rcus-20240423

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

(Amendment No.__)


Filed by the Registrant			ý
Filed by a Party other than the Registrant			o

Check the appropriate box:


o			Preliminary Proxy Statement
o			Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
ý			Definitive Proxy Statement
o			Definitive Additional Materials
o			Soliciting Material Pursuant to § 240.14a-12

Arcus Biosciences, Inc.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

Payment of Filing Fee (Check all boxes that apply)


ý			No fee required.
o			Fee paid previously with preliminary materials.
o			Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

ARCUS BIOSCIENCES, INC.

3928 Point Eden Way

Hayward, CA 94545

(510) 694-6200

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held on June 6, 2024

Dear Stockholder:

You are cordially invited to attend the 2024 Annual Meeting of Stockholders (the "Annual Meeting"), of Arcus Biosciences, Inc., a Delaware corporation (“Arcus”). The Annual Meeting will be held on Thursday, June 6, 2024, at 8:30 a.m. Pacific Time. The Annual Meeting will be a completely virtual meeting of stockholders, which will be conducted via live webcast. You will be able to attend the Annual Meeting and submit your questions and vote your shares online during the meeting by visiting www.virtualshareholdermeeting.com/RCUS2024 and using your 16-digit control number to enter the Annual Meeting. The stockholder list and instructions on how stockholders of record can view the stockholder list will also be available during the Annual Meeting at www.virtualshareholdermeeting.com/RCUS2024. In addition, the stockholder list will be available for examination for any purpose germane to the Annual Meeting during normal business hours for ten days prior to the Annual Meeting at our corporate headquarters. The Annual Meeting will be held for the following purposes:

1.To elect the Board of Directors’ three nominees to hold office as Class III directors until the 2027 Annual Meeting of Stockholders and until their successors are duly elected and qualified.

2.To ratify the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as the independent registered public accounting firm of Arcus for its fiscal year ending December 31, 2024.

3.To approve, on an advisory basis, the compensation of Arcus’s named executive officers, as disclosed in this Proxy Statement.

4.To conduct any other business properly brought before the meeting.

These items of business are more fully described in the Proxy Statement accompanying this Notice.

The record date for the Annual Meeting is April 9, 2024. Only stockholders of record at the close of business on that date may vote at the meeting or any adjournment thereof.


Important Notice Regarding the Availability of Proxy Materials for the Stockholders’ Meeting to Be Held on Thursday, June 6, 2024. The Proxy Statement and Annual Report are available at www.proxyvote.com

By Order of the Board of Directors

/s/ Terry Rosen___

Terry Rosen, Ph.D.

Chief Executive Officer and Chairman of the Board of Directors

Hayward, California

April 23, 2024


You are cordially invited to attend our Annual Meeting virtually via live webcast at www.virtualshareholdermeeting.com/RCUS2024. Whether or not you expect to attend the meeting, please vote as soon as possible. You may vote over the Internet or by a toll-free telephone number. If, however, you requested to receive paper proxy materials, then you may vote by mailing a completed, signed and dated proxy card or voting instruction card in the envelope provided with the proxy card or voting instruction card. Please note that any stockholder attending the Annual Meeting that has received a 16-digit control number with their proxy materials may vote online during the meeting, even if the stockholder has already returned a proxy card or voting instruction card. Please see the instructions in the attached proxy statement and on your proxy card or voting instruction card, or on your Notice of Internet Availability of Proxy Materials.

ARCUS BIOSCIENCES, INC.

3928 Point Eden Way

Hayward, CA 94545

(510) 694-6200

PROXY STATEMENT

FOR THE ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 6, 2024

To be held virtually at www.virtualshareholdermeeting.com/RCUS2024

on Thursday, June 6, 2024 at 8:30 am Pacific

IMPORTANT NOTICE REGARDING THE INTERNET AVAILABILITY OF PROXY MATERIALS

FOR THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 6, 2024

This proxy statement and our annual report are available on our website at www.proxyvote.com. We intend to mail the Notice of Internet Availability of Proxy Materials on or about April 23, 2024 to all stockholders of record entitled to vote at the Annual Meeting.

MEETING AGENDA

Proposal No.

Proposal

Board Vote
Recommendation

To elect the Board of Directors’ three nominees to hold office as Class III directors until the 2027 Annual Meeting of Stockholders and until their successors are duly elected and qualified.

For each Arcus director nominee

To ratify the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as the independent registered public accounting firm of Arcus for its fiscal year ending December 31, 2024.

For

To approve, on an advisory basis, the compensation of Arcus’s named executive officers, as disclosed in this Proxy Statement.

For

Table of Contents


		Page
QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING		1
PROPOSAL 1 ELECTION OF DIRECTORS		7
	Director Nominees	8
	Other Directors	8
	Director Diversity	11
CORPORATE GOVERNANCE		13
	Independence of The Board of Directors	13
	Board Leadership Structure	13
	Role of the Board in Risk Oversight	13
	Meetings of The Board of Directors	13
	Information Regarding Committees of the Board of Directors	13
	Audit Committee	14
	Compensation Committee	15
	Nominating and Corporate Governance Committee	16
	Science Committee	17
	Stockholder Communications with The Board of Directors	17
	Code of Conduct and Ethics	17
	Corporate Governance Guidelines	17
	Severance Benefits	35
	Clawback Policy	17
	Hedging Policy	18
PROPOSAL 2 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM		19
	Principal Accountant Fees and Services	19
	Pre-Approval Policies and Procedures	19
PROPOSAL 3 ADVISORY VOTE ON EXECUTIVE COMPENSATION		20
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT		21
EXECUTIVE OFFICERS		23
EXECUTIVE COMPENSATION		25
	Compensation Discussion and Analysis	25
	Summary Compensation Table	30
	2023 Grants of Plan-Based Awards	31
	Outstanding Equity Awa rds at 2023 F is cal Year End	31
	2023 Option Exercises and Stock Vested	33
	Severance and Change in Control Benefits	33
	CEO Pay Ratio	35
	Pay versus Performance	36
	Compensation Committee Interlocks and Insider Participation	38
COMPENSATION OF DIRECTORS		39
EQUITY COMPENSATION PLAN INFORMATION		41
RELATED PERSON TRANSACTIONS		42
	Policies and Procedures for Related Party Transactions	42
	Certain Related-Person Transactions	42
HOUSEHOLDING OF PROXY MATERIALS		44
OTHER MATTERS		45

QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING

Why did I receive a notice regarding the availability of proxy materials on the internet?

Pursuant to rules adopted by the Securities and Exchange Commission (the “SEC”), we have elected to provide access to our proxy materials over the internet. Accordingly, we have sent you a Notice of Internet Availability of Proxy Materials (the “Notice”) because the Board of Directors (the “Board”) of Arcus Biosciences, Inc. ("Arcus") is soliciting your proxy to vote at the 2024 Annual Meeting of Stockholders (the "Annual Meeting"), including at any adjournments or postponements of the meeting. All stockholders will have the ability to access the proxy materials on the website referred to in the Notice or request to receive a printed set of the proxy materials. Instructions on how to access the proxy materials over the internet or to request a printed copy may be found in the Notice.

What is included in the proxy materials?

The proxy materials include:

•this proxy statement, which includes information regarding the proposals to be voted on at the Annual Meeting, the voting process, corporate governance, the compensation of our directors and certain executive officers, and other required information;

•our Annual Report on Form 10-K for the year ended December 31, 2023 ("Annual Report");

•the Notice; and

•the proxy card or a voting instruction card for the Annual Meeting (which you will receive if you have requested paper copies of this proxy statement and our Annual Report).

We intend to mail the Notice on or about April 23, 2024 to all stockholders of record entitled to vote at the Annual Meeting.

How do I attend the Annual Meeting?

We will be hosting the Annual Meeting only by means of a live audio webcast. There will not be a physical meeting location and you will not be able to attend the meeting in person physically. The live audio webcast will be held on Thursday, June 6, 2024, and will begin promptly at 8:30 a.m. local time. Online check-in will begin approximately 15 minutes prior to the start of the Annual Meeting. We encourage our stockholders to access the meeting in advance of the designated start time to have ample time for check-in procedures. To attend the Annual Meeting virtually via the internet, please visit www.virtualshareholdermeeting.com/RCUS2024. You will need the 16-digit control number included in the Notice, on the proxy card or on the voting instruction card.

Why are you holding a virtual Annual Meeting?

The Annual Meeting will be conducted via a live audio webcast and online shareholder tools. We have implemented the virtual format in order to facilitate stockholder attendance and participation from any location around the world, at no cost. However, you will bear any costs associated with your internet access, such as usage charges from internet access providers and telephone companies. A virtual annual meeting makes it possible for more stockholders (regardless of size, resources or physical location) to have direct access to information more quickly, while saving our stockholders time and money. We also believe that the online tools we have selected will increase stockholder communication. For example, the virtual format allows stockholders to communicate with us in advance of, and during, the Annual Meeting so they can ask us questions.

Who can vote at the Annual Meeting?

Stockholders of record and beneficial owners at the close of business on April 9, 2024 (the "Record Date"), will be able to vote their shares electronically during the Annual Meeting by using the 16-digit control number they should have received with their proxy materials. Instructions on how to vote while participating in the Annual Meeting live via the Internet are posted at www.virtualshareholdermeeting.com/RCUS2024. On the Record Date, there were 90,952,836 shares of common stock outstanding and entitled to vote.

If you do not have your 16-digit control number, you will be able to access and listen to the Annual Meeting, but you will not be able to vote your shares or submit questions during the Annual Meeting. See caption below titled “Attending the Annual Meeting as a Guest.”

Stockholder of Record: Shares Registered in Your Name

If on the Record Date, any of your shares were registered directly in your name with our transfer agent, Computershare Trust Company, N.A., then you are the "stockholder of record" for such shares. As a stockholder of record, you may vote such shares online at the meeting or vote by proxy. Whether or not you plan to attend the meeting, we urge you to vote by proxy to ensure your vote is counted.

Beneficial Owner: Shares Registered in the Name of a Broker or Bank

If on the Record Date, any of your shares were held, not in your name, but rather in an account at a brokerage firm, bank or other similar organization, then you are considered a "beneficial owner" since you are the beneficial owner of such shares held in “street name” (and not the stockholder of record). If you are a beneficial owner, the Notice will be forwarded to you by that organization. The organization holding your account is considered to be the stockholder of record for purposes of voting such shares at the Annual Meeting. As a beneficial owner, you have the right to direct your broker, bank or other agent regarding how to vote the shares in your account. You are also invited to attend the Annual Meeting. Beneficial owners as of the Record Date who want to be able to attend and vote such shares at the Annual Meeting can attend using the 16-digit control number found on the notice and instructions received from their broker or other nominee. Beneficial owners as of the Record Date who have not received a 16-digit control number should contact their broker or other nominee for instructions on how to vote.

Attending the Annual Meeting as a Guest

Guests may enter the Annual Meeting in “listen-only” mode by entering the Annual Meeting at www.virtualshareholdermeeting.com/RCUS2024 and entering the information requested in the “Guest Login” section. Guests will not have the ability to vote at the Annual Meeting.

Who can ask questions at the Annual Meeting?

If you are attending the Annual Meeting as a stockholder of record or as a beneficial owner, questions can be submitted by accessing the meeting center at www.virtualshareholdermeeting.com/RCUS2024, entering your 16-digit control number and following the instructions. Instructions on how to ask questions and participate in the Annual Meeting are posted at www.virtualshareholdermeeting.com/RCUS2024. Guests will not have the ability to ask questions during the Annual Meeting.

List of Stockholders

A list of stockholders entitled to vote at the Annual Meeting will be available for examination for any purpose germane to the Annual Meeting during normal business hours for ten days prior to the Annual Meeting at our corporate headquarters. Please email us at investorinfo@arcusbio.com to arrange a time to review. The stockholder list will also be available during the Annual Meeting at www.virtualshareholdermeeting.com/RCUS2024. Instructions on how stockholders of record can view the stockholder list during the Annual Meeting are posted at www.virtualshareholdermeeting.com/RCUS2024.

What am I voting on?

There are three matters scheduled for a vote:

•Election of the Board's three nominees for Class III director (Proposal 1);

•Ratification of appointment by the Audit Committee of the Board of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024 (Proposal 2).

•To approve, on an advisory basis, the compensation of our named executive officers as disclosed in the Proxy Statement (Proposal 3).

What if another matter is properly brought before the meeting?

The Board knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the meeting, it is the intention of the persons named in the accompanying proxy to vote, to the extent permitted by rules promulgated by the SEC, on those matters in accordance with their best judgment.

How do I vote?

You may either vote “For” all of the nominees to the Board or you may “Withhold” your vote for any nominee you specify. For the ratification of appointment by the Audit Committee of the Board (the "Audit Committee") of Ernst &

Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024, you may vote “For” or “Against” or abstain from voting. For the approval, on an advisory basis, of the compensation of our named executive officers, you may vote “For” or “Against” or abstain from voting.

The procedures for voting are fairly simple:

Stockholder of Record: Shares Registered in Your Name

If you are a stockholder of record (see "Who can vote at the Annual Meeting?—Stockholder of Record: Shares Registered in Your Name" above), you may vote online at the Annual Meeting, vote by proxy over the telephone, vote by proxy through the internet, or vote by proxy using a proxy card that you may request or that we may elect to deliver at a later time. Whether or not you plan to attend the meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the meeting and vote online even if you have already voted by proxy.

•To vote online during the Annual Meeting, attend the Annual Meeting at www.virtualshareholdermeeting.com/RCUS2024 and vote your shares during the Annual Meeting. You will need your 16-digit control number provided in the Notice or proxy card in order to gain access to the Annual Meeting.

•To vote using the proxy card, simply complete, sign and date the proxy card that may be delivered to you and return it promptly in the envelope provided. If you return your signed proxy card to us before the Annual Meeting, we will vote your shares as you direct.

