424B5 1 MainDocument.htm 424B5

Filed Pursuant to Rule 424(b)(5)

Registration No. 333-280391

PROSPECTUS SUPPLEMENT

(To Prospectus dated June 21, 2024)

TRINITY BIOTECH PLC

Up to $4,352,314

American Depositary Shares representing Ordinary Shares

We have entered into an At the Market Offering Agreement (the “ATM Sales Agreement”), with Lucid Capital Markets, LLC (“Lucid”) relating to the sale of our American Depositary Shares (“ADSs”) representing our A Ordinary Shares, par value $0.0001 per share (“Ordinary Shares”) (each ADS represents 20 Ordinary Shares), offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of such ATM Sales Agreement, we may offer and sell our ADSs representing Ordinary Shares having an aggregate offering price of up to $4,352,314 from time to time through or to Lucid acting as our sales agent or principal.

Our ADSs are listed for trading on the Nasdaq Global Select Market (“Nasdaq”) under the symbol “TRIB.” On June 11, 2026, the closing price of an ADS on Nasdaq was $0.6751.

Sales of our ADSs, if any, under this prospectus supplement and the accompanying prospectus will be made in sales deemed to be an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended (the Securities Act). Lucid is not required to sell any specific amount of securities but will act as our sales agent using commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed terms between Lucid and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.

The compensation to Lucid for sales of ADSs sold pursuant to the ATM Sales Agreement will be 3.0% of the gross proceeds of any ADSs sold under the ATM Sales Agreement. In connection with the sale of the ADSs on our behalf, Lucid will be deemed to be an “underwriter” within the meaning of the Securities Act and the compensation of Lucid will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to Lucid with respect to certain liabilities, including liabilities under the Securities Act or the Securities Exchange Act of 1934, as amended (the Exchange Act).

Based on the closing sale price of $0.7454 of our ADSs on Nasdaq on April 17, 2026 and approximately 17,516,692 non-affiliate outstanding ADSs, the aggregate market value of our public float, calculated according to General Instruction I.B.5 of Form F-3, is approximately $13,056,942. Under the registration statement of which this prospectus supplement and the accompanying prospectus forms a part, we may not sell our securities in a primary offering with a value exceeding one-third of our public float in any 12-month period (unless our public float rises to $75.0 million or more). We have not offered any securities during the 12 calendar months preceding and including the date of this prospectus supplement pursuant to General Instruction I.B.5.

Our business and an investment in our ADSs involve significant risks. These risks are described under the caption “Risk Factors” beginning on page S-5 of this prospectus supplement and beginning on page 4 of the accompanying prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

Lucid Capital Markets

The date of this prospectus supplement is June 12, 2026

TABLE OF CONTENTS

PROSPECTUS SUPPLEMENT

	Page
FORWARD‑LOOKING STATEMENTS	S-1
PROSPECTUS SUPPLEMENT SUMMARY	S-3
THE OFFERING	S-4
RISK FACTORS	S-5
USE OF PROCEEDS	S-7
CAPITALIZATION AND INDEBTEDNESS	S-8
DILUTION	S-9
MATERIAL TAX CONSEQUENCES	S-10
PLAN OF DISTRIBUTION	S-17
LEGAL MATTERS	S-19
EXPERTS	S-19
WHERE YOU CAN FIND MORE INFORMATION	S-19
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE	S-19

BASE PROSPECTUS

	Page
NOTE ON FORWARD-LOOKING STATEMENTS	1
ABOUT THIS PROSPECTUS	2
ABOUT TRINITY BIOTECH PLC	2
RECENT DEVELOPMENTS	3
RISK FACTORS	4
OFFER STATISTICS AND EXPECTED TIMETABLE	5
CAPITALIZATION AND INDEBTEDNESS	5
USE OF PROCEEDS	5
DESCRIPTION OF SECURITIES WE MAY OFFER	5
DESCRIPTION OF ADSs REPRESENTING OUR ORDINARY SHARES	5
DESCRIPTION OF WARRANTS	6
DESCRIPTION OF DEBT SECURITIES	7
DESCRIPTION OF SUBSCRIPTION RIGHTS	8
DESCRIPTION OF UNITS	9
TAXATION	9
PLAN OF DISTRIBUTION	10
AUTHORIZED REPRESENTATIVE	13
OFFERING EXPENSES	13
MATERIAL CHANGES	14
LEGAL MATTERS	14
EXPERTS	14
WHERE YOU CAN FIND MORE INFORMATION	15
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE	16
ENFORCEABILITY OF CIVIL LIABILITIES	17

iii

Unless expressly stated otherwise, in this prospectus supplement, references to “we”, “us”, “Trinity Biotech” or the “Group” shall mean Trinity Biotech plc and its world-wide subsidiaries, collectively. References to the “Company” shall mean Trinity Biotech plc. All references to “dollars” or “$” in this prospectus supplement are to U.S. dollars, and all references to “Euro” or “€” are to European Union Euro.

This document is in two parts. The first part is this prospectus supplement, which describes the terms of this offering of our ADSs and supplements information contained in the accompanying prospectus and the documents incorporated by reference into the accompanying prospectus. The second part is the accompanying prospectus, which gives more general information about us and the ADSs that we may offer from time to time under our shelf registration statement. To the extent there is a conflict between the information contained in this prospectus supplement, on the one hand, and the information contained in the accompanying prospectus or any document incorporated by reference therein, on the other hand, the information in this prospectus supplement shall control.

You should read this document together with the additional information described under the headings “Where You Can Find More Information” and “Incorporation of Certain Information by Reference” in this prospectus supplement. We have not authorized the sales agent or other person to give any information or to make any representation other than those contained or incorporated by reference in this prospectus supplement, the accompanying prospectus and any related free writing prospectus. You should not rely upon any information or representation not contained or incorporated by reference in this prospectus supplement, the accompanying prospectus or any free writing prospectus that we may authorize to be provided to you. This prospectus supplement, the accompanying prospectus and any related free writing prospectus do not constitute an offer to sell or the solicitation of an offer to buy ADSs, nor does this prospectus supplement, the accompanying prospectus and any related free writing prospectus constitute an offer to sell or the solicitation of an offer to buy ADSs in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. You should not assume that the information contained in this prospectus supplement, the accompanying prospectus and any related free writing prospectus is accurate on any date subsequent to the date set forth on the front of the document or that any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference, even though this prospectus supplement, the accompanying prospectus and any related free writing prospectus is delivered or ADS is sold on a later date.

We further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference into the accompanying prospectus were made solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.

This prospectus supplement is not intended to be and is not a prospectus for purposes of: (i) Regulation (EU) 2017/1129 of the European Parliament and of the Council or the European Union (Prospectus) Regulations 2019 of Ireland; or (ii) Regulation (EU) 2017/1129 as it forms part of United Kingdom domestic law by virtue of the European Union (Withdrawal) Act 2018 of the United Kingdom, as amended by the Prospectus (Amendment etc.) (EU Exit) Regulations 2019 of the United Kingdom, (the UK Prospectus Regulation). No offer of shares to the public is made, or will be made, that requires the publication of a prospectus pursuant to European prospectus law or the UK Prospectus Regulation. This document has been prepared on the basis that any offer of shares in any relevant European Economic Area member state or the United Kingdom will be made pursuant to an exemption under European prospectus law and the UK Prospectus Regulation from the requirement to publish a prospectus for offers of shares and does not constitute an offer or solicitation to anyone to purchase shares in any jurisdiction in which such an offer or solicitation is not authorized nor to any person to whom it is unlawful to make such an offer or solicitation. This document has not been reviewed or approved by the Central Bank of Ireland nor by any other competent or supervisory authority of any other member state of the European Economic Area or the United Kingdom for the purposes of the EU Prospectus Regulation, or the UK Prospectus Regulation, as applicable. Any representation to the contrary is a criminal offense.

