• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI Executive AssistantNEW
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI Executive AssistantNEW
  • Settings
  • RSS Feeds
PublishGo to AppAI Helper
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI employees for your businessNEW
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form 8-K filed by Prothena Corporation plc

    6/18/25 4:16:46 PM ET
    $PRTA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $PRTA alert in real time by email
    8-K
    PROTHENA CORP PUBLIC LTD CO false 0001559053 0001559053 2025-06-13 2025-06-13
     
     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    FORM 8-K

     

     

    CURRENT REPORT

    Pursuant to Section 13 or 15(d)

    of the Securities Exchange Act of 1934

    Date of Report (Date of earliest event reported): June 13, 2025

     

     

    PROTHENA CORPORATION PUBLIC LIMITED COMPANY

    (Exact name of registrant as specified in its charter)

     

     

     

    Ireland   001-35676   98-1111119

    (State or other jurisdiction

    of incorporation)

     

    (Commission

    File Number)

     

    (I.R.S. Employer

    Identification Number)

     

    77 Sir John Rogerson’s Quay, Block C
    Grand Canal Docklands
    Dublin 2, D02 VK60, Ireland
    (Address of principal executive offices including Zip Code)

    011-353-1-236-2500

    (Registrant’s telephone number, including area code)

    N/A

    (Former name or former address, if changed since last report)

     

     

    Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

     

    ☐

    Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

     

    ☐

    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

     

    ☐

    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

     

    ☐

    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

    Securities registered pursuant to Section 12(b) of the Act:

     

    Title of each class

     

    Trading

    Symbol(s)

     

    Name of each exchange

    on which registered

    Ordinary Shares, par value $0.01 per share   PRTA   The Nasdaq Global Select Market

    Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

    Emerging growth company ☐

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

     

     
     


    Item 2.05

    Costs Associated with Exit or Disposal Activities.

    On June 18, 2025, Prothena Corporation plc (the “Company”) announced an approximate 63% reduction in its workforce to substantially reduce its operating costs to those necessary to support its remaining wholly-owned programs, its obligations to partnered programs, and its anticipated business development activities. This workforce reduction follows the Company’s May 23, 2025 announcement of its decision to discontinue further development of birtamimab. The Company expects the workforce reduction to be substantially complete by the end of the fourth quarter of 2025.

    Affected U.S. employees are eligible to receive severance payments and benefits under the Prothena Biosciences Inc Amended and Restated Severance Plan. Affected non-U.S. employees are eligible to receive statutory and/or contractual payments under the terms of their employment agreements and/or local legal requirements. In the case of certain senior executives, vesting of portions of their stock options will be accelerated and the post-employment exercise periods will be extended, pursuant to the terms of the option award agreements under which those stock options were granted.

    The Company expects to recognize approximately $16 to $20 million in total for severance and related benefits for employees laid off under the reduction in workforce and non-cash share-based compensation expense related to the acceleration of stock options. These charges are primarily one-time severance payments and are primarily cash charges. The Company may also incur other charges or cash expenditures not currently contemplated due to events that may occur as a result of, or associated with, the reduction in workforce.

    Additional details will be provided in the Company’s Quarterly Reports on Form 10-Q for the periods ending June 30, 2025, and September 30, 2025, and the Company’s Annual Report on Form 10-K for the period ending December 31, 2025.

     

    Item 5.02

    Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

    On June 18, 2025, the Company announced that in connection with the workforce reduction, the employment of Carol D. Karp, the Company’s Chief Regulatory Officer, and David A. Ford, the Company’s Chief People Officer, will terminate effective August 1, 2025. Such termination will trigger certain payments and benefits to Ms. Karp and Mr. Ford under the terms of the Prothena Biosciences Inc Amended and Restated Severance Plan and acceleration of a portion of their stock options and the post-employment exercise periods will be extended pursuant to the terms of their option award agreements under which those stock options were granted, all as described in the Company’s Definitive Proxy Statement on Schedule 14A filed with the SEC on March 28, 2025.

    Forward-Looking Statements

    This Current Report on Form 8-K contains forward-looking statements about the business prospects of the Company, including, without limitation, the number of employees impacted by the reduction in workforce and the Company’s expectations regarding the estimated costs, the timing of such costs, and the timing of completion of the reduction in workforce.

    These forward-looking statements are predictions and involve risks and uncertainties such that actual results may differ materially from these statements. These risks and uncertainties include, among others: the estimates of expenses associated with the reduction in workforce prove inaccurate; the Company incurs greater than estimated expenses in connection with the reduction in workforce; the Company’s business, financial condition or operating results are adversely affected by the reduction in workforce; and those described in the “Risk Factors” sections of our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on May 8, 2025, and discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the SEC. The Company undertakes no obligation to update publicly any forward-looking statements contained in this current report on Form 8-K as a result of new information, future events, or changes in our expectations.


