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    Amendment: SEC Form SCHEDULE 13D/A filed by Werewolf Therapeutics Inc.

    12/3/25 7:04:17 PM ET
    $HOWL
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $HOWL alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 3)


    WEREWOLF THERAPEUTICS, INC.

    (Name of Issuer)


    Common Stock

    (Title of Class of Securities)


    95075A107

    (CUSIP Number)


    Ansbert Gadicke
    c/o MPM BioImpact LLC, 339 Boylston Street, Suite 1100
    Boston, MA, 02116
    617-425-9200

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    12/01/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM BioVentures 2014, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    2,111,105.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    2,111,105.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    2,111,105.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.3 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM BioVentures 2014 (B), L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    140,807.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    140,807.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    140,807.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.3 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM Asset Management Investors BV2014 LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    72,664.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    72,664.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    72,664.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.1 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    UBS Oncology Impact Fund L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    CAYMAN ISLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    1,745,647.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    1,745,647.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    1,745,647.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM BioVentures 2014 GP LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,251,912.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,251,912.00
    11Aggregate amount beneficially owned by each reporting person

    2,251,912.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.6 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM BioVentures 2014 LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,324,576.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,324,576.00
    11Aggregate amount beneficially owned by each reporting person

    2,324,576.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.8 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    Oncology Impact Fund (Cayman) Management L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    CAYMAN ISLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,745,647.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,745,647.00
    11Aggregate amount beneficially owned by each reporting person

    1,745,647.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM BioImpact LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,745,647.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,745,647.00
    11Aggregate amount beneficially owned by each reporting person

    1,745,647.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.6 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    ANSBERT GADICKE
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    4,867,341.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    4,867,341.00
    11Aggregate amount beneficially owned by each reporting person

    4,867,341.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    10.0 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    LUKE EVNIN
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    3,121,694.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    3,121,694.00
    11Aggregate amount beneficially owned by each reporting person

    3,121,694.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    6.4 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    Todd Foley
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    2,324,576.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    2,324,576.00
    11Aggregate amount beneficially owned by each reporting person

    2,324,576.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    4.8 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM ASSET MANAGEMENT LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    334,302.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    334,302.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    334,302.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.7 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM ONCOLOGY INNOVATIONS FUND LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    462,816.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    462,816.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    462,816.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    1.0 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    95075A107


    1 Name of reporting person

    MPM Oncology Innovations Fund GP LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    462,816.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    462,816.00
    11Aggregate amount beneficially owned by each reporting person

    462,816.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    1.0 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock
    (b)Name of Issuer:

    WEREWOLF THERAPEUTICS, INC.
    (c)Address of Issuer's Principal Executive Offices:

