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    Amendment: SEC Form SCHEDULE 13G/A filed by Autolus Therapeutics plc

    5/7/25 9:00:03 AM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $AUTL alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    (Amendment No. 8)


    Autolus Therapeutics plc

    (Name of Issuer)


    Ordinary Shares, nominal value $0.000042 per share, and American Depositary Shares ("ADS"). Each ADS represents one Ordinary Share.

    (Title of Class of Securities)


    05280R100

    (CUSIP Number)


    03/31/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox not checked   Rule 13d-1(c)
    Checkbox checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Syncona Portfolio Limited
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    GUERNSEY
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    CO

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Syncona Holdings Limited
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    GUERNSEY
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    CO

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Syncona Investment Management Limited
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED KINGDOM
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    CO

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Syncona Limited
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    GUERNSEY
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    CO

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Roel Bulthuis
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    NETHERLANDS
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Christopher Hollowood
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED KINGDOM
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    CUSIP No.
    05280R100


    1Names of Reporting Persons

    Kenneth Galbraith
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    CANADA (FEDERAL LEVEL)
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    28,821,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    28,821,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    28,821,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    10.8 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  Response to Items 6, 8 and 9 consist of 12,180,333 ordinary shares and 16,640,720 American Depositary Shares ("ADSs") held directly by Syncona Portfolio Limited. Each ADS represents one ordinary share, nominal value $0.000042 per share, of the Issuer. The ordinary shares and the ADSs are collectively referred to as the "Ordinary Shares". Response to Item 11 is based on 266,128,900 Ordinary Shares outstanding as reported in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 20, 2025.


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Autolus Therapeutics plc
    (b)Address of issuer's principal executive offices:

    The Mediaworks, 191 Wood Lane, London W12 7FP, United Kingdom
    Item 2. 
    (a)Name of person filing:

    (i) Syncona Portfolio Limited; (ii) Syncona Holdings Limited; (iii)Syncona Investment Management Limited; (iv) Syncona Limited; (v) Roel Bulthuis; (vi) Christopher Hollowood; and (vii) Kenneth Galbraith
    (b)Address or principal business office or, if none, residence:

    The address of the principal business office of Syncona Portfolio Limited, Syncona Holdings Limited and Syncona Limited is Frances House, PO Box 273, Sir William Place, St. Peter Port, Guernsey, GY1 3RD, Channel Islands. The address of the principal business office of Syncona Investment Management Limited, Roel Bulthuis, Christopher Hollowood and Kenneth Galbraith is 2nd Floor, 8 Bloomsbury Street, London WC1B 3SR, United Kingdom.
    (c)Citizenship:

    Syncona Portfolio Limited, Syncona Holdings Limited and Syncona Limited's citizenship is Guernsey. Syncona Investment Management Limited and Christopher Hollowood's citizenship is United Kingdom. Roel Bulthuis' citizenship is the Netherlands. Kenneth Galbraith's citizenship is Canada.
    (d)Title of class of securities:

    Ordinary Shares, nominal value $0.000042 per share, and American Depositary Shares ("ADS"). Each ADS represents one Ordinary Share.
    (e)CUSIP No.:

    05280R100
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    28,821,053
    (b)Percent of class:

    10.8  %
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    0

     (ii) Shared power to vote or to direct the vote:

    28,821,053

     (iii) Sole power to dispose or to direct the disposition of:

    0

     (iv) Shared power to dispose or to direct the disposition of:

    28,821,053

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    Not Applicable

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Syncona Portfolio Limited
     
    Signature:/s/ Nicholas Moss
    Name/Title:Nicholas Moss, Director
    Date:05/07/2025
     
    Syncona Holdings Limited
     
    Signature:/s/ Nicholas Moss
    Name/Title:Nicholas Moss, Director
    Date:05/07/2025
     
    Syncona Investment Management Limited
     
    Signature:/s/ Christopher Hollowood
    Name/Title:Christopher Hollowood
    Date:05/07/2025
     
    Syncona Limited
     
    Signature:/s/ Robert Hutchinson
    Name/Title:Robert Hutchinson
    Date:05/07/2025
     
    Roel Bulthuis
     
    Signature:/s/ Roel Bulthuis
    Name/Title:Roel Bulthuis
    Date:05/07/2025
     
    Christopher Hollowood
     
    Signature:/s/ Christopher Hollowood
    Name/Title:Christopher Hollowood
    Date:05/07/2025
     
    Kenneth Galbraith
     
    Signature:/s/ Kenneth Galbraith
    Name/Title:Kenneth Galbraith
    Date:05/07/2025
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    Company reports Q2 2025 AUCATZYL® net product revenue of $20.9 million and $29.9 for the first six months of 2025Company recently received conditional marketing authorization from U.K. Medicines and Healthcare products Regulatory Agency (MHRA) and conditional European marketing authorization from the European Commission (EC) for AUCATZYL®Follow up data from the FELIX trial demonstrating obe-cel's potential for long-term remission in r/r B-ALL presented at the 2025 European Hematology Association (EHA) CongressCompany is on track to initiate Phase 2 pivotal clinical trial in lupus nephritis (LN) and Phase 1 clinical trial in progressive forms of multiple sclerosis (MS) by year-end 2025Confere

    8/12/25 7:00:00 AM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $AUTL
    Large Ownership Changes

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    Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

    SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

    11/14/24 4:32:31 PM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

    SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

    11/14/24 1:44:27 PM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

    SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

    11/14/24 9:12:16 AM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care