•To vote over the telephone, dial toll-free 1-800-690-6903 using a touch-tone phone and follow the recorded instructions. You will be asked to provide the company number and control number from the Notice. Your telephone vote must be received by 11:59 p.m. Eastern Time, on June 5, 2024, to be counted.

•To vote through the internet, go to www.proxyvote.com to complete an electronic proxy card. You will be asked to provide the company number and control number from the Notice. Your internet vote must be received by 11:59 p.m. Eastern Time, on June 5, 2024, to be counted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

If you are a beneficial owner (see "Who can vote at the Annual Meeting?—Beneficial Owner: Shares Registered in the Name of a Broker or Bank" above) you should have received a notice or voting instruction card containing voting instructions from the broker, bank or other agent in whose name such shares are held, rather than from us. Simply follow the voting instructions in such notice or voting instruction card to ensure that your vote is counted. To vote online at the Annual Meeting, you can do so using the 16-digit control number found on the notice and instructions received from your broker or other agent. Beneficial owners as of the Record Date who have not received a 16-digit control number should contact their broker or other nominee for instructions on how to vote. Whether or not you plan to attend the Annual Meeting, please vote by proxy as directed in your Notice or voting instruction card as soon as possible to ensure your vote is counted. You may still attend the Annual Meeting and vote online during the meeting even if you have already voted by proxy.


Internet proxy voting may be provided to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your internet access, such as usage charges from internet access providers and telephone companies.

Can I vote my shares by completing and returning the Notice?

No. The Notice will, however, provide instructions on how to vote by telephone, by Internet, by requesting and returning a paper proxy card or voting instruction card, or by voting online at the Annual Meeting.

How many votes do I have?

On each matter to be voted upon, you have one vote for each share of common stock you own as of the Record Date.

If I am a stockholder of record and I do not vote, or if I return a proxy card or otherwise vote without giving specific voting instructions, what happens?

If you are a stockholder of record (see "Who can vote at the Annual Meeting?—Stockholder of Record: Shares Registered in Your Name" above) and do not vote by completing your proxy card by telephone, through the internet or online at the Annual Meeting, your shares will not be voted.

If you return a signed and dated proxy card or otherwise vote without marking voting selections, your shares will be voted, as applicable, “For” the election of all nominees for Class III director (Proposal 1), “For” the ratification of the independent registered public accounting firm (Proposal 2), and “For” the approval, on an advisory basis, of the compensation of our named executive officers (Proposal 3). If any other matter is properly presented at the meeting, your proxyholder (one of the individuals named on your proxy card) will vote your shares, to the extent permitted by rules implemented by the SEC, in accordance with the Board's recommendations.

If I am a beneficial owner of shares held in street name and I do not provide my broker or bank with voting instructions, may my broker or bank vote my shares?

If you are a beneficial owner (see "Who can vote at the Annual Meeting?—Beneficial Owner: Shares Registered in the Name of a Broker or Bank" above) and you do not instruct your broker, bank or other agent how to vote your shares, your broker, bank or other agent may still be able to vote your shares in its discretion. In this regard, under the rules of the New York Stock Exchange ("NYSE"), brokers, banks and other securities intermediaries that are subject to NYSE rules may use their discretion to vote your “uninstructed” shares with respect to matters considered to be “routine” under NYSE rules, but not with respect to “non-routine” matters. In this regard, Proposals 1 and 3 are considered to be “non-routine” under NYSE rules meaning that your broker may not vote your shares on those proposals in the absence of your voting instructions. However, Proposal 2 is considered to be a “routine” matter under NYSE rules meaning that if you do not return voting instructions to your broker by its deadline, your shares may be voted by your broker in its discretion on Proposal 2. However, if you attend the Annual Meeting using your 16-digit control number and vote your shares, then your vote will override any vote of your shares by your broker, bank or other agent.

Who is paying for this proxy solicitation?

We will pay for the entire cost of soliciting proxies. In addition to these proxy materials, our directors and employees may also solicit proxies in person, by telephone, or by other means of communication. Directors and employees will not be paid any additional compensation for soliciting proxies. We may also reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.

What does it mean if I receive more than one Notice?

If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on the Notices to ensure that all of your shares are voted.

Can I change my vote after submitting my proxy?

Yes. You can revoke your proxy at any time before the final vote at the meeting.

Stockholder of Record: Shares Registered in Your Name

If you are a stockholder of record (see "Who can vote at the Annual Meeting?—Stockholder of Record: Shares Registered in Your Name" above), you may revoke your proxy in any one of the following ways:

•submit another properly completed proxy card with a later date;

•grant a subsequent proxy by telephone or through the internet;

•send a timely written notice that you are revoking your proxy to our General Counsel at 3928 Point Eden Way, Hayward, CA 94545; and

•attend the Annual Meeting and vote online. Simply attending the meeting will not, by itself, revoke your proxy.

Your most current proxy card or telephone or internet proxy is the one that is counted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

If you are a beneficial owner (see "Who can vote at the Annual Meeting?—Beneficial Owner: Shares Registered in the Name of a Broker or Bank" above), you should follow the instructions provided by your broker, bank or other agent, or if you have your 16-digit control number you may attend the Annual Meeting and vote online. Simply attending the meeting will not, by itself, revoke your proxy.

When are stockholder proposals and director nominations due for next year’s Annual Meeting?

If you wish to submit a proposal to be considered for inclusion in the proxy materials we prepare for next year’s annual meeting, your proposal must be submitted in writing by December 20, 2024, to Arcus Biosciences, Inc., 3928 Point Eden Way Hayward, CA 94545, Attention: General Counsel. However, if our 2025 annual meeting of stockholders is held before May 7, 2025, or after July 3, 2025, then your proposal must be received a reasonable time before we print and mail our proxy statement for the 2025 annual meeting of stockholders.

If you wish to submit a proposal (including a director nomination) at the meeting that is not to be included in next year’s proxy materials, you must do so no earlier than February 6, 2025, and no later than March 8, 2025, to Arcus Biosciences, Inc., 3928 Point Eden Way Hayward, CA 94545, Attention: General Counsel. If such proposal is submitted after March 8, 2025 or before February 6, 2025, it will be considered untimely; provided, however, that if our 2025 annual meeting of Stockholders is held before May 7, 2025, or after August 5, 2025, then your proposal must be received no earlier than 120 days prior to such annual meeting and not later than the close of business on the later of (a) the 90th day prior to such meeting and (b) the 10th day following the day on which notice of the date of the 2025 annual meeting of Stockholders is mailed or public disclosure is made, whichever occurs first. You are also advised to review our bylaws, which contain a description of the information required to be submitted as well as additional requirements about advance notice of stockholder proposals and director nominations. Please refer to our bylaws for additional information required for your proposal (including a director nomination) to be considered.

In addition, to comply with the universal proxy rules, stockholders who intend to solicit proxies in support of director nominees other than our nominees must provide notice that sets forth the information required by Rule 14a-19 under the Securities Exchange Act of 1934 (as amended, the "Exchange Act") no later than April 7, 2025; provided, however, that, in the event that the annual meeting is held before May 7, 2025, or after July 3, 2025, for your notice to be timely, it must be so received by the Secretary not earlier than the close of business on the date the later of sixty (60) days prior to such annual meeting and the tenth (10th) day following the day on which public announcement of the date of such meeting is first made by us. Please refer to our bylaws Rule 14a-19 under the Exchange Act for additional information and requirements regarding stockholder proposals and director nominations.

We will not consider any proposal or nomination that is not timely or otherwise does not meet our bylaws and the SEC’s requirements for submitting a proposal or nomination, as applicable. We reserve the right to reject, rule out of order or take other appropriate action with respect to any proposal or nomination that does not comply with these and any other applicable requirements.

How are votes counted?

Votes will be counted by the inspector of election appointed for the meeting. For Proposal 1, the inspector of election will separately count the "For" and "Withhold" votes and the broker non-votes for each nominee. For proposals 2 and 3 votes the inspector of election will separately count the “For” and “Against” votes and the abstentions and broker non-votes for each proposal.

What are “broker non-votes”?

As discussed above, when a beneficial owner of shares held in street name does not give voting instructions to his or her broker, bank or other securities intermediary holding his or her shares as to how to vote on matters deemed to be “non-routine under NYSE rules, the broker, bank or other such agent cannot vote the shares. Even when such matters are deemed “routine,” the broker, bank or other such agent may choose not to exercise its discretionary power to vote such shares. These un-voted shares are counted as “broker non-votes.” Proposals 1 and 3 are considered to be “non-routine” under NYSE rules and we therefore expect broker non-votes to exist in connection with those proposals.

How many votes are needed to approve each proposal?

For Proposal 1, the election of Class III directors, the three nominees receiving the most “For” votes from the holders of shares present or represented by proxy and entitled to vote on the election of the Class III director will be elected. Only votes “For” will affect the outcome. “Withheld” and broker non-votes will have no effect.

To be approved, Proposal 2, ratification of the selection of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024, must receive “For” votes from the holders of a majority in voting power of the votes cast by shares present or represented by proxy and voted affirmatively or negatively on such matter. Only votes “For” or “Against” will affect the outcome. Abstentions and broker non-votes will have no effect.

To be approved, Proposal 3, approval of the compensation of our named executive officers, must receive “For” votes from the holders of a majority in voting power of the votes cast by shares present or represented by proxy and voted affirmatively or negatively on such matter. Only votes “For” or “Against” will affect the outcome. Abstentions and broker non-votes will have no effect.

What is the quorum requirement?

A quorum of stockholders is necessary to hold a valid meeting. A quorum will be present if the holders of at least a majority of the outstanding shares entitled to vote are present virtually at the virtual meeting, or represented by proxy. On the Record Date, there were 90,952,836 shares outstanding and entitled to vote. Thus, the holders of 45,476,419 shares must be present at the virtual meeting or represented by proxy at the virtual meeting to have a quorum.

Your shares will be counted towards the quorum only if you submit a valid proxy (or one is submitted on your behalf by your broker, bank or other nominee) or if you vote online at the virtual meeting. If there is no quorum, the chairman of the meeting or the holders of a majority of shares present at the virtual meeting or represented by proxy may adjourn the meeting to another date.

How can I find out the results of the voting at the Annual Meeting?

Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a current report on Form 8-K that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the meeting, we intend to file a Form 8‑K to publish preliminary results and, within four business days after the final results are known to us, file an additional Form 8-K to publish the final results.

PROPOSAL 1

ELECTION OF DIRECTORS

The Board is divided into three classes, and each class has a three-year term. The terms of the Class III directors expire at the Annual Meeting, the terms of the Class I directors expire at the 2025 annual meeting of stockholders and the terms of the Class II directors expire at the 2026 annual meeting of stockholders. Vacancies on the Board may be filled only by persons appointed by a majority of the remaining directors. A director appointed by the Board to fill a vacancy in a class, including vacancies created by an increase in the number of directors, shall serve for the remainder of the full term of that class and until the director’s successor is duly elected and qualified.

There are three Class III directors whose terms of office expire at the Annual Meeting. If elected at the Annual Meeting, each of the nominees would serve as Class III directors until the 2027 annual meeting and until his or her successor has been duly elected and qualified, or, if sooner, until his or her death, resignation or removal. Dr. Rosen and Ms. Falberg were previously elected to the Board by our stockholders in June 2021. Dr. Higgins was recommended for appointment to the Board by Gilead Sciences, Inc. ("Gilead"), in connection with their rights under the Investor Rights Agreement that we entered into with them (the "Investor Rights Agreement"), and was appointed in August 2021. We invite and encourage our directors and nominees for director to attend the Annual Meeting, but have no formal policy regarding their attendance at our annual meetings. All of the then-current members of the Board attended the 2023 annual meeting of stockholders.

Directors are elected by a plurality of the votes of the holders of shares present or represented by proxy and entitled to vote on the election of directors. Accordingly, the three nominees receiving the highest number of affirmative votes will be elected. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the three nominees named below. If any nominee becomes unavailable for election as a result of an unexpected occurrence, your shares will be voted for the election of a substitute nominee proposed by the Board. Each nominee has agreed to serve if elected. We have no reason to believe that any nominee will be unable to serve.

The following table sets forth information regarding our directors as of April 1, 2024:

NAME

CLASS

AGE

POSITION HELD WITH THE COMPANY

Terry Rosen, Ph.D.

III

Chief Executive Officer, Director and Chairman

Kathryn Falberg(1)(2)

III

Director

Linda Higgins, Ph.D.(4)

III

Director

Yasunori Kaneko, M.D.(1)(2)

Director

David Lacey, M.D.(2)(3)(4)

Director

Nicole Lambert(3)

Director

Patrick Machado, J.D.(3)

Director

Johanna Mercier

Director

Merdad Parsey, M.D., Ph.D.(4)

Director

Andrew Perlman, M.D., Ph.D.(1)(4)

Director

Antoni Ribas, M.D., Ph.D.(4)

Director

(1)Member of the Audit Committee.

(2)Member of the Compensation Committee.

(3)Member of the Nominating and Corporate Governance Committee.

(4)Member of the Science Committee.

