PureTech Founded Entity Vedanta Biosciences Expands Leadership Team and Appoints Head of Commercial

Appointments support ongoing Phase 2 COLLECTiVE202 trial of VE202, pivotal Phase 3 RESTORATiVE303 trial of VE303 and planning for commercial stage activity

PureTech Health plc (NASDAQ:PRTC, LSE: PRTC))) ("PureTech" or the "Company"), a clinical-stage biotherapeutics company dedicated to changing the lives of patients with devastating diseases, noted that its Founded Entity, Vedanta Biosciences, a clinical-stage biopharmaceutical company developing medicines for the treatment of gastrointestinal diseases, today announced three appointments to its leadership team. Christof Marré, a seasoned biopharma marketing leader, joins the company as Senior Vice President and Head of Commercial. In addition, Steven Shiff, M.D., a pharmaceutical executive and physician specializing in gastroenterology, has been appointed as SVP, Clinical Research; and Jack Kyte has been promoted to SVP, Human Resources.

The full text of the announcement from Vedanta is as follows:

Vedanta Biosciences Expands Leadership Team and Appoints Head of Commercial

Appointments support ongoing Phase 2 COLLECTiVE202 trial of VE202, pivotal Phase 3 RESTORATiVE303 trial of VE303 and planning for commercial stage activity

CAMBRIDGE, MA, July 23, 2024 – Vedanta Biosciences, a clinical-stage biopharmaceutical company developing medicines for the treatment of gastrointestinal diseases, today announced three appointments to its leadership team. Christof Marré, a seasoned biopharma marketing leader, joins the company as Senior Vice President and Head of Commercial. In addition, Steven Shiff, M.D., a pharmaceutical executive and physician specializing in gastroenterology, has been appointed as SVP, Clinical Research; and Jack Kyte has been promoted to SVP, Human Resources.

"I am delighted to welcome Christof and Steve to the team," said Bernat Olle, Ph.D., Co-Founder and Chief Executive Officer of Vedanta Biosciences. "The expertise that Christof, Steve, and Jack bring are vital to our next phase of growth as we execute our ongoing pivotal Phase 3 RESTORATiVE303 trial of VE303 for C. difficile infection and Phase 2 COLLECTiVE202 trial of VE202 for ulcerative colitis, and establish our commercial function."

Christof Marré brings almost three decades of experience as a biopharma marketing leader and strategist, and most recently served as VP of Marketing & Pipeline Planning at Alpine Immune Sciences, recently acquired by Vertex Pharmaceuticals. At Alpine, he established the company's Commercial function, including building out capabilities in market research, competitive intelligence, healthcare practitioner marketing & patient advocacy, and driving indication prioritization and valuation within the company's Immunology portfolio. Earlier in his career, Mr. Marré was involved with multiple successful product launches at both established and emerging biopharma companies. He holds a Master of Science degree in Economics from The London School of Economics and Political Science (LSE).

Steven Shiff, M.D., is a gastroenterologist and clinical executive with over 20 years of experience in research and industry R&D. Dr. Shiff was most recently SVP and Head of Clinical Development at Intercept Pharmaceuticals, where he oversaw design and implementation of the company's global clinical development strategy focused on rare and serious liver diseases, including supporting an NDA filing. Previously, he served as VP, Clinical Development, and GI Therapeutic Area Head at Allergan for 14 years, in which capacity he led global clinical development of the company's GI pipeline and marketed GI product portfolio. Dr. Shiff spent the first 13 years of his career as a practicing physician and professor, initially at The Rockefeller University and later at Rutgers-Robert Wood Johnson Medical School.

Jack Kyte has served as Vice President and Head of Human Resources at Vedanta since 2020, following more than a decade of multi-industry HR experience. Mr. Kyte is responsible for developing and executing Vedanta's people strategy in alignment with the organization's current and anticipated future needs and overseeing its human resources function both internally and with external partners.

About Vedanta Biosciences

Vedanta Biosciences is a clinical-stage biopharmaceutical company developing medicines for the treatment of gastrointestinal diseases. The company's lead assets are potential first-in-class oral therapies – VE303, in a Phase 3 registrational trial for prevention of recurrent C. difficile infection, and VE202, in a Phase 2 trial for treatment of ulcerative colitis. Vedanta's pipeline has been built using the company's industry-leading product engine for the development of therapies based on defined consortia of bacteria grown from pure clonal cell banks. The product engine, supported by broad foundational intellectual property, includes one of the largest libraries of bacteria isolated from the human microbiome, vast clinical datasets, proprietary capabilities in consortium design, and end-to-end CGMP manufacturing capabilities at commercial launch scale.

About PureTech Health

PureTech is a clinical-stage biotherapeutics company dedicated to giving life to new classes of medicine to change the lives of patients with devastating diseases. The Company has created a broad and deep pipeline through its experienced research and development team and its extensive network of scientists, clinicians and industry leaders that is being advanced both internally and through its Founded Entities. PureTech's R&D engine has resulted in the development of 29 therapeutics and therapeutic candidates, including two that have received both U.S. FDA clearance and European marketing authorization and a third (KarXT) that has been filed for FDA approval. A number of these programs are being advanced by PureTech or its Founded Entities in various indications and stages of clinical development, including registration enabling studies. All of the underlying programs and platforms that resulted in this pipeline of therapeutic candidates were initially identified or discovered and then advanced by the PureTech team through key validation points.

For more information, visit www.puretechhealth.com or connect with us on X (formerly Twitter) @puretechh.

Cautionary Note Regarding Forward-Looking Statements

This press release contains statements that are or may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation those related to the VE303 and VE202 development programs, development plans and potential benefits to patients and our future prospects, developments and strategies. The forward-looking statements are based on current expectations and are subject to known and unknown risks, uncertainties and other important factors that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, those risks, uncertainties and other important factors described under the caption "Risk Factors" in our Annual Report on Form 20-F for the year ended December 31, 2023, filed with the SEC and in our other regulatory filings. These forward-looking statements are based on assumptions regarding the present and future business strategies of the Company and the environment in which it will operate in the future. Each forward-looking statement speaks only as at the date of this press release. Except as required by law and regulatory requirements, we disclaim any obligation to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise.

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