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    New insider Kordasiewicz Holly B. claimed ownership of 7,740 shares (SEC Form 3)

    1/6/26 5:34:53 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $IONS alert in real time by email
    SEC FORM 3 SEC Form 3
    FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0104
    Estimated average burden
    hours per response: 0.5
    1. Name and Address of Reporting Person*
    Kordasiewicz Holly B.

    (Last) (First) (Middle)
    2855 GAZELLE COURT

    (Street)
    CARLSBAD CA 92010

    (City) (State) (Zip)
    2. Date of Event Requiring Statement (Month/Day/Year)
    12/21/2025
    3. Issuer Name and Ticker or Trading Symbol
    IONIS PHARMACEUTICALS INC [ IONS ]
    4. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    Director 10% Owner
    X Officer (give title below) Other (specify below)
    EVP, Chief Development Officer
    5. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    X Form filed by One Reporting Person
    Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Beneficially Owned
    1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
    Common Stock 7,740 D
    Table II - Derivative Securities Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
    Date Exercisable Expiration Date Title Amount or Number of Shares
    Non-Qualified Stock Option (right to buy) 01/03/2023 01/02/2032 Common Stock 12,000 $32.6 D
    Non-Qualified Stock Option (right to buy) 01/02/2026 01/01/2035 Common Stock 10,000 $34.69 D
    Non-Qualified Stock Option (right to buy) 01/03/2024 01/02/2033 Common Stock 11,500 $37.58 D
    Non-Qualified Stock Option (right to buy) 01/02/2025 01/01/2034 Common Stock 19,800 $52.87 D
    Non-Qualified Stock Option (right to buy) 01/04/2022 01/03/2028 Common Stock 19,895 $56.78 D
    Non-Qualified Stock Option (right to buy) 01/02/2021 01/01/2027 Common Stock 28,951 $60.89 D
    Restricted Stock Unit(1) 01/15/2026(2) (2) Common Stock 31,949 $0.0 D
    Explanation of Responses:
    1. Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
    2. Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2022, January 15, 2023, January 15, 2024, and January 15, 2025. The restricted stock units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.
    By: Patrick R. O'Neil, attorney-in-fact For: Holly Kordasiewicz 01/05/2026
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
    Get the next $IONS alert in real time by email

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