    200 TALCOTT AVENUE, 2ND FLOOR, WATERTOWN, MASSACHUSETTS , 02472.
    Item 1 Comment:
    Explanatory Note: This Amendment No. 3 to Schedule 13D ("Amendment No. 3") is being filed as an amendment to the initial statement on Schedule 13D relating to the common stock (the "Common Stock"), of Werewolf Therapeutics Inc. (the 'Issuer'), as filed with the Securities and Exchange Commission (the "SEC") on May 14, 2021 and as amended by Amendment No. 1 filed November 4, 2025 and Amendment No. 2 filed November 17, 2025 (as amended, the "Original Schedule 13D"). This Schedule 13D/A is being filed by the Filing Persons to report the open market sales of the Issuer's Common Stock by certain Filing Persons. Items 5 and 7 of the Original Schedule 13D are hereby amended and supplemented to the extent hereinafter expressly set forth and, except as amended and supplemented hereby, the Original Schedule 13D remains in full force and effect. All capitalized terms used in this Amendment No. 3 but not defined herein shall have the meanings ascribed thereto in the Original Schedule 13D.
    Item 5.Interest in Securities of the Issuer
    (a)
    See rows (11) and (13) of the Filing Persons Owner Profile of this Amendment No. 3 for the aggregate number of Common Stock and percentages of the shares of Common Stock beneficially owned by the Filing Person. The Common Stock is held as follows: * 2,111,105 shares are held directly by BV 2014; * 140,807 shares are held directly by BV 2014(B); * 72,664 shares are held directly by AM BV2014 LLC; * 462,816 shares are held directly by MPM OIF; * 334,302 shares by AM LLC; and * 1,745,647 shares are held directly by UBS Oncology. BV 2014 GP and BV 2014 LLC are the direct and indirect general partners of BV 2014 and BV 2014(B) and, accordingly, may be deemed to beneficially own the shares held by BV 2014 and BV 2014(B). BV 2014 LLC is the managing member of AM BV2014 LLC and, accordingly, may be deemed to beneficially own the shares held by AM BV2014 LLC. MPM OIF GP is the general Partner of MPM OIF and, accordingly, may be deemed to beneficially own the shares held by MPM OIF. BioImpact and Oncology Cayman are the direct and indirect general partners of UBS Oncology and, accordingly, may be deemed to beneficially own the shares held by UBS Oncology. Drs. Gadicke and Evnin and Mr. Foley are the managing directors of BV 2014 LLC and, accordingly, may be deemed to beneficially own the shares held by BV 2014, BV 2014(B) and AM BV2014 LLC. Drs. Gadicke and Evnin are the members of AM LLC and managers of MPM OIF GP and, accordingly, may be deemed to beneficially own the shares held by AM LLC and MPM OIF. Dr. Gadicke is the managing partner of BioImpact and, accordingly may be deemed to beneficially own the shares held by UBS Oncology. Calculation of the percentage of the shares of Common Stock beneficially owned is based upon 48,540,200 Common Stock outstanding as of October 29, 2025, as reported in the Issuer's Form 10-Q filed with the SEC on November 4, 2025.
    (b)
    See rows (7) through (10) of the Filing Persons Owner Profile of this Amendment No. 3 for the number of shares as to which there is sole power to vote or to direct the vote, sole power to dispose or to direct the disposition, or shared power to dispose or to direct the disposition.
    (c)
    The Reporting Persons sold the following Common Stock in the open market since the date of filing Amendment No. 2: Date of Price Range Ave. Price Sold by Sold by Sold By Sold by Sold by Sold by Sale BV 2014 BV 2014(B) AM BV2014 MPM OIF AM LLC UBS Oncology LLC 11/18/25 $0.8902-$0.9601 $0.93 22,827 1,523 786 5,027 3,613 18,851 11/19/25 $0.901-$0.9806 $0.94 28,768 1,919 990 6,335 4,554 23,758 11/20/25 $0.8506-$0.9556 $0.89 17,850 1,191 614 3,931 2,825 14,741 11/21/25 $0.80-$0.8861 $0.83 27,904 1,861 960 6,145 4,417 23,044 11/24/25 $0.8733-$1.03 $0.98 38,518 2,569 1,325 8,483 6,097 31,810 11/25/25 $0.90-$0.99 $0.92 18,449 1,230 635 4,063 2,920 15,236 11/26/25 $0.9328-$1.01 $0.98 26,343 1,757 907 5,801 4,170 21,755 11/28/25 $0.9681-$1.01 $0.99 8,795 587 303 1,937 1,392 7,263 12/01/25 $0.905-$1.00 $0.94 26,423 1,762 910 5,819 4,182 21,821 12/02/25 $0.852-$0.9246 $0.89 25,712 1,715 884 5,662 4,070 21,234 12/03/25 $0.82-$0.9256 $0.87 24,821 1,656 854 5,466 3,929 20,499
    (d)
    Inapplicable.
    (e)
    Inapplicable.
    Item 7.Material to be Filed as Exhibits.
     
    Joint Filing Statement

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    MPM BioVentures 2014, L.P.
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Director of MPM BioVentures 2014 LLC, the Managing Member of MPM BioVentures 2014 GP LLC, the General Partner of MPM BioVentures 2014, L.P.
    Date:12/03/2025
     
    MPM BioVentures 2014 (B), L.P.
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Director of MPM BioVentures 2014 LLC, Managing Member of MPM BioVentures 2014 GP LLC, the General Partner of MPM BioVentures 2014 (B), L.P.
    Date:12/03/2025
     
    MPM Asset Management Investors BV2014 LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Director of MPM BioVentures 2014 LLC, the manager of MPM Asset Management Investors BV2014 LLC
    Date:12/03/2025
     
    UBS Oncology Impact Fund L.P.
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Partner of MPM BioImpact LLC, the GP of Oncology Impact Fund (Cayman) Management L.P., the GP of UBS Oncology Impact Fund L.P.
    Date:12/03/2025
     
    MPM BioVentures 2014 GP LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Director of MPM BioVentures 2014 LLC, the Managing Member of MPM BioVentures 2014 GP LLC
    Date:12/03/2025
     
    MPM BioVentures 2014 LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Director
    Date:12/03/2025
     
    Oncology Impact Fund (Cayman) Management L.P.
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Partner of MPM BioImpact LLC, the General Partner of Oncology Impact Fund (Cayman) Management L.P.
    Date:12/03/2025
     
