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    Amendment: SEC Form SCHEDULE 13D/A filed by Spruce Biosciences Inc.

    1/10/25 11:05:40 AM ET
    $SPRB
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $SPRB alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)


    SPRUCE BIOSCIENCES, INC.

    (Name of Issuer)


    Common Stock, par value $0.001 per share

    (Title of Class of Securities)


    85209E109

    (CUSIP Number)


    Jay W. Schmelter
    101 S. Hanley Road, Suite 1850,
    St. Louis, MO, 63105
    (314) 726-6700


    Gloria M. Skigen, Esq.
    Holland & Knight LLP, One Stamford Plaza, 263 Tresser Boulevard, Suite 1400
    Stamford, CT, 06901
    (203) 905-4526

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    01/07/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Fund III, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    720,656.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    720,656.00
    11Aggregate amount beneficially owned by each reporting person

    720,656.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.2 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 608,413 shares of Common Stock (as defined below) and (ii) currently exercisable warrants to acquire 112,243 shares of Common Stock (as defined below) at an exercise price of $3.96 per share. The percentage set forth in line 13 is based upon 41,302,599 shares of common stock, par value $0.001 per share ("Common Stock"), of Spruce Biosciences, Inc., a Delaware corporation (the "Issuer"), outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Fund III (Ohio), L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    38,251.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    38,251.00
    11Aggregate amount beneficially owned by each reporting person

    38,251.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.1 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 32,294 shares of Common Stock and (ii) currently exercisable warrants to acquire 5,957 shares of Common Stock at an exercise price of $3.96 per share. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Partners III (Ohio), LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    38,251.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    38,251.00
    11Aggregate amount beneficially owned by each reporting person

    38,251.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.1 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 32,294 shares of Common Stock owned by RiverVest Venture Fund III (Ohio), L.P., a Delaware limited partnership ("RiverVest III (Ohio)") and (ii) 5,957 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest Fund III (Ohio) at an exercise price of $3.96 per share. RiverVest Venture Partners III (Ohio), LLC, a Delaware limited liability company ("RiverVest Partners III (Ohio)"), is the general partner of RiverVest III (Ohio). The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Partners III, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    758,907.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    758,907.00
    11Aggregate amount beneficially owned by each reporting person

    758,907.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.2 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 608,413 shares of Common Stock owned by RiverVest Venture Fund III, L.P., a Delaware limited partnership ("RiverVest III"), (ii) 112, 243 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III, (iii) 32,294 shares of Common Stock owned by RiverVest III (Ohio), and (iv) 5,957 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III (Ohio). RiverVest Venture Partners III, L.P., a Delaware limited partnership ("RiverVest Partners III"), is the general partner of RiverVest III and the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Partners III, LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    758,907.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    758,907.00
    11Aggregate amount beneficially owned by each reporting person

    758,907.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.2 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 608,413 shares of Common Stock owned by RiverVest III, (ii) 112, 243 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III, (iii) 32,294 shares of Common Stock owned by RiverVest III (Ohio), and (iv) 5,957 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III (Ohio). RiverVest Venture Partners III, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners III, which is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Fund IV, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,000,614.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,000,614.00
    11Aggregate amount beneficially owned by each reporting person

    1,000,614.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 527,814 shares of Common Stock owned by RiverVest Venture Fund IV, L.P., a Delaware limited partnership ("RiverVest IV"), and (ii) 472,800 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest IV at an exercise price of $3.96 per share. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Partners IV, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,000,614.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,000,614.00
    11Aggregate amount beneficially owned by each reporting person

    1,000,614.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 527,814 shares of Common Stock owned by RiverVest IV, and (ii) 472,800 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest IV. RiverVest Venture Partners IV, L.P., a Delaware limited partnership ("RiverVest Partners IV"), is the general partner of RiverVest IV. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    RiverVest Venture Partners IV, LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,000,614.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,000,614.00
    11Aggregate amount beneficially owned by each reporting person

    1,000,614.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 527,814 shares of Common Stock owned by RiverVest IV, and (ii) 472,800 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest IV. RiverVest Venture Partners IV, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners IV, which is the general partner of RiverVest IV. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    John P. McKearn, Ph.D.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,759,521.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,759,521.00
    11Aggregate amount beneficially owned by each reporting person

    1,759,521.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.2 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) an aggregate of 1,168,521 shares of Common Stock owned collectively by RiverVest III, RiverVest III (Ohio) and RiverVest IV, and (ii) an aggregate of 591,000 additional shares of Common Stock issuable upon the exercise of the warrants held collectively by RiverVest III, RiverVest III (Ohio) and RiverVest IV, in each case at an exercise price of $3.96 per share. Dr. McKearn is a member of RiverVest Venture Partners III, LLC, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). Dr. McKearn is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    Jay Schmelter
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,759,521.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,759,521.00
    11Aggregate amount beneficially owned by each reporting person

    1,759,521.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.2 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) an aggregate of 1,168,521 shares of Common Stock owned collectively by RiverVest III, RiverVest III (Ohio) and RiverVest IV, and (ii) an aggregate of 591,000 additional shares of Common Stock issuable upon the exercise of the warrants held collectively by RiverVest III, RiverVest III (Ohio) and RiverVest IV, in each case at an exercise price of $3.96 per share. Mr. Schmelter is a member of RiverVest Venture Partners III, LLC, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). Mr. Schmelter is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    Thomas C. Melzer
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    758,907.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    758,907.00
    11Aggregate amount beneficially owned by each reporting person

