DiaCarta Announces Five Abstracts Accepted for Presentation at AACR Annual Meeting 2023
- Abstracts demonstrating XNA technology's improvements to assay sensitivity across different technology platforms and support for use in companion diagnostics (CDx) assay development
- Additional abstracts to further support XNA technology's potential for use in minimal residual disease (MRD) monitoring of residual cancer cells
PLEASANTON, Calif., April 16, 2023 (GLOBE NEWSWIRE) -- DiaCarta, Ltd. ("DiaCarta"), a precision molecular diagnostics company, today announced that it will present five data posters at the American Association of Cancer Research (AACR) Annual Meeting 2023, which convenes in Orlando, Florida from April 14-19, 2023.
The presentations will focus on how XNA can be used to improve the assay sensitivity of different technology platforms such as Sanger sequencing, qPCR, and Next Generation Sequencing (NGS). DiaCarta's XNA technology has demonstrated improvements to the sensitivity of traditional Sanger sequencing to comparable sensitivity levels of NGS, with much broader clinical utility and lower cost. The XNA-based Sanger sequencing and qPCR are used for sensitive companion diagnostics (CDx) assay development for identification of KRAS G12C mutation. The critical mutation currently has two targeting drugs, LUMAKRAS™ (sotorasib) and KRAZATI™ (adagrasib), approved by the FDA for target therapy on patients with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) with KRAS G12C mutation.
"We can leverage our cost-effective XNA technology for ultra-sensitive assay development, which is critical for early cancer detection and cancer recurrence monitoring," said Dr. Aiguo (Adam) Zhang, CEO and President of DiaCarta, Inc. "Our technology has great potential to be used for minimal residual disease (MRD) monitoring of residual cancer cells after initial treatment and cancer clonal recurrence. MRD monitoring is the trend for precision diagnostics and monitoring in cancer management. The current ultra-deep sequencing technology used in MRD is both time consuming and costly and our technology has the potential to overcome these two obstacles."
Details of the AACR poster presentations are as follows:
Title: Detection of actionable lung cancer fusion genes with known and novel partners from highly degraded FFPE material
Abstract #: 2191 / 1
Session: Diagnostic and Prognostic Biomarkers 2
Date/Time: April 17, 2023, 9:00 AM – 12:30 PM (ET)
Location: Section 41
Title: Detection of tumor-associated methylation and mutation signatures for early colorectal cancer diagnosis
Abstract #: 2302 / 16
Session: Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 2
Date / Time: April 17, 2023, 9:00 AM – 12:30 PM (ET)
Location: Section 44
Title: Two detection methods of clinical KRAS G12C mutation detection for companion diagnostics
Abstract #: 3298 / 6
Session: Diagnostic and Prognostic Biomarkers 3
Date / Time: April 17, 2023, 1:30 PM – 5:00 PM (ET)
Location: Section 41
Title: ColoScape test: a molecular assay to detect early-stage colorectal cancer in plasma cell-free DNA
Abstract #: 6505 / 3
Session: Early Detection and Molecular Markers of Prevention
Date / Time: April 19, 2023, 9:00 AM – 12:30 PM (ET)
Location: Section 28
Title: XNA increases assay sensitivity in sanger sequencing, qPCR, NGS and CRISPR mutant screening
Abstract #: 6681 / 1
Session: Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 5
Date / Time: April 19, 2023, 9:00 AM – 12:30 PM (ET)
Location: Section 40
The posters will also be available on DiaCarta's website following the presentations.
About DiaCarta
DiaCarta is a molecular diagnostics company that has developed innovative technologies to transform patient care by providing effective precision diagnostics using liquid biopsy. Its novel XNA technology is designed to provide a high level of sensitivity as it binds to the wild-type sequence, to enable only the mutant target sequence to be amplified. Using this technology, DiaCarta has developed its ColoScape™ colorectal cancer mutation test. Powered by its isorbDNA™ technology that amplifies the signal and requires no RNA/DNA extraction or amplification, DiaCarta has developed its RadTox™ test to personalize radiation and chemotherapy, mitigate adverse events and enhance patient care. Based in Pleasanton, California, DiaCarta is ISO certified, GMP-compliant, and offers CLIA certified laboratory services to its customers. www.diacarta.com
On October 14, 2022, DiaCarta and HH&L Acquisition Co. (NYSE:HHLA), a special purpose acquisition corporation, entered into a definitive business combination agreement that would result in DiaCarta becoming a public company.
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This communication relates to the proposed business combination between HH&L and DiaCarta (the "Business Combination"). HH&L has filed a preliminary, and will file a definitive, proxy statement, which will include a prospectus, which will be a part of a registration statement, and other relevant documents with the SEC. This communication does not contain all the information that should be considered concerning the proposed Business Combination and is not intended to form the basis of any investment decision or any other decision in respect of the Business Combination. HH&L's and DiaCarta's shareholders and other interested persons are urged to read the proxy statement/prospectus and any other relevant documents filed with the SEC when they become available, and any amendments thereto, because, among other things, they will contain updates to the financial, industry and other information herein as well as important information about HH&L, DiaCarta and the contemplated Business Combination. When available, the definitive proxy statement/prospectus and other relevant materials for the proposed Business Combination will be mailed to shareholders of HH&L as of a record date to be established for voting on the proposed Business Combination. Shareholders will be able to obtain a free copy of the proxy statement/prospectus (when filed), as well as other filings containing information about HH&L, DiaCarta and the proposed Business Combination, without charge, at the SEC's website located at www.sec.gov or by directing a request to: HH&L Acquisition Co., Suite 2001-2002, 20/F, York House, The Landmark, 15 Queen's Road Central, Central, Hong Kong. Investment in any securities described herein has not been approved or disapproved by the SEC or any other regulatory authority nor has any authority passed upon or endorsed the merits of the Business Combination or the accuracy or adequacy of the information contained herein. Any representation to the contrary is a criminal offense.
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DiaCarta and its directors and executive officers may also be deemed to be participants in the solicitation of proxies from the shareholders of HH&L in connection with the proposed Business Combination. A list of the names of such directors and executive officers and information regarding their interests in the proposed Business Combination will be included in the proxy statement/prospectus for the proposed Business Combination when available.
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