FORWARD‑LOOKING STATEMENTS

This prospectus supplement, the accompanying prospectus and the information incorporated by reference contain forward-looking statements within the meaning of Private Securities Litigation Reform Act of 1995. These statements are only predictions and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms including “anticipate,” “estimate,” “plan,” “project,” “potential,” “predict,” “continuing,” “ongoing,” “expect,” “believe,” “intend,” “may,” “should,” “will,” “would,” “could” and similar expressions intended to identify forward-looking statements. Forward-looking statements reflect our current views with respect to future events and are based on assumptions and subject to risks and uncertainties. Examples of forward-looking statements include, but are not limited to, statements about:

• the development of future products;

• the potential attributes and benefit of our products and their competitive position;

• our ability to successfully commercialize, or enter into strategic relationships with third parties to commercialize, our products;

• our estimates regarding expenses, future revenues, capital requirements and our need for additional financing;

• statements of our plans and objectives;

• our ability to acquire or in-license new product candidates;

• potential strategic relationships;

• the duration of our patent portfolio;

• the capabilities of our business operations;

• expected future economic performance;

• competition in our market; and

• assumptions underlying statements regarding us or our business.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

• our substantial indebtedness, which could impair our flexibility and access to capital and adversely affect our financial position;

• our ability to generate or raise sufficient funds to repay our debt as it becomes due and to continue as a going concern;

• our continued listing on the Nasdaq Global Select Market;

• pandemics or other public health emergencies, including ongoing effects of the COVID-19 pandemic;

• the occurrence of hostilities and political instability, including hostilities between Russia and Ukraine and between Hamas and Israel, and recent hostilities in the Middle East involving the United States, Israel, Iran and other countries, resulting volatility and other effects on global economic conditions;

• changes in customer demand;

• our ability to successfully develop and commercialize new products, including our new biosensor related products, including our continuous glucose monitoring (“CGM”) product;

• recalls of our products or liability claims in connection with our products and services and the cost and reputational harm associated with such recalls or claims and with any voluntary corrective actions or regulatory agency enforcement actions;

• delays or failures in our clinical trials and failure to maintain regulatory approvals and clearances to manufacture, market and distribute our products;

• interruptions in production at our principal manufacturing facilities, our third-party manufacturing facilities or our supplier;

S-1

• the extent to which we are successful in gaining new long-term relationships with customers or retaining existing ones;

• developments and changes in laws and regulations, including increased regulation of our industry through legislative action and revised rules and standards;

• security breaches, cybersecurity attacks and other significant disruptions;

• natural events such as severe weather, fires, floods and earthquakes or man-made or other disruptions of our business and facilities;

• strategic actions, including acquisitions and dispositions and our success in integrating acquired businesses; and

• our ability to obtain and protect rights to the intellectual property necessary for the conduct of our business and the potential costs of enforcing or defending those rights.

We caution you to carefully consider these risks and not to place undue reliance on our forward-looking statements. Forward-looking statements should not be read as a guarantee of future performance or results and will not necessarily be accurate indications of the times at, or by which, that performance or those results will be achieved. Forward-looking statements are based on information available at the time they are made and/or management’s good faith belief as of that time with respect to future events and are subject to risks and uncertainties that could cause actual performance or results to differ materially from what is expressed in or suggested by the forward-looking statements.

Forward-looking statements speak only as of the date they are made. Unless we are required to do so under U.S. federal securities laws or other applicable laws, we do not assume an obligation to or intend to update or revise any forward-looking statements. If we do update one or more forward-looking statements, no inference should be drawn that we will make additional updates with respect to those or other forward-looking statements. We caution you not to give undue weight to such projections, assumptions and estimates.

S-2

PROSPECTUS SUPPLEMENT SUMMARY

This summary highlights selected information contained elsewhere or incorporated by reference in this prospectus supplement and the accompanying prospectus. The summary does not contain all the information that you should consider before investing in our ADSs. You should read the entire prospectus supplement and the accompanying prospectus carefully, including “Risk Factors” contained in this prospectus supplement and the accompanying prospectus and the documents incorporated by reference in the accompanying prospectus, including our annual report on Form 20-F, as amended, before making an investment decision. This prospectus supplement may add to, update or change information in the accompanying prospectus.

Our Company

We are a commercial stage biotechnology company focused on diabetes management solutions and human diagnostics, including wearable biosensors. We develop, acquire, manufacture and market diagnostic systems, including both reagents and instrumentation, for the point-of-care and clinical laboratory segments of the diagnostic market and have recently entered the wearable biosensor industry, with the acquisition of the biosensor assets of Waveform Technologies Inc. and intend to develop a range of biosensor devices and related services, starting with a continuous glucose monitoring product. Our products are used to detect infectious diseases and to quantify the level of Haemoglobin A1c and other chemistry parameters in serum, plasma and whole blood. We sell our products directly in the United States and Brazil and in the United Kingdom, Germany and France and through a network of international distributors and strategic partners in approximately 100 countries worldwide.

For a full and comprehensive description of our business, markets and product lines, see our most recent Annual Report on Form 20-F and any updates in our Reports of Foreign Private Issuer on Form 6-K, to the extent that they are incorporated herein by reference.

Corporate Information

We were incorporated as a private limited company registered in Ireland in January 1992 and subsequently re-registered as a public limited company (“plc”) in July 1992. We commenced operations in 1992 and, in October 1992, completed an initial public offering of our securities in the United States. Our principal offices are located at IDA Business Park, Bray, County Wicklow, Ireland and our telephone number is +353 1276 9800. Our North American headquarters is based at 2823 Girts Rd., Jamestown, NY 14701, United States. Our website is www.trinitybiotech.com. The information on our website is not incorporated by reference herein.

Recent Developments

On June 2, 2026, the Company delivered written notice to Craig-Hallum Capital Group LLC (“Craig-Hallum”) of the termination of the At the Market Offering Agreement, dated as of July 12, 2024, between the Company and Craig-Hallum (the “CH Sales Agreement”), pursuant to Section 8(a) thereof. The ATM program contemplated by the CH Sales Agreement had not been active since March 2025.

S-3

THE OFFERING

Securities offered	ADSs, each representing 20 Ordinary Shares, having an aggregate offering price of up to $4,352,314.

The ADSs	Each ADS represents 20 Ordinary Shares, par value $0.0001 per share. You will have the rights of an ADS holder as provided in the deposit agreement by and among us, the ADS depositary and all holders and beneficial owners of ADSs issued thereunder. We encourage you to read the deposit agreement, the form of which is filed as an exhibit to the registration statement of which this prospectus supplement forms a part.

ADS Depositary	The Bank of New York Mellon

Manner of Offering	“At the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act that may be made from time to time through Lucid. See “Plan of Distribution” on page S-17.

ADSs and Ordinary Shares outstanding prior to this offering	405,017,380 Ordinary Shares (equivalent to 20,250,869 ADSs)

ADSs and Ordinary Shares to be outstanding immediately after this offering(1)	Up to 536,071,700 Ordinary Shares (equivalent to 26,803,585 ADSs), assuming the sale of 6,552,716 ADSs, representing 131,054,320 Ordinary Shares, in this offering at an assumed offering price of $0.6642 per ADS, which was the closing price of our ADSs on Nasdaq on June 9, 2026.

Use of proceeds	We intend to use the net proceeds from this offering for general corporate purposes, including working capital. See “Use of Proceeds” on page S-7.

Nasdaq symbol for ADSs	“TRIB”

Risk Factors	This investment involves a high degree of risk. See “Risk Factors” beginning on page S-5 of this prospectus supplement as well as the other information included in or incorporated by reference in this prospectus supplement and the accompanying prospectus for a discussion of risks you should consider carefully before making an investment decision.

_____________

(1)

The number of Ordinary Shares to be outstanding is based on 405,017,380 Ordinary Shares outstanding as of June 10, 2026, and excludes, as of that date, the following:

 40,017,505 Ordinary Shares issuable upon exercise of outstanding stock options at exercise prices that range from US$0.12 to US$1.10 per share;

 66,200,000 Ordinary Shares issuable upon the exercise of outstanding warrants;

 up to 3,359,019,957 Ordinary Shares represented by ADSs issuable upon conversion of obligations owed to affiliates of Perceptive Advisors, calculated assuming the minimum conversion price of $0.5061; and

 24,691,358 Ordinary Shares issuable upon conversion of the $20 million convertible note held by MiCo IVD Holdings, LLC (“MiCo”) with an ADS conversion price of $16.20 per ADS.

Except as otherwise indicated herein, all information in this prospectus assumes no exercise of outstanding options or warrants or conversion of any convertible debt. Unless otherwise stated, all information contained in this prospectus supplement reflects the assumed public offering price of $0.6642 per ADS, which was the last reported sale price of an ADS on Nasdaq on June 9, 2026.

S-4

RISK FACTORS

Investing in our securities involves significant risks. Please see the risk factors under the heading “Risk Factors” in our most recent Annual Report on Form 20-F on file with the Commission, as revised or supplemented by our reports subsequently filed after the date hereof with the Commission and incorporated by reference in this prospectus supplement. Before making an investment decision, you should carefully consider these risks as well as other information we include or incorporate by reference in this prospectus supplement. The risks and uncertainties we have described are not the only ones facing our company. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our business operations. The occurrence of any of these risks might cause you to lose all or part of your investment in the offered securities. The discussion of risks includes or refers to forward-looking statements; you should read the explanation of the qualifications and limitations on such forward-looking statements discussed elsewhere in this prospectus supplement.

Risks Related to Ownership of the ADSs

Future issuances and resales of a substantial number of ADSs, including upon conversion of outstanding convertible obligations and exercise of outstanding warrants, could cause substantial dilution, create a perception that a large number of ADSs may be sold into the market and materially depress the market price of our ADSs.

