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    Immuneering Reports Third Quarter 2022 Financial Results and Recent Business Highlights

    11/10/22 9:00:00 AM ET
    $IMRX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $IMRX alert in real time by email

    Recruiting has Commenced for Phase 1/2a Clinical Trial of IMM-1-104 in Advanced Solid Tumors with RAS Mutations (NCT05585320), with the First Patient Expected to be Dosed this Quarter 

    Shares Promising Preclinical Data on Second Program IMM-6-415 at the 37th Annual Meeting of SITC, Demonstrating Preclinical Single Agent Activity in RAF and RAS Mutant Tumors and Enhancement of PD1 and CTLA4 Checkpoint Blockade

    Cash, Cash Equivalents and Marketable Securities of $117.2M is Expected to Provide Cash Runway into Q3 2024 

    CAMBRIDGE, Mass., Nov. 10, 2022 (GLOBE NEWSWIRE) --  Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company that aims to create medicines for all patients with solid tumors driven by RAS mutations and other MAPK pathway activation events, today reported financial results for the third quarter ended September 30, 2022, and provided recent business highlights. 

    "The third quarter was a turning point for Immuneering as we submitted and cleared our first IND. Our Phase 1/2a trial for IMM-1-104 is now recruiting in what we believe is the first all-comers RAS clinical trial conducted to date," said Ben Zeskind, Chief Executive Officer of Immuneering Corporation. "Cancer patients need new treatment options, regardless of the specific mutations in KRAS, NRAS, or HRAS that might be driving their tumors. IMM-1-104 has shown pan-RAS activity in preclinical studies with good tolerability. The conventional wisdom has been that a pan-RAS approach makes it difficult to avoid hitting wild-type RAS in healthy cells, but IMM-1-104's novel deep cyclic inhibition mechanism aims to focus the therapeutic activity against RAS-driven malignant cells with the goal of largely sparing healthy cells."

    Dr. Zeskind continued, "Today, we also shared promising preclinical data on our second program IMM-6-415 at the 37th Annual Meeting of SITC. IMM-6-415 is designed to target RAF and RAS mutant tumors as monotherapy and enhance therapeutic activity in select drug-drug combinations, including checkpoint inhibitors. We are very encouraged by this data and look forward to completing ongoing IND-enabling studies and expect to submit an IND for IMM-6-415 in Q4 2023."

    Corporate Highlights  

    • IND Cleared for Phase 1/2a Trial of IMM-1-104 in September 2022; Clinical Trial (NCT05585320) is Recruiting, and First Patient is Expected to be Dosed this Quarter. On September 30, 2022, the company announced its IND application for IMM-1-104 had been cleared. The Phase 1/2a clinical trial is now recruiting and the company intends to dose its first patient this quarter. The Phase 1/2a clinical trial will interrogate IMM-1-104's safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-cancer activity for the treatment of advanced RAS mutant solid tumors. Five internationally recognized clinical sites in the United States will evaluate IMM-1-104 following a Bayesian mTPI-2 escalation design in order to determine a Recommended Phase 2 Dose. Following the Phase 1 portion, the company anticipates a dose expansion Phase 2a in RAS mutated pancreatic, melanoma, colorectal and lung cancers.



    • IMM-6-415 Presentation at SITC. Today, Immuneering presented data on its second program, IMM-6-415, during a poster session at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). IMM-6-415 demonstrates promising preclinical activity as a single agent in RAF and RAS mutant tumors and enhances PD1 and CTLA4 checkpoint blockade. IMM-6-415 is designed to provide deep cyclic inhibition of the MAPK pathway with an accelerated cadence relative to the once-daily dosing of IMM-1-104.



    • Chief People Officer Appointed. In October 2022, the company announced the appointment of Leah R. Neufeld to the newly created Chief People Officer position. Ms. Neufeld brings decades of experience in life sciences as well as human resources and will join the senior leadership team in continuing to make the company a great place for the all-star team of Immuneers to work and grow, while also helping to add new talent as the company advances a robust pipeline of novel product candidates.

    Key Development Highlights 

    • IMM-1-104 IND submission cleared in Q3 2022: The IND for IMM-1-104 cleared in under 30 days.



