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    Arena Reports Second Quarter Financial Results and Key Program Updates

    8/5/21 4:05:00 PM ET
    $ARNA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ARNA alert in real time by email

    – Phase 3 ELEVATE UC 12 trial reached full enrollment; topline data expected Q1 2022 with ELEVATE UC 52

    – Liquidity position at ~$1.0 billion as of June 30, 2021 to support continued pipeline progress

    Arena Pharmaceuticals, Inc. (NASDAQ:ARNA) today provided a corporate update and reported financial results for the second quarter ended June 30, 2021.

    "With today's announcement of the ELEVATE UC 12 trial reaching full enrollment, we look forward to a potentially transformational data readout of ELEVATE UC 12 and ELEVATE UC 52 in the first quarter of next year. We are also pleased with our recently announced partnership with Aristea to strengthen our mid-stage immunology pipeline," said Amit D. Munshi, President and CEO of Arena. "We remain excited about moving forward to Phase 3 in atopic dermatitis — a decision that is further supported by updated OLE data. We are continuing to engage regulatory agencies worldwide in the design of the program."

    Key Program & Corporate Updates

    Gastroenterology

    • In August the Phase 3 ELEVATE UC 12 trial for etrasimod in ulcerative colitis reached full enrollment
    • Topline data for both ELEVATE UC 12 and ELEVATE UC 52 expected contemporaneously in Q1 2022
    • In August announced collaboration with Second Genome to identify microbiome biomarkers associated with clinical benefit for the Phase 2/3 CULTIVATE trial sub-study A for etrasimod in Crohn's disease
    • In August increased target enrollment in CULTIVATE sub-study A from 50 participants to 70 participants; dose-ranging data to read out in early Q2 2022; enhanced data may allow Sub-Study 1 to transition to a registrational study and reduce the overall timeline on the program
    • In June the FDA granted Orphan Drug Designation status to etrasimod for the treatment of eosinophilic esophagitis

    Dermatology

    • In July we evaluated an updated OLE data set from the Phase 2 ADVISE trial for 2 mg etrasimod in atopic dermatitis that demonstrated meaningful effects at week 16 of the OLE period on validated Investigator Global Assessment (vIGA) at 47%, Eczema Area and Severity Index (EASI-75) at 72%, and Peak Pruritis Numeric Rating Scale (PP-NRS) at 61% with consistent safety profile out to one year
    • In July the Phase 2 trial for etrasimod in alopecia areata was amended to add a 3 mg cohort and expand patient population subtypes; topline data expected 2H 2022
    • In April during a late-breaking session at The American Academy of Dermatology Virtual Meeting, data from the Phase 2 ADVISE trial in atopic dermatitis was presented that measured the impact of etrasimod on patient and clinician reported outcomes

    Cardiovascular

    • In July a Phase 2 trial for temanogrel in Raynaud's phenomenon secondary to systemic sclerosis was initiated
    • In July a Phase 2 trial for APD418 in acute heart failure was initiated
    • In June the first participant was dosed in the Phase 2 trial for temanogrel in microvascular obstruction

    Corporate Updates

    • In July we entered into a strategic collaboration and option agreement with Aristea for the development of RIST4721, an oral, selective CXCR2 antagonist being developed for the treatment of palmoplantar pustulosis (PPP) and other neutrophil-mediated diseases
    • In July Doug Manion was appointed as Executive Vice President, Research & Development
    • In June Steve Schoch was appointed to the Board of Directors and as chair of the Audit Committee
    • In May and June Arena earned score upgrades from ISS (Prime rating) and MSCI (BB to A rating) following the 2021 Arena Environmental, Social, Governance (ESG) Report published in April