In December 2025, we issued a convertible promissory note to Perceptive Credit Holdings III, L.P. (“Perceptive Fund III”) and entered into a conversion rights agreement with Perceptive Credit Holdings II, L.P. (together with Perceptive Fund III, “Perceptive”), which were subsequently amended in April 2026 and pursuant to which certain existing obligations owed to Perceptive, including the outstanding term loans under our credit agreement, may be converted into ADSs from time to time at the election of Perceptive at a variable conversion price, subject to a minimum conversion price and a beneficial ownership cap (collectively, the “Perceptive Conversion Obligations”). As of June 10, 2026, we had 405,017,380 Ordinary Shares outstanding. Up to 3,359,019,957 Ordinary Shares may be issued to Perceptive upon conversion of the Perceptive Conversion Obligations (assuming conversion at the minimum conversion price). Perceptive also holds warrants exercisable for up to 66,200,000 Ordinary Shares in the aggregate. In addition, in February 2026, we entered into a Standby Equity Purchase Agreement (the “SEPA”) with YA II PN, LTD. (“Yorkville”), pursuant to which we may elect to sell up to $25.0 million of ADSs to Yorkville from time to time, at a purchase price equal to 97% of the lowest daily VWAP during a three-trading day pricing period or 95% of the VWAP during a one-trading day pricing period, subject to volume and other limits and conditions that may significantly restrict the number of ADSs we are permitted to sell, and, accordingly, we cannot predict the number of ADSs that may be sold pursuant to the SEPA.

After Perceptive or Yorkville acquires ADSs under those arrangements, each may resell those ADSs at any time or from time to time in its discretion. Sales of a substantial number of our ADSs in the public market, or the perception or indication that these sales could occur, including sales under the ATM Sales Agreement, resales by Perceptive or Yorkville, and resales by holders of other convertible instruments, including the $20 million convertible note held by MiCo IVD Holdings LLC, which is convertible into ADSs at a conversion price of $16.20 per ADS (the “MiCo Convertible Note”), could adversely affect the market price of our ADSs, increase volatility and materially impair our ability to raise capital through future equity or equity-linked offerings on favorable terms, or at all.

S-5

Risks Related to the Offering

You will experience immediate and substantial dilution in the net tangible book value per share of the ADSs you purchase and you may experience further dilution from future ADS issuances.

The public offering price per ADS will be substantially higher than the net tangible book value per share of our ADSs outstanding immediately following the completion of this offering. Therefore, if you purchase our ADSs in this offering at an assumed public offering price of $0.6642 per ADS, you will experience immediate dilution of $5.62 per ADS ($0.28 per Ordinary Share), the difference between the price you pay per ADS and our net tangible book value per ADS as of December 31, 2025, after giving pro forma effect to an increase in indebtedness since December 31, 2025 and to the issuance of the securities in this offering.

In addition, a substantial number of additional ADSs are or may become issuable under the agreements governing the Perceptive Conversion Obligations, Perceptive’s outstanding warrants, the SEPA, the MiCo Convertible Note and outstanding stock options. Any issuance of ADSs in this offering or in future offerings, any conversion of outstanding convertible or exchangeable instruments, and any exercise or repricing of outstanding warrants or options will dilute the ownership interests of investors in this offering and could cause the market price of our ADSs to fall.

The actual number of ADSs we will sell under the ATM Sales Agreement, at any one time or in total, is uncertain.

Subject to certain limitations in the ATM Sales Agreement and compliance with applicable law, we have the discretion to deliver instructions to Lucid to sell our ADSs at any time throughout the term of the ATM Sales Agreement. The number of ADSs that are sold through Lucid after our instruction will fluctuate based on a number of factors, including the market price of our ADSs during the sales period, the limits we set with Lucid in any instruction to sell shares, and the demand for our ADSs during the sales period. Because the price per ADS sold will fluctuate during this offering, it is not currently possible to predict the number of ADSs that will be sold or the gross proceeds to be raised in connection with those sales.

The ADSs offered in this offering may be sold in “at the market” offerings, and investors who buy ADSs at different times will likely pay different prices.

Investors who purchase ADSs under this prospectus supplement and the accompanying prospectus at different times will likely pay different prices, and so may experience different outcomes in their investment results. We will have discretion, subject to market demand, to vary the timing, prices, and numbers of ADSs sold, and there is no minimum or maximum sales price. Investors may experience declines in the value of their ADSs as a result of ADS sales made at prices lower than the prices they paid.

The issuance of securities in this and future offerings may trigger anti-dilution provisions in our outstanding warrants and affect the interests of our shareholders.

Our outstanding warrants contain anti-dilution provisions that may be triggered by this offering or future offerings depending on the offering price of the ADSs in this offering and any other equity issuances, and the exercise price or formula of warrants. These adjustments could reduce the proceeds received by the Company pursuant to a cash exercise of outstanding warrants, dilute the interests of our shareholders and adversely affect the trading price of the ADSs.

We will have broad discretion in the use of proceeds from this offering and may invest or spend the proceeds in ways with which you do not agree and in ways that may not increase the value of your investment.

We intend to use the net proceeds of this offering for general corporate purposes, including working capital. Our management will have significant flexibility and discretion in applying the net proceeds of this offering. You will be relying on the judgment of our management with regard to the use of these net proceeds, and you will not have the opportunity, as part of your investment decision, to assess whether the proceeds are being used appropriately. It is possible that the net proceeds will be invested in a way that does not yield a favorable, or any, return for us. The failure of our management to use such funds effectively could have a material adverse effect on our business, financial condition, prospects, operating results and cash flow.

S-6

USE OF PROCEEDS

We may sell ADSs representing Ordinary Shares having aggregate sales proceeds of up to $4,352,314 from time to time. Because there is no minimum offering amount required as a condition of this offering, the actual total public offering amount, commissions and net proceeds to us, if any, are not determinable at this time. There can be no assurance that we will sell any shares under or fully utilize the ATM Sales Agreement as a source of financing.

We currently intend to use the net proceeds, if any, from this offering primarily for general corporate purposes, including working capital. Our management will have discretion and flexibility in applying the net proceeds of this offering. We may use the proceeds of this offering for purposes with which you do not agree. See “Risk Factors ⸺ Risks Relating to the Offering ⸺ We will have broad discretion in the use of proceeds from this offering and may invest or spend the proceeds in ways with which you do not agree and in ways that may not increase the value of your investment.”

S-7

CAPITALIZATION AND INDEBTEDNESS

The following table sets forth our capitalization and indebtedness as of December 31, 2025 as derived from our financial statements, which are prepared in accordance with International Financial Reporting Standards, as issued by the International Accounting Standards Board. The information in this table should be read in conjunction with the financial statements and notes thereto and other financial information incorporated by reference into this prospectus and any prospectus supplement. The table below presents our capitalization and indebtedness (1) on an actual basis and (2) on an as adjusted basis, to give effect to an additional $2,500,000 of term loan borrowing on April 30, 2026, and the capitalization of certain paid-in-kind interest payments for interest periods from January 2026 to May 2026.

	December 31, 2025
(All figures in thousands of U.S. dollars, except for share amounts)	Actual			As Adjusted
Cash and cash equivalents		5,138			7,638
Debt
Exchangeable Notes		210			210
MiCo Convertible Note		16,330			16,330
Senior Secured Term Loan		108,015			115,581
Total debt		124,555			132,121
Equity
Ordinary shares, par value $0.0001 per share		40			40
Share Premium		63,800			63,800
Treasury shares		(24,922	)		(24,922	)
Equity component of MiCo Convertible Note		6,709			6,709
Reserves		(1,440	)		(1,440	)
Accumulated deficit		(116,169	)		(116,169	)
Total shareholders’ equity		(71,982	)		(71,982	)
Total capitalization		52,573			60,139

The number of Ordinary Shares in the table above excludes: 40,017,505 Ordinary Shares issuable upon exercise of outstanding options at exercise prices that range from US$0.12 to US$1.10 per Ordinary Share; 66,200,000 Ordinary Shares represented by ADSs issuable upon the exercise of outstanding warrants; 24,691,358 Ordinary Shares represented by ADSs issuable upon conversion of the $20 million convertible note held by MiCo IVD Holdings, LLC, with an ADS conversion price of $16.20 per ADS; and 3,359,019,957 Ordinary Shares represented by ADSs issuable upon conversion of the Perceptive Conversion Obligations, assuming the minimum conversion price of $0.5061.

S-8

DILUTION

If you invest in our securities, your ownership interest will immediately be diluted to the extent of the difference between the offering price per ADS paid by purchasers in this offering and the as adjusted net tangible book value per ADS after completion of the offering. Dilution results from the fact that the per ADS offering price is substantially in excess of the book value per ADS attributable to the existing holders of our presently outstanding ADSs.

The historical net tangible book value of the ADSs as of December 31, 2025 was approximately $(6.51) per ADS or $(0.325) per Ordinary Share. Historical net tangible book per share represents the amount of our total net tangible book value, divided by the number of ADSs outstanding as of December 31, 2025. As adjusted to give pro forma effect to an additional $2,500,000 of term loan borrowing on April 30, 2026, and the capitalization of certain paid-in-kind interest payments for interest periods from January 2026 to May 2026 (the “Pro Forma Adjustments”), the pro forma net tangible book value of the ADSs as of December 31, 2025 was approximately $(6.76) per ADS or $(0.338) per Ordinary Share.