    • First patient in Phase 1/2a trial expected to be dosed this quarter: Immuneering expects to dose the first patient in its Phase 1/2a clinical trial evaluating IMM-1-104 in advanced solid tumors with RAS mutations this quarter.



    • Second IND submission for IMM-6-415 expected in Q4 2023: IMM-6-415 is currently in IND-enabling studies. Immuneering expects to file an IND application for IMM-6-415 in Q4 2023.

    Third Quarter 2022 Financial Highlights  

    • Cash Position: Cash and cash equivalents and marketable securities as of September 30, 2022, were $117.2 million, compared with $150.2 million as of December 31, 2021.   



    • Research and Development (R&D) Expenses: R&D expenses for the third quarter ended September 30, 2022, were $9.4 million, compared with $6.2 million for the same period in 2021. The increase in R&D expenses was primarily attributable to higher preclinical costs related to the company's lead programs and increased personnel to support ongoing research and development activities. 



    • General and Administrative (G&A) Expenses: G&A expenses for the third quarter ended September 30, 2022, were $3.8 million, compared with $2.6 million for the same period of 2021. The increase in G&A expenses was primarily attributable to an increase in headcount in the company's general and administrative functions to support its business and to costs related to operating as a public company.  



    • Net Loss: Net loss attributable to common stockholders was $12.8 million, or $0.49 per share, for the third quarter ended September 30, 2022, compared to $8.5 million, or $0.47 per share, for the third quarter ended September 30, 2021.

    2022 Financial Guidance  

    • Immuneering expects full year GAAP operating expenses to be between $53.0 million and $56.0 million including estimated non-cash stock-based compensation. This compares to previous guidance of between $55.0 million and $60.0 million. The difference is primarily due to the timing of certain R&D expenses. Based on cash, cash equivalents and marketable securities as of September 30, 2022, and current operating plans, the company continues to expect its cash runway to extend into the third quarter of 2024.

    About Immuneering Corporation 

    Immuneering aims to create medicines for all patients with solid tumors driven by RAS mutations and other MAPK pathway activation events. Immuneering has more than a decade of experience applying translational bioinformatics to generate insights into drug mechanism of action and patient treatment response. Building on this experience, Immuneering's disease-agnostic discovery platform enables the company to create product candidates based on 1) biological insights that are both counterintuitive and deeply rooted in data, and 2) novel chemistry. Immuneering's lead product candidate, IMM-1-104, aims to achieve pan-RAS activity that selectively impacts cancer cells to a greater extent than healthy cells. IMM-1-104 is designed to be a highly selective third generation dual MEK inhibitor that modulates the signaling dynamics of the MAPK pathway by driving deep cyclic inhibition that deprives tumor cells of the sustained proliferative signaling required for rapid growth, while providing a cadenced, normalized level of signaling designed to spare healthy cells. IMM-1-104 is being developed to treat advanced solid tumors in patients harboring RAS mutations, and is translationally guided by Immuneering's proprietary, human-aligned 3D tumor modeling platform combined with patient-aligned bioinformatics. In addition to IMM-1-104, Immuneering is currently evaluating IMM-6-415 in IND-enabling studies. The earlier Immuneering drug discovery pipeline includes five additional oncology programs as well as two neuroscience programs.

    Forward-Looking Statements 

    This press release includes certain disclosures that contain "forward-looking statements," including, without limitation, statements regarding Immuneering's expectations regarding the treatment potential of IMM-1-104 and IMM-6-415, the timing of enrollment and dosing of the first patient in the Phase 1/2a clinical trial for IMM-1-104, the design, enrollment criteria and conduct of the Phase 1/2a clinical trial, the timing of submission of the IND and commencement of clinical trials for IMM-6-415, that the Phase 1/2a trial of IMM-1-104 is believed to be the first all-comers RAS trial conducted to date, statements regarding Immuneering's financial guidance and Immuneering's ability to advance its pipeline and further diversify its portfolio and make progress towards its longstanding goal of creating better medicines for cancer patients. Forward-looking statements are based on Immuneering's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the risks inherent in oncology and neuroscience drug research and development, including target discovery, target validation, lead compound identification, lead compound optimization, preclinical studies and clinical trials. These and other risks and uncertainties are described more fully in the section titled "Risk Factors" in Immuneering's most recent Form 10-Q filed with the U.S. Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and Immuneering undertakes no duty to update such information except as required under applicable law.

