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    Director Bvf Partners L P/Il bought $13,955,348 worth of shares (317,167 units at $44.00) (SEC Form 4)

    7/1/25 6:41:37 PM ET
    $KYMR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $KYMR alert in real time by email
    SEC FORM 4 SEC Form 4
    FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0287
    Estimated average burden
    hours per response: 0.5
      
    Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
      
    Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
    1. Name and Address of Reporting Person*
    BVF PARTNERS L P/IL

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)
    2. Issuer Name and Ticker or Trading Symbol
    Kymera Therapeutics, Inc. [ KYMR ]
    5. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    3. Date of Earliest Transaction (Month/Day/Year)
    06/25/2025
    4. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    Form filed by One Reporting Person
    X Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
    1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V Amount (A) or (D) Price
    Common Stock, $0.0001 par value(1) 06/30/2025 P 142,604(6) A $44 2,798,795 D(2)
    Common Stock, $0.0001 par value(1) 06/30/2025 P 115,783(6) A $44 2,219,858 D(3)
    Common Stock, $0.0001 par value(1) 06/30/2025 P 58,780(6) A $44 353,412 D(4)
    Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
    Stock Option (Right to Buy)(5) $46.47 06/25/2025 A 16,000 (7) 06/24/2035 Common Stock, $0.0001 par value 16,000 $0 16,000 I(5) See footnote(5)
    Pre-Funded Warrants to Purchase Common Stock(1) $0.0001 (8) (8) Common Stock, $0.0001 par value 201,546 201,546 D(2)
    Pre-Funded Warrants to Purchase Common Stock(1) $0.0001 (8) (8) Common Stock, $0.0001 par value 156,742 156,742 D(3)
    Pre-Funded Warrants to Purchase Common Stock(1) $0.0001 (8) (8) Common Stock, $0.0001 par value 550,425 550,425 D(2)
    Pre-Funded Warrants to Purchase Common Stock(1) $0.0001 (8) (8) Common Stock, $0.0001 par value 375,856 375,856 D(3)
    Pre-Funded Warrants to Purchase Common Stock(1) $0.0001 (8) (8) Common Stock, $0.0001 par value 52,733 52,733 D(4)
    Stock Option (Right to Buy)(5) $31.2 (9) 06/17/2034 Common Stock, $0.0001 par value 16,000 16,000 I(5) See footnote(5)
    Stock Option (Right to Buy)(5) $20 (9) 08/19/2030 Common Stock, $0.0001 par value 40,127 40,127 I(5) See footnote(5)
    Stock Option (Right to Buy)(5) $49.1 (9) 06/15/2031 Common Stock, $0.0001 par value 20,063 20,063 I(5) See footnote(5)
    Stock Option (Right to Buy)(5) $14.18 (9) 06/14/2032 Common Stock, $0.0001 par value 12,000 12,000 I(5) See footnote(5)
    Stock Option (Right to Buy)(5) $27.67 (9) 06/14/2033 Common Stock, $0.0001 par value 12,000 12,000 I(5) See footnote(5)
    1. Name and Address of Reporting Person*
    BVF PARTNERS L P/IL

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BIOTECHNOLOGY VALUE FUND L P

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BVF I GP LLC

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BIOTECHNOLOGY VALUE FUND II LP

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BVF II GP LLC

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    Biotechnology Value Trading Fund OS LP

    (Last) (First) (Middle)
    P.O. BOX 309 UGLAND HOUSE

    (Street)
    GRAND CAYMAN E9 KY1-1104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BVF Partners OS Ltd.

    (Last) (First) (Middle)
    P.O. BOX 309 UGLAND HOUSE

    (Street)
    GRAND CAYMAN E9 KY1-1104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BVF GP HOLDINGS LLC

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    BVF INC/IL

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    1. Name and Address of Reporting Person*
    LAMPERT MARK N

