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    SEC Form SC 13D/A filed by Cartesian Therapeutics Inc. (Amendment)

    4/10/24 4:25:28 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $RNAC alert in real time by email
    SC 13D/A 1 d729913dsc13da.htm SC 13D/A SC 13D/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 1 )*

     

     

    Cartesian Therapeutics, Inc.

    (Name of Issuer)

    Common Stock, $0.0001 par value

    (Title of Class of Securities)

    816212104

    (CUSIP Number)

    William R. Kolb

    Daniel S. Clevenger

    Foley Hoag LLP

    155 Seaport Boulevard

    Boston, MA 02210

    Tel: (617) 832-1000

    Fax: (617) 832-7000

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    April 8, 2024

    (Date of Event which Requires Filing of this Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

     

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are sent.

     

     

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 816212104    13D    Page 2 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Michael Singer

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     691,110

        8.  

     Shared Voting Power

     

     78,634

        9.  

     Sole Dispositive Power

     

     691,110

       10.  

     Shared Dispositive Power

     

     78,634

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     769,744

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     4.3%

    14.  

     Type of Reporting Person (See Instructions)

     

     HC, IN


    CUSIP No. 816212104    13D    Page 3 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Thirsty Brook 2010 Irrevocable Trust

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     383,796

        8.  

     Shared Voting Power

     

     0

        9.  

     Sole Dispositive Power

     

     383,796

       10.  

     Shared Dispositive Power

     

     0

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     383,796

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     2.2%

    14.  

     Type of Reporting Person (See Instructions)

     

     OO


    CUSIP No. 816212104    13D    Page 4 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Singer Asefzadeh Family Holding Trust

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     56,719

        8.  

     Shared Voting Power

     

     0

        9.  

     Sole Dispositive Power

     

     56,719

       10.  

     Shared Dispositive Power

     

     0

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     56,719

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     0.3%

    14.  

     Type of Reporting Person (See Instructions)

     

     OO


    CUSIP No. 816212104    13D    Page 5 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Bakezilla 2019 Irrevocable Trust

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     7,127

        8.  

     Shared Voting Power

     

     0

        9.  

     Sole Dispositive Power

     

     7,127

       10.  

     Shared Dispositive Power

     

     0

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     7,127

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     0.0%

    14.  

     Type of Reporting Person (See Instructions)

     

     OO

     


    CUSIP No. 816212104    13D    Page 6 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Baharak Asefzadeh

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     14,788

        8.  

     Shared Voting Power

     

     447,642

        9.  

     Sole Dispositive Power

     

     14,788

       10.  

     Shared Dispositive Power

     

     447,642

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     462,430

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     2.6%

    14.  

     Type of Reporting Person (See Instructions)

     

     HC, IN

     


    CUSIP No. 816212104    13D    Page 7 of 11 Pages

     

     1.   

     Names of Reporting Persons

     

     Barbara P. Martin

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a)   (b) 

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     OO

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     6.  

     Citizenship or Place of Organization

     

     United States

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.   

     Sole Voting Power

     

     10,968

        8.  

     Shared Voting Power

     

     383,796

        9.  

     Sole Dispositive Power

     

     10,968

       10.  

     Shared Dispositive Power

     

     383,796

    11.   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     394,764

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     2.2%

    14.  

     Type of Reporting Person (See Instructions)

     

     HC, IN


    This Amendment No. 1 to the joint statement on Schedule 13D with respect to the common stock, par value $0.0001 (the “Common Stock”), of Cartesian Therapeutics, Inc., a Delaware corporation (the “Issuer”), filed by Michael Singer, Thirsty Brook 2010 Irrevocable Trust (“Thirsty Brook Trust”), Singer Asefzadeh Family Holding Trust (“Singer Asefzadeh Trust”), Bakezilla 2019 Irrevocable Trust (“Bakezilla Trust” and together with Thirsty Brook Trust and Singer Asefzadeh Trust, the “Trusts”), Baharak Asefzadeh and Barbara P. Martin (collectively, the “Reporting Persons”) on November 22, 2023 (such joint statement, as amended herein, the “Schedule 13D”), amends the Schedule 13D as follows:

     

      1.

    Item 3 of the Schedule 13D is hereby amended and restated in full as follows:

     

      Item 3.

    Source and Amount of Funds or Other Consideration

    The Reporting Persons acquired the right to receive an aggregate 15,096 shares of Common Stock and 25,936.957 shares of Series A Non-Voting Convertible Preferred Stock of the Issuer, par value $0.0001 per share (the “Series A Preferred Stock”) pursuant to the Merger described in Item 4 below.

    On January 2, 2024, Dr. Singer acquired an option to purchase up to 7,600 shares of Common Stock at an exercise price of $19.656 per share in consideration of his service on the Issuer’s board of directors.

