SEC Form FWP filed by AbbVie Inc.

Filed pursuant to Rule 433

Dated February 26, 2026

Issuer Free Writing Prospectus supplementing the

Preliminary Prospectus Supplement dated
February 24, 2026 and the

Prospectus dated February 14, 2025
Registration No. 333-284980

Explanatory Note: This pricing term sheet corrects a typographical error in the Day Count Convention for the Floating Rate Notes and supersedes the pricing term sheet dated February 24, 2026.

This term sheet to the preliminary prospectus supplement dated February 24, 2026 should be read together with the preliminary prospectus supplement. The information in this term sheet supersedes the information contained in the preliminary prospectus supplement to the extent that it is inconsistent therewith.

AbbVie Inc.

Pricing Term Sheet

$750,000,000 Senior Floating Rate Notes due 2028 (the “Floating Rate Notes”)

$1,500,000,000 3.775% Senior Notes due 2028 (the “2028 Notes”)

$1,250,000,000 4.125% Senior Notes due 2031 (the “2031 Notes”)

$1,250,000,000 4.400% Senior Notes due 2033 (the “2033 Notes”)

$1,500,000,000 4.750% Senior Notes due 2036 (the “2036 Notes”)

$1,250,000,000 5.550% Senior Notes due 2056 (the “2056 Notes”)

$500,000,000 5.650% Senior Notes due 2066 (the “2066 Notes”)

Terms Applicable to Each Series of the Notes

Terms Applicable to Senior Floating Rate Notes due 2028

Terms Applicable to 3.775% Senior Notes due 2028

Terms Applicable to 4.125% Senior Notes due 2031

Terms Applicable to 4.400% Senior Notes due 2033

Terms Applicable to 4.750% Senior Notes due 2036

Terms Applicable to 5.550% Senior Notes due 2056

Terms Applicable to 5.650% Senior Notes due 2066

The Issuer has filed a registration statement (including a preliminary prospectus supplement and an accompanying prospectus) with the Securities and Exchange Commission (“SEC”) for the offering to which this communication relates.  Before you invest, you should read the prospectus in that registration statement and other documents that the Issuer has filed with the SEC, including the preliminary prospectus supplement, for more complete information about the Issuer and this offering.  You may get these documents for free by visiting the SEC website at www.sec.gov.  Alternatively, the Issuer, any underwriter or any dealer participating in the offering will arrange to send you the preliminary prospectus supplement and the accompanying prospectus if you request it by contacting J.P. Morgan Securities LLC collect at 1-212-834-4533, BofA Securities, Inc. at 1-800-294-1322, Morgan Stanley & Co. LLC at 1-866-718-1649, and Wells Fargo Securities, LLC toll-free at 1-800-645-3751.

*The Issuer expects to deliver the Notes against payment for the Notes on or about March 4, 2026, which will be the sixth business day following the date of the pricing of the Notes (this settlement cycle being referred to as “T+6”). Under Rule 15c6-1 of the Exchange Act, trades in the secondary market generally are required to settle in one business day, unless the parties to a trade expressly agree otherwise. Accordingly, purchasers who wish to trade Notes on the date of pricing will be required, by virtue of the fact that the Notes initially will settle in T+6, to specify alternative settlement arrangements to prevent a failed settlement.

**These Issuer ratings are not a recommendation to buy, sell or hold the Notes offered hereby. The ratings may be subject to revision or withdrawal at any time by the relevant rating agency. Each of the Issuer ratings included herein should be evaluated independently of any other Issuer rating.

Terms used but not defined herein shall have the meanings ascribed thereto in the Issuer’s preliminary prospectus supplement, dated February 24, 2026, to the Issuer’s prospectus, dated February 14, 2025.