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    Amendment: SEC Form SCHEDULE 13D/A filed by Tenaya Therapeutics Inc.

    5/14/25 4:18:42 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $TNYA alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 4)


    Tenaya Therapeutics, Inc.

    (Name of Issuer)


    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)


    87990A106

    (CUSIP Number)


    James Evangelista
    1 Letterman Drive, Building D, Suite DM-900
    San Francisco, CA, 94129
    (415) 865-2050

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    05/07/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    The Column Group III, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    4,414,720.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    4,414,720.00
    11Aggregate amount beneficially owned by each reporting person

    4,414,720.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    2.7 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All such shares are held of record by TCG III LP (as defined in Item 2(a) of the Original Schedule 13D). TCG III GP LP (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the Commission) on May 7, 2025 (the Form 10-Q).


    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    The Column Group III-A, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    4,985,570.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    4,985,570.00
    11Aggregate amount beneficially owned by each reporting person

    4,985,570.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.1 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All such shares are held of record by TCG III-A LP (as defined in Item 2(a) of the Original Schedule 13D). TCG III GP LP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q.


    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    The Column Group III GP, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    9,400,290.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    9,400,290.00
    11Aggregate amount beneficially owned by each reporting person

    9,400,290.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    5.8 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    Consists of (i) 4,414,720 shares held of record by TCG III LP and (ii) 4,985,570 shares held of record by TCG III-A LP. TCG III GP LP is the general partner of each of TCG III LP and TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q.


    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    The Column Group Opportunity III, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    49,313,559.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    49,313,559.00
    11Aggregate amount beneficially owned by each reporting person

    49,313,559.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    30.3 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All such shares are held of record by TCG Opportunity III LP (as defined in Item 2(a) of the Original Schedule 13D). TCG Opportunity III GP LP (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations (as defined in Item 6). Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q.


    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    The Column Group Opportunity III GP, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    49,313,559.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    49,313,559.00
    11Aggregate amount beneficially owned by each reporting person

    49,313,559.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    30.3 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    All such shares are held of record by TCG Opportunity III LP. TCG Opportunity III GP LP is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q.


    SCHEDULE 13D

    CUSIP No.
    87990A106


    1 Name of reporting person

    TCG Opportunity III GP, LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    49,313,559.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    49,313,559.00
    11Aggregate amount beneficially owned by each reporting person

    49,313,559.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    30.3 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    All such shares are held of record by TCG Opportunity III LP. TCG Opportunity III GP LP is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q.


    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, par value $0.0001 per share
    (b)Name of Issuer:

    Tenaya Therapeutics, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    171 Oyster Point Boulevard, Suite 500, South San Francisco, CALIFORNIA , 94080.
    Item 1 Comment:
    This Amendment No. 4 (this Amendment No. 4) supplements and amends the Schedule 13D relating to the Common Stock of the Issuer that was filed with the Commission on December 1, 2022 (the Initial Schedule 13D), as amended by Amendment No. 1 filed with the Commission on February 21, 2023, by Amendment No. 2 filed with the Commission on February 14, 2024 and Amendment No. 3 filed with the Commission on March 7, 2025 (the Initial Schedule 13D, together with all amendments thereto, the Original Schedule 13D). The securities originally reported on the Initial Schedule 13D were previously reported on a Schedule 13G filed with the Commission on February 11, 2022 (the Schedule 13G). The Schedule 13G was filed pursuant to Rule 13d-1(d) of the Securities Exchange Act. This Amendment No. 4 is being filed to update the aggregate percentage of the Issuer's Common Stock owned by the Reporting Persons solely due to dilution caused by, among other things, the Issuer's sales of additional shares of its Common Stock from time to time since the date of the filing of the Original Schedule 13D and not in connection with a disposition of any shares by the Reporting Persons. Such dilution resulted in a decrease of over one percent (1%) in the aggregate percentage ownership reported by the Reporting Persons in the Original Schedule 13D. Only those items that are reported are hereby amended; all other items reported in the Original Schedule 13D remain unchanged. Capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Original Schedule 13D.
    Item 2.Identity and Background
    (a)
    The information set forth in Item 2(a) of the Original Schedule 13D is incorporated herein by reference.
    (b)
    The information set forth in Item 2(b) of the Original Schedule 13D is incorporated herein by reference.
    (c)
    The information set forth in Item 2(c) of the Original Schedule 13D is incorporated herein by reference.
    (d)
    The information set forth in Item 2(d) of the Original Schedule 13D is incorporated herein by reference.
    (e)
    The information set forth in Item 2(e) of the Original Schedule 13D is incorporated herein by reference.
    (f)
    The information set forth in Item 2(f) of the Original Schedule 13D is incorporated herein by reference.
    Item 3.Source and Amount of Funds or Other Consideration
     
