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    SEC Form 4 filed by See Explanation of Responses Bvf Partners L P/Il

    6/13/25 6:23:00 PM ET
    $OLMA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $OLMA alert in real time by email
    SEC FORM 4 SEC Form 4
    FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0287
    Estimated average burden
    hours per response: 0.5
      
    Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
      
    Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
    1. Name and Address of Reporting Person*
    BVF PARTNERS L P/IL

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)
    2. Issuer Name and Ticker or Trading Symbol
    Olema Pharmaceuticals, Inc. [ OLMA ]
    5. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    3. Date of Earliest Transaction (Month/Day/Year)
    06/11/2025
    4. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    Form filed by One Reporting Person
    X Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
    1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V Amount (A) or (D) Price
    Common stock, $0.0001 par value(1) 2,655,977 D(2)
    Common stock, $0.0001 par value(1) 2,003,966 D(3)
    Common stock, $0.0001 par value(1) 347,970 D(4)
    Common stock, $0.0001 par value(1) 99,556 I(5) See footnote(5)
    Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
    Stock Option (Right to buy)(7) $4.08 06/11/2025 A 24,150 (9) 06/11/2035 Common stock, $0.0001 par value 24,150 $0 24,150 I(7) See footnote(7)
    Pre-Funded Warrant $0.0001 (6) (6) Common stock, $0.0001 par value(1) 3,291,004 3,291,004 D(2)
    Pre-Funded Warrant $0.0001 (6) (6) Common stock, $0.0001 par value(1) 2,627,590 2,627,590 D(3)
    Pre-Funded Warrant $0.0001 (6) (6) Common stock, $0.0001 par value(1) 336,288 336,288 D(4)
    Stock Option (Right to buy)(7) $12.36 (8) 06/14/2034 Common stock, $0.0001 par value 23,000 23,000 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $7.84 (8) 06/15/2033 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $3.61 (8) 06/16/2032 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $27.66 (8) 06/08/2031 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $19 (8) 11/17/2030 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $19 (8) 11/17/2030 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    Stock Option (Right to buy)(7) $19 (8) 11/17/2030 Common stock, $0.0001 par value 21,520 21,520 I(7) See footnote(7)
    1. Name and Address of Reporting Person*
    BVF PARTNERS L P/IL

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BIOTECHNOLOGY VALUE FUND L P

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BVF I GP LLC

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BIOTECHNOLOGY VALUE FUND II LP

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BVF II GP LLC

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    Biotechnology Value Trading Fund OS LP

    (Last) (First) (Middle)
    P.O. BOX 309 UGLAND HOUSE

    (Street)
    GRAND CAYMAN E9 KY1-1104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BVF Partners OS Ltd.

    (Last) (First) (Middle)
    P.O. BOX 309 UGLAND HOUSE

    (Street)
    GRAND CAYMAN E9 KY1-1104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BVF GP HOLDINGS LLC

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    BVF INC/IL

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    1. Name and Address of Reporting Person*
    LAMPERT MARK N

    (Last) (First) (Middle)
    44 MONTGOMERY ST.
    40TH FLOOR

    (Street)
    SAN FRANCISCO CA 94104

    (City) (State) (Zip)