    Financial Update

    Second Quarter 2021 Financial Results

    • Research and development (R&D) expenses for the second quarter totaled $112.5 million compared to $64.9 million in the same period 2020. This increase was primarily driven by our advancing clinical studies, including the etrasimod Phase 3 program, as well as an increase in personnel expenses to support our clinical programs. The R&D non-cash, share-based compensation was $8.7 million in the second quarter as compared to $6.3 million in the same period 2020
    • Selling, general and administrative (SG&A) expenses for the second quarter totaled $31.9 million, compared to $22.9 million in the second quarter of 2020. This increase was primarily driven by an increase in personnel expenses and other professional fees. The SG&A non-cash, share-based compensation was $9.1 million in the second quarter as compared to $6.0 million in the same period 2020
    • Net loss for the second quarter was $146.1 million compared to net loss of $84.9 million for the same period in 2020
    • Basic and diluted net loss per share for the second quarter was $2.40 compared to basic and diluted net loss per share of $1.61 for the same period in 2020
    • Cash, cash equivalents and marketable securities were $1.0 billion at June 30, 2021 as compared to $1.1 billion at December 31, 2020

    Conference Call & Webcast Information

    Arena will host a conference call and live webcast to discuss the results with the investment community today, Thursday, August 5, 2021, at 4:30 PM ET, to discuss the financial results and corporate update.

    Conference call will be broadcast live in listen-only mode on the company's investor relations website at https://invest.arenapharm.com/events-presentations. Shortly after the event, a recording will be archived under the investor relations section of Arena's website for 30 days.

    About Arena Pharmaceuticals

    ARENA Pharmaceuticals is a team with a singular purpose – deliver important medicines to patients.

    In a rapidly changing global market, we work with a sense of urgency every day to understand the needs of all our stakeholders, identify bold, sometimes disruptive, ideas to get medicines to patients, and relentlessly execute until it's done.

    ARENA - Care More. Act Differently.

    Etrasimod, temanogrel, and APD418 are investigational compounds that are not approved for any use in any country.

    Forward-Looking Statements

    Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements may be identified by words such as "expected," "look forward to," "on track for," "plans," and "will," and include, without limitation, statements about the following: Arena's clinical programs, including expectations regarding study progress, the timing of data readouts for ongoing and anticipated trials, expectations regarding the commencement of additional studies, plans to provide updates on programs and trials, and other statements under "Key Program & Corporate Updates" above. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the following: topline data may not accurately reflect the complete results of a particular study or trial; results of clinical trials and other studies are subject to different interpretations and may not be predictive of future results; clinical trials and other studies may not proceed at the time or in the manner expected or at all; the timing and outcome of research, development and regulatory review is uncertain, and Arena's drug candidates may not advance in development or be approved for marketing; enrolling patients in Arena's ongoing and intended clinical trials is competitive and challenging; the duration and severity of the coronavirus disease (COVID-19) pandemic, including but not limited to the impact on Arena's clinical operations, the operations of Arena's suppliers, partners, collaborators, licensees, and capital markets, which in each case remains uncertain; risks related to developing and commercializing drugs; Arena will need additional funds to advance all of its programs; the impact of competition; risks related to unexpected or unfavorable new data; the risk that regulatory agencies may interpret or weigh the importance of data differently and reach different conclusions than Arena or others, request additional information, have additional recommendations or change their guidance or requirements before or after approval; satisfactory resolution of litigation or other disagreements with others; and risks related to the enforcement of Arena's and third parties' intellectual property rights. Additional factors that could cause actual results to differ materially from those stated or implied by Arena's forward-looking statements are disclosed in Arena's filings with the Securities and Exchange Commission (SEC), including but not limited to Arena's Quarterly Report on Form 10-Q for the quarter ended March 31, 2021, which was filed with the SEC on May 5, 2021. These forward-looking statements represent Arena's judgment as of the time of this release. Arena disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

     

    Arena Pharmaceuticals, Inc.