Below we provide a brief biography of each nominee for election to a three-year term as a Class III Director at the Annual Meeting:

Kathryn Falberg has served as a member of the Board since September 2017. She served as the Executive Vice President and Chief Financial Officer of Jazz Pharmaceuticals plc (Nasdaq: JAZZ), a biopharmaceutical company, from March 2012 to March 2014, after serving as its Senior Vice President and Chief Financial Officer since December 2009. From 2001 through 2009, Ms. Falberg worked with a number of smaller companies while serving as a corporate director and audit committee chair for several companies. From 1995 to 2001, Ms. Falberg was with Amgen, Inc. (Nasdaq: AMGN), where she served in various roles including Senior Vice President, Finance and Strategy, Chief Financial Officer, Vice President, Chief Accounting Officer, and Vice President, Treasurer. Ms. Falberg also serves as a member of the boards of directors, and on the audit committee, of biopharmaceutical company Nuvation Bio Inc. (NYSE: NUVB) and is a member of the board of directors of The Trade Desk, Inc. (Nasdaq: TTD), a technology company. Ms. Falberg has previously served on the boards of directors of multiple companies including Tricida, Inc. from April 2018 to June 2023, Urogen Pharma Ltd. (Nasdaq: URGN), from May 2015 until June 2022, Aimmune Therapeutics, Inc. from May 2015 until its acquisition by Nestlé S.A. in October 2020, Sio Gene Therapies Inc. (f.k.a, Axovant Sciences, Ltd.) (Nasdaq: SIOX) from April 2017 until February 2018, BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) from July 2016 until June 2017, aTyr Pharma, Inc. (Nasdaq: LIFE) from July 2014 until May 2017, Medivation, Inc. from January 2013 until its acquisition by Pfizer Inc. in September 2016 and Halozyme Therapeutics, Inc. (Nasdaq: HALO) from May 2007 until May 2016. Ms. Falberg holds an M.B.A. in Finance and B.A. in Economics from the University of California, Los Angeles and is an inactive certified public accountant. We believe Ms. Falberg is able to make valuable contributions to the Board due to her extensive business experience as an executive in the pharmaceutical industry and her service as a director and audit committee member of various other companies.

Linda Higgins, Ph.D. has served as a member of the Board since August 2021. Dr. Higgins is currently the Senior Vice President Research, Strategy, Innovation and Portfolio at Gilead Sciences, Inc. (Nasdaq: GILD). Dr. Higgins joined Gilead in December 2010 and in her first nine years led its Biology group, leading a significant expansion of the therapeutic area scope and capabilities of the department. Prior to joining Gilead, Dr. Higgins previously served as the President & Chief Executive Officer of InteKrin Therapeutics from April 2007 until November 2010 and as Head of Research at Scios, Inc., a Johnson & Johnson company, from September 1991 until March 2007, where she provided leadership for drug discovery, preclinical development, and translational medicine. Dr. Higgins obtained her B.A. degree in Behavioral Physiology from Kenyon College and her Ph.D. in Neuroscience from the University of California, San Diego School of Medicine and conducted her post-doctoral research in Molecular Genetics at the Howard Hughes Medical Institute at the University of California, Berkeley. Dr. Higgins currently serves on the Supervisory Board of Galapagos NV (Nasdaq: GLPG) and the board of directors of Tizona Therapeutics. Dr. Higgins was selected to be appointed to the Board pursuant to the Investor Rights Agreement and we believe she is able to make valuable contributions to the Board due to her extensive research and business experience.

Terry Rosen, Ph.D. is our co-founder and has served as the Chairman of the Board since December 2017, our Chief Executive Officer since May 2015 and as a member of the Board since April 2015. Previously, Dr. Rosen co-founded (with Dr. Jaen) and served as the Chief Executive Officer of Flexus Biosciences, Inc. from October 2013 to April 2015, when it was acquired by Bristol-Myers Squibb. Prior to that, Dr. Rosen was at Amgen, Inc. (Nasdaq: AMGN), a biopharmaceutical company, from 2004 to January 2013 where he most recently served as Vice President of Therapeutic Discovery from 2011 to January 2013. He also worked at Tularik Inc., a biopharmaceutical company, from 1993 to 2004 when it was acquired by Amgen, Inc., Pfizer Central Research, a division of Pfizer Inc. (NYSE: PFE), a biopharmaceutical company, from 1987 to 1993, and Abbott Laboratories (NYSE: ABT), a health care company, from 1985 to 1987. Dr. Rosen serves on the Berkeley Board of Visitors and on the board of trustees of the Berkeley Foundation, the California Life Sciences Association, and the Salk Institute. He also serves on the boards of Epiodyne, Inc., Ideaya Biosciences, Inc. (Nasdaq: IDYA), Simcha Therapeutics Holding Company, LLC and Sonoma Biotherapeutics, Inc. Dr. Rosen holds a B.S. in Chemistry from the University of Michigan and a Ph.D. in Chemistry from the University of California, Berkeley. We believe that Dr. Rosen should serve as a director based on his position as one of our founders and as our Chief Executive Officer, his extensive experience in general management and business development and his experience in the field of biosciences.

THE BOARD OF DIRECTORS RECOMMENDS

A VOTE IN FAVOR OF EACH NOMINEE.

The following is a brief biography of each director who is not up for reelection at the Annual Meeting and whose term on the Board will continue as noted below:

Class I Directors Continuing in Office until the 2025 Annual Meeting

Andrew Perlman, M.D., Ph.D. has served as a member of the Board since December 2020. Dr. Perlman currently serves as Managing Director and Head of non-clinical Development of X-37, LLC, an artificial intelligence-enabled drug discovery company since November 2018. He is also Managing Director and Chief Medical Officer of Velocity Pharmaceutical Development LLC, a pharmaceutical company that acquires attractive drug candidates and rapidly advances them through a commercially relevant clinical proof-of-concept, a position he has held since 2011. Dr. Perlman also served as President of Vitesse Biologics, LLC, a biotech company focused on the development of antibody and protein-based therapeutics in the areas of immunology, hematology, and oncology, which was a joint collaboration among Velocity Pharmaceutical Development LLC, Shire plc and the Mayo Clinic, until its acquisition in December 2020. From 2004 to October 2016, Dr. Perlman was Chief Executive Officer at Innate Immune Inc., a biotech company focused on developing therapies for asthma and autoimmune diseases. From 1993 to 2004, Dr. Perlman served as Vice President and then Executive Vice President of Tularik Inc. (acquired by Amgen Inc.), except for nine months in 2002 when he served as Chief Executive Officer of Affymax Inc. At Tularik Inc., Dr, Perlman’s responsibilities included clinical trial design and implementation, business development and financing activities, culminating with Tularik Inc.'s acquisition by Amgen Inc. in 2004 for $1.3 billion. Dr. Perlman began his notable career in drug development at Genentech, Inc., where he played a key role in the development, FDA approval, and marketing of Nutropin, a human growth hormone, and was responsible for the development of Genentech’s portfolio of endocrine drugs and drug candidates. Dr. Perlman also serves as an advisor to various companies, including venture capital firms 8 LLC, Avestria Ventures Management LLC and V2M Capital LLC, and biotechnology companies Hexagon Bio, Inc., Hinge Bio, Inc., Mantra Bio,Inc., Shasqi, Inc., Acelot Inc. and Escalante, Inc. Dr. Perlman has a B.S. in Physics from MIT and an M.D. and Ph.D. in physiology from New York University. He did his Ph.D. research in the laboratory of Nobel laureate Professor Eric Kandel and received postgraduate clinical training at Stanford School of Medicine and NYU. From 1984 to 1987 he was an assistant professor at Stanford University where he engaged in clinical work, teaching and research on hypertension. We believe Dr. Perlman is able to make valuable contributions to the Board due to his extensive business, finance and development experience in the biopharmaceutical industry.

Antoni Ribas, M.D., Ph.D. has served as a member of the Board since October 2019. Dr. Ribas has also served as a member of the Scientific Advisory Board since its creation in 2015. Dr. Ribas is an internationally recognized physician-scientist who conducts translational and clinical research aimed at understanding how the immune system can be used to treat cancer. He has been a leader in the research and clinical development of multiple types of therapeutic agents, including immune checkpoint inhibitors, gene-engineered T cells, and BRAF-targeted therapies. His efforts have been instrumental in transforming the treatment paradigm for oncology patients, particularly those with malignant melanoma, having served as principal investigator for multiple trials, including those involving the breakthrough cancer therapy, Keytruda®. Dr. Ribas has served as Professor of Medicine, Surgery, and Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA) since July 2011, Director of the Tumor Immunology Program at the UCLA Jonsson Comprehensive Cancer Center since June 2010, and Director of the Parker Institute for Cancer Immunotherapy Center at UCLA since 2016. He was the President for the American Association for Cancer Research (AACR) from April 2020 to April 2021. Dr. Ribas has founded or advised several successful biopharma companies, such as Kite Pharma Inc. and Flexus Biosciences, Inc. Most recently, he co-founded PACT Pharma, Inc., a company developing personalized cancer neoantigen-targeted T cell therapies, together with Professors David Baltimore and Jim Heath and Arcus cofounders, Terry Rosen and Juan Jaen. Dr. Ribas received MD and Ph.D. degrees from the Universidad de Barcelona (Spain). He completed his internship and residency in medical oncology at the University Hospital Vall d’Hebron (Barcelona, Spain) and conducted postdoctoral research at UCLA. Following a fellowship in hematology/oncology in the Department of Medicine at UCLA, he has held numerous faculty and administrative positions at UCLA since 2001. Dr. Ribas has received a myriad of awards and honors, including the AACR-CRI Lloyd J. Old Award in Cancer Immunology, the AACR Richard and Hinda Rosenthal Award and the National Cancer Institute Outstanding Investigator Award. Dr. Ribas has also served on the board of directors of leading scientific organizations such as the AACR and the Society for Immunotherapy for Cancer. We believe Dr. Ribas is able to make valuable contributions to the Board due to his extensive experience in medicine and clinical research.

Patrick Machado, J.D. has served as a member of the Board since December 2019. Mr. Machado has over two decades of experience growing biopharmaceutical organizations from development through commercialization. He has extensive operational experience, having led finance, business development and legal functions at multiple companies. Mr. Machado co-founded and served as Chief Financial Officer and Chief Business Officer at Medivation, Inc. from August 2003 until his retirement in April 2014 and served as a member of Medivation’s board of directors from April 2014 until its acquisition by Pfizer Inc. in September 2016. During his tenure at Medivation, Mr. Machado helped lead the company

through substantial growth and challenges, providing strong leadership during the clinical development and successful commercial launch of XTANDI® in prostate cancer. Prior to Medivation, Mr. Machado worked at ProDuct Health, Inc. from 1998 until 2001 where he held positions as Chief Financial Officer, Senior Vice President of Business Development and General Counsel; Mr. Machado was also responsible for working with national health plans in the U.S. to expand access to patients in need of ductal lavage. Earlier in his career, Mr. Machado served as chief legal counsel to the Chiron Technologies business unit at Chiron Corporation from 1996 until 1998 and led the transaction teams for all substantial Chiron Technologies collaborations. Prior to joining Chiron, Mr. Machado worked for Morrison & Foerster LLP from 1990 until 1996, a leading international law firm, and for the Massachusetts Supreme Judicial Court from 1989 until 1990. Mr. Machado also serves as a member of the board of directors of Adverum Biotechnologies, Inc. (Nasdaq: ADVM), Xenon Pharmaceuticals (Nasdaq: XENE) and ACELYRIN, Inc. (Nasdaq: SLRN). Mr. Machado also serves on the board of Chimerix, Inc. (Nasdaq: CMRX) since June 2014; however, he has resigned from the Chimerix board and from the audit committee of the Chimerix board effective as of the date of Chimerix’s next annual meeting, scheduled for June 20, 2024. Mr. Machado previously served on the board of directors of Turnstone Biologics Corp. (Nasdaq: TSBX) from August 2018 until April 2024, Sio Gene Therapies Inc. (f.k.a. Axovant Sciences, Inc.) (Nasdaq: SIOX) from June 2017 until February 2018, Endocyte, Inc. from February 2018 until December 2018, Rocket Pharmaceuticals, Inc. (f.k.a. Inotek Pharmaceuticals Corporation) (Nasdaq: RCKT) from August 2016 until January 2018, Principia Biopharma Inc. from June 2019 until its acquisition by Sanofi S.A. in September 2020, Roivant Sciences Ltd. (Nasdaq: ROIV) from October 2016 until June 2022, SCYNEXIS, Inc. (Nasdaq: SCYX) from October 2016 until June 2022 and Turning Point Therapeutics, Inc. from May 2019 until its acquisition by Bristol-Myers Squibb Co. in September 2022. Mr. Machado received his J.D. degree from Harvard Law School and holds both a Bachelor of Science degree in Economics and a Bachelor of Arts degree in German from Santa Clara University in California. We believe Mr. Machado is able to make valuable contributions to the Board due to his extensive business experience as an executive and public company director in the pharmaceutical industry.

Yasunori Kaneko, M.D. has served as a member of the Board since May 2015. Dr. Kaneko was a Managing Director at Skyline Venture Partners, L.P., a venture capital firm, from January 1999 to January 2019. Dr. Kaneko previously served as Chief Financial Officer and Vice President, Business Development at Tularik, Inc., a biopharmaceutical company, at various times from 1992 until 1999. Dr. Kaneko served as a Senior Vice President and Chief Financial Officer of Ionis Pharmaceuticals, Inc. (Nasdaq: IONS), a pharmaceutical company, which went public in May 1991 during his tenure from 1991 to 1992. Dr. Kaneko began his career at Genentech, Inc., a biotechnology company, where he served in a business development role, from 1981 to 1987 and as head of corporate finance in the investment banking division of Paribas Capital Markets LTD, from 1987 to 1991. Dr. Kaneko is a member of the Stanford Interdisciplinary Life Sciences Council and serves on the board of Provigate Inc. Dr. Kaneko served on the board of Nippon Paint Holdings Co., Ltd. (TYO: 4612) from March 2018 to March 2020, and LeukoSite Inc., a biopharmaceutical company, from February 1998 until its merger with Millennium Pharmaceuticals, Inc. in December 1999. Dr. Kaneko received an undergraduate degree and a medical degree from Keio University in Tokyo, and an M.B.A. from Stanford Graduate School of Business. We believe Dr. Kaneko is able to make valuable contributions to the Board due to his educational background in medicine, as well as his experience in the life science, pharmaceutical and related financial industries.

