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    Amendment: SEC Form SCHEDULE 13D/A filed by Tectonic Therapeutic Inc.

    4/7/25 5:19:24 PM ET
    $TECX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $TECX alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)


    Tectonic Therapeutic, Inc.

    (Name of Issuer)


    Common Stock, $0.0001 par value per share

    (Title of Class of Securities)


    878972108

    (CUSIP Number)


    Lauren Crockett
    One Marina Park Drive, 8th Floor
    Boston, MA, 02210
    (781) 290-0770

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    04/03/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Terrance McGuire
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    657,976.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    657,976.00
    11Aggregate amount beneficially owned by each reporting person

    657,976.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    6.3 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    Consists of (i) 20,262 shares of Common Stock (as defined in Item 1 of the Original Schedule 13D (as defined below)) held by PFC I (as defined in Item 2(a) of the Original Schedule 13D), (ii) 64,652 shares of Common Stock held by PFC II (as defined in Item 2(a) of the Original Schedule 13D) and (iii) 573,062 shares of Common Stock held by PP IX (as defined in Item 2(a) of the Original Schedule 13D). The aggregate amount beneficially owned does not include 11,760 shares of Common Stock underlying stock options granted to Mr. McGuire in his capacity as a director of the Issuer because such options are not exercisable as of the date of filing this Amendment (as defined in Item 1 below) or within 60 days thereafter. PFCM I (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of PFC I. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's (as defined in Item 1 of the Original Schedule 13D) board of directors, are managing members of PFCM I. Each of PFCM I, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC I. PFCM II (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of PFC II. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM II. Each of PFCM II, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC II. PP GP IX (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of PP IX. The PP GP IX Managing Members (as defined in Item 2(c) of the Original Schedule 13D) are the managing members of PP GP IX, and Mr. McGuire, a member of the Issuer's board of directors, is an interest holder in PP GP IX. Each of PP GP IX, the PP GP IX Managing Members and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Issuer's Annual Report on Form 10-K for the year ended December 31, 2024, filed with the United States Securities and Exchange Commission (the "Commission") on March 20, 2025 (the "Form 10-K").


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Partners IX, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    573,062.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    573,062.00
    11Aggregate amount beneficially owned by each reporting person

    573,062.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.1 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All shares are held of record by PP IX. PP GP IX is the general partner of PP IX. The PP GP IX Managing Members are the managing members of PP GP IX, and Mr. McGuire, a member of the Issuer's board of directors, is an interest holder in PP GP IX. Each of PP GP IX, the PP GP IX Managing Members and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Partners GP IX, L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    573,062.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    573,062.00
    11Aggregate amount beneficially owned by each reporting person

    573,062.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.1 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    All shares are held of record by PP IX. PP GP IX is the general partner of PP IX. The PP GP IX Managing Members are the managing members of PP GP IX, and Mr. McGuire, a member of the Issuer's board of directors, is an interest holder in PP GP IX. Each of PP GP IX, the PP GP IX Managing Members and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Founders Capital Fund I, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    20,262.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    20,262.00
    11Aggregate amount beneficially owned by each reporting person

    20,262.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.1 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All shares are held of record by PFC I. PFCM I is the general partner of PFC I. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM I. Each of PFCM I, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC I. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Founders Capital Fund Management Co. I, L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    20,262.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    20,262.00
    11Aggregate amount beneficially owned by each reporting person

    20,262.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.1 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    All shares are held of record by PFC I. PFCM I is the general partner of PFC I. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM I. Each of PFCM I, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC I. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Founders Capital Fund II, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    64,652.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    64,652.00
    11Aggregate amount beneficially owned by each reporting person

    64,652.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.3 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All shares are held of record by PFC II. PFCM II is the general partner of PFC II. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM II. Each of PFCM II, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC II. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Polaris Founders Capital Fund Management Co. II, L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    64,652.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    64,652.00
    11Aggregate amount beneficially owned by each reporting person

    64,652.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.3 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    All shares are held of record by PFC II. PFCM II is the general partner of PFC II. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM II. Each of PFCM II, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC II. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    CUSIP No.
    878972108


    1 Name of reporting person

    Jonathan Flint
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    84,914.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    84,914.00
    11Aggregate amount beneficially owned by each reporting person

    84,914.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.5 %
    14Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:
    Consists of (i) 20,262 shares of Common Stock held by PFC I and (ii) 64,652 shares of Common Stock held by PFC II. PFCM I is the general partner of PFC I. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM I. Each of PFCM I, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC I. PFCM II is the general partner of PFC II. Each of Mr. Flint and Mr. McGuire, a member of the Issuer's board of directors, are managing members of PFCM II. Each of PFCM II, Mr. Flint and Mr. McGuire may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PFC II. Percentage based on 18,662,672 shares of Common Stock outstanding as of March 1, 2025, as set forth in the Form 10-K.


