UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

(Amendment No. )

NOTICE OF INTERNET AVAILABILITY OF PROXY MATERIALS

The Annual Meeting of Stockholders of Cardiff Oncology, Inc. will be held on June 26, 2025, at 9:00 a.m. local time at the Company’s offices located at

11055 Flintkote Avenue, San Diego, California 92121

PROXY STATEMENT AND 2024 ANNUAL REPORT ON FORM 10-K ARE AVAILABLE AT:

https://annualgeneralmeetings.com/crdf2025

Dear Stockholder:

The Annual Meeting of Stockholders of Cardiff Oncology, Inc. has been called to consider and act upon the following

matters:

Proposal 1: Election of seven (7) Directors;

Proposal 2: Ratification of BDO USA, P.C. as Cardiff Oncology’s independent registered public accountants for fiscal year ending December 31, 2025;

Proposal 3: Approve an amendment to the Company’s 2021 Omnibus Equity Incentive Plan to increase the number of shares issuable thereunder to 12,150,000 shares from 8,150,000 shares; and

Proposal 4: Approve, on an advisory basis, the compensation of the Company’s named executive officers.

Our Board of Directors recommends a vote “FOR” all nominees listed in proposal 1 and “FOR” proposals 2, 3 and 4.

You are receiving this communication because you hold shares in the company named above. Complete proxy materials,

including the proxy card, are available to you on-line at https://annualgeneralmeetings.com/crdf2025 or upon your request by e-mail or first-class mail. We encourage you to access and review all of the important information contained in the proxy materials before voting.

This is not a ballot. You cannot use this notice to vote your shares. You may vote on-line, by mail or in person. If you wish to vote on-line, you will need your “Control Number” (which can be found in the bottom right hand corner of this notice) and the web address, all of which will be included with or on the proxy card located on the Internet website stated above or mailed to you at your request. No other personal information will be required in order to vote in this manner. If you wish to vote by mail, simply print out the proxy card located on the Internet website stated above, mark the proxy card accordingly, sign and return it to us at the address indicated on the proxy card. If you wish to vote in person at the Annual Meeting of Stockholders, simply check the box on the proxy card that you plan to attend. Your proxy card will not be used if you vote in person. Please check the meeting materials for any special requirements for meeting attendance and how to obtain directions to the meeting.

Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting To Be Held on June 26, 2025:

To request a paper copy of these items:

Please clearly identify the items you are requesting; Cardiff Oncology, Inc., and your name along with the Control Number

located in the lower right hand corner of this notice and the name and address to which the materials should be mailed.

By Order of the Board of Directors

/s/ Dr. Rodney S. Markin MD, Ph.D. Chairman of the Board of Directors