Class II Directors Continuing in Office until the 2026 Annual Meeting

David Lacey, M.D. has served as a member of the Board since May 2020. From 1994 until his retirement in 2011, Dr. Lacey held various positions at Amgen Inc. (Nasdaq: AMGN), including Senior Vice President of Discovery Research. By the end of his tenure, he oversaw a research organization of approximately 1200 employees, encompassing four broad therapeutic areas: Inflammation, Oncology, Metabolic Disorders and Neurosciences that utilized both large and small molecules to interdict validated targets across these focus areas. Kepivance, Prolia, Xgeva, and Repatha were among a number of drugs that emerged from Amgen laboratories while under his supervision. Since July 2011, Dr. Lacey has provided services as a biopharmaceutical consultant to a number of private companies, academic institutions and venture capital firms through his company, David L. Lacey LLC. He currently serves on the board of directors of Atreca, Inc. (Nasdaq: BCEL), Nurix, Inc. (Nasdaq: NRIX) and Inbiomotion SL. Previously, Dr. Lacey served on the Boards of Directors of Argenx SE (Nasdaq: ARGX) from July 2014 until May 2021 and UNITY Biotechnology, Inc. (Nasdaq: UBX) from February 2018 to December 2020. He obtained both his B.A. in Biology and M.D. from the University of Colorado and received his formal training in Anatomic Pathology at Washington University in St. Louis, Missouri. We believe Dr. Lacey is able to make valuable contributions to the Board due to his extensive experience in drug discovery and management of large research organizations.

Johanna Mercier Ms. Mercier has served as a member of the Board since January 2024. Ms. Mercier has served as the Chief Commercial Officer of Gilead Sciences, Inc. (Nasdaq: GILD), a biopharmaceutical company, since May 2019. In her role at Gilead, she is responsible for overseeing the global commercialization of all of Gilead’s medicines throughout

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the product lifecycle. Under her leadership, Gilead works to ensure that patients around the world have access to the company’s transformational medicines. Prior to Gilead, she served in a number of executive leadership positions over 25 years at Bristol-Myer Squibb including as President, U.S. & Large Markets from September 2018 until May 2019, President, U.S. from August 2017 until October 2018 and President, European Markets, Australia & Canada from August 2016 until August 2017. In her time there, she gained broad experience across geographies and in all aspects of the commercial business and she successfully evolved the culture and drove strong commercial execution with double-digit growth and multiple launches that changed the standard of care in melanoma and renal cancers. Ms. Mercier holds a bachelor’s degree in biology from the University of Montreal and an MBA from Concordia University. She currently serves on the board of directors of Neurocrine Biosciences, Inc. (NASDAQ: NBIX) and the University of Southern California’s Leonard D. Schaeffer Center for Health Policy and Economics. Ms. Mercier was selected to be appointed to the Board pursuant to the Investor Rights Agreement and we believe she is able to make valuable contributions to the Board due to her extensive commercial experience.

Merdad Parsey, M.D., Ph.D. has served as a member of the Board since July 2020. Dr. Parsey is currently the Chief Medical Officer of Gilead Sciences, Inc. (Nasdaq: GILD), a biopharmaceutical company, where he is responsible for overseeing Gilead’s global clinical development and medical affairs organizations, a role he has held since November 2019. From October 2015 to November 2019, Dr. Parsey served as Senior Vice President of Early Clinical Development at Genentech, Inc., a biotechnology company, where he led clinical development for areas including inflammation, oncology and infectious diseases. Prior to Genentech, Dr. Parsey served as President and Chief Executive Officer of 3-V Biosciences Inc. (now Sagimet BioSciences Inc.) from September 2006 to October 2015. Prior to Sagimet BioSciences, Dr. Parsey held development roles at Sunovion Pharmaceuticals Inc. (f.k.a. Sepracor, Inc.) from 2004 to 2006, Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) from 2002 to 2004 and Merck & Co., Inc. (NYSE: MRK) from 1998 to 2000, and was Assistant Professor of Medicine and Director of Critical Care Medicine at the New York University School of Medicine from 2000 to 2002. Dr. Parsey completed his M.D. and Ph.D. at the University of Maryland, Baltimore, his residency in Internal Medicine at Stanford University and his fellowship in Pulmonary and Critical Care Medicine at the University of Colorado. He currently also serves on the boards of directors for Sagimet BioSciences Inc., TransCelerate BioPharma Inc., the Gilead Foundation and the Institute for Human Virology. Dr. Parsey was selected to be appointed to the Board pursuant to the Investor Rights Agreement and we believe he is able to make valuable contributions to the Board due to his extensive clinical development experience.

Nicole Lambert has served as a member of the Board since August 2021. Ms. Lambert has served as the Chief Operating Officer of Myriad Genetics, Inc. (Nasdaq: MYGN), a genetic testing and precision medicine company, since December 2021, where she is responsible for accelerating the company’s transformation and growth plans, elevating products to their full potential, and implementing operational efficiencies to better serve patients and healthcare providers. Ms. Lambert served in various roles since joining Myriad Genetics in 2001 including Group President of Myriad Oncology, Myriad Women’s Health and Myriad International from March 2019 until December 2021, General Manager for Myriad Genetics' Oncology business from July 2018 to February 2019, and General Manager for its Urology business unit from June 2015 to June 2018. Prior to Myriad Genetics, she was a genetic councilor at Laboratory Corporation of America Holdings from February 2000 to May 2001. Ms. Lambert received her bachelor's degree in Biology and Sociology from Boston College and her master’s degree in Genetic Counseling from Mt. Sinai School of Medicine at New York University. We believe Ms. Lambert is able to make valuable contributions to the Board due to her extensive commercial experience.

Director Diversity

While we do not have a formal policy with respect to diversity, the Board values overall diversity among members of the Board in order to provide us with a range of viewpoints. Of our 11 current directors, four self-identify as female and four self-identify as being from an underrepresented community, meaning that they self-identify as Black, African American, Latino, Asian, Pacific Islander, Native American, Native Hawaiian, or Alaska Native or as lesbian, gay, bisexual or transgender.

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Board Diversity Matrix
Total number of directors	11
	Female	Male
Gender identity
Directors	4	7
Demographic background
Hispanic or Latinx	—	1
Asian	—	1
White	4	5
Other	—	—
Two or more races or ethnicities	—	—
LGBTQ+	2

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CORPORATE GOVERNANCE

Independence of The Board of Directors

As required under the NYSE listing standards, a majority of the members of a listed company’s board of directors must qualify as “independent,” as affirmatively determined by the board of directors. The Board consults with counsel to ensure that the Board’s determinations are consistent with relevant securities and other laws and regulations regarding the definition of “independent,” including those set forth in pertinent listing standards of the NYSE, as in effect from time to time.

Consistent with these considerations, after a review of all relevant identified transactions or relationships between each director, or any of his or her family members, and us, including our senior management and independent auditors, the Board has affirmatively determined that the following seven directors are independent directors within the meaning of the applicable NYSE listing standards: Ms. Falberg, Dr. Kaneko, Dr. Lacey, Ms. Lambert, Mr. Machado, Dr. Perlman and Dr. Ribas. In making this determination, the Board found that none of these directors had a material or other disqualifying relationship with us. Dr. Rosen is not independent by virtue of being one of our executive officers, and Dr. Higgins, Ms. Mercier and Dr. Parsey are not independent by virtue of their relationship with Gilead.

Board Leadership Structure

Our Bylaws and Corporate Governance Guidelines provide the Board with the flexibility to combine or separate the positions of Chairman of the Board and Chief Executive Officer. Dr. Rosen, our Chief Executive Officer, currently serves as our Chairman of the Board and Dr. Kaneko serves as our lead independent director. As lead independent director, Dr. Kaneko presides over periodic meetings of our independent directors, serves as a liaison between our Chief Executive Officer and the independent directors and performs such additional duties as the Board may otherwise determine and delegate. We believe that our current leadership structure is appropriate as it allows the Board to benefit from Dr. Rosen’s in-depth knowledge of our business in formulating and implementing strategic initiatives, provides a unified leadership to confront challenges facing our business, and enhances our ability to communicate our message and strategy clearly and consistently to stockholders. We will continue to periodically review our leadership structure and may make changes in the future if appropriate.

Role of the Board in Risk Oversight

One of the key functions of the Board is informed oversight of our risk management process. In particular, the Board is responsible for monitoring and assessing strategic risk exposure. Our executive officers are responsible for the day-to-day management of the material risks we face. The Board administers its oversight function directly as a whole, as well as through various standing committees that address risks inherent in their respective areas of oversight. Our Audit Committee oversees the management of risks associated with our financial reporting, accounting, auditing and cybersecurity matters; the Compensation Committee of the Board (the "Compensation Committee") oversees the management of risks associated with our compensation policies and programs; the Nominating and Corporate Governance Committee of the Board (the "Nominating and Corporate Governance Committee") oversees the management of risks associated with director independence, conflicts of interest, composition and organization of the Board and director succession planning; and the Science Committee of the Board (the "Science Committee") oversees the management of risks associated with our research and development strategy.

Meetings of The Board of Directors

The Board met nine times during the last fiscal year. As required under applicable NYSE listing standards, in fiscal year 2023, our independent directors met in regularly scheduled executive sessions at which only independent directors were present. All of our directors attended at least 75% of the aggregate number of meetings of the Board and of the committees on which they served, held during the portion of the last fiscal year for which they were directors or committee members, respectively.

Information Regarding Committees of the Board of Directors

During the year ended December 31, 2023, the Board had three committees: an Audit Committee, a Compensation Committee and a Nominating and Corporate Governance Committee. The following table provides membership and meeting information for each of the committees during our 2023 fiscal year (Drs. Rosen, Higgins, Parsey and Ribas, and Ms. Mercier did not serve on any committees in 2023):

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Name

Audit

Compensation

Nominating
and Corporate
Governance

Kathryn Falberg

—

Yasunori Kaneko, M.D.

—

David Lacey, M.D.

—

Patrick Machado, J.D.

—

Andrew Perlman, M.D., Ph.D.

—

Nicole Lambert

—

Total meetings during 2023 fiscal year

*Committee Chairperson

Each of the committees has authority to engage legal counsel or other experts or consultants, as it deems appropriate to carry out its responsibilities. The Board has determined that each member of each committee shown above meets the applicable NYSE rules and regulations regarding “independence.” In January 2024, the Board formed its Science Committee which is chaired by Dr. Perlman and has Dr. Higgins, Dr. Lacey, Dr. Parsey and Dr. Ribas as members. Below is a description of each committee of the Board.

Audit Committee

The Audit Committee is established by the Board in accordance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), to oversee our corporate accounting and financial reporting processes and audits of its financial statements. For this purpose, the Audit Committee performs several functions. The Audit Committee assists the Board with:

•oversight of the integrity of our consolidated financial statements;

•overseeing our cybersecurity risk management processes, including oversight and mitigation of risks from cybersecurity threats;

•our compliance with legal and regulatory requirements; the qualifications, independence and performance of the independent registered public accounting firm; and

•the design and implementation of our financial risk assessment and risk management.

Among other things, our Audit Committee is responsible for reviewing and discussing with our management the adequacy and effectiveness of our disclosure controls and procedures. The Audit Committee also discusses with our management and independent registered public accounting firm the annual audit plan and scope of audit activities, scope and timing of the annual audit of our consolidated financial statements, and the results of the audit, quarterly reviews of our consolidated financial statements and, as appropriate, initiates inquiries into certain aspects of our financial affairs. Our Audit Committee is responsible for establishing and overseeing procedures for the receipt, retention and treatment of any complaints regarding accounting, internal accounting controls or auditing matters, as well as for the confidential and anonymous submissions by our employees of concerns regarding questionable accounting or auditing matters. In addition, our Audit Committee has direct responsibility for the appointment, compensation, retention and oversight of the work of our independent registered public accounting firm. Our Audit Committee has sole authority to approve the hiring and discharging of our independent registered public accounting firm, all audit engagement terms and fees and all permissible non-audit engagements with the independent auditor. Our Audit Committee reviews and oversees all related person transactions in accordance with our policies and procedures.

The Audit Committee is currently composed of the three following directors: Ms. Falberg, Dr. Kaneko and Dr. Perlman. Each member of our Audit Committee is independent under the rules and regulations of the SEC and the listing standards of the NYSE applicable to audit committee members. Ms. Falberg is the chair of the Audit Committee. The Board has determined that each of Ms. Falberg and Dr. Kaneko qualify as an audit committee financial expert within the meaning of SEC regulations and meet the financial sophistication requirements of the NYSE. The Board has adopted a written Audit Committee charter that is available to stockholders on our website at www.arcusbio.com.

Report of the Audit Committee

The Audit Committee has reviewed and discussed the audited financial statements for the fiscal year ended December 31, 2023 with management of the company. The Audit Committee has discussed with the independent registered public accounting firm the matters required to be discussed by the applicable requirements of the Public Company

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Accounting Oversight Board (“PCAOB”) and the SEC. The Audit Committee has also received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the PCAOB regarding the independent accountants’ communications with the Audit Committee concerning independence, and has discussed with the independent registered public accounting firm the accounting firm’s independence. Based on the foregoing, the Audit Committee has recommended to the Board that the audited financial statements be included in the company’s annual report on Form 10‑K for the fiscal year ended December 31, 2023.


			Kathryn Falberg (Chair) Yasunori Kaneko, M.D. Andrew Perlman, M.D., Ph.D.

Compensation Committee

The Compensation Committee is composed of three directors: Ms. Falberg, Dr. Kaneko and Dr. Lacey. Each member of the Compensation Committee is independent (as independence is currently defined in NYSE Listed Company Manual Section 303A.02 as applied to compensation committee members). Dr. Kaneko is the chair of the Compensation Committee. The Board has adopted a written Compensation Committee charter that is available to stockholders on our website at www.arcusbio.com.

