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    Amendment: SEC Form SCHEDULE 13G/A filed by Lyell Immunopharma Inc.

    5/15/25 4:04:57 PM ET
    $LYEL
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $LYEL alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    (Amendment No. 2)


    Lyell Immunopharma, Inc.

    (Name of Issuer)


    Common Stock, par value $0.0001

    (Title of Class of Securities)


    55083R104

    (CUSIP Number)


    03/31/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox checked   Rule 13d-1(c)
    Checkbox not checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Fund IV, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    16,007,999.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    16,007,999.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    16,007,999.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    5.4 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  Note to Row 5: 16,007,999 shares, except that Foresite Capital Management IV, LLC ("FCM IV"), the general partner of Foresite Capital Fund IV, L.P. ("FCF IV"), may be deemed to have sole power to vote these shares, and James Tananbaum ("Tananbaum"), the managing member of FCM IV, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 16,007,999 shares, except that FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of Lyell Immunopharma, Inc. (the "Issuer") as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Management IV, LLC
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    16,007,999.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    16,007,999.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    16,007,999.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    5.4 %
    12Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:  Note to Row 5: 16,007,999 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 16,007,999 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Fund V, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    8,133,047.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    8,133,047.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    8,133,047.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    2.8 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  Note to Row 5: 8,133,047 shares, except that Foresite Capital Management V, LLC ("FCM V"), the general partner of Foresite Capital Fund V, L.P. ("FCF V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 8,133,047 shares, except that FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Management V, LLC
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    8,133,047.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    8,133,047.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    8,133,047.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    2.8 %
    12Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:  Note to Row 5: 8,133,047 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 8,133,047 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Opportunity Fund V, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    3,020,846.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    3,020,846.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,020,846.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    1.0 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  Note to Row 5: 3,020,846 shares, except that Foresite Capital Opportunity Management V, LLC ("FCM Opp V"), the general partner of Foresite Capital Opportunity Fund V, L.P. ("FCF Opp V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 3,020,846 shares, except that FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    Foresite Capital Opportunity Management V, LLC
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    3,020,846.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    3,020,846.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,020,846.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    1.0 %
    12Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:  Note to Row 5: 3,020,846 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 3,020,846 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    CUSIP No.
    55083R104


    1Names of Reporting Persons

    James B. Tananbaum
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    27,161,892.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    27,161,892.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    27,161,892.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.2 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  Note to Row 5: 27,161,892 shares, of which 16,007,999 shares are directly owned by FCF IV, 8,133,047 shares are directly owned by FCF V and 3,020,846 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 27,161,892 shares, of which 16,007,999 shares are directly owned by FCF IV, 8,133,047 shares are directly owned by FCF V and 3,020,846 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 295,228,868 Common Stock outstanding of the Issuer as of March 6, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 11, 2025.


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Lyell Immunopharma, Inc.
    (b)Address of issuer's principal executive offices:

    201 Haskins Way South San Francisco, CA, 94080
    Item 2. 
    (a)Name of person filing:

    This Schedule is filed by Foresite Capital Fund IV, L.P., a Delaware limited partnership ("FCF IV"), Foresite Capital Management IV, LLC, a Delaware limited liability company ("FCM IV"), Foresite Capital Fund V, L.P., a Delaware limited partnership ("FCF V"), Foresite Capital Management V, LLC, a Delaware limited liability company ("FCM V"), Foresite Capital Opportunity Fund V, L.P., a Delaware limited partnership ("FCF Opp V"), Foresite Capital Opportunity Management V, LLC, a Delaware limited liability company ("FCM Opp V") and James Tananbaum. The foregoing entities and individuals are collectively referred to as the "Reporting Persons."
    (b)Address or principal business office or, if none, residence:

    c/o Foresite Capital Management 900 Larkspur Landing Circle, Suite 150 Larkspur, CA 94939
    (c)Citizenship:

    See Row 4 of cover page for each Reporting Person.
    (d)Title of class of securities:

    Common Stock, par value $0.0001
    (e)CUSIP No.:

    55083R104
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    See Row 9 of cover page for each Reporting Person.
    (b)Percent of class:

    See Row 11 of cover page for each Reporting Person.
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    See Row 5 of cover page for each Reporting Person.