After giving further effect to the sale of 6,552,716 ADSs, representing 131,054,320 Ordinary Shares, in this offering of $4,352,314 at an assumed offering price of $0.6642 per ADS, which was the closing price of our ADSs on Nasdaq on June 9, 2026, and after deducting estimated offering commissions and other estimated offering expenses, our as adjusted pro forma net tangible book value as of December 31, 2025 would have been $(132.7) million, or approximately $(4.95) per ADS ($(0.248) per Ordinary Share). This represents an immediate increase in the net tangible book value of $1.80 per ADS ($0.09 per Ordinary Share) to our existing shareholders and an immediate and substantial dilution in net tangible book value of $5.62 per ADS ($0.28 per Ordinary Share) to new investors.

The following table sets forth the estimated net tangible book value per ADS after the offering and the dilution to persons purchasing ADSs based on the foregoing offering assumptions.

Assumed offering price per ADS				$	0.6642
Historical net tangible book value per ADS as of December 31, 2025	$	(6.51	)
Pro forma net tangible book value per ADS as of December 31, 2025	$	(6.76	)
Increase in net tangible book value per ADS attributable to new investors	$	1.80
As-adjusted pro forma net tangible book value per ADS as of December 31, 2025, after giving effect to this offering				$	(4.95	)
Dilution per ADS to investors in this offering				$	5.62

The number of ADSs shown above to be outstanding after this offering is based on the ADSs outstanding as of December 31, 2025, as adjusted for 6,552,716 ADSs sold under the ATM Sales Agreement, and excludes:

• 40,017,505 Ordinary Shares issuable upon exercise of exercisable stock options outstanding as of June 10, 2026, at exercise prices that range from $0.12 to $1.10 per share;

• 66,200,000 Ordinary Shares issuable upon the exercise of outstanding warrants;

• up to 3,359,019,957 Ordinary Shares represented by ADSs issuable upon conversion of the Perceptive Conversion Obligations, calculated assuming the minimum conversion price of $0.5061; and

• 24,691,358 Ordinary Shares issuable upon conversion of the MiCo Convertible Note.

It also assumes no exercise of any outstanding options or warrants or the conversion of any convertible debt.

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MATERIAL TAX CONSEQUENCES

The following discussion is based on U.S. and Ireland tax law, statutes, treaties, regulations, rulings and decisions all as of the date of this prospectus supplement. Taxation laws are subject to change, from time to time, and no representation is or can be made as to whether such laws will change, or what impact, if any, such changes will have on the statements contained in this summary. No assurance can be given that proposed amendments will be enacted as proposed, or that legislative or judicial changes, or changes in administrative practice, will not modify or change the statements expressed herein.

This summary is of a general nature only. It does not constitute legal or tax advice nor does it discuss all aspects of taxation that may be relevant to any particular U.S. Holder or Irish Holder or of Ordinary Shares or ADSs.

This summary does not discuss all aspects of Irish and U.S. federal income taxation that may be relevant to a particular holder of ADSs in light of the holder’s own circumstances or to certain types of investors subject to special treatment under applicable tax laws (for example, financial institutions, life insurance companies, tax-exempt organisations, and non-U.S. taxpayers) and it does not discuss any tax consequences arising under the laws of taxing jurisdictions other than Ireland and the U.S. federal government. The tax treatment of holders of ADSs may vary depending upon each holder’s own particular situation.

Prospective purchasers of ADSs are advised to consult their own tax advisors as to the US, Irish or other tax consequences of the purchase, ownership and disposition of such ADSs.

U.S. Federal Income Tax Consequences to U.S. Holders

The following is a summary of certain material U.S. federal income tax consequences that generally would apply with respect to the ownership and disposition of ADSs, in the case of a holder of such ADSs who is a U.S. Holder (as defined below) and who holds the ADSs as capital assets. This summary is based on the U.S. Internal Revenue Code of 1986, as amended (the “Code”), Treasury Regulations promulgated thereunder, and judicial and administrative interpretations thereof, all as in effect on the date hereof and all of which are subject to change either prospectively or retroactively. For the purposes of this summary, a “U.S. Holder” is: an individual who is a citizen or tax resident of the United States; a corporation created or organised in or under the laws of the United States or any political subdivision thereof; an estate whose income is subject to U.S. federal income tax regardless of its source; or a trust that (a) is subject to the primary supervision of a court within the United States and the control of one or more U.S. persons or (b) has a valid election in effect under applicable U.S. Treasury regulations to be treated as a U.S. person.

This summary does not address all tax considerations that may be relevant with respect to an investment in ADSs. This summary does not discuss all the tax consequences that may be relevant to a U.S. Holder in light of such U.S. Holder’s particular circumstances or to U.S. Holders or other persons subject to special rules, including persons that are not U.S. holders, broker dealers, financial institutions, certain insurance companies, investors liable for alternative minimum tax, tax exempt organisations, regulated investment companies, non-resident aliens of the United States or taxpayers whose functional currency is not the U.S. Dollar, persons who hold ADSs through partnerships or other pass-through entities, persons who acquired their ADSs through the exercise or cancellation of employee stock options or otherwise as compensation for services, investors that actually or constructively own 10% or more of the Company’s voting shares, and investors holding ADSs as part of a straddle or appreciated financial position or as part of a hedging or conversion transaction.

If an entity treated as a partnership for U.S. federal income tax purposes owns ADSs, the U.S. federal income tax treatment of a partner in such a partnership will generally depend upon the status of the partner and the activities of the partnership. The partners in a partnership which owns ADSs should consult their tax advisors about the U.S. federal income tax consequences of holding and disposing of ADSs.

This summary does not address the effect of any U.S. federal taxation other than U.S. federal income taxation. In addition, this summary does not include any discussion of state, local or foreign taxation. You are urged to consult your tax advisors regarding the foreign and U.S. federal, state and local tax considerations of an investment in ADSs.

For U.S. federal income tax purposes, U.S. Holders of ADSs will be treated as owning the underlying Class Ordinary Shares represented by the ADSs held by them. This discussion assumes such treatment is respected.

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Dividends and Other Distributions on ADSs

The gross amount of any distribution made by the Company to U.S. Holders with respect to the underlying shares represented by the ADSs held by them, including the amount of any Irish taxes withheld from such distribution, will be treated for U.S. federal income tax purposes as a dividend to the extent of Trinity Biotech’s current and accumulated earnings and profits, as determined for U.S. federal income tax purposes. The amount of any such distribution that exceeds Trinity Biotech’s current and accumulated earnings and profits will be applied against and reduce a U.S. Holder’s tax basis in the U.S. Holder’s ADSs, and any amount of the distribution remaining after the U.S. Holder’s tax basis has been reduced to zero will constitute capital gain. However, there can be no assurances we will calculate earnings and profits under U.S. federal income tax principles. Therefore, any distribution we make to you may be reported as a dividend. The capital gain will be treated as a long-term or short-term capital gain depending on whether or not the U.S. Holder’s ADSs have been held for more than one year as of the date of the distribution.

Dividends paid by the Company generally will not qualify for the dividends received deduction otherwise available to U.S. corporate shareholders.

Subject to complex limitations, any Irish withholding tax imposed on dividends will be a foreign income tax eligible for credit against a U.S. Holder’s U.S. federal income tax liability (or, alternatively, for deduction against income in determining such tax liability) where certain conditions are satisfied. The limitations set out in the Code include computational rules under which foreign tax credits allowable with respect to specific classes of income, commonly referred to as “baskets,” cannot exceed the U.S. federal income taxes otherwise payable with respect to each such class of income. Dividends generally will be treated as foreign-source passive category income or, in the case of certain U.S. Holders, general category income for U.S. foreign tax credit purposes. Further, there are special rules for computing the foreign tax credit limitation of a taxpayer who receives dividends subject to a reduced tax, see discussion below.

A U.S. Holder will be denied a foreign tax credit with respect to Irish income tax withheld from dividends received on the ADSs to the extent such U.S. Holder has not held the ADSs for at least 16 days of the 31-day period beginning on the date which is 15 days before the ex-dividend date, or to the extent such U.S. Holder is under an obligation to make related payments with respect to substantially similar or related property. Any days during which a U.S. Holder has substantially diminished its risk of loss on the ADSs are not counted toward meeting the 16-day holding period required by the Code. If a refund of the tax withheld is available to you under the laws of Ireland or under the United States and Ireland income tax treaty (the “Treaty”), the amount of tax withheld that is refundable will not be eligible for such credit against your U.S. federal income tax liability (and will not be eligible for the deduction against your U.S. federal taxable income). The rules relating to the determination of the foreign tax credit are complex, and you should consult with your personal tax advisors to determine whether and to what extent you would be entitled to this credit against your U.S. federal income tax liability.

