship Opportunities Fund II, may be deemed to beneficially own the shares directly held by Flagship Opportunities Fund II. FPN, L.P ("FPN Fund") directly holds 1,617,646 shares of Common Stock. FPN General Partner LLC ("FPN GP"), as general partner of FPN Fund, may be deemed to beneficially own the shares directly held by FPN Fund. Flagship VentureLabs V, LLC ("VentureLabs V") directly holds 2,197,059 shares of Common Stock. Flagship VentureLabs V Manager LLC ("VentureLabs V Manager"), as manager of VentureLabs V, may be deemed to beneficially own the shares directly held by VentureLabs V. Flagship Pioneering Fund VII, L.P. ("Flagship Fund VII" and together with Flagship Fund V Rx, Flagship Fund V, Flagship Fund VI, Nutritional LTP, Flagship Opportunities Fund II, FPN Fund and VentureLabs V, the "Flagship Funds") directly holds 1,329,324 shares of Common Stock. Flagship Pioneering Fund VII General Partner LLC ("Flagship Fund VII GP"), as general partner of Flagship Fund VII, may be deemed to beneficially own the shares directly held by Flagship Fund VII. Flagship Pioneering, Inc. ("Flagship Pioneering"), as the manager of each of Flagship Fund VI GP, Nutritional LTP GP, Flagship Opportunities II GP, FPN GP, VentureLabs V Manager and Flagship Fund VII GP, may be deemed to beneficially own the shares held directly by Flagship Fund VI, Nutritional LTP, Flagship Opportunities Fund II, FPN Fund, VentureLabs V and Flagship Fund VII. Dr. Afeyan, as the sole manager of Flagship Fund V GP and as CEO, sole shareholder and director of Flagship Pioneering, may be deemed to beneficially own the shares directly held by the Flagship Funds. Mirai does not own any shares of Common Stock
    (b)
    See above.
    (c)
    None of the Reporting Persons have effected any transactions in the Issuer's Common Stock during the past sixty days.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Flagship V VentureLabs Rx Fund, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Manager of General Partner
    Date:12/31/2024
     
    Flagship Ventures Fund V, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Manager of General Partner
    Date:12/31/2024
     
    Flagship Ventures Fund V General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Manager
    Date:12/31/2024
     
    Flagship Pioneering Fund VI, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    Flagship Pioneering Fund VI General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    Nutritional Health LTP Fund, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    Nutritional Health LTP Fund General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    Flagship Pioneering Special Opportunities Fund II, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    Flagship Pioneering Special Opportunities Fund II General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    FPN, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    FPN General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    Flagship VentureLabs V, LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    Flagship VentureLabs V Manager LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    Flagship Pioneering Fund VII, L.P.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager of General Partner
    Date:12/31/2024
     
    Flagship Pioneering Fund VII General Partner LLC
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer of Manager
    Date:12/31/2024
     
    Flagship Pioneering, Inc.
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D., Chief Executive Officer
    Date:12/31/2024
     
    Noubar Afeyan
     
    Signature:/s/ Noubar B. Afeyan, Ph.D.
    Name/Title:Noubar B. Afeyan, Ph.D.
    Date:12/31/2024
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