Analyses from Cognition's Positive Phase 2 'SHINE' Study of CT1812 in Mild-to-Moderate Alzheimer's Disease will be Presented in a Podium Presentation at CTAD

Presenting prespecified analysis of cognitive impact on plasma p-Tau 217 subgroups in ‘SHINE'

Poster Presentation details baseline characteristics from the signal-finding ‘SHIMMER' trial in DLB

PURCHASE, N.Y., Oct. 23, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc., (the Company or Cognition) (NASDAQ:CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, announced Michael Woodward, MD, FRACP, head of dementia research at Austin Health in Melbourne, Australia, will deliver an oral presentation at the Clinical Trials on Alzheimer's Disease (CTAD) conference, which is taking place October 29 - November 1, 2024, in Madrid, Spain.

"Dr. Woodward will present results from pre-specified analyses that give a robust picture of the positive results from the Phase 2 ‘SHINE' trial of CT1812 in mild-to-moderate Alzheimer's disease," explained Anthony O. Caggiano, MD, PhD, Cognition's CMO and head of R&D. "We believe the consistent efficacy signals observed in patients treated with CT1812 for six months, coupled with a favorable tolerability profile, support our plans to advance CT1812 for the treatment of people with mild-to-moderate Alzheimer's disease."

Dr. Caggiano continued, "Further, for the first time, we are reporting the baseline characteristics of the patients with mild-to-moderate dementia with Lewy bodies (DLB) who were enrolled into the Phase 2 signal-finding SHIMMER trial. This information will provide insights into the severity of the symptoms experienced by SHIMMER participants as they entered the study, such as cognitive and movement impairment, fluctuating attention and sleep disorder."

Cognition Therapeutics at CTAD:

The poster and slide presentation will be made available on the Cognition Therapeutics website in accordance with the congress' embargo policy.

About CT1812

CT1812 is an experimental orally delivered small molecule oligomer antagonist that penetrates the blood-brain barrier and binds selectively to the sigma-2 receptor complex. Preclinical and clinical data demonstrate that this binding results in the displacement of toxic oligomers. The sigma-2 receptor complex is involved in the regulation of key cellular processes such as membrane trafficking and autophagy that are damaged by oligomers and other stressors. This damage to sensitive synapses can progress to a loss of synaptic function, which drives the progression of neurodegenerative diseases like Alzheimer's disease and DLB.

About Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc., is a clinical-stage biopharmaceutical company discovering and developing innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. We currently are investigating our lead candidate CT1812 in clinical programs in Alzheimer's disease, dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). We believe CT1812 and our pipeline of σ-2 receptor modulators can regulate pathways that are impaired in these degenerative diseases, with an approach that is functionally distinct from other treatments. More about Cognition Therapeutics and our pipeline can be found at https://cogrx.com.  

Forward-Looking Statements

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