Subject to certain limitations, including the PFIC rules discussed below, “qualified dividend income” received by a noncorporate U.S. Holder will be subject to tax at lower rates. Distributions taxable as dividends paid on the ADSs should qualify as qualified dividend income provided that either: (i) we are entitled to benefits under the Treaty or (ii) the ADSs are readily tradable on an established securities market in the U.S. and certain other requirements are met. We believe that we are entitled to benefits under the Treaty and that the ADSs currently are readily tradable on an established securities market in the U.S. However, no assurance can be given that the ADSs will remain readily tradable. The rate reduction does not apply unless certain holding period requirements are satisfied. With respect to the ADSs, the U.S. Holder must have held such ADSs for at least 61 days during the 121-day period beginning 60 days before the ex-dividend date. The rate reduction also does not apply to dividends received from passive foreign investment companies, see discussion below, or in respect of certain hedged positions or in certain other situations. The legislation enacting the reduced tax rate contains special rules for computing the foreign tax credit limitation of a taxpayer who receives dividends subject to the reduced tax rate. U.S. Holders of ADSs should consult their own tax advisors regarding the effect of these rules in their particular circumstances.

Dispositions of the ADSs

Upon a sale or exchange of ADSs, a U.S. Holder will recognise a gain or loss for U.S. federal income tax purposes in an amount equal to the difference between the amount realised on the sale or exchange and the U.S. Holder’s adjusted tax basis in the ADSs sold or exchanged. Such gain or loss generally will be capital gain or loss and will be long-term or short-term capital gain or loss depending on whether the U.S. Holder has held the ADSs sold or exchanged for more than one year at the time of the sale or exchange. If you are a non-corporate U.S. Holder, long-term capital gains may be eligible for reduced tax rates.

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Passive Foreign Investment Company

For U.S. federal income tax purposes, a foreign corporation is treated as a “passive foreign investment company” (or “PFIC”) in any taxable year in which, after taking into account the income and assets of the corporation and certain of its subsidiaries pursuant to the applicable “look through” rules, either (1) at least 75% of the corporation’s gross income is passive income or (2) at least 50% of the average value of the corporation’s assets is attributable to assets that produce passive income or are held for the production of passive income. Based on the nature of its present business operations, assets and income, the Company believes that for the year 2025, it is not a PFIC. However, no assurance can be given that changes will not occur in our business operations, assets and income that might cause the Company to be treated as a PFIC at some future time.

If the Company were to become a PFIC, a U.S. Holder of ADSs would be required to allocate to each day in the holding period for such U.S. Holder’s ADSs a pro rata portion of any distribution received (or deemed to be received) by the U.S. Holder from the Company, to the extent the distribution so received constitutes an “excess distribution,” as defined under U.S. federal income tax law. Generally, a distribution received during a taxable year by a U.S. Holder with respect to the underlying shares represented by any of the U.S. Holder’s ADSs would be treated as an “excess distribution” to the extent that the distribution so received, plus all other distributions received (or deemed to be received) by the U.S. Holder during the taxable year with respect to such underlying shares, is greater than 125% of the average annual distributions received by the U.S. Holder with respect to such underlying shares during the three preceding years (or during such shorter period as the U.S. Holder may have held the ADSs). Any portion of an excess distribution that is treated as allocable to one or more taxable years prior to the year of distribution during which the Company was classified as a PFIC would be subject to U.S. federal income tax in the year in which the excess distribution is made, but it would be subject to tax at the highest tax rate applicable to the U.S. Holder in the prior tax year or years. The U.S. Holder also would be subject to an interest charge, in the year in which the excess distribution is made, on the amount of taxes deemed to have been deferred with respect to the excess distribution. In addition, any gain recognised on a sale or other disposition of a U.S. Holder’s ADSs, including any gain recognised on a liquidation of the Company, would be treated in the same manner as an excess distribution. Any such gain would be treated as ordinary income rather than as capital gain.

If the Company became a PFIC, a U.S. Holder may make a “qualifying electing fund” (or “QEF”) election in the year the Company first becomes a PFIC or in the year the U.S. Holder acquires the ADSs, whichever is later. This election provides for a current inclusion of Trinity Biotech’s ordinary income and capital gain income in the U.S. Holder’s U.S. taxable income. In return, any gain on sale or other disposition of a U.S. Holder’s, if it were classified as a PFIC, will be treated as capital, and the interest penalty will not be imposed. This election is not made by the Company, but by each U.S. Holder. In order for the U.S. Holder to maintain the election, the Company must make available certain information, which the Company may choose not to provide. U.S. Holders should contact their tax advisor for further information about the election.

Alternatively, if the ADSs are considered “marketable stock” a U.S. Holder may elect to “mark-to-market” its ADSs, and such U.S. Holder would not be subject to the rules described above. Instead, such U.S. Holder would generally include in income any excess of the fair market value of the ADSs at the close of each tax year over its adjusted basis in the ADSs. If the fair market value of the ADSs had fallen below the U.S. Holder’s adjusted basis at the close of the tax year, the U.S. Holder may generally deduct the excess of the adjusted basis of the ADSs over its fair market value at that time. However, such deductions generally would be limited to the net mark-to-market gains, if any, that the U.S. Holder included in income with respect to such ADSs in prior years. Income recognised and deductions allowed under the mark-to-market provisions, as well as any gain or loss on the disposition of ADSs with respect to which the mark-to-market election is made, is treated as ordinary income or loss (except that loss is treated as capital loss to the extent the loss exceeds the net mark-to-market gains, if any, that a U.S. Holder included in income with respect to such ADSs in prior years). However, gain or loss from the disposition of ADSs (as to which a “mark-to-market” election was made) in a year in which the Company is no longer a PFIC, will be capital gain or loss. The ADSs should be considered “marketable stock” if they traded at least 15 days during each calendar quarter of the relevant calendar year in more than de minimis quantities.

If a U.S. Holder owns ADSs during any year in which the Company is a PFIC, the U.S. Holder generally must file an IRS Form 8621 with respect to the Company, generally with the U.S. Holder’s federal income tax return for that year.

Information Reporting and Backup Withholding

Distributions made with respect to underlying shares represented by ADSs and proceeds from the sale, exchange or other disposition of ADSs may be subject to information reporting to the IRS and to US backup withholding tax. Backup withholding will not apply, however, if the U.S. Holder (i) is a corporation or comes within certain exempt categories, and demonstrates its eligibility for exemption when so required, or (ii) furnishes a correct taxpayer identification number and makes any other required certification.

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Backup withholding is not an additional tax. Amounts withheld under the backup withholding rules may be credited against a U.S. Holder’s U.S. tax liability, and a U.S. Holder may obtain a refund of any excess amounts withheld under the backup withholding rules by filing the appropriate claim for refund with the IRS.

Information with Respect to Foreign Financial Assets

U.S. individuals (and, under proposed regulations, certain entities) that hold certain specified foreign financial assets, including stock in a foreign corporation, with values in excess of certain thresholds are required to file with their U.S. federal income tax return Form 8938, on which information about the assets, including their value, is provided. Taxpayers who fail to file the form when required are subject to penalties. An exemption from reporting applies to foreign assets held through certain financial institutions. Investors are encouraged to consult with their own tax advisors regarding the possible application of this disclosure requirement to their investment in ADSs.

Medicare Contribution Tax

In addition to the income taxes described above, U.S. Holders that are individuals, estates or trusts and whose income exceeds certain thresholds will be subject to a 3.8% Medicare contribution tax on net investment income, which includes dividends and capital gains.

U.S. Holders may be subject to state or local income and other taxes with respect to their purchase, ownership and disposition of ADSs. U.S. Holders of ADSs should consult their own tax advisers as to the applicability and effect of any such taxes.

Ireland Taxation

For the purposes of this summary, an “Irish Holder” means a holder of Ordinary Shares or ADSs evidenced by ADSs that (i) beneficially owns the Ordinary Shares or ADSs registered in its name; (ii) in the case of individual holders, are resident, ordinarily resident and domiciled in Ireland under Irish taxation laws; (iii) in the case of holders that are companies, are resident in Ireland under Irish taxation laws.

Solely for the purposes of this summary of Republic of Ireland Taxation, a “U.S. Holder” means a holder of Ordinary Shares or ADSs evidenced by ADSs that (i) beneficially owns the Ordinary Shares or ADSs registered in its name; (ii) is resident in the United States for the purposes of the Republic of Ireland/United States Double Taxation Convention (the Treaty); (iii) in the case of an individual holder, is not also resident or ordinarily resident in Ireland for Irish tax purposes; (iv) in the case of a corporate holder, is not a resident in Ireland for Irish tax purposes and is not ultimately controlled by persons resident in Ireland; and (v) is not engaged in any trade or business in Ireland and does not perform independent personal services through a permanent establishment or fixed base in Ireland.

