• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
PublishGo to App
    Quantisnow Logo

    © 2026 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI superconnector for talent & startupsNEWLLM Arena
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form S-8 filed by Instil Bio Inc.

    3/4/25 7:44:30 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $TIL alert in real time by email
    S-8 1 s-8evergreenq1x25.htm S-8 Document

    As filed with the Securities and Exchange Commission on March 4, 2025
    Registration No. 333-
    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
    FORM S-8
    REGISTRATION STATEMENT
    UNDER
    THE SECURITIES ACT OF 1933
    Instil Bio, Inc.
    (Exact name of Registrant as specified in its charter)
    Delaware
    83-2072195
    (State or other jurisdiction of incorporation or organization)
    (I.R.S. Employer Identification No.)
    3963 Maple Avenue, Suite 350
    Dallas, TX 75219
    (Address of principal executive offices)(Zip code)
    2021 Equity Incentive Plan
    2021 Employee Stock Purchase Plan
    (Full title of the plans)

    Bronson Crouch
    Chief Executive Officer
    Instil Bio, Inc.
    3963 Maple Avenue, Suite 350
    Dallas TX 75219
    (972) 499-3350
    (Name and address of agent for service)(Telephone number, including area code, of agent for service)

    Copies to:
    Divakar Gupta
    Courtney M.W. Tygesson
    Cooley LLP
    55 Hudson Yards
    New York, NY 10001
    Telephone: (212) 479-6000
    Facsimile: (212) 479-6275
    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

    Large accelerated filer ☐
    Accelerated filer ☐
    Non-accelerated filer ☒
    Smaller reporting company ☒
    Emerging growth company ☒

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐




    PART I

    INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

    Pursuant to General Instruction E of Form S-8, Instil Bio, Inc. (the “Registrant”) is filing this Registration Statement with the Securities and Exchange Commission (the “Commission”) to register an additional 326,294 shares of common stock under the 2021 Equity Incentive Plan and an additional 65,259 shares of common stock under the 2021 Employee Stock Purchase Plan, pursuant to the provisions of each plan which provide for annual automatic increases in the number of shares of common stock reserved for issuance under each respective plan. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of the Form S-8 has been omitted from this Registration Statement.

    The contents of the Registrant’s Registration Statements on Form S-8, filed with the Commission on April 20, 2021 (File No. 333-255355) and March 21, 2024 (File No. 333-278154), are incorporated by reference into this Registration Statement.




    PART II

    ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE

    The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:

    (a) The Registrant’s Annual Report on Form 10-K (File No. 001-40215) for the fiscal year ended December 31, 2024, filed with the Commission on March 4, 2025;

    (b) The Registrant’s Current Report on Form 8-K (File No. 001-40215) filed with the Commission on January 14, 2025, to the extent the information in such report is filed and not furnished; and

    (c) The description of the Registrant’s Common Stock which is contained in the Registrant’s Registration Statement on Form 8-A filed on March 15, 2021 (File No. 001-40215) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as updated by the description of the Registrant’s securities filed as Exhibit 4.1 to the Registrant’s Annual Report on Form 10-K for the fiscal year ended December 31, 2021, filed with the Commission on March 7, 2022, including any amendment or report filed for the purpose of updating such description.

    All documents, reports and definitive proxy or information statements filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered hereby have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

    ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL

    As of the date hereof, GC&H Investments, LLC, an entity consisting of current and former partners and associates of Cooley LLP, beneficially holds an aggregate of 6,370 shares of the Registrant’s common stock.

    ITEM 8. EXHIBITS
    Exhibit Number
    Description
    Incorporated by Reference
    Filed Herewith
    Schedule Form
    File Number
    Exhibit
    Filing Date
    4.1
    Amended and Restated Certificate of Incorporation, as amended
    10-K
    001-40215
    3.1
    March 21, 2024
    4.2
    Amended and Restated Bylaws
    8-K
    001-40215
    3.2
    March 23, 2021
    4.3
    2021 Equity Incentive Plan and Forms of Option Grant Notice and Agreement, Exercise Notice, Early Exercise Notice and Restricted Stock Award Notice
    S-1
    333-253620
    10.2
    March 15, 2021
    4.4
    2021 Employee Stock Purchase Plan
    S-1
    333-253620
    10.4
    March 15, 2021
    5.1
    Opinion of Cooley LLP
    X
    23.1
    Consent of Deloitte & Touche LLP, independent registered public accounting firm
    X
    23.2
    Consent of Cooley LLP (included in Exhibit 5.1)
    X
    24.1
    Power of Attorney (included in signature pages of Registration Statement)
    X
    107
    Filing Fee Table
    X




    SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Dallas, State of Texas, on this 4th day of March, 2025.

