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    Amendment: SEC Form SCHEDULE 13G/A filed by Beam Therapeutics Inc.

    5/15/25 5:04:40 PM ET
    $BEAM
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $BEAM alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    (Amendment No. 4)


    Beam Therapeutics Inc.

    (Name of Issuer)


    Common Stock par value $0.01 per share

    (Title of Class of Securities)


    07373V105

    (CUSIP Number)


    03/31/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox not checked   Rule 13d-1(c)
    Checkbox checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    ARCH Venture Fund IX, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,540,132.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    ARCH Venture Fund IX Overage, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,540,132.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    ARCH Venture Partners IX, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,540,132.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    ARCH Venture Partners IX Overage, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,540,132.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    ARCH Venture Partners IX, LLC
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,540,132.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    OO


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    Keith Crandell
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    17,730.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    17,730.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,557,862.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    Clinton Bybee
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    10,498.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    10,498.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,550,630.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.
    07373V105


    1Names of Reporting Persons

    Robert Nelsen
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    60,615.00
    6Shared Voting Power

    4,540,132.00
    7Sole Dispositive Power

    60,615.00
    8Shared Dispositive Power

    4,540,132.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,600,747.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.6 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Beam Therapeutics Inc.
    (b)Address of issuer's principal executive offices:

    238 Main Street, Cambridge, MA 02142
    Item 2. 
    (a)Name of person filing:

    ARCH Venture Fund IX, L.P. ("AVF IX"); ARCH Venture Partners IX, L.P. ("AVP IX LP"); ARCH Venture Partners IX, LLC ("AVP IX LLC"); ARCH Venture Fund IX Overage, L.P. ("AVF IX Overage"); ARCH Venture Partners IX Overage, L.P. ("AVP IX Overage GP") (collectively, the "Reporting Entities" and individually, each a "Reporting Entity"); and Keith Crandell ("Crandell"), Robert Nelsen ("Nelsen") and Clinton Bybee ("Bybee") (collectively, the "Managing Directors" and individually, each a "Managing Director"). The Reporting Entities and the Managing Directors collectively are referred to as the "Reporting Persons".
    (b)Address or principal business office or, if none, residence:

    8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631
    (c)Citizenship:

    Each of AVF IX, AVP IX LP, AVF IX Overage and AVP IX Overage GP, are limited partnerships organized under the laws of the State of Delaware. AVP IX LLC is a limited liability company organized under the laws of the State of Delaware. Each Managing Director is a US citizen.
    (d)Title of class of securities:

    Common Stock par value $0.01 per share
    (e)CUSIP No.:

    07373V105
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Checkbox checked    Ownership of 5 percent or less of a class
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    Not Applicable

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    ARCH Venture Fund IX, L.P.
     
    Signature:ARCH Venture Partners IX, L.P.
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:ARCH Venture Partners IX, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Fund IX Overage, L.P.
     
    Signature:ARCH Venture Partners IX Overage, L.P.
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:ARCH Venture Partners IX, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners IX, L.P.
     
    Signature:ARCH Venture Partners IX, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners IX Overage, L.P.
     
    Signature:ARCH Venture Partners IX, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners IX, LLC
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    Keith Crandell
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell
    Date:05/15/2025
     
    Clinton Bybee
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Clinton Bybee
    Date:05/15/2025
     
    Robert Nelsen
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Robert Nelsen
    Date:05/15/2025

    Comments accompanying signature:  * This Schedule 13G was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Beam Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on February 5, 2020 and incorporated herein in its entirety by reference.
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    Presentation to Include Updated Data from 17 Sickle Cell Disease Patients in the Ongoing BEACON Phase 1/2 Clinical Trial Evaluating Safety and Efficacy of BEAM-101 Beam to Host Investor Webcast on Friday, June 13, 2025, at 4:00 p.m. ET CAMBRIDGE, Mass., May 14, 2025 (GLOBE NEWSWIRE) -- Beam Therapeutics Inc. (NASDAQ:BEAM), a biotechnology company developing precision genetic medicines through base editing, today announced that the company will present new data from the BEACON Phase 1/2 clinical trial of BEAM-101 in sickle cell disease (SCD) at the European Hematology Association 2025 Congress (EHA2025), taking place June 12-15, 2025, in Milan, Italy. BEAM-101 is an investigational ge

    5/14/25 9:30:00 AM ET
    $BEAM
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Beam Therapeutics Announces Positive Initial Data for BEAM-302 in the Phase 1/2 Trial in Alpha-1 Antitrypsin Deficiency (AATD), Demonstrating First Ever Clinical Genetic Correction of a Disease-causing Mutation

    Single Dose of BEAM-302 Led to Durable, Dose-dependent Increases in Total and Functional Alpha-1 Antitrypsin (AAT), Production of Corrected M-AAT, and Decreases in Mutant Z-AAT in Circulation Across Initial Three Dose Levels Third Dose Level of BEAM-302 (60 mg, N=3) Achieved Mean Total AAT of 12.4µM at Day 28, Exceeding Protective Therapeutic Threshold, and Reduced Mutant Z-AAT up to 78% Initial Safety Findings Demonstrated BEAM-302 was Well Tolerated at All Dose Levels with No Serious Adverse Events or Dose-Limiting Toxicities Observed Clinical Profile Supports Continued Dose Escalation, with Updated Data from Part A of the Phase 1/2 Trial Expected to be Presented at Medical Conference

    3/10/25 6:00:00 AM ET
    $BEAM
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care