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    FibroGen Reports Fourth Quarter and Full Year 2024 Financial Results

    3/17/25 4:05:00 PM ET
    $FGEN
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $FGEN alert in real time by email
    • Announced sale of FibroGen China to AstraZeneca for a total consideration of approximately $160 million
      • Transaction expected to close by mid-2025
    • Upon close of sale of FibroGen China, cash runway extended into 2027

    • Initiation of the Phase 2 monotherapy trial of FG-3246, a potential first-in-class antibody-drug conjugate (ADC) targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC), expected by mid-2025

    • Topline results from Phase 2 portion of the investigator-sponsored study of FG-3246 in combination with enzalutamide in patients with mCRPC expected in 2H 2025

    • FibroGen to host conference call and webcast presentation today at 5:00 PM ET

    SAN FRANCISCO, March 17, 2025 (GLOBE NEWSWIRE) -- FibroGen, Inc. (NASDAQ:FGEN) today reported financial results for the fourth quarter and full year 2024 and provided an update on the company's recent developments.

    "We entered 2025 optimistic about our future, highlighted by the planned initiation of the Phase 2 monotherapy trial of FG-3246, our first-in-class ADC targeting CD46 for the treatment of mCRPC, by mid-2025," said Thane Wettig, Chief Executive Officer. "Through the successful implementation of our cost reduction plan, and upon the closing of our recently announced sale of FibroGen China, we will be a leaner and more focused organization, with a stronger financial position and a cash runway that takes us into 2027, with multiple potential value-creating milestones in sight."

    Recent Developments and Key Highlights of 2024:

    • Announced the sale of FibroGen China to AstraZeneca for a total consideration of approximately $160 million, representing an enterprise value of $85 million plus estimated net cash held in China at closing of approximately $75 million. The transaction is expected to close by mid-2025.
      • Upon closing, FibroGen will repay its term loan to Morgan Stanley Tactical Value, further simplifying the Company's capital structure.
      • FibroGen maintains its rights to roxadustat in the U.S. and in all markets outside of China, South Korea, and those licensed to Astellas.
    • Appointed David DeLucia, CFA, as Senior Vice President and Chief Financial Officer.
    • Completed previously announced cost reduction program.

    Upcoming Milestones:

    FG-3246 (CD46 Targeting ADC) and FG-3180 (CD46 Targeting PET Imaging Agent)

    • Anticipate initiation of Phase 2 monotherapy dose optimization study of FG-3246 in mCRPC by mid-2025.
      • Phase 2 trial will include a sub-study of FG-3180 to enable assessment of its diagnostic performance and the potential correlation between CD46 expression and response to FG-3246.
    • Topline results from the Phase 2 portion of the investigator-sponsored Phase 1b/2 study conducted by UCSF of FG-3246 in combination with enzalutamide in patients with mCRPC expected in 2H 2025.
      • Phase 2 portion of the study will include data on FG-3180.

    Roxadustat

    • Plan to meet with FDA in 2Q 2025 to determine the potential next steps for the development of roxadustat in anemia associated with lower-risk myelodysplastic syndrome (LR-MDS), an indication with significant unmet medical need, in the U.S.

    Financial:

    • Total revenue from continuing operations for the fourth quarter of 2024 was $3.1 million, as compared to $3.6 million for the fourth quarter of 2023.
    • Total revenue from continuing operations for the full year 2024 was $29.6 million, as compared to $46.8 million for the full year 2023.
    • Net loss from continuing operations for the fourth quarter of 2024 was $8.7 million, or $0.08 net loss per basic and diluted share, compared to a net loss of $62.5 million, or $0.63 net loss per basic and diluted share, one year ago.
    • Net loss from continuing operations for the full year 2024 was $153.1 million, or $1.53 net loss per basic and diluted share, compared to a net loss of $323.0 million, or $3.32 net loss per basic and diluted share, for the full year 2023.
    • At December 31, 2024, FibroGen reported $51.0 million in cash, cash equivalents and accounts receivable in the U.S. and $121.1 million in total consolidated cash, cash equivalents and accounts receivable.
    • Upon closing of the announced sale of FibroGen China, the Company expects its cash, cash equivalents and accounts receivable to be sufficient to fund operations into 2027.

