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    SEC Form S-8 filed by 4D Molecular Therapeutics Inc.

    2/28/25 4:57:30 PM ET
    $FDMT
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $FDMT alert in real time by email
    S-8 1 d841501ds8.htm S-8 S-8

    As filed with the Securities and Exchange Commission on February 28, 2025

    Registration No. 333-   

     

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    FORM S-8

    REGISTRATION STATEMENT

    UNDER

    THE SECURITIES ACT OF 1933

     

     

    4D Molecular Therapeutics, Inc.

    (Exact name of registrant as specified in its charter)

     

     

     

    Delaware   47-3506994

    (State or other jurisdiction of

    incorporation or organization)

     

    (I.R.S. Employer

    Identification No.)

    5858 Horton Street #455

    Emeryville, California 94608

    (510) 505-2680

      94608
    (Address of Principal Executive Offices)   (Zip Code)

    2020 Incentive Award Plan

    2020 Employee Stock Purchase Plan

    2025 Employment Inducement Award Plan

    (Full title of the plan)

    David Kirn, M.D.

    Chief Executive Officer

    4D Molecular Therapeutics, Inc.

    5858 Horton Street #455

    Emeryville, California 94608

    (Name and address of agent for service)

    (510) 505-2680

    (Telephone number, including area code, of agent for service)

     

     

    Copies to:

    Mark V. Roeder, Esq.

    John C. Williams, Esq.

    Latham & Watkins LLP

    140 Scott Drive

    Menlo Park, CA 94025

    (650) 328-4600

     

     

    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

     

    Large accelerated filer   ☒    Accelerated filer   ☐
    Non-accelerated filer   ☐    Smaller reporting company   ☒
         Emerging growth company   ☐

     

     

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

     

     

     


    EXPLANATORY NOTE

    This Registration Statement on Form S-8 is being filed by 4D Molecular Therapeutics, Inc. (the “Registrant”) for the purpose of registering (1) an additional 2,289,625 shares of the Registrant’s common stock, par value $0.0001 (the “Common Stock”), issuable under the 2020 Incentive Award Plan as a result of the operation of an automatic annual increase provision therein, and 150,000 shares of the Registrant’s Common Stock, issuable under the 2020 Employee Stock Purchase Plan pursuant to the annual increase provision therein, and (2) 500,000 shares of the Registrant’s Common Stock, that may be offered or issued under the Registrant’s 2025 Employment Inducement Award Plan (the “Inducement Plan”).

    On February 3, 2025, the Registrant’s board of directors adopted the “Inducement Plan”) pursuant to which the Registrant reserved 500,000 shares of its common stock to be used exclusively for grants of awards to individuals who were not previously employees or directors of the Registrant, as an inducement material to the individual’s entry into employment with the Registrant within the meaning of Rule 5635(c)(4) of the Marketplace Rules of the Nasdaq Stock Market. The Inducement Plan provides for the grant of equity-based awards in the form of nonqualified stock options, restricted stock units, and other stock-based awards. The Inducement Plan was adopted by the Registrant’s board of directors without stockholder approval pursuant to Rule 5635(c)(4) of the Marketplace Rules of the Nasdaq Stock Market.

    PART I

    INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

    The information called for in Part I of Form S-8 is not being filed with or included in this Form S-8 (by incorporation by reference or otherwise) in accordance with the rules and regulations of the Securities and Exchange Commission (the “SEC”).

    PART II

    INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

    In this registration statement, 4D Molecular Therapeutics, Inc. is sometimes referred to as “Registrant,” “we,” “us” or “our.”

    Item 3. Incorporation of Documents by Reference.

    The SEC allows us to incorporate by reference the information we file with them, which means that we can disclose important information to you by referring you to those documents. The information incorporated by reference is considered to be part of this registration statement, and later information filed with the SEC will update and supersede this information. We hereby incorporate by reference into this registration statement the following documents previously filed with the SEC:

     

      •  

    our Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on February 28, 2025;

     

      •  

    our Current Reports on Form 8-K filed with the SEC on January  10, 2025 (solely with respect to Item 8.01) and February 10, 2025; and

     

      •  

    the description of our common stock set forth in our registration statement on Form 8-A filed with the SEC on December  8, 2020 including any amendment or report filed for the purpose of updating such description, including Exhibit 4.1 to our Annual Report on Form 10-K filed with the SEC on February 28, 2025.