    Instil Bio, Inc.
    By: /s/ Bronson Crouch
    Name: Bronson Crouch
    Title: Chief Executive Officer

    POWER OF ATTORNEY

    KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bronson Crouch and Sandeep Laumas, M.D., and each of them, as his true and lawful agents, proxies and attorneys-in-fact, with full power of substitution and resubstitution, for him or her and in his name, place and stead, in any and all capacities, to (i) act on, sign and file with the Securities and Exchange Commission any and all amendments (including post-effective amendments) to this registration statement together with all schedules and exhibits thereto and any subsequent registration statement filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, together with all schedules and exhibits thereto, (ii) act on, sign and file such certificates, instruments, agreements and other documents as may be necessary or appropriate in connection therewith, (iii) act on and file any supplement to any prospectus included in this registration statement or any such amendment or any subsequent registration statement filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, and (iv) take any and all actions which may be necessary or appropriate to be done, as fully for all intents and purposes as he might or could do in person, hereby approving, ratifying and confirming all that such agent, proxy and attorney-in-fact or any of his substitutes may lawfully do or cause to be done by virtue thereof.

    Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

    NamePositionDate
    /s/ Bronson Crouch
    Chief Executive Officer and Director
    (Principal Executive Officer)
    March 4, 2025
    Bronson Crouch
    /s/ Sandeep Laumas, M.D.
    Chief Financial Officer and Chief Business Officer
    (Principal Financial and Accounting Officer)
    March 4, 2025
    Sandeep Laumas, M.D.
    /s/ Gwendolyn Binder, Ph.D.DirectorMarch 4, 2025
    Gwendolyn Binder, Ph.D.
    /s/ Neil Gibson, Ph.D.DirectorMarch 4, 2025
    Neil Gibson, Ph.D.
    /s/ George Matcham, Ph.D.DirectorMarch 4, 2025
    George Matcham, Ph.D.
    /s/ R. Kent McGaughy, Jr.DirectorMarch 4, 2025
    R. Kent McGaughy, Jr.

    Get the next $TIL alert in real time by email

    Crush Q1 2026 with the Best AI Superconnector

    Stay ahead of the competition with Standout.work - your AI-powered talent-to-startup matching platform.

    AI-Powered Inbox
    Context-aware email replies
    Strategic Decision Support
    Get Started with Standout.work

    Recent Analyst Ratings for
    $TIL

    DatePrice TargetRatingAnalyst
    1/7/2026Buy → Neutral
    H.C. Wainwright
    1/6/2026$7.00Outperform → Neutral
    Robert W. Baird
    1/7/2025$11.00 → $52.00Hold → Buy
    Jefferies
    1/7/2025$11.00 → $52.00Hold → Buy
    Truist
    11/4/2024Mkt Perform
    JMP Securities
    4/12/2024$5.00 → $11.00Buy → Hold
    Jefferies
    11/1/2022$16.00 → $6.00Buy → Hold
    Truist
    11/1/2022Outperform → Market Perform
    Cowen
    More analyst ratings

    $TIL
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    View All

    Instil Bio downgraded by H.C. Wainwright

    H.C. Wainwright downgraded Instil Bio from Buy to Neutral

    1/7/26 9:03:18 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio downgraded by Robert W. Baird with a new price target

    Robert W. Baird downgraded Instil Bio from Outperform to Neutral and set a new price target of $7.00

    1/6/26 12:20:40 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio upgraded by Jefferies with a new price target

    Jefferies upgraded Instil Bio from Hold to Buy and set a new price target of $52.00 from $11.00 previously

    1/7/25 8:29:55 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $TIL
    Press Releases

    Fastest customizable press release news feed in the world

    View All

    Instil Bio's Subsidiary Discontinues Clinical Development of AXN-2510 and Terminates License and Collaboration Agreement with ImmuneOnco

    DALLAS, Jan. 06, 2026 (GLOBE NEWSWIRE) -- Instil Bio, Inc. (NASDAQ:TIL) ("Instil") today announced that Axion Bio, Inc. ("Axion"), a wholly-owned subsidiary of Instil, has decided to discontinue clinical development of AXN-2510 and that Axion and ImmuneOnco Biopharmaceuticals (Shanghai) Inc. (HKEX: 1541.HK) ("ImmuneOnco") have entered into an agreement terminating their license and collaboration agreement for AXN-2510 and AXN-27M ("Termination Agreement"). Under the terms of the Termination Agreement, all rights previously licensed to Axion, including global development and commercial rights outside Greater China, have reverted to ImmuneOnco, subject to a limited license to Axion to wind

    1/6/26 7:00:00 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio Reports Third Quarter 2025 Financial Results and Provides Corporate Update

    DALLAS, Nov. 13, 2025 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("Instil") (NASDAQ:TIL), a clinical-stage biopharmaceutical company focused on developing a pipeline of novel therapies, today reported its third quarter 2025 financial results and provided a corporate update. Recent Highlights: In September, ImmuneOnco, Instil's collaborator, presented updated data from additional patients with relapsed/refractory squamous non-small cell lung cancer treated with ‘2510 as monotherapy in a poster presentation at the 2025 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer.In October, Axion Bio, Instil's subsidiary, dosed the first patient in its Pha