    Conference Call and Webcast Presentation

    The FibroGen management team will host a conference call and webcast presentation to discuss the financial results and provide a business update. A live Q&A session will follow the brief presentation. Interested parties may access a live audio webcast of the conference call here. To access the call by phone, please register here, and you will be provided with dial in details. A replay of the webcast will also be available for a limited time on the Events & Presentations page on FibroGen's website.

    About FG-3246

    FG-3246 (FOR46) is a potential first-in-class fully human antibody-drug conjugate (ADC), exclusively in-licensed from Fortis Therapeutics, and is being developed by FibroGen for metastatic castration-resistant prostate cancer and potentially other tumor types. FG-3246 binds to an epitope of CD46, a cell receptor target, that induces internalization upon antibody binding, is present at high levels in prostate cancer and other tumor types and demonstrates very limited expression in most normal tissues. FG-3246 is comprised of an anti-CD46 antibody, YS5, linked to the anti-mitotic agent, MMAE, which is a clinically and commercially validated ADC payload. FG-3246 has demonstrated anti-tumor activity in both preclinical and clinical studies.

    FG-3246 is currently in an ongoing Phase 1b/2 study being conducted at UCSF as an investigator-sponsored trial to evaluate FG-3246 in combination with enzalutamide. An additional investigator-sponsored radiopharmaceutical marker trial using a zirconium-89 positron emission tomography (PET) tracer for CD46 that utilizes the YS5 antibody is also underway at UCSF. The initiation of the Phase 2 monotherapy dose optimization trial for FG-3246 in metastatic castration-resistant prostate cancer is anticipated by mid-2025. FG-3246 is an investigational drug and not approved for marketing by any regulatory authority.

    About Roxadustat

    Roxadustat, an oral medication, is the first in a new class of medicines comprising HIF-PH inhibitors that promote erythropoiesis, or red blood cell production, through increased endogenous production of erythropoietin, improved iron absorption and mobilization, and downregulation of hepcidin. Roxadustat is in clinical development for chemotherapy-induced anemia (CIA) and a Supplemental New Drug Application (sNDA) has been accepted by the China Health Authority. 

    Roxadustat is approved in China, Europe, Japan, and numerous other countries for the treatment of anemia of CKD in adult patients on dialysis (DD) and not on dialysis (NDD). FibroGen has the sole rights to roxadustat in the United States, Canada, Mexico, and in all markets not held by AstraZeneca or licensed to Astellas. Astellas and FibroGen are collaborating on the commercialization of roxadustat for the treatment of anemia in territories including Japan, Europe, Turkey, Russia, and the Commonwealth of Independent States, the Middle East, and South Africa.

    About FibroGen

    FibroGen, Inc. is a biopharmaceutical company focused on development of novel therapies at the frontiers of cancer biology and anemia. Roxadustat (爱瑞卓®, EVRENZO™) is currently approved in China, Europe, Japan, and numerous other countries for the treatment of anemia in chronic kidney disease (CKD) patients on dialysis and not on dialysis. The Company continues to evaluate a development plan for roxadustat in anemia associated with lower-risk myelodysplastic syndrome (LR-MDS) in the U.S. FG-3246 (also known as FOR46), a first-in-class antibody-drug conjugate (ADC) targeting CD46 is in development for the treatment of metastatic castration-resistant prostate cancer. This program also includes the development of FG-3180, an associated CD46-targeted PET biomarker. For more information, please visit www.fibrogen.com. 

    Forward-Looking Statements

    This release contains forward-looking statements regarding FibroGen's strategy, future plans and prospects, including statements regarding its commercial products and clinical programs and those of its collaboration partners Fortis and UCSF. These forward-looking statements include, but are not limited to, statements regarding the efficacy, safety, and potential clinical or commercial success of FibroGen products and product candidates, statements under the caption "Upcoming Milestones", the net cash portion of the purchase price and closing of the sale of FibroGen China as well as the payoff of the Morgan Stanley Tactical Value term loan, statements regarding cash, such as the expectation that cash, cash equivalents and accounts receivable will be sufficient to fund FibroGen's operating plans into 2027, and statements about FibroGen's plans and objectives. These forward-looking statements are typically identified by use of terms such as "may," "will", "should," "on track," "could," "expect," "plan," "anticipate," "believe," "estimate," "predict," "potential," "continue" and similar words, although some forward-looking statements are expressed differently. FibroGen's actual results may differ materially from those indicated in these forward-looking statements due to risks and uncertainties related to the continued progress and timing of its various programs, including the enrollment and results from ongoing and potential future clinical trials, and other matters that are described in FibroGen's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q, each as filed with the Securities and Exchange Commission (SEC), including the risk factors set forth therein. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release, and FibroGen undertakes no obligation to update any forward-looking statement in this press release, except as required by law.