    All documents that the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment to the registration statement which indicates that all of the shares of common stock offered have been sold or which deregisters all of such shares then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of the filing of such documents, except as to any portion of any future annual or quarterly report to stockholders or document or current report furnished under current Items 2.02 or 7.01 of Form 8-K, and exhibits furnished on such form that relate to such items, that is not deemed filed under such provisions. For the purposes of this registration statement, any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.

    Under no circumstances will any information filed under current Items 2.02 or 7.01 of Form 8-K, and exhibits furnished on such form that relate to such items, be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.

    Item 4. Description of Securities.

    Not applicable.

    Item 5. Description of Securities.

    Not applicable.

    Item 6. Indemnification of Directors and Officers.

    As permitted by Section 102 of the Delaware General Corporation Law, we have adopted provisions in our amended and restated certificate of incorporation (the “Certificate of Incorporation”) filed with the Secretary of State of the State of Delaware and our amended and restated bylaws (the “Bylaws”) that limit or eliminate the personal liability of our directors for a breach of their fiduciary duty of care as a director. The duty of care generally requires that, when acting on behalf of the corporation, directors exercise an informed business judgment based on all material information reasonably available to them. Consequently, a director will not be personally liable to us or our stockholders for monetary damages for breach of fiduciary duty as a director, except for liability for:

     

      •  

    any breach of the director’s duty of loyalty to us or our stockholders;

     

      •  

    any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

     

      •  

    any act related to unlawful stock repurchases, redemptions or other distributions or payment of dividends; or

     

      •  

    any transaction from which the director derived an improper personal benefit.

    These limitations of liability do not affect the availability of equitable remedies such as injunctive relief or rescission. Our Certificate of Incorporation also authorizes us to indemnify our officers, directors and other agents to the fullest extent permitted under Delaware law.

    As permitted by Section 145 of the Delaware General Corporation Law, our Bylaws provide that:

     

      •  

    we may indemnify our directors, officers and employees to the fullest extent permitted by the Delaware General Corporation Law, subject to limited exceptions;

     

      •  

    we may advance expenses to our directors, officers and employees in connection with a legal proceeding to the fullest extent permitted by the Delaware General Corporation Law, subject to limited exceptions; and

     

      •  

    the rights provided in our Bylaws are not exclusive.


    Our Certificate of Incorporation and our Bylaws provide for the indemnification provisions described above and elsewhere herein. We have entered or will enter into, and intend to continue to enter into, separate indemnification agreements with our directors and officers that may be broader than the specific indemnification provisions contained in the Delaware General Corporation Law. These indemnification agreements generally require us, among other things, to indemnify our officers and directors against certain liabilities that may arise by reason of their status or service as directors or officers, other than liabilities arising from willful misconduct. These indemnification agreements also generally require us to advance any expenses incurred by the directors or officers as a result of any proceeding against them as to which they could be indemnified. These indemnification provisions and the indemnification agreements may be sufficiently broad to permit indemnification of our officers and directors for liabilities, including reimbursement of expenses incurred, arising under the Securities Act of 1933, as amended, or the Securities Act.

    We have purchased and currently intend to maintain insurance on behalf of each and every person who is or was a director or officer of the company against any loss arising from any claim asserted against him or her and incurred by him or her in any such capacity, subject to certain exclusions.

    Item 7. Exemption from Registration Claimed.

    Not applicable.

    Item 8. Exhibits.

    EXHIBIT INDEX

     

