SEC Form DEFA14A filed by Incyte Corp.

Step 1: Go to www.envisionreports.com/INCY. Step 2: Click on Cast Your Vote or Request Materials. Step 3: Follow the instructions on the screen to log in. www.envisionreports.com/INCY Online Go to www.envisionreports.com/INCY or scan the QR code — login details are located in the shaded bar below. Stockholder Meeting Notice 044YVA Important Notice Regarding the Availability of Proxy Materials for the Incyte Corporation Stockholder Meeting to be Held on June 10, 2025 Under Securities and Exchange Commission rules, you are receiving this notice that the proxy materials for the annual stockholders’ meeting are available on the Internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The 2025 Proxy Statement and the Annual Report on Form 10-K for the year ended December 31, 2024 are available at: Obtaining a Copy of the Proxy Materials – If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before May 29, 2025 to facilitate timely delivery. 2NOT Easy Online Access — View your proxy materials and vote. When you go online, you can also help the environment by consenting to receive electronic delivery of future materials. Step 4: Make your selections as instructed on each screen for your delivery preferences. Step 5: Vote your shares. Votes submitted electronically must be received by June 9, 2025 at 11:59 A.M. (EDT)

Here’s how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. — Internet – Go to www.envisionreports.com/INCY. Click Cast Your Vote or Request Materials. — Phone – Call us free of charge at 1-866-641-4276. — Email – Send an email to [email protected] with “Proxy Materials Incyte Corporation” in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by May 29, 2025. Incyte Corporation’s Annual Meeting of Stockholders will be held on June 10, 2025 at 1815 Augustine Cut-off, Wilmington, Delaware 19803, at 9:00 a.m. (EDT). Proposals to be voted on at the meeting are listed below along with the Board of Directors’ recommendations. The Board of Directors recommend a vote FOR EACH nominee listed and FOR Proposals 2, 3, 4, and 5: 1. Election of Directors: 01 - Julian C. Baker 02 - Jean-Jacques Bienaimé 03 - Otis W. Brawley 04 - Paul J. Clancy 05 - Jacqualyn A. Fouse 06 - Edmund P. Harrigan 07 - Katherine A. High 08 - Hervé Hoppenot 09 - Susanne Schaffert 2. Approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers. 3. Approve amendments of the Company’s Amended and Restated 2010 Stock Incentive Plan. 4. Approve an amendment of the Company’s 1997 Employee Stock Purchase Plan. 5. Ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for 2025. PLEASE NOTE – YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. If you wish to attend and vote at the meeting, please bring this notice with you. Stockholder Meeting Notice