The Compensation Committee acts on behalf of the Board to review, adopt and oversee our compensation strategy, policies, plans and programs, including:

•establishment of corporate and individual performance objectives relevant to the compensation of our directors, officers and employees and evaluation of performance in light of these stated objectives;

•review and approval of the compensation and other terms of employment or service, including severance and change-in-control arrangements, of our Chief Executive Officer and the other executive officers and directors; and

•administration of our equity administration policy, equity compensation plans, pension and profit-sharing plans, deferred compensation plans and other similar plan and programs.

Compensation Committee Processes and Procedures

Typically, the Compensation Committee meets at least annually and with greater frequency if necessary. The Compensation Committee meets regularly in executive session. However, from time to time, various members of management and other employees as well as outside advisors or consultants may be invited by the Compensation Committee to make presentations, to provide financial or other background information or advice or to otherwise participate in Compensation Committee meetings. The Chief Executive Officer may not participate in, or be present during, any deliberations or determinations of the Compensation Committee regarding his compensation. The charter of the Compensation Committee grants the Compensation Committee full access to all books, records, facilities and personnel of Arcus. In addition, under the charter, the Compensation Committee has the authority to obtain, at the expense of Arcus, advice and assistance from compensation consultants and internal and external legal, accounting or other advisors and other external resources that the Compensation Committee considers necessary or appropriate in the performance of its duties. The Compensation Committee has direct responsibility for the oversight of the work of any consultants or advisers engaged for the purpose of advising the Compensation Committee. In particular, the Compensation Committee has the sole authority to retain, in its sole discretion, compensation consultants to assist in its evaluation of executive and director compensation, including the authority to approve the consultant’s reasonable fees and other retention terms. Under the charter, the Compensation Committee may select, or receive advice from, a compensation consultant, legal counsel or other adviser to the Compensation Committee, other than in-house legal counsel and certain other types of advisers, only after taking into consideration six factors, prescribed by the SEC and NYSE, that bear upon the adviser’s independence; however, there is no requirement that any adviser be independent.

The Compensation Committee has engaged Radford, Inc. (“Radford”), a nationally-recognized compensation consulting firm, to assist the Compensation Committee in developing appropriate incentive plans for our directors and executives on an annual basis, to provide the Compensation Committee with advice and ongoing recommendations regarding material executive compensation decisions, and to review compensation proposals of management. The Compensation Committee reviewed the independence of Radford, taking into consideration the six factors prescribed by the SEC and NYSE. Based on this assessment, the Compensation Committee determined that the engagement of Radford does not raise any conflicts of interest. In addition, the Compensation Committee evaluated the independence of its other

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outside advisors to the Compensation Committee, including outside legal counsel, considering the same independence factors.

Under its charter, the Compensation Committee may form, and delegate authority to, subcommittees as appropriate. In 2018, the Compensation Committee formed an Equity Committee, currently composed of Dr. Jaen, to which it delegated authority to grant, without any further action required by the Compensation Committee, equity awards to employees who are not officers of Arcus. The purpose of this delegation of authority is to enhance the flexibility of equity administration within Arcus and to facilitate the timely grant of equity awards to non-management employees, including any annual grants to continuing employees, within specified limits approved by the Compensation Committee.

The specific determinations of the Compensation Committee with respect to executive compensation for fiscal year 2023 are described in greater detail in the “Executive Compensation” section of this proxy statement.

Compensation Committee Report

The Compensation Committee of the Board of Directors of Arcus Biosciences, Inc. has reviewed and discussed with management the Compensation Discussion and Analysis contained in this proxy statement. Based on this review and discussion, the Compensation Committee has recommended to the Board that the Compensation Discussion and Analysis be included in this proxy statement and incorporated into Arcus Biosciences, Inc.’s annual report on Form 10-K for the fiscal year ended December 31, 2023.


			Yasunori Kaneko, M.D. (Chair) Kathryn Falberg David Lacey, M.D.

The material provided under "Compensation Committee Report" in this report is not “soliciting material”, is not deemed “filed” with the SEC and is not to be incorporated by reference in any of our filings under the Securities Act or the Exchange Act, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing.

Nominating and Corporate Governance Committee

The Nominating and Corporate Governance Committee is responsible for identifying, reviewing and evaluating candidates to serve as our directors (consistent with criteria approved by the Board), reviewing and evaluating incumbent directors, recommending to the Board for selection candidates for election to the Board, making recommendations to the Board regarding the membership of the committees of the Board, assessing the performance of the Board, and recommending to the Board a set of corporate governance principles for us.

The Nominating and Corporate Governance Committee is composed of three directors: Dr. Lacey, Ms. Lambert and Mr. Machado. Dr. Lacey is the chair of the Nominating and Corporate Governance Committee. All members of the Nominating and Corporate Governance Committee are independent (as independence is currently defined in NYSE Listed Company Manual Section 303A.02). The Board has adopted a written Nominating and Corporate Governance Committee charter that is available to stockholders on our website, www.arcusbio.com.

The Nominating and Corporate Governance Committee considers several factors in evaluating potential candidates for the Board. The director qualifications that the Nominating and Corporate Governance Committee has developed to date focus on what the Nominating and Corporate Governance Committee believes to be essential competencies to effectively serve on the Board, including possessing relevant expertise upon which to be able to offer advice and guidance to management, demonstrated excellence in his or her field, having the ability to exercise sound business judgment, having the commitment to rigorously represent the long-term interests of our stockholders, and having sufficient time to devote to our affairs. The Nominating and Corporate Governance Committee identifies potential candidates by using its network of contacts as well as solicits additional potential candidates from the Board.

The Nominating and Corporate Governance Committee does not have a formal policy with regard to the consideration of diversity in identifying director nominees, but the Nominating and Corporate Governance Committee strives to nominate directors with a variety of individual backgrounds and complementary skills so that, as a group, the Board will possess the appropriate talent, skills and expertise to oversee our business and operations.

The Nominating and Corporate Governance Committee will consider director candidates recommended by stockholders. Stockholders who wish to recommend individuals for consideration by the Nominating and Corporate Governance Committee to become nominees for election to the Board may do so by delivering a written recommendation to the Corporate Secretary at 3928 Point Eden Way, Hayward, CA 94545 at least 120 days prior to the anniversary date of the mailing of the proxy statement for the last annual meeting of stockholders and must include the following information:

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•name and address of the nominating stockholder;

•a representation that the nominating stockholder is a record holder;

•a representation that the nominating stockholder intends to appear in person or by proxy at the annual meeting to nominate the person or persons specified;

•information regarding each nominee that would be required to be included in a proxy statement;

•a description of any arrangements or understandings between the nominating stockholder and the nominee; and

•the consent of each nominee to serve as a director, if elected.

The Nominating and Corporate Governance Committee will evaluate candidates recommended by a stockholder in the same manner as candidates identified by any other person, including members of the Board.

Science Committee

The Science Committee is responsible for overseeing, on behalf of the Board, our research and development strategy, including with respect to our clinical programs and the capabilities of our product candidates. Among other responsibilities, the Science Committee:

•advises the Board on the direction of any progress made towards our research and development strategy;

•monitors the status, progress and outcomes of our key clinical trials; and

•reviews the potential effect of developments in the competitive scientific landscape and emerging science trends on our clinical programs.

The Science Committee is composed of directors: Dr. Higgins, Dr. Lacey, Dr. Parsey, Dr. Perlman and Dr. Ribas. Dr. Perlman is the chair of the Science Committee.

Stockholder Communications with The Board of Directors

Stockholders and any interested party may direct correspondence to the Board or an individual director, including Dr. Kaneko, our lead independent director, to our Corporate Secretary at our principal executive offices at 3928 Point Eden Way, Hayward, CA 94545. The Corporate Secretary will review all correspondence and will forward the communications on to the relevant individual director or the whole Board; however, the Corporate Secretary generally will not forward communications that are primarily solicitations for products or services, matters of a personal nature that are not relevant for stockholders, matters that are of a type that render them improper or irrelevant to the functioning of the Board, or requests for general information about Arcus.

Code of Conduct and Ethics

We have adopted the Arcus Biosciences, Inc. Code of Conduct and Ethics that applies to all officers, directors and employees. The Code of Conduct and Ethics is available on our website at www.arcusbio.com. If we make any substantive amendments to the Code of Conduct and Ethics or grants any waiver from a provision of the Code to any executive officer or director, Arcus will promptly disclose the nature of the amendment or waiver on its website or in a Current Report on Form 8-K.

Corporate Governance Guidelines

The Board adopted Corporate Governance Guidelines to document the governance practices we follow and to assure that the Board will have the necessary authority and practices in place to review and evaluate our business operations as needed and to make decisions that are independent of our management. The guidelines are also intended to align the interests of directors and management with those of Arcus’s stockholders. The Corporate Governance Guidelines set forth the practices the Board intends to follow with respect to Board composition and selection, Board meetings and involvement of senior management, Chief Executive Officer performance evaluation and succession planning and Board committees and compensation. The Corporate Governance Guidelines, as well as the charters for each committee of the Board, may be viewed at www.arcusbio.com.

Clawback Policy

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We maintain a Compensation Clawback Policy which is administered by our Compensation Committee. Under this policy, our Compensation Committee is required to recoup applicable excess incentive-based compensation received by our executive officers in the event of a covered financial restatement. This policy is designed to comply with the Dodd-Frank Wall Street Reform, Consumer Protection Act and requirements of NYSE Listed Company Manual Section 303A.14.

Hedging Policy

Our Insider Trading Policy provides that directors, officers and employees should not (i) engage in any short sales, (ii) acquire, sell, or trade in any interest or position relating to the future price of our securities, such as a put or call option or other derivative contracts or transactions, nor (iii) borrow from a brokerage firm, bank or similar entity in order to purchase our securities.

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PROPOSAL 2

RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Audit Committee has selected Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024, and has further directed that management submit the selection of its independent registered public accounting firm for ratification by the stockholders at the Annual Meeting. Ernst & Young LLP has audited our financial statements since 2016. Representatives of Ernst & Young LLP are expected to be present at the Annual Meeting. They will have an opportunity to make a statement if they so desire and will be available to respond to appropriate questions.

Neither our Bylaws nor other governing documents or law require stockholder ratification of the selection of Ernst & Young LLP as our independent registered public accounting firm. However, the Audit Committee is submitting the selection of Ernst & Young LLP to the stockholders for ratification as a matter of good corporate practice. If the stockholders fail to ratify the selection, the Audit Committee will reconsider whether or not to retain that firm. Even if the selection is ratified, the Audit Committee, in its discretion, may direct the appointment of different independent auditors at any time during the year if they determine that such a change would be in our best interests and the best interests of our stockholders.

The affirmative vote of the holders of a majority of the shares present or represented by proxy and cast on the matter at the Annual Meeting will be required to ratify the selection of Ernst & Young LLP.

Principal Accountant Fees and Services

The following table represents aggregate fees billed to us for the fiscal years end December 31, 2023 and 2022, by Ernst & Young LLP (in thousands):


	Fiscal Year Ended
	2023		2022
Audit Fees (1)	$	2,239	$	1,861
Audit-related Fees	—		—
Tax Fees (2)	60		72
All Other Fees(3)	7		4
Total Fees	$	2,306	$	1,937

(1)Consists of the aggregate fees billed for professional services rendered for the audit of our annual financial statements included in our Annual Reports on Form 10-K; review of our interim financial statements included in our quarterly reports on Form 10-Q; consultation on technical accounting matters; assistance with registration statements filed with the SEC; and the issuance of comfort letters and consents.

(2)Consists of fees billed for professional services rendered for tax compliance and studies of our research and development tax credits.

(3)Consists of fees billed in the indicated year for an annual subscription to Ernst & Young LLP's online resource library.

All fees described above were pre-approved by the Audit Committee.

In connection with our engagement of Ernst & Young LLP, we entered into an engagement agreement with Ernst & Young LLP that sets forth the terms by which Ernst & Young LLP will perform audit services for us. The terms of such agreement are subject to alternative dispute resolution procedures.

Pre-Approval Policies and Procedures

The Audit Committee must pre-approve audit and non-audit services rendered by our independent registered public accounting firm, Ernst & Young. Pre-approval may also be given as part of the Audit Committee’s approval of the scope of the engagement of the independent auditor or on an individual, explicit, case-by-case basis before the independent auditor is engaged to provide each service. The pre-approval of services may be delegated to one or more of the Audit Committee’s members, but the decision must be reported to the full Audit Committee at its next scheduled meeting. The Audit Committee has approved all services by Ernst & Young prior to performance of the services.

THE BOARD OF DIRECTORS RECOMMENDS

A VOTE IN FAVOR OF PROPOSAL 2.

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PROPOSAL 3

ADVISORY VOTE ON EXECUTIVE COMPENSATION

Under the Dodd-Frank Wall Street Reform and Consumer Protection Act and Section 14A of the Exchange Act, our stockholders are entitled to cast an advisory vote at the Annual Meeting to approve the compensation of our named executive officers as disclosed in this Proxy Statement. This vote is not intended to address any specific item of compensation, but rather the overall compensation of our named executive officers and the philosophy, policies and practices described in this Proxy Statement. Our stockholders have recommended, and the Board has approved, a frequency of each year for advisory votes on executive compensation. Accordingly, the next advisory vote on executive compensation will be at our 2025 Annual Meeting of Stockholders.

The compensation of our named executive officers subject to the vote is disclosed in the “Compensation Discussion and Analysis,” compensation tables, and related narrative disclosure contained in this Proxy Statement. Our executive compensation program is focused on pay-for-performance with a goal of providing competitive overall compensation that attracts and retains top performers and aligns their interests with those of our stockholders. Approximately 96% of the votes cast on the say-on-pay proposal at our 2023 annual meeting of stockholders voted in support of the compensation paid to our named executive officers for 2022. We are again requesting your non-binding vote on the following resolution:

“RESOLVED, that the compensation paid to the named executive officers of Arcus Biosciences, Inc., as disclosed pursuant to Item 402 of Regulation S-K, including the Compensation Discussion and Analysis, compensation tables and narrative discussion, is hereby APPROVED.”