    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, $0.0001 par value per share
    (b)Name of Issuer:

    Tectonic Therapeutic, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    490 Arsenal Way, Suite 210, Watertown, MASSACHUSETTS , 02472.
    Item 1 Comment:
    Explanatory Note: This Amendment No. 2 (this "Amendment") amends and supplements the Schedule 13D originally filed by the Reporting Persons with the Commission on June 25, 2024, as amended by Amendment No. 1 filed with the Commission on February 7, 2025 (collectively, the "Original Schedule 13D"). Only those items that are hereby reported are amended; all other items reports in the Original Schedule 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13D.
    Item 5.Interest in Securities of the Issuer
    (a)
    See Items 7-11 and 13 of the cover pages of this Amendment for each Reporting Person and the corresponding comments.
    (b)
    See Items 7-11 and 13 of the cover pages of this Amendment for each Reporting Person and the corresponding comments.
    (c)
    On April 3, 2025, PP IX entered into Stock Purchase Agreements with each of Timothy A. Springer ("Dr. Springer") and TAS Partners LLC ("TAS"), pursuant to which Dr. Springer purchased 87,500 shares of Common Stock from PP IX at a purchase price of $17.10 per share, or $1,496,250 in the aggregate, and TAS purchased 412,500 shares of Common Stock at a purchase price of $17.10 per share, or $7,053,750 in the aggregate. The closing occurred on April 7, 2025.
    (e)
    April 7, 2025

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Terrance McGuire
     
    Signature:/s/ Lauren Crockett*
    Name/Title:Lauren Crockett/Attorney-in-Fact
    Date:04/07/2025
     
    Polaris Partners IX, L.P.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/General Counsel of Polaris Partners GP IX, L.L.C. the General Partner of Polaris Partners IX, L.P.
    Date:04/07/2025
     
    Polaris Partners GP IX, L.L.C.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/General Counsel
    Date:04/07/2025
     
    Polaris Founders Capital Fund I, L.P.
     
    Signature:/s/ Gregg Rubin
    Name/Title:Gregg Rubin/General Partner of Polaris Founders Capital Management Co. I, L.L.C. the General Partner of Polaris Founders Capital Fund I, L.P.
    Date:04/07/2025
     
    Polaris Founders Capital Fund Management Co. I, L.L.C.
     
    Signature:/s/ Gregg Rubin
    Name/Title:Gregg Rubin/General Partner
    Date:04/07/2025
     
    Polaris Founders Capital Fund II, L.P.
     
    Signature:/s/ Harold Friedman
    Name/Title:Harold Friedman/Vice President of Polaris Founders Capital Management Co. II, L.L.C. the General Partner of Polaris Founders Capital Fund II, L.P.
    Date:04/07/2025
     
    Polaris Founders Capital Fund Management Co. II, L.L.C.
     
    Signature:/s/ Harold Friedman
    Name/Title:Harold Friedman/Vice President
    Date:04/07/2025
     
    Jonathan Flint
     
    Signature:/s/ Lauren Crockett*
    Name/Title:Lauren Crockett/Attorney-in-Fact
    Date:04/07/2025
    Comments accompanying signature:
    [* This Amendment was executed pursuant to a Power of Attorney. Note that copies of the applicable Powers of Attorney are already on file with the appropriate agencies.]
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    • Director Springer Timothy A bought $2,299,015 worth of shares (141,923 units at $16.20), increasing direct ownership by 0.49% to 4,334,846 units (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      4/11/25 6:12:08 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Director Springer Timothy A bought $8,550,000 worth of shares (500,000 units at $17.10), increasing direct ownership by 2% to 4,313,558 units (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      4/9/25 5:38:10 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Director Springer Timothy A bought $39,999,977 worth of shares (789,294 units at $50.68), increasing direct ownership by 3% to 4,226,058 units (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      2/7/25 4:21:19 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TECX
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

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    • Director Springer Timothy A bought $2,299,015 worth of shares (141,923 units at $16.20), increasing direct ownership by 0.49% to 4,334,846 units (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      4/11/25 6:12:08 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Director Springer Timothy A bought $8,550,000 worth of shares (500,000 units at $17.10), increasing direct ownership by 2% to 4,313,558 units (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      4/9/25 5:38:10 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Director Mcguire Terrance sold $8,550,000 worth of shares (500,000 units at $17.10) (SEC Form 4)

      4 - Tectonic Therapeutic, Inc. (0001681087) (Issuer)

      4/7/25 5:02:43 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TECX
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • Amendment: SEC Form SC 13G/A filed by Tectonic Therapeutic Inc.

      SC 13G/A - Tectonic Therapeutic, Inc. (0001681087) (Subject)

      11/14/24 4:05:11 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13D/A filed by Tectonic Therapeutic Inc.

      SC 13D/A - Tectonic Therapeutic, Inc. (0001681087) (Subject)

      10/28/24 6:08:43 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13D/A filed by Tectonic Therapeutic Inc.

      SC 13D/A - Tectonic Therapeutic, Inc. (0001681087) (Subject)

      10/24/24 5:12:09 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $TECX
    SEC Filings

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    • Amendment: SEC Form SCHEDULE 13G/A filed by Tectonic Therapeutic Inc.

      SCHEDULE 13G/A - Tectonic Therapeutic, Inc. (0001681087) (Subject)

      5/15/25 2:24:51 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by Tectonic Therapeutic Inc.

      SCHEDULE 13G/A - Tectonic Therapeutic, Inc. (0001681087) (Subject)

      5/12/25 10:43:30 AM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 424B3 filed by Tectonic Therapeutic Inc.

      424B3 - Tectonic Therapeutic, Inc. (0001681087) (Filer)

      5/8/25 4:33:19 PM ET
      $TECX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care