FORM 6-K
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
Report
of Foreign Issuer
Pursuant
to Rule 13a-16 or 15d-16 of
the
Securities Exchange Act of 1934
For the
month of November 2025
Commission
File Number: 001-11960
AstraZeneca PLC
1
Francis Crick Avenue
Cambridge
Biomedical Campus
Cambridge
CB2 0AA
United
Kingdom
Indicate
by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.
Form
20-F X Form 40-F __
Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(1):
Indicate
by check mark if the registrant is submitting the Form 6-K in paper
as permitted by Regulation S-T Rule 101(b)(7): ______
Indicate
by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information
to the Commission pursuant to Rule 12g3-2(b) under the Securities
Exchange Act of 1934.
Yes __
No X
If
“Yes” is marked, indicate below the file number
assigned to the Registrant in connection with Rule 12g3-2(b):
82-_____________
AstraZeneca PLC
INDEX
TO EXHIBITS
1.
Director/PDMR Shareholding
10 November 2025
Transaction by Person Discharging Managerial
Responsibilities
AstraZeneca PLC (the Company) announces that, on 7 November 2025,
it was notified by Pascal Soriot, Executive Director and Chief
Executive Officer, that, on 7 November 2025, Mr Soriot ceased to be
beneficially interested in 136,537 ordinary shares of $0.25 each in
the Company, following the gift of those shares to family members
for nil consideration.
Further details are set out in the attached notification, made in
accordance with the requirements of the EU Market Abuse Regulation
(as it forms part of UK law pursuant to the European Union
(Withdrawal) Act 2018).
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1
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Details of the person discharging managerial responsibilities /
person closely associated
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a)
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Name
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Pascal
Soriot
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2
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Reason for the notification
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a)
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Position/status
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Chief
Executive Officer
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b)
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Initial notification /Amendment
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Initial
notification
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3
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Details of the issuer, emission allowance market participant,
auction platform, auctioneer or auction monitor
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a)
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Name
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AstraZeneca
PLC
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b)
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LEI
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PY6ZZQWO2IZFZC3IOL08
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4
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Details of the transaction(s): section to be repeated for (i) each
type of instrument; (ii) each type of transaction; (iii) each date;
and (iv) each place where transactions have been
conducted
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a)
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Description of the financial instrument, type of
instrument
Identification
code
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Ordinary Shares of US$0.25 each in AstraZeneca PLC
GB0009895292
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b)
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Nature of the transaction
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Gift of
shares to family members for nil consideration
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c)
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Price(s) and volume(s)
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Price(s)
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Volume(s)
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0
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136,537
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d)
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Aggregated information
- Aggregated volume
- Price
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Not applicable - single transaction
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e)
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Date of the transaction
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7
November 2025
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f)
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Place of the transaction
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Outside
a trading venue
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AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led
biopharmaceutical company that focuses on the discovery,
development, and commercialisation of prescription medicines in
Oncology, Rare Diseases, and BioPharmaceuticals, including
Cardiovascular, Renal & Metabolism, and Respiratory &
Immunology. Based in Cambridge, UK, AstraZeneca's innovative
medicines are sold in more than 125 countries and used by millions
of patients worldwide. Please visit www.astrazeneca.com and
follow the Company on social media @AstraZeneca.
Contacts
For details on how to contact the Investor Relations Team, please
click here. For
Media contacts,
click here.
Matthew Bowden
Company Secretary
AstraZeneca PLC
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.
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AstraZeneca
PLC
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Date: 10 November 2025
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By: /s/
Matthew Bowden
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Name:
Matthew Bowden
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Title:
Company Secretary
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