    11/13/25 7:00:00 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio Announces ImmuneOnco's Presentation of '2510 Monotherapy Data in Patients with 2L+ Squamous NSCLC at the 2025 World Conference on Lung Cancer (WCLC)

    ORR of 35% in previously treated squamous NSCLC patients with responses across PD-L1 TPS scores Differentiated structure of ‘2510 potentially results in best-in-class monotherapy activity in 2L+ NSCLC for PD-(L)1xVEGF bispecifics DALLAS, Sept. 10, 2025 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("Instil") (NASDAQ:TIL), a clinical-stage biopharmaceutical company focused on developing a pipeline of novel therapies, today announced that ImmuneOnco Biopharmaceuticals (Shanghai) Inc. (HKEX Code: 1541.HK) ("ImmuneOnco") presented preliminary efficacy and safety data of ‘2510 (IMM2510/AXN-2510) as monotherapy in a Phase 1 study of patients in China with previously treated squamous non-small cell lung

    9/10/25 7:00:00 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $TIL
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    View All

    CFO and CBO Laumas Sandeep sold $701,667 worth of shares (30,000 units at $23.39) and exercised 30,000 shares at a strike of $12.07 (SEC Form 4)

    4 - Instil Bio, Inc. (0001789769) (Issuer)

    9/12/25 5:00:55 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form 4 filed by Director Binder Gwendolyn

    4 - Instil Bio, Inc. (0001789769) (Issuer)

    5/29/25 7:13:10 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form 4 filed by Director Gibson Neil W

    4 - Instil Bio, Inc. (0001789769) (Issuer)

    5/29/25 7:12:03 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $TIL
    SEC Filings

    View All

    Instil Bio Inc. filed SEC Form 8-K: Termination of a Material Definitive Agreement

    8-K - Instil Bio, Inc. (0001789769) (Filer)

    1/6/26 5:00:13 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form 10-Q filed by Instil Bio Inc.

    10-Q - Instil Bio, Inc. (0001789769) (Filer)

    11/13/25 7:08:27 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio Inc. filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

    8-K - Instil Bio, Inc. (0001789769) (Filer)

    11/13/25 7:05:18 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $TIL
    Leadership Updates

    Live Leadership Updates

    View All

    Instil Bio Reports Second Quarter 2025 Financial Results and Provides Corporate Update

    With the clearance of the U.S. IND, initiation of the U.S. clinical trial of AXN-2510/IMM2510 ("‘2510") anticipated before the end of 2025 Updated ‘2510 monotherapy data in squamous-NSCLC to be presented at IASLC's 2025 World Conference on Lung Cancer (WCLC) by ImmuneOnco DALLAS, Aug. 13, 2025 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("Instil") (NASDAQ:TIL), a clinical-stage biopharmaceutical company focused on developing a pipeline of novel therapies, today reported its second quarter 2025 financial results and provided a corporate update. Recent Highlights: In June, announced the appointment of Jamie Freedman, M.D., Ph.D., as Chief Medical OfficerIn July, announced the Investigational Ne

    8/13/25 6:00:00 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio Announces Appointment of Jamie Freedman, M.D., Ph.D., as Chief Medical Officer

    DALLAS, June 02, 2025 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("Instil") (NASDAQ:TIL), a clinical-stage biopharmaceutical company focused on developing a pipeline of novel cancer therapies, today announced the appointment of Jamie Freedman, M.D., Ph.D., as Chief Medical Officer. Dr. Freedman brings deep experience in oncology drug development and other therapeutic areas, and a track record of leading programs through all phases of development, regulatory approval and commercialization. Bronson Crouch, CEO of Instil, stated, "We are thrilled to welcome Dr. Freedman as Chief Medical Officer. Jamie's extensive experience and leadership in biopharmaceutical R&D will be a tremendous asset in adva

    6/2/25 7:00:00 AM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Instil Bio Reports Third Quarter 2022 Financial Results and Provides Corporate Update

    Manufacturing update on voluntary pause of DELTA-1 trial of ITIL-168 in advanced melanoma expected in Q1'23 Reprioritization of resources with enrollment deferred in DELTA-2 trial of ITIL-168 First patient with non-small cell lung cancer dosed with ITIL-306, the first engineered TIL therapy using CoStAR Platform, with plans to share clinical data in 2023 Appointment of cell therapy pioneer Dr. Robert Hawkins as Head of Research and Development, and resignation of Chief Medical Officer, Dr. Zachary Roberts Company confirms cash runway into 2025 with anticipated sale-leaseback transaction of its Tarzana manufacturing facility DALLAS, Nov. 14, 2022 (GLOBE NEWSWIRE) -- Instil Bio, Inc. ("

    11/14/22 4:07:40 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $TIL
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    View All

    Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

    SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

    11/14/24 6:59:16 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

    SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

    11/14/24 5:48:56 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Instil Bio Inc.

    SC 13G/A - Instil Bio, Inc. (0001789769) (Subject)

    10/25/24 9:42:03 PM ET
    $TIL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care