    The information set forth under Item 4 of this Schedule 13D is incorporated by reference into this Item 3.

     

      2.

    Item 4 of the Schedule 13D is hereby amended by inserting the following at the end of such section:

    Amendment to Certificate of Designation

    On March 26, 2024, the Company, with the consent of the holders of Series A Preferred Stock required thereby, amended the Certificate of Designation (such amendment, the “Amendment to the Certificate of Designation”) such that the Automatic Conversion (as defined in the Certificate of Designation) will occur at 5:00 p.m. eight business days following stockholder approval of the Conversion Proposal.

    Reverse Stock Split

    On April 4, 2024, the Company effected a reverse stock split of the Common Stock at a ratio of 1-for-30, whereby every 30 shares of Common Stock outstanding were combined, automatically and without any action on the part of the Company or its stockholders, into one new share of Common Stock. Proportionate adjustments were made to the conversion ratio of the Series A Preferred Stock in accordance with the Certificate of Designations. All share amounts in this Amendment No. 1 are presented on a split-adjusted basis.


    Conversion of Series A Preferred Stock

    Pursuant to the terms of the Certificate of Designation, as amended by the Amendment to the Certificate of Designation, on April 8, 2024, following stockholder approval of the issuance of shares of Common Stock upon conversion of the Series A Preferred Stock, each share of Series A Preferred Stock automatically converted into 33-1/3 shares of Common Stock, subject to beneficial ownership limitations.

     

      3.

    Item 5 of the Schedule 13D is hereby amended and restated in full as follows:

     

      Item 5.

    Interest in Securities of the Issuer

    (a, b) The percentages of beneficial ownership reported in this Item 5, and on each Reporting Person’s cover page to this Schedule 13D, are based on a total of 17,779,787 shares of Common Stock issued and outstanding as of April 8, 2024, as reported in the Issuer’s Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2024. All of the share numbers reported herein are as of April 10, 2024, unless otherwise indicated. Each Reporting Person’s cover page to this Schedule 13D is incorporated by reference into this Item 5(a, b).

    In aggregate, the Reporting Persons have voting and dispositive power over 780,712 shares of Common Stock, representing approximately 4.3% of such class of securities.

    The beneficial ownership of each Reporting Person is as follows.

     

      (i)

    Dr. Singer beneficially owns 769,744 shares of Common Stock representing approximately 4.3% of the class, which includes 1,055 shares of Common Stock underlying stock options exercisable by Dr. Singer within 60 days of the date hereof. Dr. Singer has the sole power to vote and dispose of (a) 114,876 shares of Common Stock held directly by him, (b) 192,438 shares of Common Stock that are held for the benefit of Dr. Singer’s minor children in custodial accounts established pursuant to the Uniform Transfer to Minors Act for which Dr. Singer serves as custodian, and (c) 383,796 shares of Common Stock held directly by Thirsty Brook Trust that Dr. Singer has the right to acquire pursuant to a right of substitution in exchange for assets with an equal value to such shares. Dr. Singer has shared power to vote and dispose of (x) 56,719 shares of Common Stock held directly by Singer Asefzadeh Trust for which Dr. Singer is a trustee, (y) 7,127 shares of Common Stock held directly by Bakezilla Trust for which Dr. Singer is a trustee, and (z) 14,788 shares of Common Stock held directly by Dr. Asefzadeh. The foregoing excludes (A) 6,545 shares of Common Stock underlying stock options held by Dr. Singer that are not exercisable within 60 days of the date hereof and (B) 5,933 shares of Common Stock underlying restricted stock units held by Dr. Singer that will vest more than 60 days after the date hereof.

     

      (ii)

    Thirsty Brook Trust beneficially owns 383,796 shares of Common Stock representing approximately 2.2% of the class. Thirsty Brook Trust has the sole power to vote and dispose of the shares of Common Stock beneficially owned by it.


      (iii)

    Singer Asefzadeh Trust beneficially owns 56,719 shares of Common Stock representing approximately 0.3% of the class. Singer Asefzadeh Trust has the sole power to vote and dispose of the shares of Common Stock beneficially owned by it.

     

      (iv)

    Bakezilla Trust beneficially owns 7,127 shares of Common Stock representing approximately 0.0% of the class. Bakezilla Trust has the sole power to vote and dispose of the shares of Common Stock beneficially owned by it.

     

      (v)

    Dr. Asefzadeh beneficially owns 462,430 shares of Common Stock representing approximately 2.6% of the class. Dr. Asefzadeh has shared power to vote and dispose of (a) 383,796 shares of Common Stock held directly by Thirsty Brook Trust for which Dr. Asefzadeh is a trustee, (b) 56,719 shares of Common Stock held directly by Singer Asefzadeh Trust for which she serves as trustee, (c) 7,127 shares of Common Stock held directly by Bakezilla Trust for which she serves as trustee, and (d) 14,788 shares of Common Stock held directly by her.