Although the vote is an advisory vote only and is not binding on us or the Board, the Compensation Committee and the Board value your opinions and will consider the outcome of the vote in establishing compensation philosophy and making future compensation decisions. Your vote will serve as an additional tool to guide the Compensation Committee and Board in continuing to improve the alignment of our executive compensation programs with business objectives and performance and with the interests of our stockholders.

Vote Required; Recommendation of the Board of Directors

The affirmative vote of a majority of shares cast is required for approval of this proposal. Votes “For” and “Against” will affect the outcome. Abstentions and broker non-votes are not considered to be votes cast and therefore will have no effect.

THE BOARD OF DIRECTORS RECOMMENDS

A VOTE IN FAVOR OF PROPOSAL 3.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table presents information as to the beneficial ownership of our common stock as of March 1, 2024, for:

•each person, or group of affiliated persons, known by us to beneficially own more than 5% of our common stock;

•each named executive officer;

•each of our directors; and

•all executive officers and directors as a group.

Beneficial ownership is determined in accordance with the rules of the SEC and generally includes voting or investment power with respect to securities. Unless otherwise indicated below, to our knowledge, the persons and entities named in the table have sole voting and sole investment power with respect to all shares beneficially owned, subject to community property laws where applicable. Common stock (i) subject to options that are currently exercisable or exercisable within 60 days of March 1, 2024 and (ii) underlying restricted stock units that are scheduled to vest within 60 days of March 1, 2024, are deemed to be outstanding and to be beneficially owned by the person holding the options for the purpose of computing the beneficial ownership of that person (including for the purpose of computing beneficial ownership of all current directors and officers), but are not treated as outstanding for the purpose of computing the beneficial ownership of any other person.

Percentages of beneficial ownership of our common stock in the table is based on 90,868,496 shares of common stock issued and outstanding on March 1, 2024.


Name of Beneficial Owners	Shares Owned	Shares that May be Acquired Within 60 days	Total Shares Beneficially Owned	Percentage of Beneficial Ownership
5% Stockholders (other than directors and named executive officers):
Gilead Sciences, Inc. (1)	30,061,124	2,661,542	32,722,666	35.0	%
BlackRock, Inc. (2)	10,035,170	—	10,035,170	11.0	%
FMR LLC(3)	4,728,782	—	4,728,782	5.2	%
The Vanguard Group (4)	4,680,716	—	4,680,716	5.2	%
Directors and Named Executive Officers:
Terry Rosen, Ph.D. (5)	4,351,923	1,091,620	5,443,543	5.9	%
Robert C. Goeltz II	15,456	373,862	389,318	*
Juan Carlos Jaen, Ph.D. (6)	1,421,141	633,010	2,054,151	2.2	%
Jennifer Jarrett	50,279	1,485,031	1,535,310	1.7	%
Dimitry Nuyten, M.D., Ph.D.	13,820	121,127	134,947	*
Kathryn Falberg (7)	142,206	79,900	222,106	*
Linda Higgins, Ph.D.	—	—	—	*
Yasunori Kaneko, M.D. (8)	903,755	44,900	948,655	1.0	%
David Lacey, M.D.	42,452	85,900	128,352	*
Nicole Lambert	7,234	36,089	43,323	*
Patrick Machado, J.D.	10,100	94,900	105,000	*
Johanna Mercier	—	—	—	*
Merdad Parsey, M.D., Ph.D.	—	—	—	*
Andrew Perlman, M.D., Ph.D.	14,125	51,900	66,025	*
Antoni Ribas, M.D., Ph.D. (9)	23,703	99,900	123,603	*
All current directors and executive officers as a group (16 persons) (10)	7,039,065	4,745,773	11,784,838	12.3	%

*Represents beneficial ownership of less than one percent of the outstanding common stock.

(1)Based on Schedule 13D filed with the SEC on January 31, 2024 by Gilead. The number of shares that may be acquired within 60 days is the number of shares that may be acquired pursuant to the terms of the Third Amended and Restated Common Stock Purchase Agreement, dated January 29,

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2024 between Gilead and us, which number is the maximum that will cause Gilead’s beneficial ownership to be 35.0% subsequent to the issuance of such shares. The principal business address of Gilead is 333 Lakeside Drive, Foster City, California 94404.

(2)Based on Schedule 13G/A filed with the SEC on January 23, 2023 by BlackRock, Inc. Blackrock, Inc. has sole dispositive power with respect to all of these shares and sole voting power with respect to 9,783,260 of these shares. Blackrock Fund Advisors may also be deemed to beneficially own 5% or more of our outstanding shares of common stock. The principal business address of BlackRock, Inc. is 55 East 52nd Street, New York, NY 10055.

(3)Based on Schedule 13G filed with the SEC on February 9, 2024 by FMR LLC and Abigail P. Johnson. FMR LLC has sole dispositive power with respect to all of these shares and sole voting power with respect 4,728,058 of these shares. Abigail P. Johnson is deemed to have sole dispositive power with respect to all of these shares. The principal business address of FMR LLC and Abigail P. Johnson is 245 Summer Street, Boston, Massachusetts 02210.

(4)Based on Schedule 13G/A filed with the SEC on February 13, 2024 by The Vanguard Group, Inc. The Vanguard Group, Inc. has sole dispositive power with respect to 4,576,359 of these shares, shared dispositive power with respect to 104,357 of these shares and shared voting power with respect to 52,209 of these shares. The principal business address of The Vanguard Group, Inc. is 100 Vanguard Blvd., Malvern, PA 19355.

(5)Shares owned includes 632,974 shares of common stock held in family trusts in which Dr. Rosen has no pecuniary interest but retains voting and dispositive power.

(6)Shares owned includes 1,188,233 shares of common stock held by trusts.

(7)Shares owned includes 102,106 shares of common stock held by trusts.

(8)Shares owned consists of (a) 505,050 shares of common stock held by Kaneko Capital, LLC, (b) 252,524 shares of common stock held by Kaneko Investments, LLC, and (c) 146,181 shares of common stock held by trusts.

(9)Shares owned includes 8,553 shares of common stock held by trusts.

(10)Consists of the number of shares of common stock beneficially owned by all executive officers and directors as of March 1, 2024.

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EXECUTIVE OFFICERS

The following table sets forth information regarding our executive officers as of April 1, 2024:

NAME

AGE

POSITION HELD WITH THE COMPANY

Terry Rosen, Ph.D.

Chief Executive Officer, Director and Chairman

Robert C. Goeltz, II

Chief Financial Officer

Juan Carlos Jaen, Ph.D.

President and Director

Jennifer Jarrett

Chief Operating Officer and Director

Dimitry Nuyten, M.D., Ph.D.

Chief Medical Officer

Carolyn Tang

General Counsel

For a biography of Dr. Rosen, see “Proposal 1 – Election of Directors.”

Robert C. Goeltz II has served as our Chief Financial Officer since August 2020. Mr. Goeltz joined us from UNITY Biotechnology, Inc. (Nasdaq: UBX), a healthcare company focused on age-associated diseases, where he served as Chief Financial Officer and Senior Vice President from September 2017 to July 2020, in which position he was responsible for investor and public relations, accounting, financial planning and analysis, information systems, real estate, insurance, procurement and facilities. Prior to Unity, Mr. Goeltz was Chief Financial Officer and Senior Vice President at CytomX Therapeutics, Inc. (Nasdaq: CTMX), a biotechnology company focused on cancer therapeutics, from May 2015 to May 2017, in which position he was responsible for investor relations, finance, real estate, insurance, procurement, facilities and information systems. Prior to that, Mr. Goeltz served as Chief Financial Officer of Onyx Pharmaceuticals, Inc. after its acquisition by Amgen Inc., from October 2013 until May 2015. Previously, Mr. Goeltz held roles of increasing responsibility at Amgen Inc., including in Business Development, Commercial Finance, R&D Finance and Corporate Accounting from 2004 to 2013. He began his career working in the audit practice of Ernst & Young LLP. Mr. Goeltz received a B.B.A. in Business from Emory University and an M.B.A. from the UCLA Anderson School of Management. He is also a Certified Public Accountant (inactive).

Juan Carlos Jaen, Ph.D. is our co-founder and has served as our President since May 2015. Dr. Jaen also served as a member of the Board from April 2015 until January 2024. Previously, Dr. Jaen co- founded (with Dr. Rosen) and served as the President and Head of Research and Development at Flexus Biosciences, Inc. from October 2013 to April 2015, when it was acquired by Bristol-Myers Squibb. Prior to that, Dr. Jaen served as Senior Vice President of Drug Discovery and as the Chief Scientific Officer of ChemoCentryx, Inc., a biopharmaceutical company, from 2007 to September 2013. From 2004 to 2006, Dr. Jaen was Vice President of Chemistry at Amgen Inc. (Nasdaq: AMGN) and from 1996 to 2004, Dr. Jaen held positions as Director of Medicinal Chemistry and Vice President of Chemistry at Tularik, Inc. Prior to that, Dr. Jaen held several positions in drug discovery and program management, from 1983 to 1996, at the Parke-Davis Pharmaceutical Research division of Warner-Lambert Company, a pharmaceutical company. Dr. Jaen also serves on the board of directors of the Bella Charitable Foundation, Breakpoint Therapeutics GmbH, Hexagon Bio, Inc., R2M Pharma, Inc. and Shasqi, Inc. Dr. Jaen previously served on the board of directors of PACT Pharma, Inc. from October 2016 until October 2022. Dr. Jaen holds a B.S. in Chemistry from the Universidad Complutense de Madrid and a Ph.D. in Organic Chemistry from the University of Michigan.

Jennifer Jarrett has served as our Chief Operating Officer since October 2020. She also served as a member of the Board from January 2019 until January 2024. Prior to joining us, Ms. Jarrett served as Vice President, Corporate Development and Capital Markets at Uber, Inc. (NYSE: UBER), a technology company providing a platform for mobility, delivery and freight services, from January 2019 to October 2020 and prior to that, served as our Chief Operating and Financial Officer from June 2018 to January 2019, and as our Chief Business Officer and Chief Financial Officer from March 2017 to June 2018. From April 2016 to September 2016, Ms. Jarrett was the Chief Financial Officer of Medivation, Inc., a biopharmaceutical company, which was acquired by Pfizer Inc. Prior to that, Ms. Jarrett spent 20 years in investment banking, most recently as Managing Director at Citigroup from July 2010 to April 2016, where she was responsible for managing their west coast life sciences investment banking practice. Before that, Ms. Jarrett was a Director and Managing Director at Credit Suisse from 2000 to 2010, and an associate at Donaldson, Lufkin & Jenrette from 1998 to 2000. During her tenure as an investment banker, Ms. Jarrett covered biotechnology and pharmaceutical companies, primarily in the San Francisco Bay Area. She currently serves on the board of directors of Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX), Zura Bio Ltd (Nasdaq: ZURA), Cajal Neuroscience and LifeMine Therapeutics and previously served on the boards of directors of Arena Pharmaceuticals, Inc. from July 2017 until its acquisition by Pfizer in March 2022, Audentes Therapeutics from July 2017 until its acquisition by Astellas Pharma Inc. in January 2020, Radius Health, Inc. from May 2022 until its acquisition by Gurnet Point Capital and Patient Square Capital in August 2022 and Consonance- HFW Acquisition Corp. from December 2020 until its business combination with Surrozen Operating, Inc. in August 2021.

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Ms. Jarrett holds a B.A. in Economics, cum laude, from Dartmouth College and an M.B.A. from Stanford Graduate School of Business.

Dimitry S.A. Nuyten, M.D., Ph.D. has served as our Chief Medical Officer since August 2022. Prior to joining us, Dr. Nuyten served as Senior Vice President and Chief Medical Officer of Nektar Therapeutics (Nasdaq: NKTR), a biopharmaceutical company, from July 2021 to June 2022, in which role he was responsible for the development strategy and leading the development organization and the clinical development, clinical pharmacology, clinical operations, clinical and non-clinical pharmacology, biometrics and safety departments. Prior to Nektar he served as Chief Medical Officer of Aduro Biotech, Inc., a biopharmaceutical company, from May 2019 to until its merger with Chinook Therapeutics, Inc. in October 2020, in which role he was responsible for the company’s development strategy and operations. Following the merger, Dr. Nuyten served as a consultant to Chinook Therapeutics until December 2020. From July 2013 to April 2019, Dr. Nuyten was with Pfizer Inc. (NYSE: PFE), a global pharmaceutical and biotechnology company, most recently serving as Vice President and ImmunoOncology Development Leader from March 2017 to April 2019, in which role he was responsible for leading the clinical team and the clinical development and strategy for the immuno-oncology portfolio. From 2008 to June 2013, Dr. Nuyten was with Bristol-Myers Squibb, Co. (NYSE: BMY), a global biopharmaceutical company. Dr. Nuyten received his medical degree from the University of Groningen and his Ph.D. in Cancer Biology from the University of Amsterdam Medical School and trained as radiation-oncologist at the Netherlands Cancer Institute in Amsterdam, The Netherlands.

Carolyn Tang has served as our General Counsel since September 2019. Ms. Tang joined us in July 2017, and previously held the role of Vice President of Legal starting in August 2018 and Head of Legal from July 2017. From July 2015 to March 2017, Ms. Tang was Director of Securities and Transactions at Medivation, Inc., a biopharmaceutical company, where she was responsible for securities, corporate governance and strategic transactions until the company’s acquisition by Pfizer, Inc. From 2004 to 2015, Ms. Tang was at InterMune, Inc., a biotechnology company focused on pulmonology and orphan fibrotic diseases, ultimately having responsibility for the company’s global intellectual property portfolio, strategic transactions, and supporting the company’s corporate and securities activities, including the establishment and administration of its European subsidiaries, until InterMune’s acquisition by Roche Holdings, Inc. Ms. Tang received her law degree from Santa Clara University School of Law and her B.A. in Molecular and Cell Biology, with an emphasis in Neurobiology, from the University of California at Berkeley.