    MPM BioImpact LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Managing Partner
    Date:12/03/2025
     
    ANSBERT GADICKE
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Ansbert Gadicke
    Date:12/03/2025
     
    LUKE EVNIN
     
    Signature:/s/ Luke Evnin
    Name/Title:Luke Evnin
    Date:12/03/2025
     
    Todd Foley
     
    Signature:/s/ Todd Foley
    Name/Title:Todd Foley
    Date:12/03/2025
     
    MPM ASSET MANAGEMENT LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Member
    Date:12/03/2025
     
    MPM ONCOLOGY INNOVATIONS FUND LP
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Manager of MPM Oncology Innovations Fund GP LLC, the General Partner of MPM Oncology Innovations Fund, L.P.
    Date:12/03/2025
     
    MPM Oncology Innovations Fund GP LLC
     
    Signature:/s/ Ansbert Gadicke
    Name/Title:Manager
    Date:12/03/2025
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    144 - Werewolf Therapeutics, Inc. (0001785530) (Subject)

    12/10/25 5:03:37 PM ET
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    Werewolf Therapeutics Presents Data Expanding Its PREDATOR® Platform at the Society for Immunotherapy of Cancer's (SITC) 40th Annual Meeting

    Novel INDUCER™ T Cell Engager Platform designed to mitigate systemic toxicities Sequential dosing of INDUKINE™ molecules in preclinical model showed potent antitumor activity with improved safety First-in-kind real-time pharmacokinetic data in a mouse tumor model confirmed WTX-124 selective activation in tumors, sparing healthy tissue WATERTOWN, Mass., Nov. 07, 2025 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of conditionally activated therapeutics engineered to stimulate the body's immune system for the treatment of cancer and other immune-mediated conditions, today share

    11/7/25 9:00:00 AM ET
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    Werewolf Therapeutics Reports Third Quarter 2025 Financial Results and Provides Business Update

    – Update on WTX-124 Phase 1/1b clinical trial interim data and End of Phase 1 meeting with the U.S. Food & Drug Administration (FDA) is expected to be provided later in the fourth quarter of 2025 – – Update on Phase 1b/2 clinical trial of WTX-330 and potential further development plan is expected to be provided later in the fourth quarter of 2025 – – WTX-1011, Company's first INDUCER™ T-cell engager development candidate targeting STEAP1, continues IND-enabling studies – WATERTOWN, Mass., Nov. 04, 2025 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of conditionally activat

    11/4/25 7:00:00 AM ET
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    Werewolf Therapeutics Receives Fast Track Designation from the U.S. FDA for WTX-124, an Investigational Therapy for the Treatment of Cancer

    Fast Track Designation underscores the promise of Werewolf's INDUKINE™ platform WATERTOWN, Mass., Oct. 08, 2025 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), pioneering the development of therapeutics engineered to stimulate the body's immune system for the treatment of cancer and other immune-mediated conditions, today announced that the Company has received Fast Track Designation for the use of WTX-124 for the potential treatment of patients with locally advanced or metastatic cutaneous melanoma after standard of care immunotherapy. WTX-124 is a conditionally activated interleukin 2 (IL-2) INDUKINE therapy. Fast Track Designation is intende

    10/8/25 8:00:00 AM ET
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    Director Evnin Luke sold $88,587 worth of shares (82,971 units at $1.07) (SEC Form 4)

    4 - Werewolf Therapeutics, Inc. (0001785530) (Issuer)

    12/12/25 5:32:31 PM ET
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    Director Evnin Luke sold $94,787 worth of shares (95,179 units at $1.00) (SEC Form 4)

    4 - Werewolf Therapeutics, Inc. (0001785530) (Issuer)

    12/9/25 5:07:35 PM ET
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    Director Evnin Luke sold $117,623 worth of shares (128,185 units at $0.92) (SEC Form 4)

    4 - Werewolf Therapeutics, Inc. (0001785530) (Issuer)

    12/4/25 6:20:30 PM ET
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    JMP Securities initiated coverage on Werewolf Therapeutics with a new price target

    JMP Securities initiated coverage of Werewolf Therapeutics with a rating of Mkt Outperform and set a new price target of $12.00

    4/3/24 7:44:47 AM ET
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    Wedbush initiated coverage on Werewolf Therapeutics with a new price target

    Wedbush initiated coverage of Werewolf Therapeutics with a rating of Outperform and set a new price target of $9.00

    8/24/23 7:17:30 AM ET
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    Jefferies resumed coverage on Werewolf Therapeutics with a new price target

    Jefferies resumed coverage of Werewolf Therapeutics with a rating of Buy and set a new price target of $12.00 from $11.00 previously