     

      (vi)

    Ms. Martin beneficially owns 394,764 shares of Common Stock representing approximately 2.2% of the class. Ms. Martin has the sole power to vote and dispose of 10,968 shares of Common Stock held directly by her. Ms. Martin has shared power to vote and dispose of 383,796 shares of Common Stock held directly by Thirsty Brook Trust for which Ms. Martin is a trustee.

    (c) No Reporting Person effected any transaction in the Common Stock from February 10, 2024 (the date 60 days prior to the filing of this Schedule 13D) to April 10, 2024.

    (d) No person other than the Reporting Persons is known to have the right to receive or the power to direct the receipt of dividends from or the proceeds from the sale of shares of the Common Stock.

    (e) The Reporting Persons ceased to be the beneficial owner of more than five percent of the Common Stock on April 8, 2024.

     

      4.

    Item 7 of the Schedule 13D is hereby amended and restated in full as follows:

     

      Item 7.

    Material to be Filed as Exhibits

     

    Exhibit 1    Joint Filing Agreement by and among Michael Singer, Thirsty Brook 2010 Irrevocable Trust, Singer Asefzadeh Family Holding Trust, Bakezilla 2019 Irrevocable Trust, Baharak Asefzadeh and Barbara P. Martin dated November 22, 2023 (incorporated by reference to Exhibit 1 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).


    Exhibit 2    Confirming Statement of Thirsty Brook 2010 Irrevocable Trust dated November 22, 2023 (incorporated by reference to Exhibit 2 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).
    Exhibit 3    Confirming Statement of Singer Asefzadeh Family Holding Trust dated November 22, 2023 (incorporated by reference to Exhibit 3 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).
    Exhibit 4    Confirming Statement of Bakezilla 2019 Irrevocable Trust dated November 22, 2023 (incorporated by reference to Exhibit 4 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).
    Exhibit 5    Confirming Statement of Baharak Asefzadeh dated November 22, 2023 (incorporated by reference to Exhibit 5 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).
    Exhibit 6    Confirming Statement of Barbara P. Martin dated November 22, 2023 (incorporated by reference to Exhibit 6 of the Reporting Persons’ Schedule 13D filed with the SEC on November 22, 2023).
    Exhibit 7    Agreement and Plan of Merger, dated November 13, 2023, by and among Selecta Biosciences, Inc. Sakura Merger Sub I, Inc., Sakura Merger Sub II, LLC and Cartesian Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by the Issuer with the Securities and Exchange Commission on November 13, 2023).
    Exhibit 8    Certificate of Designation of Series A Non-Voting Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Current Report on Form 8-K filed by the Issuer with the Securities and Exchange Commission on November 13, 2023).
    Exhibit 9    Securities Purchase Agreement, dated November 13, 2023, by and among Selecta Biosciences, Inc. and the Purchasers named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed by the Issuer with the Securities and Exchange Commission on November 13, 2023).
    Exhibit 10    Registration Rights Agreement, dated November 13, 2023, by and among Selecta Biosciences, Inc. and the Purchasers named therein (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed by the Issuer with the Securities and Exchange Commission on November 13, 2023).

    [signature page follows]


    Signature

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    DATE: April 10, 2024
    /s/ Michael Singer
    Michael Singer
    THIRSTY BROOK 2010 IRREVOCABLE TRUST
    By:   /s/ Michael Singer
      Michael Singer, Authorized Person
    SINGER ASEFZADEH FAMILY HOLDING TRUST
    By:   /s/ Michael Singer
      Michael Singer, Authorized Person
    BAKEZILLA 2019 IRREVOCABLE TRUST
    By:   /s/ Michael Singer
      Michael Singer, Authorized Person
    BAHARAK ASEFZADEH
    By:   /s/ Michael Singer
      Michael Singer, Authorized Person


    BARBARA P. MARTIN
    By:   /s/ Michael Singer
      Michael Singer, Authorized Person
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    Director Barabe Timothy C bought $205,797 worth of shares (30,000 units at $6.86), increasing direct ownership by 123% to 54,366 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    12/8/25 4:07:12 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Director Springer Timothy A bought $1,522,517 worth of shares (149,075 units at $10.21), increasing direct ownership by 0.26% to 8,643,685 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    4/11/25 5:29:40 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Director Springer Timothy A bought $1,371,154 worth of shares (89,863 units at $15.26), increasing direct ownership by 1% to 8,621,325 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    3/20/25 7:50:25 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    $RNAC
    Insider Trading