    758,907.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.2 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 8, 10 and 11 represent (i) 608,413 shares of Common Stock owned by RiverVest III, (ii) 112, 243 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III, (iii) 32,294 shares of Common Stock owned by RiverVest III (Ohio), and (iv) 5,957 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest III (Ohio). Mr. Melzer is a member of RiverVest Venture Partners III, LLC, which is the general partner of RiverVest Partners III. RiverVest Partners III is (a) the general partner of RiverVest III and (b) the sole member of RiverVest Partners III (Ohio), which is the general partner of RiverVest III (Ohio). The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    CUSIP No.
    85209E109


    1 Name of reporting person

    Niall O'Donnell, Ph.D.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    32,500.00
    8Shared Voting Power

    1,000,614.00
    9Sole Dispositive Power

    32,500.00
    10Shared Dispositive Power

    1,000,614.00
    11Aggregate amount beneficially owned by each reporting person

    1,000,614.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox checked
    13Percent of class represented by amount in Row (11)

    2.4 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    The amounts set forth in lines 7 and 9 represent 32,500 shares of Common Stock options owned by Mr. O'Donnell. The amounts set forth in lines 8, 10 and 11 represent (i) 527,814 shares of Common Stock owned by RiverVest IV, and (ii) 472,800 additional shares of Common Stock issuable upon the exercise of the warrants held by RiverVest IV. Mr. O'Donnell is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. The percentage set forth in line 13 is based upon 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.


    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, par value $0.001 per share
    (b)Name of Issuer:

    SPRUCE BIOSCIENCES, INC.
    (c)Address of Issuer's Principal Executive Offices:

    611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO, CALIFORNIA , 94080.
    Item 2.Identity and Background
    (a)
    No change.
    (b)
    No change.
    (c)
    No change.
    (d)
    No change.
    (e)
    No change.
    (f)
    No change.
    Item 3.Source and Amount of Funds or Other Consideration
     
    No change.
    Item 4.Purpose of Transaction
     
    No change.
    Item 5.Interest in Securities of the Issuer
    (a)
    The aggregate number and percentage of the shares of Common Stock outstanding beneficially owned by each Reporting Person set forth below and on the cover pages hereof are based on 41,302,599 shares of Common Stock outstanding as of November 8, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 12, 2024.
    (b)
    (i) sole power to vote or to direct the vote: See line 7 of cover sheets; (ii) shared power to vote or to direct the vote: See line 8 of cover sheets; (iii) sole power to dispose or to direct the disposition: See line 9 of cover sheets; (iv) shared power to dispose or to direct the disposition: See line 10 of cover sheets. By virtue of the relationships described herein, the Reporting Persons may be deemed to constitute a "group" for purposes of Section 13(d)(3) of the Act. The filing of this Statement shall not be construed as an admission that the Reporting Persons are a group, or have agreed to act as a group. Each Reporting Person expressly disclaims beneficial ownership of the securities reported herein, except to the extent such Reporting Person actually exercises voting or dispositive power with respect to such securities.
    (c)
    Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the Issuer's Common Stock during the last 60 days.
    (d)
    No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons.
    (e)
    The Reporting Persons ceased to own more than five percent of the outstanding Common Stock on January 7, 2025.
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    No change.
    Item 7.Material to be Filed as Exhibits.
     
    Exhibit A: Joint Filing Agreement, dated October 23, 2020, by and among RiverVest Venture Fund III, L.P., RiverVest Venture Fund III (Ohio), L.P., RiverVest Venture Partners III (Ohio), LLC, RiverVest Venture Partners III, L.P., RiverVest Venture Partners III, LLC, RiverVest Venture Fund IV, L.P., RiverVest Venture Partners IV, L.P., RiverVest Venture Partners IV, LLC, John P. McKearn, Jay Schmelter, Thomas C. Melzer and Niall O'Donnell.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    RiverVest Venture Fund III, L.P.
     
    Signature:By: RiverVest Venture Partners III, L.P., its general partner By: RiverVest Venture Partners III, LLC, its general partner By:/s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Fund III (Ohio), L.P.
     
    Signature:By: RiverVest Venture Partners III (Ohio), LLC, its general partner, as indicated in the signature block that immediately follows.
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Partners III (Ohio), LLC
     
    Signature:By: RiverVest Venture Partners III, L.P., its sole member By: RiverVest Venture Partners III, LLC, its general partner By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Partners III, L.P.
     
    Signature:By: RiverVest Venture Partners III, LLC, its general partner By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Partners III, LLC
     
    Signature:By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Fund IV, L.P.
     
    Signature:By: RiverVest Venture Partners IV, L.P., its general partner By: RiverVest Venture Partners IV, LLC, its general partner By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Partners IV, L.P.
     
    Signature:By: RiverVest Venture Partners IV, LLC, its general partner By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    RiverVest Venture Partners IV, LLC
     
    Signature:By: /s/ Jay Schmelter
    Name/Title:Jay Schmelter/Member
    Date:01/10/2025
     
    John P. McKearn, Ph.D.
     
    Signature:/s/ John P. McKearn, Ph.D.
    Name/Title:John P. McKearn, Ph.D.
    Date:01/10/2025
     
    Jay Schmelter
     
    Signature:/s/ Jay Schmelter
    Name/Title:Jay Schmelter
    Date:01/10/2025
     
    Thomas C. Melzer
     
    Signature:/s/ Thomas C. Melzer
    Name/Title:Thomas C. Melzer
    Date:01/10/2025
     
    Niall O'Donnell, Ph.D.
     
    Signature:/s/ Niall O'Donnell, Ph.D.
    Name/Title:Niall O'Donnell, Ph.D.
    Date:01/10/2025
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