    Relationship of Reporting Person(s) to Issuer
    X Director 10% Owner
    Officer (give title below) X Other (specify below)
    See Explanation of Responses
    Explanation of Responses:
    1. This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF I GP LLC ("BVF GP"), BVF II GP LLC ("BVF2 GP"), BVF GP Holdings LLC ("BVF GPH"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group with respect to the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.
    2. Securities owned directly by BVF. As the general partner of BVF, BVF GP may be deemed to beneficially own the securities owned directly by BVF. As the sole member of BVF GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF. As the investment manager of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.
    3. Securities owned directly by BVF2. As the general partner of BVF2, BVF2 GP may be deemed to beneficially own the securities owned directly by BVF2. As the sole member of BVF2 GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF2. As the investment manager of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.
    4. Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.
    5. Securities held in a certain Partners managed account (the "Partners Managed Account"). Partners may be deemed to have indirect beneficial ownership of the securities of the Issuer held by the Partners Managed Account for purposes of Rule 16a-1(a)(2) because the securities account for more than 10% of the market value of the portfolio of the Partners Managed Account as of the reporting date. Partners, as the investment manager of the Partners Managed Account, may be deemed to beneficially own the securities held by the Partners Managed Account. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities held by the Partners Managed Account. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities held by the Partners Managed Account.
    6. Each Pre-Funded Warrant may be exercised for one share of Common Stock. The Pre-Funded Warrants are exercisable immediately after the issue date and may be exercised at any time until all of the Pre-Funded Warrants are exercised in full. A holder of Pre-Funded Warrants (together with its affiliates and other attribution parties) may not exercise any portion of a Pre-Funded Warrant to the extent that immediately prior to or after giving effect to such exercise the holder would own more than 9.99% of the shares of Common Stock outstanding immediately after exercise.
    7. Partners, BVF Inc. and Mr. Lampert may be deemed to have a pecuniary interest in the securities reported owned herein due to a certain agreement between Partners and Gorjan Hrustanovic, who serves on the Issuer's board of directors and as a member of Partners, pursuant to which Dr. Hrustanovic is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners. As such, Dr. Hrustanovic disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein.
    8. The shares subject to the option have fully vested.
    9. The shares subject to the option vest in a series of 12 successive equal monthly installments measured from June 11, 2025, subject to Dr. Hrustanovic's continuous service through each applicable vesting date. Such shares vest in full on the date of the Issuer's next annual meeting of stockholders if such stock option is not otherwise fully vested by such date, subject to Dr. Hrustanovic's continuous service through such vesting date.
    Remarks:
    For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each of the Reporting Persons may be deemed to be a director by deputization of the Issuer due to a member of Partners, Gorjan Hrustanovic, serving on the Board of Directors of the Issuer, and his agreement to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners.
    BVF Partners L.P., By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 06/13/2025
    Biotechnology Value Fund, L.P., By: BVF I GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 06/13/2025
    BVF I GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 06/13/2025
    Biotechnology Value Fund II, L.P., By: BVF II GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 06/13/2025
    BVF II GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 06/13/2025
    BVF Partners OS Ltd., By: BVF Partners L.P., its sole member, By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 06/13/2025
    Biotechnology Value Trading Fund OS LP, By: BVF Partners L.P., its investment manager, BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 06/13/2025
    BVF GP Holdings LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 06/13/2025
    BVF Inc., By: /s/ Mark N. Lampert, President 06/13/2025
    /s/ Mark N. Lampert 06/13/2025
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
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    • Olema Oncology Presents Updated Clinical Results for Palazestrant in Combination with Ribociclib at the San Antonio Breast Cancer Symposium

      Palazestrant, in combination with ribociclib, demonstrated promising clinical activity, a safety profile consistent with ribociclib and endocrine therapy, and favorable tolerability in patients with ER+/HER2- advanced or metastatic breast cancer With a median follow-up of 12 months, median progression-free survival (PFS) has not been reached6-month PFS rate was 73% in all patients, 81% in patients with ESR1 mutations, 70% in ESR1 wild-type patients, and 68% in patients with prior CDK4/6 inhibitor treatment; data continue to mature Conference call today at 8:00 a.m. ET SAN FRANCISCO, Dec. 10, 2024 (GLOBE NEWSWIRE) -- Olema Pharmaceuticals, Inc. (("Olema" or "Olema Oncology", NASDAQ:OLMA),

      12/10/24 7:00:00 AM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Olema Oncology to Present New Data Combining Palazestrant with Ribociclib at the San Antonio Breast Cancer Symposium

      SAN FRANCISCO, Nov. 25, 2024 (GLOBE NEWSWIRE) -- Olema Pharmaceuticals, Inc. (("Olema" or "Olema Oncology", NASDAQ:OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced that it will present new data from the Phase 1b/2 clinical study of palazestrant (OP-1250) in combination with CDK4/6 inhibitor ribociclib at the San Antonio Breast Cancer Symposium (SABCS 2024) being held December 10-13, 2024, at the Henry B. Gonzalez Convention Center in San Antonio, Texas. Poster Details Title: A Phase 1b/2 study of palazestrant (OP-1250) in combination with ribociclib, in patien

      11/25/24 5:30:00 PM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Olema Oncology Announces Promising New Data for Palazestrant in Combination with Ribociclib Presented at the 2024 ESMO Breast Cancer Congress

      Across 50 treated patients, palazestrant (OP-1250) in combination with ribociclib was well tolerated with no new safety signals or increased toxicity and no clinically meaningful impact on drug exposure of either therapy85% clinical benefit rate (CBR) observed to date across all CBR-eligible patients supports promising preliminary efficacy profile of the palazestrant-ribociclib combination Olema will host an investor conference call today at 8:00 a.m. ET SAN FRANCISCO, May 15, 2024 (GLOBE NEWSWIRE) -- Olema Pharmaceuticals, Inc. (("Olema" or "Olema Oncology, NASDAQ:OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted the

      5/15/24 7:01:00 AM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Olema Pharmaceuticals Inc.

      SC 13G - Olema Pharmaceuticals, Inc. (0001750284) (Subject)

      12/11/24 4:30:15 PM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13D/A filed by Olema Pharmaceuticals Inc.

      SC 13D/A - Olema Pharmaceuticals, Inc. (0001750284) (Subject)

      12/4/24 7:49:50 PM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Olema Pharmaceuticals Inc.

      SC 13G/A - Olema Pharmaceuticals, Inc. (0001750284) (Subject)

      11/14/24 4:34:56 PM ET
      $OLMA
      Biotechnology: Pharmaceutical Preparations
      Health Care