     (ii) Shared power to vote or to direct the vote:

    See Row 6 of cover page for each Reporting Person.

     (iii) Sole power to dispose or to direct the disposition of:

    See Row 7 of cover page for each Reporting Person.

     (iv) Shared power to dispose or to direct the disposition of:

    See Row 8 of cover page for each Reporting Person.

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.


    Under certain circumstances set forth in the limited partnership agreements of FCF IV, FCF V and FCF Opp V and the limited liability company agreements of FCM IV, FCM V and FCM Opp V, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member.
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Foresite Capital Fund IV, L.P.
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member of the General Partner
    Date:05/15/2025
     
    Foresite Capital Management IV, LLC
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member
    Date:05/15/2025
     
    Foresite Capital Fund V, L.P.
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member of the General Partner
    Date:05/15/2025
     
    Foresite Capital Management V, LLC
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member
    Date:05/15/2025
     
    Foresite Capital Opportunity Fund V, L.P.
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member of the General Partner
    Date:05/15/2025
     
    Foresite Capital Opportunity Management V, LLC
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum, Managing Member
    Date:05/15/2025
     
    James B. Tananbaum
     
    Signature:/s/ James Tananbaum
    Name/Title:James Tananbaum
    Date:05/15/2025
    Exhibit Information

    Agreement of Joint Filing The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Common Stock of the Issuer shall be filed on behalf of each of the undersigned. Note that a copy of the applicable Agreement of Joint Filing is already on file with the appropriate agencies.

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      LYL314 demonstrated robust clinical responses, with an 88% overall response rate and a 72% complete response rate in patients treated in the third- or later-line setting (N = 25)71% of patients with complete response remained in complete response at ≥ 6 monthsManageable safety profile appropriate for outpatient administration with no Grade ≥ 3 cytokine release syndrome and low rates of Grade ≥ 3 ICANS with rapid resolutionPivotal single-arm PiNACLE trial is underway in CAR T-naïve patients with large B-cell lymphoma treated in the third- or later-line settingLyell to host an investor webcast at 8:00 AM ET today SOUTH SAN FRANCISCO, Calif., June 17, 2025 (GLOBE NEWSWIRE) -- Lyell Immunoph

      6/17/25 6:30:00 AM ET
      $LYEL
      Biotechnology: Pharmaceutical Preparations
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    • Lyell Immunopharma Strengthens Clinical and Commercial Capabilities with Key Board and Executive Appointments

      Mark J. Bachleda, PharmD, MBA appointed as independent member of the Board of DirectorsDavid Shook, MD appointed as Chief Medical Officer, Mark Meltz, JD as General Counsel and Corporate Secretary, and Jarrad Aguirre, MD, MBA as Senior Vice-President of Medical Affairs SOUTH SAN FRANCISCO, Calif., June 09, 2025 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc. (NASDAQ:LYEL), a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with cancer, today announced the appointment of Mark J. Bachleda, PharmD, MBA as an independent member of the Board of Directors, David Shook, MD as Chief Medical Officer, and Mark Meltz, JD as General Counsel and Corporate

      6/9/25 4:05:00 PM ET
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    SEC Filings

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    • SEC Form 8-K filed by Lyell Immunopharma Inc.

      8-K - Lyell Immunopharma, Inc. (0001806952) (Filer)

      6/26/25 4:07:08 PM ET
      $LYEL
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    • SEC Form 8-K filed by Lyell Immunopharma Inc.

      8-K - Lyell Immunopharma, Inc. (0001806952) (Filer)

      6/17/25 8:49:17 AM ET
      $LYEL
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    • SEC Form 8-K filed by Lyell Immunopharma Inc.