    6/6/23 9:09:19 AM ET
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    Director Ra Capital Management, L.P. bought $487,188 worth of shares (536,426 units at $0.91) (SEC Form 4)

    4 - Werewolf Therapeutics, Inc. (0001785530) (Issuer)

    5/14/25 6:08:19 PM ET
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    Werewolf Therapeutics Appoints Steven Bloom as Chief Business Officer

    WATERTOWN, Mass., April 17, 2025 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of conditionally activated therapeutics engineered to stimulate the body's immune system for the treatment of cancer and other immune-mediated conditions, today announced the appointment of Steven Bloom as Chief Business Officer. Mr. Bloom brings more than 35 years of experience in the life sciences industry leading teams in corporate development, commercial planning, corporate affairs, and strategic consulting. "Steve brings deep experience in strategic transactions to Werewolf at this critical tim

    4/17/25 8:00:00 AM ET
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    Werewolf Therapeutics Appoints Anil Singhal, Ph.D., to its Board of Directors

    WATERTOWN, Mass., Feb. 24, 2025 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of conditionally activated therapeutics engineered to stimulate the body's immune system for the treatment of cancer and immunological diseases, today announced the appointment of Anil Singhal, Ph.D., President and Chief Executive Officer of Trishula Therapeutics, as a member of its board of directors. "I am thrilled to join Werewolf's board of directors as the company advances its novel INDUKINE molecules through clinical development," said Dr. Singhal. "Werewolf is demonstrating the power of the PREDATORTM protein engineering p

    2/24/25 7:30:00 AM ET
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    Werewolf Therapeutics Appoints Michael Atkins, M.D., to its Board of Directors

    WATERTOWN, Mass., Jan. 04, 2024 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of novel, conditionally activated INDUKINE™ therapeutics engineered to stimulate the body's immune system for the treatment of cancer, today announced the appointment of Michael B. Atkins, M.D., to its Board of Directors. "Mike is a world-renowned oncologist and clinical researcher who has made countless contributions to the field of cancer immunotherapy. I am delighted to have Mike join our Board at this important time in the clinical development of our WTX-124 and WTX-330 INDUKINE molecules," sai

    1/4/24 4:05:00 PM ET
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    Amendment: SEC Form SC 13G/A filed by Werewolf Therapeutics Inc.

    SC 13G/A - Werewolf Therapeutics, Inc. (0001785530) (Subject)

    11/14/24 4:04:06 PM ET
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    Amendment: SEC Form SC 13G/A filed by Werewolf Therapeutics Inc.

    SC 13G/A - Werewolf Therapeutics, Inc. (0001785530) (Subject)

    11/14/24 11:54:33 AM ET
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    Amendment: SEC Form SC 13G/A filed by Werewolf Therapeutics Inc.

    SC 13G/A - Werewolf Therapeutics, Inc. (0001785530) (Subject)

    11/13/24 4:30:24 PM ET
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    Werewolf Therapeutics Presents Preliminary Monotherapy Data from Phase 1/1b Clinical Trial Establishing Proof of Mechanism for WTX-124 at the Society for Immunotherapy of Cancer's (SITC) 38th Annual Meeting

    Preliminary data on WTX-124 provide compelling early evidence of dose-dependent biomarker and antitumor activity in patients with advanced or metastatic solid tumors relapsed or refractory to standard of care therapy, including two patients with ongoing unconfirmed partial responses (uPR) in the highest dose tested to date, cohort 4 (12 mg) - Safety data indicate WTX-124 is generally well-tolerated through cohort 4 with no dose limiting toxicities and no indication of vascular leak syndrome (VLS) or other typically severe IL-2-mediated toxicities - Preliminary data support the potential of WTX-124 to be a differentiated next-generation IL-2 compound by showing immune cell activation in the

    11/3/23 7:00:00 AM ET
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    Werewolf Therapeutics to Present Clinical and Preclinical Data at the Society for Immunotherapy of Cancer's (SITC) 38th Annual Meeting

    Interim, first-in-human clinical results from initial monotherapy dose-escalation cohorts in ongoing Phase 1/1b study of WTX-124 including safety and preliminary antitumor activity to be described in poster presentation.Additional posters representing an expansive body of data demonstrating the potential of Werewolf's PREDATOR™ platform and INDUKINE™ product candidates will also be presented.Company to host conference call and webcast to review WTX-124 initial clinical results November 3, 2023, at 8:30 am ET WATERTOWN, Mass., Oct. 31, 2023 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the d

    10/31/23 9:00:00 AM ET
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