In 2011, the board of the Company decided that it was an appropriate time to commence a dividend policy for the first time in the Company’s history but the payment of dividends has subsequently been suspended (see section in our Annual Report on Form 20-F, as amended, for the year ended December 31, 2021 under the heading “Dividend Policy”). Up to 31 December 2019, the payment of a dividend was generally subject to dividend withholding tax (“DWT”) at the standard rate of income tax in force at the time the dividend is paid (the applicable rate was 20% in 2019). However, the rate of DWT has increased to 25% in respect of dividends paid on or after 1 January 2020. Under current legislation, where DWT applies, Trinity Biotech will be responsible for withholding it at source.

DWT will not be withheld where an exemption applies and where Trinity Biotech has received all necessary documentation from the recipient prior to payment of the dividend.

Corporate Irish Holders will generally be entitled to claim an exemption from DWT by delivering a declaration which confirms that the company is resident in Ireland for tax purposes to Trinity Biotech in the form prescribed by the Irish Revenue Commissioners. Such corporate Irish Holders will generally not otherwise be subject to Irish tax in respect of dividends received.

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Individual Irish Holders will be subject to income tax on the gross amount of any dividend (that is the amount of the dividend received plus any DWT withheld), at their marginal rate of income tax, currently either 20% or 40% depending on the individual’s circumstances, excluding Pay Related Social Insurance (“PRSI”) and the Universal Social Charge (“USC”). Individual Irish Holders will be able to claim a credit against their resulting income tax liability in respect of DWT withheld. Individual Irish Holders may, depending on their circumstances, also be subject to USC of up to 8%, with a further 3% surcharge also arising on certain income in excess of €100,000 and a PRSI contribution of up to 4% in respect of their dividend income.

Under the Irish Taxes Consolidation Act 1997, dividends paid by Trinity Biotech to non-Irish shareholders will, unless exempted, be subject to DWT. Such non-Irish shareholders will not suffer DWT on dividends if the shareholder is:

 an individual resident in the U.S. (or an EU member State, European Economic Area (“EEA”) state, or certain other countries with which Ireland has a double taxation treaty) and who is neither resident nor ordinarily resident in Ireland; or

 a U.S. tax resident corporation (or a corporation resident in an EU member State, EEA state, or certain other countries, with which Ireland has a double taxation treaty) not under the control of Irish residents; or

 a corporation that is not resident in Ireland and which is ultimately controlled by persons resident in the U.S. (or persons resident in an EU member State, EEA state or certain other countries with which Ireland has a double taxation treaty), with such person or persons not under the control of persons who are not so resident; or

 a corporation that is not resident in Ireland and the principal class of whose shares (or its 75% parent’s principal class of shares) is substantially or regularly traded on a recognised stock exchange in Ireland or an EU member State, EEA state or a country with which Ireland has a double taxation treaty; or

 is otherwise entitled to an exemption from DWT.

In order to avail of the above exemptions, certain declarations must be made in advance to the paying company.

A self-assessment system applies to a company tax resident in a treaty jurisdiction receiving dividends, under which a non-resident company or individual will provide a declaration and certain information to the dividend paying company or intermediary to claim the exemption.

Special DWT arrangements are available in the case of shares in Irish companies held by U.S. resident holders through American depository banks using ADSs where such banks enter into intermediary agreements with the Irish Revenue Commissioners and are viewed as qualifying intermediaries under Irish Tax legislation. Under such agreements, American depository banks who receive dividends from Irish companies and pay the dividends on to the U.S. resident ADS holders are allowed to receive and pass on a dividend from the Irish company on a gross basis (without any withholding) if:

 the person is the direct beneficial owner of the ADSs, is beneficially entitled to the dividend, and the depository bank’s ADS register shows that the direct beneficial owner of the dividends has a U.S. address on the register, and

 there is an intermediary which satisfies the requirements for Irish Tax legislation between the depository bank and the shareholder beneficially entitled to the dividend and the depository bank receives confirmation from the intermediary that such shareholder’s address in the intermediary’s records is in the U.S.

Where the above procedures have not been complied with and DWT is withheld from dividend payments to U.S. Holders of Ordinary Shares or ADSs evidenced by ADSs, such U.S. Holders can apply to the Irish Revenue Commissioners claiming a full refund of DWT paid by filing a declaration / claim in the form prescribed by the Irish Revenue Commissioners. Certain accompanying information should also be included when making such claims.

The DWT rate applicable to U.S. Holders is reduced to 5% under the terms of the Treaty for corporate U.S. Holders holding 10% or more of voting shares and to 15% for other U.S. Holders. While this will, subject to the application of Article 23 of the Treaty, generally entitle U.S. Holders to claim a partial refund of DWT from the Irish Revenue Commissioners, U.S. Holders will, in most circumstances, likely prefer to seek a full refund of DWT under Irish domestic legislation (see above).

Disposals of Ordinary Shares or ADSs

Irish Holders that acquire Ordinary Shares or ADSs will generally be considered, for Irish tax purposes, to have acquired their Ordinary Shares or ADSs at a base cost equal to the amount paid for the Ordinary Shares or ADSs. On subsequent dispositions, Ordinary Shares or ADSs acquired at an earlier time will generally be deemed, for Irish tax purposes, to be disposed of on a “first in first out” basis before Ordinary Shares or ADSs acquired at a later time (unless the Ordinary Shares or ADSs were acquired within four weeks prior to the disposition). Irish Holders that dispose of their Ordinary Shares or ADSs will be subject to Irish capital gains tax (“CGT”) to the extent that the proceeds realised from such disposition exceed the indexed base cost of the Ordinary Shares or ADSs disposed of and any incidental expenses. Non-Irish Holders who have used their Ordinary Shares or ADSs for the purposes of a trade carried on by the holder in Ireland through a branch or agency, or whose Ordinary Shares or ADSs were used or held or acquired for use by or for the purposes of such a branch or agency should also be subject to CGT on the disposal of their Ordinary Shares or ADSs. The current rate of CGT is 33% and this applies to disposals made on or after 6 December 2012. Indexation of the base cost of the Ordinary Shares or ADSs is available up to 31 December 2002, and only in respect of Ordinary Shares or ADSs held for more than 12 months prior to their disposal.

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Irish Holders that have unutilised capital losses from other sources in the current, or any previous tax year, may be able to apply such losses to reduce gains realised on the disposal of the Ordinary Shares or ADSs.

An annual exemption allows individuals to realise chargeable gains of up to €1,270 in each tax year without giving rise to CGT. This exemption is specific to the individual and cannot be transferred between spouses. Irish Holders are required, under Ireland’s self-assessment system, to file tax returns reporting any chargeable gains arising to them in a particular tax year.

Where disposal proceeds are received in a currency other than Euro they must be translated into Euro amounts to calculate the amount of any chargeable gain or loss. Similarly, acquisition costs denominated in a currency other than Euro must be translated at the date of acquisition in Euro amounts.

Irish Holders that realise a loss on the disposal of Ordinary Shares or ADSs may be entitled to offset such allowable losses against capital gains realised from other sources in determining their CGT liability in that year. Allowable losses which remain unrelieved in a year may generally be carried forward indefinitely for CGT purposes and applied against capital gains in future years.

Transfers between spouses who live together will not give rise to any chargeable gain or loss for CGT purposes with the acquiring spouse acquiring the same pro rata base cost and acquisition date as that of the transferring spouse.

U.S. Holders will not be subject to CGT on the disposal of Ordinary Shares or ADSs provided that such Ordinary Shares or ADSs are quoted on a stock exchange at the time of disposition. The stock exchange for this purpose is Nasdaq. While it is our intention to continue the quotation of ADSs on Nasdaq, no assurances can be given in this regard.

If, for any reason, our ADSs cease to be quoted on Nasdaq or another stock exchange, U.S. Holders will not be subject to CGT on the disposal of their Ordinary Shares or ADSs provided that the Ordinary Shares or ADSs do not, at the time of the disposal, derive the greater part of their value from land, buildings, minerals, or mineral rights or exploration rights in Ireland.

A gift or inheritance of Ordinary Shares will be, or in the case of ADSs may be, within the charge to capital acquisitions tax, regardless of where the disponer or the donee/successor in relation to the gift/inheritance is domiciled, resident or ordinarily resident. Capital acquisitions tax is levied at a rate of 33% on the taxable value of the gift or inheritance above certain tax-free thresholds and this rate applies in respect of gifts and inheritances taken on or after 6 December 2012. The tax-free threshold is determined by the amount of the current benefit and of previous benefits received within the group threshold since 5 December 1991, which are within the charge to capital acquisitions tax and the relationship between the former holder and the successor. Gifts and inheritances between spouses are not subject to the capital acquisitions tax. Gifts of up to €3,000 can be received each year from any given individual without triggering a charge to capital acquisitions tax. Where a charge to Irish CGT and capital acquisitions tax arises on the same event, capital acquisitions tax payable on the event can be reduced by the amount of the CGT payable. There should be no clawback of the same event credit of CGT offset against capital acquisitions tax provided the donee does not dispose of the Ordinary Shares or ADSs within two years from the date of gift.