      8-K - Lyell Immunopharma, Inc. (0001806952) (Filer)

      6/9/25 4:23:34 PM ET
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    Insider Trading

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    • SEC Form 4 filed by Director Bachleda Mark

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      6/11/25 5:48:27 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • SEC Form 4 filed by General Counsel Meltz Mark A

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      6/11/25 5:47:11 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Chief Medical Officer Shook David was granted 21,900 shares (SEC Form 4)

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      6/11/25 5:45:48 PM ET
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    $LYEL
    Insider Purchases

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    • Director Brawley Otis W bought $19,958 worth of shares (35,640 units at $0.56) (SEC Form 4)

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      4/2/25 3:46:01 PM ET
      $LYEL
      Biotechnology: Pharmaceutical Preparations
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    • Director Ramachandra Sumant bought $115,220 worth of shares (200,000 units at $0.58) (SEC Form 4)

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      3/25/25 6:46:17 PM ET
      $LYEL
      Biotechnology: Pharmaceutical Preparations
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    • Director Klausner Richard bought $94,942 worth of shares (158,000 units at $0.60) (SEC Form 4)

      4 - Lyell Immunopharma, Inc. (0001806952) (Issuer)

      3/18/25 8:07:51 PM ET
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    Financials

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    • Lyell Immunopharma Announces Positive New Clinical Data Demonstrating High Rates of Durable Complete Responses from the Phase 1/2 Trial of LYL314 for the Treatment of Aggressive Large B-cell Lymphoma

      LYL314 demonstrated robust clinical responses, with an 88% overall response rate and a 72% complete response rate in patients treated in the third- or later-line setting (N = 25)71% of patients with complete response remained in complete response at ≥ 6 monthsManageable safety profile appropriate for outpatient administration with no Grade ≥ 3 cytokine release syndrome and low rates of Grade ≥ 3 ICANS with rapid resolutionPivotal single-arm PiNACLE trial is underway in CAR T-naïve patients with large B-cell lymphoma treated in the third- or later-line settingLyell to host an investor webcast at 8:00 AM ET today SOUTH SAN FRANCISCO, Calif., June 17, 2025 (GLOBE NEWSWIRE) -- Lyell Immunoph

      6/17/25 6:30:00 AM ET
      $LYEL
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Lyell Immunopharma to Acquire ImmPACT Bio and Prioritizes its Pipeline to Focus on Next-Generation CAR T-cell Therapies

      Strengthens Lyell's clinical pipeline with the addition of IMPT-314, a dual-targeting CD19/CD20 CAR T-cell product candidateData from ImmPACT's multi-center Phase 1-2 clinical trial of IMPT-314 in patients with large B-cell lymphoma treated in the 3rd line CAR-naïve setting to be presented at a major medical conference later this year; initiation of a pivotal trial for IMPT-314 expected in 2025Lyell has prioritized its pipeline to focus on next-generation CAR T-cell therapies, including IMPT-314 and LYL119, and is discontinuing development of LYL797, LYL845 and earlier-stage TIL programsCash runway following the close of the transaction is expected to fund operations into 2027, through impor

      10/24/24 4:00:00 PM ET
      $LYEL
      Biotechnology: Pharmaceutical Preparations
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    • Lyell Immunopharma Reports Dose-dependent Clinical Activity from Phase 1 Trial of LYL797, a ROR1-targeted CAR-T Cell Product Candidate Enhanced with its Proprietary Anti-exhaustion Technology

      Dose-dependent antitumor clinical activity in ROR1+ relapsed/refractory triple-negative breast cancer; 40% objective response rate and 60% clinical benefit rate at the highest dose cleared to date (150 x 106 CAR T cells)First demonstration that CAR T cells enhanced with anti-exhaustion technology can both expand and infiltrate into solid tumorsNo significant safety signal related to LYL797 observed in patients without lung involvement; treatable pneumonitis observed in patients with lung metastatic disease; dose escalation continues in separate cohortsExpanding development into new tumor types including ROR1+ relapsed/refractory platinum-resistant ovarian cancer, endometrial cancer, multiple

      6/26/24 7:00:00 AM ET
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    $LYEL
    Large Ownership Changes

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    • Amendment: SEC Form SC 13G/A filed by Lyell Immunopharma Inc.

      SC 13G/A - Lyell Immunopharma, Inc. (0001806952) (Subject)

      11/12/24 4:04:21 PM ET
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    • Amendment: SEC Form SC 13G/A filed by Lyell Immunopharma Inc.

      SC 13G/A - Lyell Immunopharma, Inc. (0001806952) (Subject)

      11/4/24 1:30:41 PM ET
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    • SEC Form SC 13G filed by Lyell Immunopharma Inc.

      SC 13G - Lyell Immunopharma, Inc. (0001806952) (Subject)

      10/31/24 6:00:17 PM ET
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