    The information set forth in Item 3 of the Original Schedule 13D is incorporated herein by reference.
    Item 4.Purpose of Transaction
     
    The information set forth in Item 4 of the Original Schedule 13D is incorporated herein by reference.
    Item 5.Interest in Securities of the Issuer
    (a)
    See Items 7-11 of the cover pages of this Amendment No. 4.
    (b)
    See Items 7-11 of the cover pages of this Amendment No. 4.
    (c)
    Except as reported in this Statement, none of the Reporting Persons has affected any transactions in the Issuer's securities within the past 60 days.
    (d)
    Under certain circumstances set forth in the limited partnership agreements of each of TCG III LP, TCG III-A LP and TCG Opportunity III LP, the general partner and limited partners of TCG III LP, TCG III-A LP and TCG Opportunity III LP, as applicable, may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner.
    (e)
    Not applicable.
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    The information set forth in Item 6 of the Original Schedule 13D is incorporated herein by reference.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    The Column Group III, LP
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
     
    The Column Group III-A, LP
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
     
    The Column Group III GP, LP
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
     
    The Column Group Opportunity III, LP
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
     
    The Column Group Opportunity III GP, LP
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
     
    TCG Opportunity III GP, LLC
     
    Signature:/s/ James Evangelista, Attorney in Fact
    Name/Title:James Evangelista, Attorney in Fact
    Date:05/14/2025
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    SOUTH SAN FRANCISCO, Calif., Dec. 16, 2024 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ:TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, will announce initial Cohort 1 data from the MyPEAK-1 Phase 1b/2 clinical trial of TN-201 gene therapy for MYBPC3-associated hypertrophic cardiomyopathy (HCM) on Tuesday, December 17. Conference Call and Webcast Tenaya management will host a live webcast and conference call to review the initial data from MyPEAK-1 on Tuesday, December 17th, 2024 at 8:00 a.m. ET. To access the live webcast, participants may register her

    12/16/24 4:30:00 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

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    Tenaya Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Update

    Enrollment Complete in Cohorts 1 and 2 of MyPEAK™-1 Phase 1b/2 Trial of TN-201 for MYBPC3-associated HCM; Positive DSMB Safety Review Enables Enrollment of Expansion Cohorts Cohort 1 of RIDGE™-1 Phase 1b Trial of TN-401 Enrolled and First PKP2-associated ARVC Patient Dosed in Cohort 2 Following DSMB Recommendation to Dose Escalate and Expand Data Readouts from Both TN-201 and TN-401 Clinical Programs Planned for the Fourth Quarter of 2025 Cash Runway into Second Half of 2026 SOUTH SAN FRANCISCO, Calif., Aug. 06, 2025 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ:TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potent

    8/6/25 4:30:00 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Oxford Biomedica Appoints Leone Patterson as Non-Executive Director

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    4/26/23 7:00:00 AM ET
    $NKTX
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    Biotechnology: Pharmaceutical Preparations
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    Biotechnology: Biological Products (No Diagnostic Substances)

    Tenaya Therapeutics Appoints Amy Burroughs to Board of Directors

    SOUTH SAN FRANCISCO, Calif., Dec. 07, 2022 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ:TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the appointment of Amy Burroughs to its Board of Directors. Ms. Burroughs currently serves as President and Chief Executive Officer of Cleave Therapeutics, a clinical-stage company focused on developing novel medicines for oncology and neurodegenerative diseases. "We are pleased to welcome Ms. Burroughs to the Tenaya Board. Her substantial and diverse industry experience in the development and commercia

    12/7/22 4:30:00 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Amendment: SEC Form SC 13G/A filed by Tenaya Therapeutics Inc.

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    11/14/24 5:46:12 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Tenaya Therapeutics Inc.

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    11/14/24 1:22:39 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
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    2/14/24 5:01:36 PM ET
    $TNYA
    Biotechnology: Biological Products (No Diagnostic Substances)
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