             Incorporated by Reference         

    Exhibit

    Number

      Description    Form      Exhibit     Date Filed     

    Filed

    Herewith

     
      4.1   Amended and Restated Certificate of Incorporation of 4D Molecular Therapeutics, Inc.      8-K        3.1       12/15/2020     
      4.2   Amended and Restated Bylaws of 4D Molecular Therapeutics, Inc.      8-K        3.1       11/22/2023     
      4.3   Form of Common Stock Certificate.      S-1/A        4.2       12/07/2020     
      4.4   Form of Pre-Funded Warrant issued in conjunction with February 2024 offering.      8-K        4.1       2/9/2024     
      4.5   Form of Pre-Funded Warrant issued in conjunction with November 2024 exchange.      10-Q        4.4       11/13/2024     
      4.6   Form of Pre-Funded Warrant issued in conjunction with December 2024 exchange.      8-K        4.1       12/11/2024     
      5.1   Opinion of Latham & Watkins LLP.              X  
     23.1   Consent of Latham & Watkins LLP (included in Exhibit 5.1).              X  
     23.2   Consent of Independent Registered Public Accounting Firm.              X  
     24.1   Power of Attorney (included in the signature page to this registration statement).              X  
     99.1(a)#   4D Molecular Therapeutics, Inc. 2020 Incentive Award Plan.      S-8        99.2 (a)      12/15/2020     
     99.1(b)#   Form of Stock Option Grant Notice and Stock Option Agreement under the 2020 Incentive Award Plan.      S-1/A        10.2 (b)      12/07/2020     
     99.1(c)#   Form of Restricted Stock Award Grant Notice and Restricted Stock Award Agreement under the 2020 Incentive Award Plan.      S-1/A        10.2 (c)      12/07/2020     
     99.1(d)#   Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit Award Agreement under the 2020 Incentive Award Plan.      S-1/A        10.2 (d)      12/07/2020     
     99.2#   4D Molecular Therapeutics, Inc. 2020 Employee Stock Purchase Plan.      S-8        99.3       12/15/2020     
     99.3(a)#   4D Molecular Therapeutics, Inc. 2025 Employment Inducement Award Plan.     
    10-K
     
         10.19       2/28/2025     
     99.3(b)#   Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit Award Agreement under the 2025 Employment Inducement Award Plan.      10-K        10.20       2/28/2025     
     99.3(c)#   Form of Stock Option Grant Notice and Stock Option Agreement under the 2025 Employment Inducement Award Plan.      10-K        10.21       2/28/2025     
    107.1   Calculation of Filing Fee Table.              X  

     

    #

    Indicates management contract or compensatory plan.


    Item 8. Undertakings.

    1. The Registrant hereby undertakes:

    (a) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

    (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

    (ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement;

    (iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

    Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8 and the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.

    (b) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

    (c) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

    (d) That, for the purpose of determining liability of the Registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the undersigned Registrant undertakes that in a primary offering of securities of the undersigned Registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned Registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

    (i) Any preliminary prospectus or prospectus of the undersigned Registrant relating to the offering required to be filed pursuant to Rule 424;


    (ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned Registrant or used or referred to by the undersigned Registrant;

    (iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned Registrant or its securities provided by or on behalf of the undersigned Registrant; and

    (iv) Any other communication that is an offer in the offering made by the undersigned Registrant to the purchaser.

    2. The Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant’s annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

    3. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.


    SIGNATURES

    Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Emeryville, State of California, on February 28, 2025.

     

    4D Molecular Therapeutics, Inc.

    By:   /s/ Uneek Mehra
      Uneek Mehra
      Chief Financial and Business Officer

    POWER OF ATTORNEY

    KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints David Kirn, M.D. and Uneek Mehra, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement, including post-effective amendments or any abbreviated registration statement and any amendments thereto filed, with all exhibits thereto and other documents in connection therewith, with the SEC, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

    Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.

     

    Name

      

    Title

     

    Date

    /s/ David Kirn

    David Kirn, M.D.

      

    Chief Executive Officer and Director

    (Principal Executive Officer)

      February 28, 2025

    /s/ Uneek Mehra

    Uneek Mehra

      

    Chief Financial and Business Officer

    (Principal Financial and Accounting Officer)

      February 28, 2025

    /s/ John F. Milligan

    John F. Milligan, Ph.D.

      

    Executive Chairman

      February 28, 2025

    /s/ Jacob Chacko

    Jacob Chacko, M.D., MBA

      

    Director

      February 28, 2025

    /s/ Susannah Gray

    Susannah Gray, MBA

      

    Director

      February 28, 2025

    /s/ Nancy Miller-Rich

    Nancy Miller-Rich

      

    Director

      February 28, 2025

    /s/ Charles P. Theuer

    Charles P. Theuer, M.D., Ph.D.