    SIGNATURES

    Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

     

        PROTHENA CORPORATION PLC
    Dated: June 18, 2025     By:  

    /s/ Tran B. Nguyen

        Name:   Tran B. Nguyen
        Title:   Chief Strategy Officer and Chief Financial Officer
    Get the next $PRTA alert in real time by email

    Crush Q3 2025 with the Best AI Executive Assistant

    Stay ahead of the competition with Tailforce.ai - your AI-powered business intelligence partner.

    AI-Powered Inbox
    Context-aware email replies
    Strategic Decision Support
    Get Started with Tailforce.ai

    Recent Analyst Ratings for
    $PRTA

    DatePrice TargetRatingAnalyst
    5/28/2025$4.00Neutral → Underperform
    BofA Securities
    5/27/2025Outperform → Perform
    Oppenheimer
    5/27/2025$6.00Buy → Hold
    Jefferies
    5/27/2025Overweight → Neutral
    Cantor Fitzgerald
    12/20/2024$40.00Buy
    Chardan Capital Markets
    1/30/2024$68.00 → $38.00Buy → Neutral
    BofA Securities
    12/12/2023$62.00Buy
    Deutsche Bank
    4/24/2023$80.00Outperform
    SVB Securities
    More analyst ratings

    $PRTA
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • SEC Form 4 filed by Director Welch Daniel G

      4 - PROTHENA CORP PUBLIC LTD CO (0001559053) (Issuer)

      5/16/25 4:57:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4 filed by Director Selkoe Dennis J.

      4 - PROTHENA CORP PUBLIC LTD CO (0001559053) (Issuer)

      5/16/25 4:54:31 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4 filed by Director Kim Helen Susan

      4 - PROTHENA CORP PUBLIC LTD CO (0001559053) (Issuer)

      5/16/25 4:52:37 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    SEC Filings

    See more
    • SEC Form 8-K filed by Prothena Corporation plc

      8-K - PROTHENA CORP PUBLIC LTD CO (0001559053) (Filer)

      6/18/25 4:16:46 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 8-K filed by Prothena Corporation plc

      8-K - PROTHENA CORP PUBLIC LTD CO (0001559053) (Filer)

      6/16/25 7:30:24 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by Prothena Corporation plc

      SCHEDULE 13G/A - PROTHENA CORP PUBLIC LTD CO (0001559053) (Subject)

      6/5/25 7:43:51 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • Prothena Announces Corporate Restructuring

      Prothena Corporation plc (NASDAQ:PRTA) today announced that the Company has initiated an approximate 63% reduction in its workforce to substantially reduce its operating costs to those necessary to support its remaining wholly owned programs, its obligations to partnered programs, and its anticipated business development activities. "We have incredible Prothenians who are among the industry's most talented professionals and have dedicated their careers to advancing new treatments for patients," said Gene Kinney, Ph.D., President and Chief Executive Officer, Prothena. "I want to express my sincere gratitude to each Prothenian being affected by today's announcement and thank them for their

      6/18/25 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena's Partner Roche to Advance Prasinezumab into Phase III Development for Early-Stage Parkinson's Disease

      Data from Phase IIb PADOVA study and longer term follow-up data suggest clinical benefit on top of symptomatic treatment in early-stage Parkinson's disease Prasinezumab is a potential first-in-class anti-alpha-synuclein antibody, targeting a known biological driver of Parkinson's disease progression Parkinson's disease affects over 10 million people globally and significant unmet need remains Prothena Corporation plc (NASDAQ:PRTA) today announced partner Roche will advance prasinezumab, an investigational anti-alpha-synuclein antibody, into Phase III development in early-stage Parkinson's disease. This decision is informed by data from the Phase IIb PADOVA study and ongoing open-l

      6/16/25 1:06:00 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena Announces Phase 3 AFFIRM-AL Clinical Trial for Birtamimab in Patients with AL Amyloidosis Did Not Meet Primary Endpoint

      Birtamimab did not meet the primary endpoint of time to all-cause mortality or the secondary endpoints Birtamimab development will be discontinued, including stopping the open label extension of the AFFIRM-AL clinical trial Company will decrease ongoing operating expenses, including an expected substantial reduction in organizational size, and plans to provide a further update in June Prothena Corporation plc (NASDAQ:PRTA) today announced the Phase 3 AFFIRM-AL clinical trial evaluating birtamimab in patients with AL amyloidosis did not meet its primary endpoint (HR=0.915, p-value=0.7680). Based on these results, the Company will discontinue the development of birtamimab, including st

      5/23/25 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Prothena downgraded by BofA Securities with a new price target

      BofA Securities downgraded Prothena from Neutral to Underperform and set a new price target of $4.00

      5/28/25 8:10:50 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena downgraded by Oppenheimer

      Oppenheimer downgraded Prothena from Outperform to Perform

      5/27/25 9:09:16 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena downgraded by Jefferies with a new price target

      Jefferies downgraded Prothena from Buy to Hold and set a new price target of $6.00