The Estate Tax Convention between Ireland and the United States generally provides for Irish capital acquisitions tax paid on inheritances in Ireland to be credited, in whole or in part, against tax payable in the United States, in the case where an inheritance of Ordinary Shares or ADSs is subject to both Irish capital acquisitions tax and U.S. federal estate tax. The Estate Tax Convention does not apply to Irish capital acquisitions tax paid on gifts.

Irish stamp duty, which is a tax imposed on certain documents, is payable on all transfers of Ordinary Shares (other than transfers made between spouses, certain transfers made between 90% associated companies, or certain other exempt transfers) regardless of where the document of transfer is executed. Irish stamp duty can also be payable on electronic transfers of Ordinary Shares. A transfer of Ordinary Shares made as part of a sale or gift will generally be stampable at the ad valorem rate of 1% of the value of the consideration received for the transfer, or, if higher, the market value of the shares transferred. Any instrument executed on or after 24 December 2008 which transfers stock or marketable securities on sale where the amount or value of the consideration is €1,000 or less may be exempt from stamp duty. Where the consideration for a sale is expressed in a currency other than Euro, the duty will be charged on the Euro equivalent calculated at the rate of exchange prevailing at the date of the transfer.

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Transfers of Ordinary Shares where no beneficial interest passes (e.g. a transfer of shares from a beneficial owner to a nominee) will generally not be subject to Irish stamp duty provided the transfer is not made in contemplation of sale.

Transfers of ADSs are exempt from Irish stamp duty as long as the ADSs are dealt in on any recognised stock exchange in the U.S. or Canada. The ADSs are currently quoted on Nasdaq. While it is our intention to continue the quotation of ADSs on Nasdaq, no assurances can be given in this regard.

If, for any reason, our ADSs cease to be dealt in on Nasdaq or another recognized stock exchange in the US or Canada, transfers of ADSs may be subject to stamp duty, subject to any other reliefs or exemptions.

Transfers of Ordinary Shares from the Depositary or the Depositary’s custodian upon surrender of ADSs for the purposes of withdrawing the underlying Ordinary Shares from the ADS system, and transfers of Ordinary Shares to the Depositary or the Depositary’s custodian for the purposes of transferring Ordinary Shares onto the ADS system, will be stampable at the ad valorem rate of 1% of the value of the shares transferred if there is a transfer of beneficial ownership or the transfer is made in contemplation of sale. Such transfers will be exempt from Irish stamp duty if the transfer does not relate to or involve any change in the beneficial ownership in the underlying Ordinary Shares and the transfer is not made in contemplation of sale. The person accountable for the payment of stamp duty is the transferee or, in the case of a transfer by way of gift or for consideration less than the market value, both parties to the transfer. Stamp duty is normally payable within 44 days after the date of execution of the transfer. Late or inadequate payment of stamp duty may result in liability for interest, penalties, surcharge and fines.

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PLAN OF DISTRIBUTION

We have entered into the ATM Sales Agreement with Lucid pursuant to which we may sell our ADSs, each representing 20 Ordinary Shares, par value $0.0001 per share, through Lucid, acting as our sales agent or principal. Sales of the ADSs, if any, will be made by any method permitted that is deemed an “at the market” offering as defined in Rule 415 promulgated under the Securities Act. Pursuant to this prospectus supplement and the accompanying prospectus, we may sell up to $4,352,314 of ADSs. This summary of the material provisions of the ATM Sales Agreement does not purport to be a complete statement of its terms and conditions. A copy of the ATM Sales Agreement will be filed as an exhibit to a current report on Form 6-K and is incorporated by reference into this prospectus supplement. See “Where You Can Find More Information” below.

Each time we wish to sell our ADSs under the ATM Sales Agreement, we will notify Lucid of the number of ADSs to be issued, the dates on which such sales are anticipated to be made, any limitation on the number of ADSs to be sold in any one day and any minimum price below which sales may not be made. Once we have so instructed Lucid, unless Lucid declines to accept the terms of such notice, Lucid has agreed to use its commercially reasonable efforts consistent with its normal trading and sales practices to sell such ADSs up to the amount specified on such terms. The obligations of Lucid under the ATM Sales Agreement to sell our ADSs are subject to a number of conditions that we must meet.

The settlement of sales of ADSs between us and Lucid will occur on the first trading day following the date on which the sale was made, or any such shorter settlement cycle as may be in effect pursuant to Rule 15c6-1 under the Exchange Act, or on some other date that is agreed upon by us and Lucid in connection with a particular transaction. Sales of our ADSs as contemplated in this prospectus supplement will be settled through the facilities of The Depository Trust Company or by such other means as we and Lucid may agree upon. There is no arrangement for funds to be received in an escrow, trust or similar arrangement.

We will pay Lucid a commission equal to 3.0% of aggregate gross proceeds we receive from the sale of our ADSs sold pursuant to the ATM Sales Agreement. Because there is no minimum offering amount required as a condition of this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable at this time. We have also agreed to reimburse Lucid for certain specified expenses, including the fees and disbursements of its legal counsel in an aggregate amount not exceeding $40,000.

Lucid will provide written confirmation to us following the close of trading on Nasdaq on each trading day on which our ADSs are sold under the ATM Sales Agreement. Each confirmation will include the number of ADSs sold on that day, the price or prices at which such ADSs were sold, the aggregate gross proceeds of such sales, the proceeds to us and the commission payable to Lucid with respect to such sales.

In connection with the sale of our ADSs on our behalf, Lucid will be deemed to be an “underwriter” within the meaning of the Securities Act, and the compensation of Lucid will be deemed to be underwriting commissions or discounts. We have agreed to indemnify Lucid against certain civil liabilities, including liabilities under the Securities Act. We have also agreed to contribute to payments Lucid may be required to make in respect of such liabilities.

The offering of our ADSs pursuant to the ATM Sales Agreement will terminate upon the earlier of (i) the sale of all of our ADSs subject to the ATM Sales Agreement and (ii) the termination of the ATM Sales Agreement as permitted therein. We and Lucid may each terminate the ATM Sales Agreement at any time by giving written notice in accordance with the ATM Sales Agreement.

Our ADSs are listed on Nasdaq and trade under the symbol “TRIB.” The depositary for the ADS program is The Bank of New York Mellon.

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Lucid and its affiliates may in the future provide various investment banking, commercial banking, financial advisory and other financial services for us and our affiliates, for which services they may in the future receive customary fees. In the course of its business, Lucid may actively trade our securities for its own account or for the accounts of customers, and, accordingly, Lucid may at any time hold long or short positions in such securities. To the extent required by Regulation M promulgated under the Exchange Act, Lucid will not engage in any transactions that stabilize our ADSs while the offering pursuant to this prospectus supplement is ongoing.

A prospectus supplement and the accompanying prospectus in electronic format may be made available on a website maintained by Lucid, and Lucid may distribute the prospectus supplement and the accompanying prospectus electronically.

Offer restrictions outside the United States

Other than in the United States, no action has been taken by us or Lucid that would permit a public offering of the securities offered by this prospectus supplement in any jurisdiction where action for that purpose is required. The securities offered by this prospectus supplement and the accompanying base prospectus may not be offered or sold, directly or indirectly, nor may this prospectus supplement or any other offering material or advertisements in connection with the offer and sale of any such securities be distributed or published in any jurisdiction, except under circumstances that will result in compliance with the applicable rules and regulations of that jurisdiction. Persons into whose possession this prospectus supplement comes are advised to inform themselves about and to observe any restrictions relating to the offering and the distribution of this prospectus supplement. This prospectus supplement does not constitute an offer to sell or a solicitation of an offer to buy any securities offered by this prospectus supplement in any jurisdiction in which such an offer or a solicitation is unlawful.

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LEGAL MATTERS

Carter Ledyard & Milburn LLP, New York, New York, will be passing upon matters of United States law for us with respect to securities offered by this prospectus supplement. The validity of our Ordinary Shares represented by the ADSs offered hereby will be passed upon for us by Matheson LLP, Dublin, Ireland. Lucid Capital Markets, LLC is being represented in connection with this offering by Ellenoff Grossman & Schole LLP, New York, New York.

EXPERTS

The audited consolidated financial statements incorporated by reference in this prospectus and elsewhere in this registration statement have been so incorporated by reference in reliance upon the report of Grant Thornton, independent registered public accountants, upon the authority of said firm as experts in auditing and accounting.

WHERE YOU CAN FIND MORE INFORMATION

This prospectus supplement is a part of a registration statement on Form F-3 that we filed on June 21, 2024, with the Commission under the Securities Act. We refer you to this registration statement, for further information about us and the securities offered hereby.

We file annual and special reports and other information with the Securities and Exchange Commission (Commission File Number 000-22320). These filings contain important information that does not appear in this prospectus. Our SEC filings are also available on the Commission Internet site at www.sec.gov, which contains periodic reports and other information regarding issuers that file electronically.

INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

We file annual and special reports and other information with the Commission (File Number 000-22320). These filings contain important information which does not appear in this prospectus. The Commission allows us to “incorporate by reference” information into this prospectus, which means that we can disclose important information to you by referring you to other documents which we have filed or will file with the Commission. We are incorporating by reference in this prospectus supplement the documents listed below and all amendments or supplements we may file to such documents, as well as any future filings we may make with the Commission on Form 20-F under the Exchange Act before the time that all of the securities offered by this prospectus have been sold or de-registered.

	●	Our Annual Report on Form 20-F for the fiscal year ended December 31, 2025, filed with the SEC on April 30, 2026 (the “Annual Report”).

	●	Our reports of foreign private issuer on Form 6-K (including exhibits thereto) filed with the SEC on May 6, 2026 and June 5, 2026.

	●	The description of our ADSs and the Ordinary Shares contained in the Annual Report.

In addition, we may incorporate by reference into this prospectus supplement our reports on Form 6-K filed after the date of this prospectus supplement (and before the time that all of the securities offered by this prospectus supplement have been sold or de-registered) if we identify in the report that it is being incorporated by reference in this prospectus supplement.

Certain statements in and portions of this prospectus update and replace information in the above listed documents incorporated by reference. Likewise, statements in or portions of a future document incorporated by reference in this prospectus may update and replace statements in and portions of this prospectus or the above listed documents.

We will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this prospectus supplement, other than exhibits to such documents which are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to Trinity Biotech plc, IDA Business Park, Bray, County Wicklow, Ireland, Attn: Corporate Secretary, telephone number +(353) 1 276 9800. You may also obtain information about us by visiting our website at www.trinitybiotech.com. Information contained in our website is not part of this prospectus supplement.

S-19

You should rely only on the information contained or incorporated in this prospectus supplement and the accompanying prospectus. We have not authorized anyone else to provide you with different information. You should not rely on any other representations. Our affairs may change after this prospectus supplement is distributed. You should not assume that the information in this prospectus supplement or the accompanying prospectus is accurate as of any date other than the date on the front of those documents. You should read all information supplementing this prospectus supplement and the accompanying prospectus.

We are an Irish company and are a “foreign private issuer” as defined in Rule 3b-4 under the Exchange Act. As a result, (i) our proxy solicitations are not subject to the disclosure and procedural requirements of Regulation 14A under the Exchange Act, (ii) our officers, directors, and principal shareholders are exempt from the short swing profit recovery provisions contained in Section 16 of the Exchange Act and our principal shareholders are also exempt from the reporting provisions contained in Section 16 of the Exchange Act; and (iii) we are not required under the Exchange Act to file periodic reports and financial statements as frequently or as promptly as U.S. companies whose securities are registered under the Exchange Act.

S-20

PROSPECTUS

TRINITY BIOTECH PLC

Graphics

$50,000,000

A Ordinary Shares

Warrants

Debt Securities

Subscription Rights

Units

We may offer to the public from time to time in one or more series or issuances:

• A Ordinary Shares;

• warrants to purchase A Ordinary Shares or debt securities;

• debt securities (including convertible debt securities);

• subscription rights;

or any combination of the above, separately or as units.

We refer to the A Ordinary Shares, warrants, debt securities, subscription rights and units collectively as “securities” in this prospectus. American Depositary Shares (each representing 20 A Ordinary Shares, par value $0.0109 per share) (our “ADSs”) are listed on the NASDAQ Global Select Market (“Nasdaq”) under the symbol “TRIB.” On June 20, 2024, the last reported sale price of an ADS on Nasdaq was $2.47.

We have not yet determined whether any of the other securities that may be offered by this prospectus will be listed on any exchange, inter-dealer quotation system or over-the-counter market. If we decide to seek listing of any such securities, a prospectus supplement relating to those securities will disclose the exchange, quotation system or market on which the securities will be listed and the date when we expect trading to begin.

This prospectus provides a general description of the securities we may offer. Each time we sell securities, we will provide specific terms of the securities offered in a supplement to this prospectus. The prospectus supplement may also add, update, or change information contained in this prospectus. This prospectus may not be used to consummate a sale of securities unless accompanied by the applicable prospectus supplement. You should read both this prospectus and any prospectus supplement together with additional information described under the heading “Where You Can Find More Information” and the documents incorporated or deemed to be incorporated by reference carefully before you make your investment decision.

We will sell these securities directly to our shareholders or to purchasers or through agents on our behalf or through underwriters or dealers as designated from time to time. If any agents or underwriters are involved in the sale of any of these securities, the applicable prospectus supplement will provide the names of the agents or underwriters and any applicable fees, commissions, or discounts. The prospectus supplement for each offering of securities will describe in detail the plan of distribution for that offering. For general information about the distribution of securities offered, please see “Plan of Distribution” in this prospectus on page 10.

The aggregate market value of our outstanding ADSs held by non-affiliates on June 13, 2024 as calculated in accordance with General Instruction I.B.5 of Form F-3, was approximately $16,590,000. Pursuant to General Instruction I.B.5, in no event will we sell securities pursuant to this prospectus with a value of more than one-third of the aggregate market value of our ADSs held by non-affiliates in any 12-month period, so long as the aggregate market value of our ADSs held by non-affiliates is less than $75,000,000.

Investing in these securities involves certain risks. Please carefully consider the “Risk Factors” in Item 3(D) of our most recent Annual Report on Form 20-F incorporated by reference in this prospectus, the “Risk Factors” beginning on page 4 of this prospectus, and in any applicable prospectus supplement, for a discussion of the factors you should consider carefully before deciding to purchase these securities.

Neither the Securities and Exchange Commission (the “Commission”) nor any state securities commission has approved or disapproved of the securities being offered by this prospectus, or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is June 28, 2024.

You should rely only on the information contained or incorporated by reference in this prospectus. We have not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus is accurate only as of the date on the front cover of this prospectus. Our business, financial condition, results of operation and prospects may have changed since that date.

TABLE OF CONTENTS

NOTE ON FORWARD-LOOKING STATEMENTS	1
ABOUT THIS PROSPECTUS	2
ABOUT TRINITY BIOTECH PLC	2
RECENT DEVELOPMENTS	3
RISK FACTORS	4
OFFER STATISTICS AND EXPECTED TIMETABLE	5
CAPITALIZATION AND INDEBTEDNESS	5
USE OF PROCEEDS	5
DESCRIPTION OF SECURITIES WE MAY OFFER	5
DESCRIPTION OF ADSs REPRESENTING OUR ORDINARY SHARES	5
DESCRIPTION OF WARRANTS	6
DESCRIPTION OF DEBT SECURITIES	7
DESCRIPTION OF SUBSCRIPTION RIGHTS	8
DESCRIPTION OF UNITS	9
TAXATION	9
PLAN OF DISTRIBUTION	10
AUTHORIZED REPRESENTATIVE	13
OFFERING EXPENSES	13
MATERIAL CHANGES	14
LEGAL MATTERS	14
EXPERTS	14
WHERE YOU CAN FIND MORE INFORMATION	15
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE	16
ENFORCEABILITY OF CIVIL LIABILITIES	17

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NOTE ON FORWARD-LOOKING STATEMENTS

This prospectus, including the information incorporated by reference into this prospectus, contains, and any prospectus supplement may include forward-looking statements within the meaning of Private Securities Litigation Reform Act of 1995. These statements are only predictions and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms including “anticipate,” “estimate,” “plan,” “project,” “potential,” “predict” “continuing,” “ongoing,” “expect,” “believe,” “intend,” “may,” “should,” “will,” “would,” “could” and similar expressions intended to identify forward-looking statements. Forward-looking statements reflect our current views with respect to future events and are based on assumptions and subject to risks and uncertainties. Examples of forward-looking statements include, but are not limited to, statements about:

• the development of future products;

• the potential attributes and benefit of our products and their competitive position;

• our ability to successfully commercialize, or enter into strategic relationships with third parties to commercialize, our products;

• our estimates regarding expenses, future revenues, capital requirements and our need for additional financing;

• statements of our plans and objectives;

• our ability to acquire or in-license new product candidates;

• potential strategic relationships;

• the duration of our patent portfolio; and

• statements regarding the capabilities of our business operations;

• statements of expected future economic performance;

• statements regarding competition in our market; and

• assumptions underlying statements regarding us or our business.

• our substantial indebtedness, which could impair our flexibility and access to capital and adversely affect our financial position;

• our ability to generate or raise sufficient funds to repay our debt as it becomes due and to continue as a going concern;

• our ability to meet the continued listing requirements of Nasdaq and the impact of a potential de-listing of the ADSs on our ability to raise additional funds and other potential development opportunities;

• pandemics or other public health emergencies, including ongoing effects of the COVID-19 pandemic;

• the occurrence of hostilities and political instability, including hostilities between Russia and Ukraine and between Hamas and Israel, and resulting volatility and other effects on global economic conditions;

SEC Form 424B5 filed by Trinity Biotech plc