      

    Director

      February 28, 2025

    /s/ Shawn Cline Tomasello

    Shawn Cline Tomasello, MBA

      

    Director

      February 28, 2025
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      4DMT acquires all world-wide rights to short-form human complement factor H (sCFH) from Aevitas Therapeutics, Inc.; technology invented at University of PennsylvaniaAnnounces sCFH as payload for 4D-175 lead product candidate for geographic atrophy (GA); sCFH extensively characterized in 3 genetic mouse models and in non-human primates (NHP)CFH variants with reduced complement inhibitory function are a well-validated genetic risk factor for GA secondary to age-related macular degeneration (AMD), with approximately 75% of AMD patients carrying a high-risk variant of CFH; utilizing a precision medicine approach, this population represents a potential target population for 4D-175Continues expans

      4/24/23 8:00:00 AM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • 4D Molecular Therapeutics Presents Interim Data from 4D-310 INGLAXA Phase 1/2 Clinical Trials & Development Plans for Fabry Disease Cardiomyopathy at WORLDSymposium™

      All three patients with 12 months of follow-up demonstrated improvement in multiple FDA-recommended cardiac endpoints at relatively low dose of 1E13 vg/kgCardiac biopsy demonstrated selective and widespread transgene expression within ~50% of cardiomyocytes Engaging with FDA to lift clinical hold and resume enrollment with updated exclusion criteria and highly effective rituximab/sirolimus immunosuppressive regimen to reduce risk of atypical hemolytic uremic syndrome ("aHUS")Otherwise, generally well-tolerated with no liver, heart, or dorsal root ganglia ("DRG") toxicity observedCompany to host live webcast today at 4:30 p.m. EST EMERYVILLE, Calif., Feb. 22, 2023 (GLOBE NEWSWIRE) -- 4D Mo

      2/22/23 4:05:00 PM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • 4D Molecular Therapeutics Announces Interim Clinical Data from On-going Phase 1/2 Clinical Trial of Intravitreal 4D-150 for Wet Age-Related Macular Degeneration (wet AMD)

      Cohort 1 patients (n=5) received a single intravitreal injection of 4D-150 (3E10 vg/eye); these patients were high need patients who in the 12 months preceding trial enrollment had a mean annualized anti-VEGF injection rate of ~11Following intravitreal 4D-150, Cohort 1 patients' annualized anti-VEGF injection rate was reduced by 96.7%80% of Cohort 1 patients had not received any supplemental aflibercept injections for up to ~10 months after 4D-150 dosingCohort 1 safety and tolerability of 4D-150 demonstrated to date, with no clinically significant intraocular inflammation or hypotony reportedConference call & webcast to be held Monday November 14, 2022 at 8:00 AM E.T. EMERYVILLE, Calif.

      11/14/22 7:30:00 AM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $FDMT
    Insider Trading

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    • SEC Form 4 filed by Chief Legal Officer Bizily Scott

      4 - 4D Molecular Therapeutics, Inc. (0001650648) (Issuer)

      3/10/25 8:00:20 PM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 4 filed by Chief Executive Officer Kirn David

      4 - 4D Molecular Therapeutics, Inc. (0001650648) (Issuer)

      3/10/25 7:58:59 PM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 4 filed by Chief Medical Officer Kim Robert Young

      4 - 4D Molecular Therapeutics, Inc. (0001650648) (Issuer)

      3/10/25 7:58:05 PM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $FDMT
    Analyst Ratings

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    • 4D Molecular Therapeutics downgraded by BMO Capital Markets with a new price target

      BMO Capital Markets downgraded 4D Molecular Therapeutics from Outperform to Market Perform and set a new price target of $15.00 from $40.00 previously

      1/13/25 7:43:59 AM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Morgan Stanley initiated coverage on 4D Molecular Therapeutics with a new price target

      Morgan Stanley initiated coverage of 4D Molecular Therapeutics with a rating of Underweight and set a new price target of $8.00

      11/21/24 7:33:52 AM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • 4D Molecular Therapeutics downgraded by Cantor Fitzgerald

      Cantor Fitzgerald downgraded 4D Molecular Therapeutics from Overweight to Neutral

      9/23/24 7:31:34 AM ET
      $FDMT
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care