    Condensed Consolidated Balance Sheets


    (In thousands)

      December 31, 2024  December 31, 2023 
      (Unaudited) 
    Assets      
    Current assets:      
    Cash and cash equivalents $50,482  $81,553 
    Short-term investments  —   121,898 
    Accounts receivable, net  481   5,121 
    Inventory  3,155   17,173 
    Prepaid expenses and other current assets  31,542   40,038 
    Current assets held for sale  110,849   65,776 
    Total current assets  196,509   331,559 
    Restricted time deposits  —   1,658 
    Property and equipment, net  —   4,785 
    Operating lease right-of-use assets  —   64,939 
    Other assets  1,405   2,538 
    Long-term assets held for sale  16,611   18,050 
    Total assets $214,525  $423,529 
           
    Liabilities, stockholders' equity and non-controlling interests      
    Current liabilities:      
    Accounts payable $5,064  $15,778 
    Accrued and other liabilities  62,035   132,987 
    Deferred revenue  27,290   12,740 
    Operating lease liabilities, current  —   12,647 
    Current liabilities held for sale  38,917   43,516 
    Total current liabilities  133,306   217,668 
    Product development obligations  17,012   17,763 
    Deferred revenue, net of current  114,708   157,555 
    Operating lease liabilities, non-current  —   65,033 
    Senior secured term loan facilities, non-current  73,092   71,934 
    Liability related to sale of future revenues, non-current  58,864   51,413 
    Other long-term liabilities  822   2,858 
    Long-term liabilities held for sale  356   1,504 
    Total liabilities  398,160   585,728 
           
    Redeemable non-controlling interests  21,480   21,480 
    Total stockholders' deficit attributable to FibroGen  (225,602)  (204,166)
    Nonredeemable non-controlling interests  20,487   20,487 
    Total deficit  (205,115)  (183,679)
    Total liabilities, redeemable non-controlling interests and deficit $214,525  $423,529 



    Condensed Consolidated Statements of Operations


    (In thousands, except per share data)

      Three Months Ended December 31,  Years Ended December 31, 
      2024  2023  2024  2023 
      (Unaudited) 
    Revenue:            
    License revenue $—  $—  $—  $9,649 
    Development and other revenue  416   2,575   1,948   18,401 
    Drug product revenue, net  2,720   1,052   27,673   18,753 
    Total revenue  3,136   3,627   29,621   46,803 
                 
    Operating costs and expenses:            
    Cost of goods sold  (5,845)  1,201   15,561   3,962 
    Research and development  6,870   48,710   95,692   266,473 
    Selling, general and administrative  8,345   16,378   49,330   86,483 
    Restructuring charge  900   —   19,454   12,606 
    Total operating costs and expenses  10,270   66,289   180,037   369,524 
    Loss from operations  (7,134)  (62,662)  (150,416)  (322,721)
                 
    Interest and other, net:            
    Interest expense  (2,217)  (2,175)  (8,247)  (8,095)
    Interest income and other income (expenses), net  688   2,314   5,296   7,594 
    Total interest and other, net  (1,529)  139   (2,951)  (501)
                 
    Loss from continuing operations before income taxes  (8,663)  (62,523)  (153,367)  (323,222)
    Benefit from income taxes  2   10   (269)  (252)
    Loss from continuing operations  (8,665)  (62,533)  (153,098)  (322,970)
    Income from discontinued operations, net of tax  26,647   6,301   105,519   38,738 
    Net income (loss) $17,982  $(56,232) $(47,579) $(284,232)
                 
    Loss from continuing operations per share – basic and diluted $(0.08) $(0.63) $(1.53) $(3.32)
    Income from discontinued operations per share – basic and diluted  0.26   0.06   1.05   0.40 
    Net income (loss) per share – basic and diluted $0.18  $(0.57) $(0.48) $(2.92)
                 
    Weighted average number of common shares used to calculate net income (loss) per share – basic and diluted  100,830   98,496   100,044   97,303 



    For Investor Inquiries:


    David DeLucia, CFA

    Senior Vice President and Chief Financial Officer

    [email protected]



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