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EXECUTIVE COMPENSATION

Compensation Discussion and Analysis

This Compensation Discussion and Analysis provides an overview of the material components of our executive compensation program for the year ended December 31, 2023, for named executive officers, whose compensation is set forth in the Summary Compensation Table and other compensation tables contained in this Proxy Statement. For the year ended December 31, 2023, our “named executive officers” are:

•Terry Rosen, Ph.D., our Chief Executive Officer

•Robert C. Goeltz, our Chief Financial Officer

•Juan C. Jaen, Ph.D., our President

•Jennifer Jarrett, our Chief Operating Officer

•Dimitry S.A. Nuyten, M.D., Ph.D., our Chief Medical Officer

This discussion and analysis is intended to enhance your understanding of the information provided in the compensation tables below and to provide additional context regarding our overall executive compensation program.

Executive Summary

We are a clinical-stage biopharmaceutical company focused on creating best-in-class therapies. Using our robust and highly efficient drug discovery capability, we have created a significant portfolio of investigational products which are in clinical development, with our most advanced molecule, an anti-TIGIT antibody, in multiple Phase 3 registrational studies targeting lung and gastrointestinal cancers. Our deep portfolio of novel small molecules and enabling antibodies allows us to create highly differentiated therapies, which we are developing to treat multiple large indications. We expect our clinical-stage portfolio to continue to expand and to include molecules targeting immuno-oncology, cancer cell-intrinsic and immunological pathways. Our vision is to create, develop and commercialize highly differentiated therapies that have a meaningful impact on patients.

2023 Say-on-Pay Vote

At our 2023 annual meeting of stockholders, approximately 96% of the votes cast on the say-on-pay proposal voted in support of the compensation paid to our named executive officers for 2022. While this vote was only advisory and not binding, the Compensation Committee believes that the 2023 stockholder vote generally endorsed our compensation philosophy and the decisions made for 2022. As such, we did not make any significant changes to our core compensation philosophies and practices in 2023. We hold a say-on-pay vote on an annual basis.

2023 Business Highlights

The following summarizes key highlights of our corporate performance during our fiscal year ended on December 31, 2023:

◦Significantly advanced our late-stage domvanalimab and zimberelimab programs towards potential commercialization by successfully managing study start up and early enrollment activities for STAR-221 and STAR-121. As a result, both of these Phase 3 studies are enrolling faster than projected and are expected to complete enrollment in 2024.

▪Our clinical advances in STAR-221 triggered clinical milestones for domvanalimab and zimberelimab under our collaboration agreement with Taiho. As a result, Taiho became obligated to pay us $28 million.

◦Generated compelling data in an interim analysis of ARC-8, our Phase 1b study in metastatic pancreatic cancer evaluating quemliclustat plus chemotherapy with or without zimberelimab. Median overall survival (mOS) was 15.7 months for all patients treated with a 100 mg quemliclustat-based regimen (pooled analysis) and exceeds the historical benchmark data for chemotherapy alone. Furthermore, a 37% reduction in risk of death and a 5.9-month improvement in mOS was observed for patients treated with quemliclustat-based regimens when compared to a Synthetic Control Arm of 1:1 matched patients who were treated with gemcitabine/nab-paclitaxel in Phase 2 and 3 clinical studies in a post hoc analysis. The strength of this data supports further development of quemliclustat and we are working to initiate a Phase 3 trial in pancreatic cancer by early 2025.

◦Efficiently advanced casdatifan through dose escalation and completed enrollment in a first expansion cohort in 2023. In addition, we entered into a clinical trial collaboration with Exelixis for STELLAR-009, a Phase 1b/2 trial evaluating zanzalintinib, Exelixis’ next-generation TKI, in

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combination with casdatifan in patients with clear cell renal cell carcinoma. Patient enrollment for STELLAR-009 opened before the end of 2023.

◦We diversified our clinical pipeline with new molecules, AB598 and AB801, entering the clinic:

▪AB598 is being evaluated in ARC-25, a Phase 1/1b study. The dose escalation portion is in patients with advanced malignancies and the dose expansion portion will evaluate AB598 with and without zimberelimab and chemotherapy in lung and gastric cancers.

▪AB801 has been evaluated in ARC-26, a healthy volunteer study, and is being evaluated in ARC-27, a Phase 1b study. The dose escalation portion is in patients with advanced malignancies and the dose expansion phase will evaluate AB801 with and without chemotherapy and zimberelimab in non-small cell lung cancer.

◦We expanded our collaboration with Gilead to include two research-stage programs against targets that are applicable to inflammatory diseases. For each research program Gilead exercises its option at the earlier time point under the expanded collaboration, we will be eligible to receive up to $420 million in option and milestone payments as well as tiered royalties for each optioned program.

◦Ended the year with a cash runway into mid-2026, which was extended into 2027 in January 2024 following Gilead’s additional equity investment of $320 million.

Compensation Philosophy and Objectives

The goals of our executive compensation program are to align our executive officers’ compensation with our corporate objectives and the interests of our stockholders. To do this, we focus on the following principles to guide decisions regarding executive compensation:

•Competitive Total Compensation Package. We compete for qualified employees, including executive officers, both in the San Francisco Bay Area (where our principal offices are located) and in the pharmaceutical and biotechnology industries, where competition for talented employees is fierce. We strive to offer a market-competitive compensation package that enables us to attract and retain superior executive officers and other employees with outstanding skills and values who contribute to our long-term success.

•Pay-for-Performance. We structure our executive compensation program so that executives are appropriately incentivized to achieve our annual corporate goals and longer-term business strategies and objectives. The annual bonus and equity awards for our executive officers are determined based on an assessment of the company's performance and such executive officer’s contribution to the achievement of the company's goals and objectives.

•Alignment with Stockholders. We use equity-based awards to align executive incentives with the creation of stockholder value. For our executive officers, our equity awards are predominately weighted towards options as we believe that options provide a strong alignment with our stockholders’ interests because their entire value depends on future stock price appreciation; to a lesser extent we also grant restricted stock units “RSUs” as we believe that RSUs also promote retention and allow us to deliver value while using fewer authorized shares.

•Flexibility, Simplicity and Parity. Our compensation program is intended to be flexible so that we can adapt to rapid changes in the competitive environment for executives in the biotechnology industry and simple in design to facilitate communication, understanding and administration. We also strive to provide internal parity for similarly situated executives within the company.

•Avoidance of Excessive Perquisites. In general, we do not offer our executive officers any enhanced benefits or perquisites as compared to our overall employee population. However, from time-to-time, we may provide a perquisite if appropriate and also determined by our Compensation Committee to be aligned with the overall interests of the company.

Overview of Executive Compensation Process

Our Compensation Committee oversees the compensation policies, plans, and programs for all of our employees generally, but only reviews and specifically approves the compensation for our executive officers and Section 16 officers. In making its executive compensation determinations, our Compensation Committee considers recommendations from our Chief Executive Officer (except with respect to his own performance and compensation). The Compensation Committee considers our Chief Executive Officer’s input in executive sessions and can accept, reject or modify these

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recommendations in its discretion. The Compensation Committee may consult with compensation consultants, legal counsel and other advisors in designing our compensation program, including in evaluating the competitiveness of individual compensation packages.

A key objective of our executive compensation program is to ensure that the overall compensation packages we offer our executive officers remain competitive with the packages offered by companies with which we compete for executive talent. Accordingly, our Compensation Committee, with the assistance of its compensation consultant, Radford, has developed a peer group of companies to serve as the basis for comparing our executive compensation program to the market. The Compensation Committee annually reviews the composition of the peer group to account for changes in both our business and the businesses of the companies in the peer group, considering:

•Industry: biopharmaceutical companies, with a therapeutic focus on oncology;

•Stage of Development: clinical-stage companies, with an emphasis on companies in late-stage clinical development;

•Market Capitalization: market capitalization of between $500.0 million to $5.0 billion, representing a range of approximately one-third to three and one-third times our market capitalization at the time of review;

•Headcount: headcount between 150 and 1,500 employees, with such outer range representing approximately 3 times our size at the time of review; and

•Geography: geographically situated in a biotechnology hub within the U.S., with a preference for those located in Northern California.

Following this review, the Compensation Committee approved the peer group set forth below to help set executive compensation for our fiscal year 2023, which differed from the prior year peer group as three companies were added and four companies were removed. The changes to our peer group from the prior year are largely due to changes in stage of development and market capitalization.


Agios Pharmaceuticals, Inc.	Alector, Inc.	Allogene Therapeutics, Inc.
Apellis Pharmaceuticals, Inc.	Arrowhead Pharmaceutics, Inc.	Cytokinetics Inc.
Denali Therapeutics Inc.	Editas Medicine, Inc.	Fate Therapeutics Inc.
ImmunoGen, Inc.	Intella Therapeutics Inc.	Iovance Biotherapeutics, Inc.
Kura Oncology, Inc.	Mirati Therapeutics Inc.	Prothena Corporation Plc
REGENXBIO Inc.	Revance Therapeutics, Inc.	SpringWorks Therapeutics, Inc.
Syndax Pharmaceuticals Inc.	Xencor Inc.

Elements of Compensation

Our executive compensation program generally consists of three principal components:

•Base salary;

•Short-term incentives in the form of an annual cash bonus opportunity; and

•Long-term incentives in the form of equity incentive awards (stock options and RSUs).

As part of our pay-for-performance philosophy, a substantial portion of executive compensation is variable and at risk. However, we do not have any formal policies for allocating compensation among salary, cash bonus opportunity and equity incentives, or among cash and non-cash compensation. Instead, the Compensation Committee uses its judgment to establish a total compensation program for each executive officer that it believes is appropriate to achieve the goals of our executive compensation program and our corporate objectives.

Base Salary

Base salary is intended to provide financial security through a fixed amount of cash compensation to compensate our executive officers for performing their day-to-day duties and responsibilities. We believe this balances against the impact of having the remainder of their compensation at risk in the form of annual cash bonuses and equity-based incentive compensation. The Compensation Committee establishes base salary amounts based on a number of factors, including the market data from peer companies provided by our compensation consultant, Radford, generally targeting the 50th to 75th percentile. However, the Compensation Committee also considers the scope of the executive officer’s responsibilities,

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experience, achievements, leadership, teamwork and value to us. The Compensation Committee reviews the base salary of each of our executive officers on an annual basis.

For 2023, Dr. Rosen's base salary was increased from $400,000 to $650,000. The increase in 2023 is the first increase accepted by Dr. Rosen since 2019.

For 2023, Mr. Goeltz received a base salary of $490,000 (an increase of $20,000 from the prior year), Dr. Jaen received $575,000 (an increase of $25,000 from the prior year), Ms. Jarrett received $575,000 (an increase of $25,000 from the prior year) and Dr. Nuyten, who joined us in August 2022, received $562,000 (an increase of $22,000 from his annualized base salary in 2022).

Cash Bonus

Cash bonus is intended to motivate and reward our executive officers for attaining rigorous annual corporate performance goals that relate to our key business objectives. The Compensation Committee generally reviews annually the target bonus amounts, calculated as a percentage of base salary, which are determined based upon competitive bonus opportunities among our peer group, generally targeting the 50th to 75th percentile. The Compensation Committee determines actual bonus amounts earned after the end of the year based on our overall performance and each individual’s achievement and contributions.

Our annual corporate performance goals are typically established around the beginning of each year. Management prepares a set of goals covering corporate, development and financial objectives and key activities, which is then reviewed and, following any modification the Compensation Committee deems appropriate, approved by our Compensation Committee. For 2023, our Compensation Committee approved corporate performance goals, which included:

•ensure timely start-up activities and strong early enrollment for key Phase 3 studies, including STAR-121 and STAR-221;

•present data from ARC-7 and EDGE-Gastric to support enrollment in our Phase 3 studies evaluating domvanalimab and zimberelimab;

•generate proof of concept data for quemliclustat and etrumadenant to support advancement of the clinical programs;

•initiate a Phase 1b combination study with casdatifan and remain on track to initiate a Phase 3 study by early 2025;

•advance two development candidates into clinical development; and

•maintain a significant cash runway that extends through 2026.

We do not disclose the specific portions or weighting of these goals, because they include highly sensitive and competitive data, and therefore, we believe that such disclosure would result in competitive harm to us.

The Compensation Committee does not use a formula to calculate any individual’s performance. Rather, it evaluates the totality of the company’s achievements relative to its corporate goals, overall progress and performance and contribution towards the creation of long-term stockholder value, and each individual's contributions. Achievements considered by the Compensation Committee include the “2023 Business Highlights” discussed above and the 2023 bonuses approved by the Compensation Committee for each named executive officer are set forth below:


Name and Title	2023 Bonus Target (%)	2023 Bonus Target ($)	Bonus Payout for 2023 Performance ($)
Terry Rosen, Ph.D., Chief Executive Officer	85%	552,500	550,000
Robert C. Goeltz, II, Chief Financial Officer	45%	220,500	220,000
Juan Carlos Jaen, Ph.D., President	50%	287,500	300,000
Jennifer Jarrett, Chief Operating Officer	50%	287,500	300,000
Dimitry Nuyten, M.D., Ph.D., Chief Medical Officer	45%	252,900	250,000

The Compensation Committee considered our 2023 achievements, particularly the enrollment status of STAR-121 and STAR-221 in 2023 and the overall progress of our clinical development pipeline, which the Committee considered

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critical to the company’s success. In recognition of Dr. Rosen’s leadership of the company, the Compensation Committee awarded him a bonus in the amount set forth in the table above.