      5/27/25 9:09:16 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Large owner Scully William P received a gift of 430,000 units of Ordinary Shares, bought $2,749,916 worth of Ordinary Shares (207,436 units at $13.26) and gifted 747,700 units of Ordinary Shares, decreasing direct ownership by 7% to 735,993 units (SEC Form 4)

      4 - PROTHENA CORP PUBLIC LTD CO (0001559053) (Issuer)

      5/2/25 10:29:05 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • Amendment: SEC Form SC 13G/A filed by Prothena Corporation plc

      SC 13G/A - PROTHENA CORP PUBLIC LTD CO (0001559053) (Subject)

      11/14/24 1:22:34 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Prothena Corporation plc

      SC 13G/A - PROTHENA CORP PUBLIC LTD CO (0001559053) (Subject)

      11/13/24 7:00:50 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Prothena Corporation plc

      SC 13G/A - PROTHENA CORP PUBLIC LTD CO (0001559053) (Subject)

      11/13/24 6:06:27 AM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Leadership Updates

    Live Leadership Updates

    See more
    • Prothena Reports Third Quarter 2024 Financial Results and Business Highlights

      Net cash used in operating and investing activities was $45.2 million and $102.5 million for the third quarter and first nine months of 2024, respectively; quarter-end cash and restricted cash position was $520.1 million PRX012, a potential single-injection once-monthly subcutaneous treatment, is designed to address the unmet need of millions of patients with presymptomatic or early symptomatic Alzheimer's disease; Prothena expects to report multiple clinical readouts starting in mid-2025 and continuing throughout the year from the ongoing Phase 1 ASCENT clinical trials Results from partner Roche evaluating prasinezumab in patients with early Parkinson's disease from the Phase 2 PASA

      11/12/24 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena Reports First Quarter 2024 Financial Results and Business Highlights

      Net cash used in operating and investing activities was $73.2 million in the first quarter of 2024; quarter-end cash and restricted cash position was $548.7 million Advanced potential best-in-class Alzheimer's disease portfolio: initial data supportive of ongoing Phase 1 clinical trial for PRX012, an anti-amyloid beta antibody; received FDA clearance for IND application and Fast Track designation for PRX123, a dual amyloid beta/tau vaccine; Phase 2 clinical trial initiated in patients with early Alzheimer's disease for BMS-986446 (formerly PRX005) by partner Bristol Myers Squibb Strengthened leadership position in the amyloidosis community with ongoing enrollment of the confirmatory

      5/8/24 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena Appoints David Ford to Newly Created Chief People Officer Position

      Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of investigational therapeutics built on protein dysregulation expertise, today announced that it has named David Ford to a newly created position of Chief People Officer, reporting to Prothena President and Chief Executive Officer Gene Kinney, PhD. In this role, Mr. Ford will be responsible for people, culture, and human resources strategy to drive the company's vision and overall growth strategy. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240304692974/en/David Ford, Chief People Officer, Prothena (Photo: Business Wire

      3/4/24 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PRTA
    Financials

    Live finance-specific insights

    See more
    • Prothena to Report First Quarter 2025 Financial Results on May 8

      Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of investigational therapeutics built on protein dysregulation expertise, today announced that it will report its first quarter 2025 financial results on Thursday, May 8, 2025, after the close of the U.S. financial markets. Consistent with past practice, the Company will not be conducting a conference call in conjunction with the financial results release on May 8. About Prothena Prothena Corporation plc is a late-stage clinical biotechnology company with expertise in protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of deva

      5/1/25 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena Reports Fourth Quarter and Full Year 2024 Financial Results, and Provides Financial Guidance and Business Highlights

      Net cash used in operating and investing activities was $47.8 million in the fourth quarter and $150.3 million for the full year of 2024; quarter-end cash and restricted cash position was $472.2 million The company expects cash guidance for the full year 2025 net cash used in operating and investing activities to be $168 to $175 million and expects to end the year with approximately $301 million in cash (midpoint) Topline results expected in 2Q 2025 from the confirmatory Phase 3 AFFIRM-AL clinical trial of birtamimab in patients with Mayo Stage IV AL amyloidosis being conducted under a SPA agreement with the FDA with a primary endpoint of all-cause mortality (time-to-event) at a statis

      2/20/25 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Prothena to Report Fourth Quarter and Full Year 2024 Financial Results on February 20, 2025

      Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of investigational therapeutics built on protein dysregulation expertise, today announced that it will report its fourth quarter and full year 2024 financial results on Thursday, February 20, 2025, after the close of the U.S. financial markets. The announcement will be followed by a live audio conference call at 4:30 PM ET. The conference call will be made available on the Company's website at www.prothena.com under the Investors tab in the Events and Presentations section. Following the live audio webcast, a replay will be available on the Company's website for at least 90 days. T

      2/13/25 4:05:00 PM ET
      $PRTA
      Biotechnology: Pharmaceutical Preparations
      Health Care