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    SEC Form S-8 filed by Zentalis Pharmaceuticals Inc.

    5/14/25 4:15:53 PM ET
    $ZNTL
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ZNTL alert in real time by email
    S-8 1 zentalis-sx8may2025.htm S-8 Document


    As filed with the Securities and Exchange Commission on May 14, 2025
    Registration No. 333-            
    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
    FORM S-8
    REGISTRATION STATEMENT
    UNDER
    THE SECURITIES ACT OF 1933
    Zentalis Pharmaceuticals, Inc.
    (Exact name of Registrant as specified in its charter)
    Delaware82-3607803
    (State or other jurisdiction of
    Incorporation or organization)
    (I.R.S. Employer
    Identification No.)
    10275 Science Center Dr., Suite 200
    San Diego, California 92121
    (858) 263-4333
    (Address of principal executive offices) (Zip code)

    Zentalis Pharmaceuticals, Inc. 2022 Employment Inducement Incentive Award Plan
    Zentalis Pharmaceuticals, Inc. 2020 Incentive Award Plan
    (Full titles of the plans)

    Andrea Paul
    Chief Legal Officer and Corporate Secretary
    Zentalis Pharmaceuticals, Inc.
    10275 Science Center Dr., Suite 200
    San Diego, California 92121
    (858) 263-4333
    (Name and address of agent for service) (Telephone number, including area code, of agent for service)
    With copies to:
    Nathan Ajiashvili
    Jenna Cooper
    Salvatore Vanchieri
    Latham & Watkins LLP
    1271 Avenue of the Americas
    New York, NY 10020
    (212) 906-1200 
    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
    Large accelerated filer☐Accelerated filer☐
    Non-accelerated filer☒Smaller reporting company☒
    Emerging growth company☐
    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of Securities Act. ☐



    EXPLANATORY NOTE
    This Registration Statement registers the offer and sale of (i) 5,500,000 shares of common stock of Zentalis Pharmaceuticals, Inc. (the “Company”) for issuance under the Zentalis Pharmaceuticals, Inc. 2022 Employment Inducement Incentive Award Plan (as amended and/or restated from time to time, the “Inducement Plan”), and (ii) an additional 1,200,000 shares of common stock of the Company for issuance under the Zentalis Pharmaceuticals, Inc. 2020 Incentive Award Plan (as amended and/or restated from time to time, the “2020 Plan”) pursuant to its terms.
    INCORPORATION BY REFERENCE OF CONTENTS OF
    REGISTRATION STATEMENTS ON FORM S-8
    The contents of the Registration Statements on Form S-8 (File Nos. 333-237593, 333-266702, and 333-277550), including any amendments thereto, filed with the Securities and Exchange Commission, relating to the 2020 Plan and the Inducement Plan, are incorporated herein by reference.
    Item 8.    Exhibits
    Incorporated by Reference
    Exhibit
    Number
    DescriptionFormExhibitDate FiledFile Number
    Filed
    Herewith
    4.1
    Certificate of Incorporation of Zentalis Pharmaceuticals, Inc.
    S-84.104/07/2020333-237593
    4.2
    Certificate of Amendment to Certificate of Incorporation of Zentalis Pharmaceuticals, Inc., dated June 16, 2023
    8-K3.106/16/2023001-39263
    3
    Amended and Restated Bylaws of Zentalis Pharmaceuticals, Inc.
    8-K3.102/15/2024001-39263
    4
    Specimen of Common Stock Certificate evidencing the shares of common stock
    S-14.203/06/2020333-236959
    5.1
    Opinion of Latham & Watkins LLP
    X
    10.1
    Zentalis Pharmaceuticals, Inc. 2022 Employment Inducement Incentive Award Plan, as amended
    10-K
    10.5.1
    03/26/2025
    001-39263
    10.2
    Form of Option Agreement pursuant to the Zentalis Pharmaceuticals, Inc. 2022 Employment Inducement Incentive Award Plan.
    8-K10.207/22/2022001-39263
    10.3
    Form of RSU Agreement pursuant to the Zentalis Pharmaceuticals, Inc. 2022 Employment Inducement Incentive Award Plan.
    8-K10.307/22/2022001-39263
    10.4
    Zentalis Pharmaceuticals, Inc. 2020 Incentive Award Plan and forms of stock option agreement and restricted stock unit agreement thereunder Zentalis
    S-1/A10.203/30/2020333-236959
    10.5
    Amendment No. 1 to the Zentalis Pharmaceuticals, Inc. 2020 Incentive Award Plan
    10-Q10.305/17/2021001-39263
    23.1
    Consent of Independent Registered Public Accounting Firm
    X
    23.2
    Consent of Latham & Watkins LLP (included in Exhibit 5.1) hereto
    X
    24.1
    Power of Attorney (see signature page)
    X
    107.1
    Filing Fee Table
    X



    SIGNATURES
    Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, California, on May 14, 2025.
    ZENTALIS PHARMACEUTICALS, INC.
    By:/s/ Julie Eastland
    Julie Eastland
    President and Chief Executive Officer
    POWER OF ATTORNEY
    Each person whose signature appears below hereby constitutes and appoints Julie Eastland or Vincent Vultaggio, or each of them singly, with full power to act without the other, such person’s true and lawful attorneys-in-fact and agents, with full power of substitution and re-substitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign this registration statement and any and all amendments, including post-effective amendments to this registration statement, and to file the same, with exhibits and schedules thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary or desirable to be done in connection therewith as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
    Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
    SignatureTitleDate
    /s/ Julie EastlandPresident and Chief Executive OfficerMay 14, 2025
    Julie Eastland(principal executive officer)
    /s/ Vincent A. Vultaggio                                                                             Senior Vice President, Finance and Principal Accounting OfficerMay 14, 2025
    Vincent A. Vultaggio(principal financial and accounting officer)
    /s/ Scott MyersChairpersonMay 14, 2025
    Scott Myers
    /s/ David JohnsonDirectorMay 14, 2025
    David Johnson
    /s/ Enoch KariukiDirectorMay 14, 2025
    Enoch Kariuki
    /s/ Jan SkvarkaDirectorMay 14, 2025
    Jan Skvarka
    /s/ Karan TakharDirectorMay 14, 2025
    Karan Takhar
    /s/ Luke Walker, M.D.DirectorMay 14, 2025
    Luke Walker, M.D.

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