With respect to Mr. Goeltz, key performance highlights included the continuous assessment of our budget and cash forecast during 2023 which allowed us to efficiently assess strategic decisions around clinical programs with a high degree of confidence. Additionally, he led a strategic planning exercise to align a broad portfolio of molecules and clinical trials against a scenario analysis, including timing and other critical variables, with the corresponding capital requirements; the results of the exercise enabled us to evaluate the financial impact of the terms of our recent amendments to our agreements with Gilead, which transaction extended our cash runway by approximately 12 months. Mr. Goeltz's leadership, strategic planning and foresight are critical to ensuring that we optimize the financial benefits of and opportunities associated with our relationships with Gilead and other collaboration partners.

With respect to Dr. Jaen, key performance highlights included continued productivity of our discovery platform, including the expansion of the collaboration with Gilead to include two targets that are applicable to inflammatory disease and the continued development of the outstanding small molecule discovery team and its leadership. He also led the efforts resulting in two new molecules entering clinical development, including an AXL inhibitor that we believe is the first such inhibitor with the potency and selectivity against the target to truly evaluate the therapeutic benefit associated with this target and mechanism. His team also has continued to generate important translational data in support of our clinical programs, a notable example involved our CD73 inhibitor quemliclustat in ARC-8 (pancreatic cancer). He also works very closely with the clinical development group in bringing the biological and mechanism of action perspectives to decision making affecting our selections of combinations, settings and trial design.

With respect to Ms. Jarrett, key performance highlights included continued leadership of our corporate governance framework to support ongoing improvement in collaboration and cooperation amongst teams, as well as enhancing alignment with our counterparts at Gilead, working towards a seamless integration of our teams to enable the most efficient decision-making and cross-company execution of our joint clinical development plan. These efforts were evident in the expansion of the Gilead collaboration to include two new targets applicable to inflammatory disease. Ms. Jarrett’s leadership and efforts on the corporate development and the medical affairs fronts, both strategic and tactical, have laid the groundwork for an opportunity for us to fully leverage the advantages associated with our HIF-2a inhibitor casdatifan and enable its potential as a best-in-class agent as well as component in best-in-class combinations. She has also positioned us well to begin the work necessary to be ready to launch and commercialize our initial product candidates, balancing the needs to create the necessary human infrastructure with the opportunity to leverage this strength in our partner Gilead.

Dr. Nuyten continues to bolster the clinical team with high-quality hires and leads the team with a clear vision and operational framework. These efforts were important in the successful advancement of casdatifan and enrollment results seen in our STAR-221 and STAR-121 studies, the former of which we are operationalizing and is anticipated to be fully enrolled ahead of schedule. His team also worked with an external group to generate a robust synthetic control arm, crucial to the data analysis, for the ARC-8 dataset and also delivered an outstanding dataset for ARC-9, our randomized phase 2 trial in colorectal cancer, the results of which will be presented at a medical conference in 2024. Perhaps of greatest importance, given the promise of our most advanced program, the domvanalimab/zimberelimab (anti-TIGIT/anti-PD-1) combination, Dr. Nuyten led the generation of an interim analysis of our EDGE-Gastric trial (upper GI cancers), a dataset presented at ASCO Plenary, which provided proof of concept data for the anti-TIGIT mechanism in this setting and further data supporting the differentiation of domvanalimab from the other anti-TIGITs in late-stage development.

Equity Incentives

We believe that equity grants provide our executives with a strong link to our long-term performance, create an ownership culture and help to align the interests of our executives and our stockholders. Therefore, equity awards represent the largest at-risk component of our executive compensation program. For our 2023 annual equity awards, our Compensation Committee determined that the appropriate mix for our equity grants be split, with approximately 67% of the value delivered through stock options and 33% of the value delivered through RSUs. The Compensation Committee believes that this equity mix helps to ensure long-term performance and strong alignment with our stockholders’ interests because their value predominantly depends on future stock price appreciation. Including RSUs also promotes retention and allows us to deliver value while using fewer authorized shares.

In determining the aggregate value of the equity awards granted to our executive officers, the Compensation Committee considers a number of factors, including corporate and individual performance, current equity holdings and their retention value and total ownership, historical value of our stock, internal equity amongst executives and market data provided by Radford.

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For our 2023 annual equity awards, the Compensation Committee approved these awards at its meeting in the first quarter of 2023 following completion of our annual performance review process. We do not time the grant of our equity awards to be in advance of the announcement of any material information.

Other Benefits

Our executive officers are eligible to participate in our health and welfare plans to the same extent as are all full-time employees generally. We have established a 401(k) tax-deferred savings plan, which permits participants, including our executive officers, to make contributions by salary deduction pursuant to Section 401(k) of the Internal Revenue Code of 1986, as amended. We are responsible for administrative costs of the 401(k) plan. In 2022, we began providing a company match to all eligible employees. For the 2023 plan year, we matched 100% of the participant’s salary deferrals up to 6% of their salary and a maximum of $5,000 per participant for the plan year. In addition, we provided a health and wellness and commute/telecommute stipend of $300 per quarter for each eligible employee.

Summary Compensation Table

The following table shows compensation awarded to or paid to, or earned by, our named executive officers for the fiscal years ended December 31, 2023, 2022 and 2021:


Name and Principal Position	Year	Salary ($)		Bonus ($)		Stock Awards(1) ($)	Stock Options(2) ($)	Non-Equity Incentive Plan Compensation(3) ($)	All Other Compensation ($)		Total ($)
Terry Rosen, Ph.D. Chief Executive Officer and Director	2023	650,000		—		2,327,514	6,582,319	550,000	11,112		10,120,945
	2022	350,000	(4)	—		2,146,950	6,145,370	400,000	6,112		9,048,432
	2021	366,875	(4)	300,000	(5)	1,652,850	6,896,008	—	267,606	(6)	9,483,339
Robert C. Goeltz, II Chief Financial Officer	2023	490,000		—		748,680	2,120,458	220,000	8,694		3,587,832
	2022	470,000		—		511,965	1,396,675	270,000	5,294		2,653,934
	2021	435,000		—		459,125	1,847,145	175,000	2,810		2,919,080
Juan Carlos Jaen, Ph.D. President	2023	575,000		—		1,008,516	2,852,338	300,000	14,544		4,750,398
	2022	550,000		—		1,032,188	2,793,350	370,000	11,144		4,756,682
	2021	535,000		—		711,644	2,863,075	300,000	5,564		4,415,283
Jennifer Jarrett Chief Operating Officer	2023	575,000		—		1,008,516	2,852,338	300,000	8,694		4,744,548
	2022	550,000		—		1,032,188	2,793,350	370,000	5,294		4,750,832
	2021	525,000		—		14,692,000	—	300,000	3,242		15,520,242
Dimitry Nuyten, M.D., Ph.D. (7) Chief Medical Officer	2023	562,000		—		748,680	2,120,458	250,000	11,784		3,692,922
	2022	225,000		—		1,105,000	3,114,689	160,000	337		4,605,026

(1)The amount represents the aggregate grant date fair value of restricted stock units on the date of grant, computed in accordance with FASB ASC Topic 718. The valuation assumptions used in determining fair values for option awards are described in Note 8 to our financial statements included in our Annual Report.

(2)The amount represents the aggregate grant date fair value of stock options computed in accordance with FASB ASC Topic 718. The valuation assumptions used in determining fair values for option awards are described in Note 8 to our financial statements included in our Annual Report.

(3)The amounts disclosed represent cash bonuses earned upon achievement of annual corporate performance goals for the applicable year and were payable after the end of the year according to the terms of the bonus program, based on the company's overall performance and each individual's achievement and contributions.

(4)Dr. Rosen voluntarily agreed to reduce his salary from $400,000 for the fiscal years 2022 and 2021 to fund an employee meal program.

(5)Reflects a discretionary bonus paid in recognition of Dr. Rosen's leadership and performance that contributed to our 2021 achievements, particularly the validation of our programs with Gilead's option exercises.

(6)Includes $262,041 paid on Dr. Rosen's behalf for HSR filing fees and related payroll taxes.

(7)Dr. Nuyten joined our company August 2022.

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2023 Grants of Plan-Based Awards

The following table shows certain additional information regarding grants of plan-based awards to our named executive officers for the 2023 fiscal year:


			Estimated Future Payouts Under Non-Equity Incentive Plan Awards (1)			All Other Stock Awards: Number of Shares of Stock or Units	All Other Option Awards: Number of Securities Underlying Options	Exercise or Base Price of Option Award	Grant-Date Fair Value of Stock and Option Award (2)
Name	Award Type	Grant Date	Threshold ($)	Target ($)	Maximum ($)	(#)	(#)	($ per share)	($)
Terry Rosen, Ph.D.	Option	1/23/2023	—	—	—	—	429,000	22.02	6,582,319
	RSU	1/23/2023	—	—	—	105,700	—	—	2,327,514
	Bonus	N/A	—	552,500	—	—	—	—	—
Robert C. Goeltz, II	Option	1/23/2023	—	—	—	—	138,200	22.02	2,120,458
	RSU	1/23/2023	—	—	—	34,000	—	—	748,680
	Bonus	N/A	—	220,500	—	—	—	—	—
Juan Carlos Jaen, Ph.D.	Option	1/23/2023	—	—	—	—	185,900	22.02	2,852,338
	RSU	1/23/2023	—	—	—	45,800	—	—	1,008,516
	Bonus	N/A	—	287,500	—	—	—	—	—
Jennifer Jarrett	Option	1/23/2023	—	—	—	—	185,900	22.02	2,852,338
	RSU	1/23/2023	—	—	—	45,800	—	—	1,008,516
	Bonus	N/A	—	287,500	—	—	—	—	—
Dimitry Nuyten, M.D., Ph.D.	Option	1/23/2023	—	—	—	—	138,200	22.02	2,120,458
	RSU	1/23/2023	—	—	—	34,000	—	—	748,680
	Bonus	N/A	—	252,900	—	—	—	—	—

(1)Reflects the target award each named executive officer was eligible to receive. Actual amounts paid in early 2023 are presented in the Summary Compensation Table above. There were no threshold or maximum amounts established.

(2)Represents the grant-date fair value of each equity award, calculated in accordance with Topic 718.

Outstanding Equity Awards at 2023 Fiscal Year End

The following table shows certain information regarding outstanding equity awards of our named executive officers as of December 31, 2023:

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		Option Awards					Stock Awards
		Number of Securities Underlying Unexercised Options			Option Exercise Price ($)	Option Expiration Date	Number of Shares or Units That Have Not Yet Vested (#)		Market Value of Shares or Units That Have Not Yet Vested(1) ($)
Name	Grant Date	Exercisable (#)		Unexercisable (#)
Terry Rosen, Ph.D.	1/16/2019	200,000	(2)	—	10.36	1/15/2029	—		—
	1/17/2020	342,708	(3)	7,292	10.23	1/16/2030	—		—
	1/19/2021	204,167	(3)	75,833	36.73	1/18/2031	—		—
	3/8/2022	131,771	(3)	143,229	33.03	3/7/2032	—		—
	1/23/2023	98,313	(3)	330,687	22.02	1/22/2033	—		—
	6/4/2020	—		—	—	—	25,000	(8)	477,500
	1/19/2021	—		—	—	—	11,250	(9)	214,875
	3/8/2022	—		—	—	—	32,500	(9)	620,750
	1/18/2023	—		—	—	—	79,275	(9)	1,514,153
Robert C. Goeltz, II	8/3/2020	208,333	(4)	41,667	21.06	8/2/2030	—		—
	1/19/2021	54,688	(3)	20,312	36.73	1/18/2031	—		—
	3/8/2022	29,948	(3)	32,552	33.03	3/7/2032	—		—
	1/23/2023	31,671	(3)	106,529	22.02	1/22/2033	—		—
	1/19/2021	—		—	—	—	3,125	(9)	59,688
	3/8/2022	—		—	—	—	7,750	(9)	148,025
	1/23/2023	—		—	—	—	25,500	(9)	487,050
Juan Carlos Jaen, Ph.D.	1/16/2019	200,000	(2)	—	10.36	1/15/2029	—		—
	1/17/2020	195,833	(3)	4,167	10.23	1/16/2030	—		—
	1/19/2021	84,766	(3)	31,484	36.73	1/18/2031	—		—
	3/8/2022	59,896	(3)	65,104	33.03	3/7/2032	—		—
	1/23/2023	42,602	(3)	143,298	22.02	1/22/2033	—		—
	6/4/2020	—		—	—	—	13,750	(8)	262,625
	1/19/2021	—		—	—	—	4,843	(9)	92,501
	3/8/2022	—		—	—	—	15,624	(9)	298,418
	1/23/2023	—		—	—	—	34,350	(9)	656,085
Jennifer Jarrett	3/15/2017	181,166	(5)	—	1.23	3/14/2027	—		—
	1/4/2018	107,694	(5)	—	5.39	1/3/2028	—		—
	6/8/2018	161,114	(5)	—	16.95	6/7/2028	—		—
	1/14/2019	35,000	(5)	—	9.07	1/13/2029	—		—
	6/6/2019	35,000	(5)	—	7.99	6/5/2029	—		—
	6/4/2020	14,000	(5)	—	30.05	6/3/2030	—		—
	10/1/2020	712,500	(6)	187,500	17.17	9/30/2030	—		—
	3/8/2022	59,896	(3)	65,104	33.03	3/7/2032	—		—
	1/23/2023	42,602	(3)	143,298	22.02	1/22/2033	—		—
	1/19/2021	—		—	—	—	100,000	(10)	1,910,000
	3/8/2022	—		—	—	—	15,624	(9)	298,418
	1/23/2023	—		—	—	—	34,350	(9)	656,085
Dimitry Nuyten, M.D., Ph.D.	8/23/2022	56,667	(7)	113,333	26.00	8/22/2032	—		—
	1/23/2023	31,671	(3)	106,529	22.02	1/22/2033

SEC Form DEF 14A filed by Arcus Biosciences Inc.