    Corporate Contact:  

    Rebecca Kusko, Ph.D.  

    Immuneering Corporation  

    [email protected]  

    617-500-8080  

      

    Investor Contact:  

    Susan A. Noonan 

    S.A. Noonan Communications 

    [email protected] 

    917-513-5303 

    IMMUNEERING CORPORATION

    CONSOLIDATED STATEMENTS OF OPERATIONS

    (Unaudited)

                 
      Three Months Ended September 30,  Nine Months Ended September 30, 
         2022     2021     2022     2021 
                 
    Revenue $38,380  $482,130  $316,497  $1,890,370 
    Cost of revenue  19,343   219,088   158,122   946,852 
                 
    Gross profit  19,037   263,042   158,375   943,518 
                 
    Operating expenses                
    Research and development  9,363,838   6,207,486   26,395,355   18,590,471 
    General and administrative  3,836,032   2,598,940   11,500,144   5,123,361 
    Amortization of intangible asset  7,317   —   22,737   — 
    Total operating expenses  13,207,187   8,806,426   37,918,236   23,713,832 
    Loss from operations  (13,188,150)  (8,543,384)  (37,759,861)  (22,770,314)
                 
    Other income (expense)                
    Interest income  222,985   17,400   498,288   27,014 
    Other income (expense)  120,835   (8,089)  (6,434)  (8,089)
    Net loss $ (12,844,330) $ (8,534,073) $ (37,268,007) $ (22,751,389)
                 
    Net loss per share attributable to common stockholders, basic and diluted $(0.49) $(0.47) $(1.41) $(2.41)
    Weighted-average common shares outstanding, basic and diluted  26,394,490   18,286,352   26,380,101   9,445,862 
                 
    Other comprehensive loss:            
    Unrealized gains/(losses) from marketable securities  39,088   (4,751)  (93,464)  (4,751)
    Comprehensive Loss $(12,805,242) $(8,538,824) $(37,361,471) $(22,756,140)

    IMMUNEERING CORPORATION

    CONSOLIDATED BALANCE SHEETS

    (Unaudited)

           
         September 30, 2022    December 31, 2021
           
    Assets        
    Current assets:        
    Cash and cash equivalents $76,417,850  $74,888,145 
    Marketable securities, current  40,779,440   74,311,203 
    Accounts receivable  70,180   246,040 
    Prepaids and other current assets  2,757,220   2,888,608 
    Total current assets  120,024,690   152,333,996 
           
    Marketable securities, non-current  —   996,560 
    Property and equipment, net  1,310,067   807,223 
    Goodwill  6,690,431   6,701,726 
    Intangible asset  416,263   439,000 
    Right-of-use assets, net  4,512,883   5,324,198 
    Other assets  737,293   102,129 
    Total assets $133,691,627  $166,704,832 
           
    Liabilities and Stockholders' Equity        
    Current liabilities:        
    Accounts payable $2,338,380  $1,394,340 
    Accrued expenses  4,564,136   3,965,447 
    Other liabilities, current  44,562   — 
    Lease liabilities, current  308,694   274,039 
    Total current liabilities  7,255,772   5,633,826 
           
    Long-term liabilities:        
    Lease liabilities, non-current  4,542,653   5,090,897 
    Total liabilities  11,798,425   10,724,723 
    Commitments and contingencies (Note 12)        
    Stockholders' equity:        
    Preferred stock, $0.001 par value; 10,000,000 shares authorized at September 30, 2022 and December 31, 2021; 0 shares issued or outstanding at September 30, 2022 and December 31, 2021  —   — 
    Class A common stock, $0.001 par value, 200,000,000 shares authorized at September 30, 2022 and December 31, 2021; 26,404,732 and 26,320,199 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively  26,405   26,320 
    Class B common stock, $0.001 par value, 20,000,000 shares authorized at September 30, 2022 and December 31, 2021; 0 shares issued and outstanding at September 30, 2022 and December 31, 2021  —   — 
    Additional paid-in capital  218,550,665   215,276,186 
    Accumulated other comprehensive loss  (142,473)  (49,009)
    Accumulated deficit  (96,541,395)  (59,273,388)
    Total stockholders' equity  121,893,202   155,980,109 
    Total liabilities and stockholders' equity $133,691,627  $166,704,832 

     



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