    (Last) (First) (Middle)
    44 MONTGOMERY STREET
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Remarks and Footnotes
    Explanation of Responses:
    1. This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF I GP LLC ("BVF GP"), BVF II GP LLC ("BVF2 GP"), BVF GP Holdings LLC ("BVF GPH"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.
    2. Securities owned directly by BVF. As the general partner of BVF, BVF GP may be deemed to beneficially own the securities owned directly by BVF. As the sole member of BVF GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF. As the investment manager of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.
    3. Securities owned directly by BVF2. As the general partner of BVF2, BVF2 GP may be deemed to beneficially own the securities owned directly by BVF2. As the sole member of BVF2 GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF2. As the investment manager of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.
    4. Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.
    5. Partners, BVF Inc. and Mr. Lampert may be deemed to have a pecuniary interest in the securities reported owned herein due to a certain agreement between Partners and Gorjan Hrustanovic, who serves on the Issuer's board of directors and as a member of Partners, pursuant to which Mr. Hrustanovic is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners. As such, Mr. Hrustanovic disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein.
    6. Shares of the Issuer's common stock acquired in the Issuer's underwritten public offering at the public offering price of $44.00 per share.
    7. The shares underlying this stock option shall vest in full upon the earlier to occur of (i) June 25, 2026 and (ii) the date of the next annual meeting of the Issuer's stockholders.
    8. The Pre-Funded Warrants are exercisable at any time after the date of issuance, subject to certain conditions and limitations, and do not expire.
    9. The shares subject to the option have fully vested.
    Remarks:
    For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each of the Reporting Persons may be deemed to be a director by deputization of the Issuer due to a member of Partners, Gorjan Hrustanovic, serving on the Board of Directors of the Issuer, and his agreement to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners.
    BVF Partners L.P., By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 07/01/2025
    Biotechnology Value Fund, L.P., By: BVF I GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 07/01/2025
    BVF I GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 07/01/2025
    Biotechnology Value Fund II, L.P., By: BVF II GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 07/01/2025
    BVF II GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 07/01/2025
    BVF Partners OS Ltd., By: BVF Partners L.P., its sole member, By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 07/01/2025
    Biotechnology Value Trading Fund OS LP, By: BVF Partners L.P., its investment manager, BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 07/01/2025
    BVF GP Holdings LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 07/01/2025
    BVF Inc., By: /s/ Mark N. Lampert, President 07/01/2025
    /s/ Mark N. Lampert 07/01/2025
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
    Get the next $KYMR alert in real time by email

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      KT-621, a potent, selective, oral STAT6 degrader, demonstrated comparable or superior activity to dupilumab in a newly disclosed preclinical chronic asthma model reversing disease progression KT-621 Phase 1 healthy volunteer SAD/MAD trial completed with data to be reported in June 2025 KT-621 BroADen Phase 1b trial in moderate to severe atopic dermatitis (AD) ongoing with data expected in 4Q25 Two parallel Phase 2b trials in AD and asthma planned to start in 4Q25 and 1Q26, respectively WATERTOWN, Mass., May 19, 2025 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ:KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines for

      5/19/25 12:15:00 PM ET
      $KYMR
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Kymera Therapeutics Announces First Quarter 2025 Financial Results and Provides a Business Update

      Completed KT-621 (STAT6) SAD/MAD Phase 1 healthy volunteer trial with data to be reported in June 2025 First patient dosed in KT-621 (STAT6) BroADen Phase 1b trial in moderate to severe atopic dermatitis (AD) with data expected in 4Q25 KT-579 (IRF5) new oral immunology degrader program, with broad clinical potential in rheumatic and other autoimmune diseases, expected to enter Phase 1 clinical trial in early 2026 KT-474/SAR444656 (IRAK4) Phase 2b trials in HS and AD ongoing, led by partner Sanofi; Kymera achieved a $20 million milestone payment as part of the IRAK4 collaboration in April 2025 Strategic decision made not to advance KT-295 (TYK2) into further clini

      5/9/25 7:00:00 AM ET
      $KYMR
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

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    • Amendment: SEC Form SC 13G/A filed by Kymera Therapeutics Inc.

      SC 13G/A - Kymera Therapeutics, Inc. (0001815442) (Subject)

      11/14/24 4:31:20 PM ET
      $KYMR
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Kymera Therapeutics Inc.

      SC 13G/A - Kymera Therapeutics, Inc. (0001815442) (Subject)

      11/14/24 1:22:39 PM ET
      $KYMR
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Kymera Therapeutics Inc.

      SC 13G/A - Kymera Therapeutics, Inc. (0001815442) (Subject)

      11/14/24 9:30:22 AM ET
      $KYMR
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care