SEC FORM 4

SEC FORM 4 SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

FMR LLC

(Last)

(First)

(Middle)

245 SUMMER STREET

(Street)

BOSTON

02210

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Structure Therapeutics Inc. [ GPCR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

Director	X	10% Owner
Officer (give title below)	X	Other (specify below)
		See Remark 1

3. Date of Earliest Transaction (Month/Day/Year)
12/08/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Ordinary Shares								36,909	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
Ordinary Shares								434,298	I	F-Prime Capital Partners Life Sciences Fund VI LP

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
American Depositary Shares	⁽¹⁾							⁽¹⁾	⁽¹⁾	Ordinary Shares	4,546,674		1,515,558	I	Shares held by persons and entities whose shares are subject to reporting by the undersigned
American Depositary Shares	⁽¹⁾	12/08/2025		S			709	⁽¹⁾	⁽¹⁾	Ordinary Shares	2,127	$92.52⁽²⁾	3,393	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			183	⁽¹⁾	⁽¹⁾	Ordinary Shares	549	$94⁽³⁾	3,210	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			475	⁽¹⁾	⁽¹⁾	Ordinary Shares	1,425	$94.61⁽⁴⁾	2,735	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			1,414	⁽¹⁾	⁽¹⁾	Ordinary Shares	4,242	$61.05⁽⁵⁾	1,321	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			1,320	⁽¹⁾	⁽¹⁾	Ordinary Shares	3,960	$61.45⁽⁶⁾	1	I	F-Prime Capital Partners Life Sciences Advisors Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			8,337	⁽¹⁾	⁽¹⁾	Ordinary Shares	25,011	$92.52⁽²⁾	39,918	I	F-Prime Capital Partners Life Sciences Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			2,159	⁽¹⁾	⁽¹⁾	Ordinary Shares	6,477	$94⁽³⁾	37,759	I	F-Prime Capital Partners Life Sciences Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			5,589	⁽¹⁾	⁽¹⁾	Ordinary Shares	16,767	$94.61⁽⁴⁾	32,170	I	F-Prime Capital Partners Life Sciences Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			16,635	⁽¹⁾	⁽¹⁾	Ordinary Shares	49,905	$61.05⁽⁵⁾	15,535	I	F-Prime Capital Partners Life Sciences Fund VI LP
American Depositary Shares	⁽¹⁾	12/08/2025		S			15,535	⁽¹⁾	⁽¹⁾	Ordinary Shares	46,605	$61.45⁽⁶⁾	0	I	F-Prime Capital Partners Life Sciences Fund VI LP

Explanation of Responses:

1. Reported securities are American Depositary Shares, each of which represents three Ordinary Shares of the Issuer. Any one American Depositary Share may be converted into three Ordinary Shares, and any three Ordinary Shares into one American Depositary Share, at any time at the election of the holder upon notice.

2. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $92.29 to $92.93. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

3. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $93.27 to $94.26. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

4. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $94.28 to $94.88. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

5. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $60.32 to $61.31. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

6. The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $61.32 to $61.64. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

Remarks:

Remark 1: Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. The address of Abigail P. Johnson is c/o FMR LLC, 245 Summer Street, Boston, MA 02110. Remark 2: The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the undersigned are the beneficial owners of any securities reported herein. Remark 3: F-Prime Capital Partners Life Sciences Advisors Fund VI LP (FPCPLSA) is the general partner of F-Prime Capital Partners Life Sciences Fund VI LP. FPCPLSA is solely managed by Impresa Management LLC, the managing member of its general partner and its investment manager. Impresa Management LLC is owned, directly or indirectly, by various shareholders and employees of FMR LLC, including certain members of the Johnson family.

	/s/ Stephanie J. Brown, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and Abigail P. Johnson	12/10/2025
	** Signature of Reporting Person	Date
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SEC Form 4 filed by See Remark 1 Fmr Llc