    Condensed Consolidated Statements of Operations

    (In thousands, except per share amounts)

    (Unaudited)

     

     

     

     

     

     

     

    Three Months Ended

    June 30,

     

    Six Months Ended

    June 30,

     

     

    2021

     

    2020

     

    2021

     

    2020

    Revenues:

     

     

     

     

    Royalty revenue

    $

    —

     

    $

    —

     

    $

    —

     

    $

    262

     

    Total revenues

    —

     

    —

     

    —

     

    262

     

    Operating Costs and Expenses:

     

     

     

     

    Research and development

    112,453

     

    64,946

     

    214,988

     

    143,479

     

    Selling, general and administrative

    31,938

     

    22,877

     

    61,396

     

    49,319

     

    Total operating costs and expenses

    144,391

     

    87,823

     

    276,384

     

    192,798

     

    Loss from operations

    (144,391

    )

    (87,823

    )

    (276,384

    )

    (192,536

    )

    Interest and Other Income (Expense):

     

     

     

     

    Interest income

    328

     

    3,065

     

    1,018

     

    8,011

     

    Interest expense

    (1,051

    )

    (1,144

    )

    (2,124

    )

    (2,307

    )

    Other (expense) income, net

    (981

    )

    974

     

    (891

    )

    1,697

     

    Gain from Longboard equity method investment

    —

     

    —

     

    13,869

     

    —

     

    Total interest and other income (expense), net

    (1,704

    )

    2,895

     

    11,872

     

    7,401

     

    Net loss

    $

    (146,095

    )

    $

    (84,928

    )

    $

    (264,512

    )

    $

    (185,135

    )

     

     

     

     

     

    Net loss per share, basic and diluted:

    $

    (2.40

    )

    $

    (1.61

    )

    $

    (4.39

    )

    $

    (3.59

    )

     

     

     

     

     

    Shares used in calculating net loss per share, basic and diluted:

    60,786

     

    52,771

     

    60,286

     

    51,500

     

     

    Arena Pharmaceuticals, Inc.

    Condensed Consolidated Balance Sheet Data

    (In thousands, except share data)

    (Unaudited)

     

     

     

     

     

     

     

    June 30,

    2021

     

    December 31,

    2020

    Assets

     

     

     

     

    Current assets:

     

     

     

     

    Cash and cash equivalents

     

    $

    514,177

     

    $

    219,544

    Short-term investments, available-for-sale

     

    457,359

     

    884,497

    Prepaid expenses and other current assets

     

    18,899

     

    35,266

    Total current assets

     

    990,435

     

    1,139,307

    Investments, available-for-sale

     

    34,419

     

    —

    Land, property and equipment, net

     

    20,388

     

    22,090

    Other non-current assets

     

    39,417

     

    29,323

    Total assets

     

    $

    1,084,659

     

    $

    1,190,720

    Liabilities and Stockholders' Equity

     

     

     

     

    Current liabilities:

     

     

     

     

    Accounts payable and other accrued liabilities

     

    $

    23,417

     

    $

    35,351

    Accrued clinical and preclinical study fees

     

    36,701

     

    18,325

    Current portion of lease financing obligations

     

    4,719

     

    4,401

    Total current liabilities

     

    64,837

     

    58,077

    Other long-term liabilities

     

    9,962

     

    10,963

    Lease financing obligations, less current portion

     

    38,780

     

    41,211

    Commitments and contingencies

     

     

     

     

    Stockholders' equity:

     

     

     

     

    Preferred stock, $0.0001 par value, 7,500,000 shares authorized, no shares issued and outstanding at June 30, 2021 and December 31, 2020

     

    —

     

    —

    Common stock, $0.0001 par value, 147,000,000 shares authorized at June 30, 2021 and December 31, 2020; 61,044,996 and 58,611,210 shares issued and outstanding at June 30, 2021 and December 31, 2020, respectively

     

    6

     

    6

    Additional paid-in capital

     

    2,743,225

     

    2,587,494

    Accumulated other comprehensive income

     

    92

     

    700

    Accumulated deficit

     

    (1,772,243)

     

    (1,507,731)

    Total stockholders' equity

     

    971,080

     

    1,080,469

    Total liabilities and stockholders' equity

     

    $

    1,084,659

     

    $

    1,190,720

     

    View source version on businesswire.com: https://www.businesswire.com/news/home/20210805006093/en/

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