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    President and CEO Brunn Carsten sold $162,077 worth of shares (23,766 units at $6.82), decreasing direct ownership by 7% to 323,530 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    1/8/26 4:20:02 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Chief Financial Officer Davis Blaine sold $72,227 worth of Common Stock (10,591 units at $6.82), decreasing direct ownership by 8% to 121,220 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    1/8/26 4:19:50 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Chief Medical Officer Miljkovic Milos sold $24,367 worth of Common Stock (3,573 units at $6.82), decreasing direct ownership by 6% to 58,820 units (SEC Form 4)

    4 - Cartesian Therapeutics, Inc. (0001453687) (Issuer)

    1/8/26 4:19:56 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    $RNAC
    Analyst Ratings

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    Wedbush initiated coverage on Cartesian Therapeutics with a new price target

    Wedbush initiated coverage of Cartesian Therapeutics with a rating of Outperform and set a new price target of $38.00

    7/9/25 8:26:19 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    BTIG Research initiated coverage on Cartesian Therapeutics with a new price target

    BTIG Research initiated coverage of Cartesian Therapeutics with a rating of Buy and set a new price target of $42.00

    12/19/24 8:25:53 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    TD Cowen initiated coverage on Cartesian Therapeutics

    TD Cowen initiated coverage of Cartesian Therapeutics with a rating of Buy

    8/6/24 6:25:49 AM ET
    $RNAC
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    $RNAC
    Leadership Updates

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    Cartesian Therapeutics Highlights Recent Progress and Outlines 2026 Outlook

    Enrollment on track in Phase 3 AURORA trial of Descartes-08 in myasthenia gravis  IND application for Descartes-08 in myositis accepted by FDA; seamless adaptive clinical trial offering potential opportunity for a single pivotal trial expected to commence in 1H26 Phase 1/2 pediatric trial of Descartes-08 in juvenile dermatomyositis initiated Cash resources expected to support planned operations, including completion of planned Phase 3 trial for Descartes-08 for myasthenia gravis, into mid-2027 FREDERICK, Md., Jan. 09, 2026 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ:RNAC) (the "Company"), a clinical-stage biotechnology company pioneering cell therapy for autoimmune dise

    1/9/26 8:04:14 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Cartesian Therapeutics Announces the Appointment of Adrian Bot to Board of Directors

    FREDERICK, Md., Dec. 18, 2025 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ:RNAC) (the "Company"), a clinical-stage biotechnology company pioneering cell therapy for autoimmune diseases, today announced the appointment of Adrian Bot, M.D., Ph.D., to the Company's Board of Directors. Dr. Bot is a biopharma executive with three decades of experience in research and development (R&D) with a focus on immune, cell, gene therapy and nanomedicines. He will serve as a member of the Science and Technology Committee of the Board. "Dr. Bot brings a unique perspective shaped by pioneering work in first-in-class CAR T cell therapies, including the recent historic acquisition of Capstan's no

    12/18/25 4:05:00 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Cartesian Therapeutics Reports Third Quarter 2024 Financial Results and Provides Business Update

    Company expects to commence Phase 3 trial of Descartes-08 in patients with myasthenia gravis in 1H2025 following recent meeting with U.S. Food and Drug Administration Presentation of updated efficacy and safety data from Phase 2b trial and Phase 3 trial design of Descartes-08 in patients with myasthenia gravis expected by year-end Dosing underway in Phase 2 trial of Descartes-08 in patients with systemic lupus erythematosus Dosing underway in first-in-human Phase 1 trial of Descartes-15 Approximately $220.9M of cash, cash equivalents, and restricted cash as of September 30, 2024 expected to support planned operations, including completion of planned Phase

    11/7/24 7:00:00 AM ET
    $RNAC
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    Large Ownership Changes

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    Amendment: SEC Form SC 13D/A filed by Cartesian Therapeutics Inc.

    SC 13D/A - Cartesian Therapeutics, Inc. (0001453687) (Subject)

    11/18/24 9:44:37 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Amendment: SEC Form SC 13D/A filed by Cartesian Therapeutics Inc.

    SC 13D/A - Cartesian Therapeutics, Inc. (0001453687) (Subject)

    10/15/24 4:30:56 PM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Amendment: SEC Form SC 13D/A filed by Cartesian Therapeutics Inc.

    SC 13D/A - Cartesian Therapeutics, Inc. (0001453687) (Subject)

    10/4/24 6:08:15 PM ET
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    Cartesian Therapeutics Announces Positive Updated Results from Phase 2b Trial of Descartes-08 in Participants with Myasthenia Gravis and Outlines Design of Planned Phase 3 Trial

    Phase 3 AURORA trial on track to commence in 1H2025; Primary endpoint to assess proportion of Descartes-08-treated participants with myasthenia gravis demonstrating an MG-ADL improvement of ≥3 points at Month 4 relative to placebo Deepening responses observed over time in Phase 2b trial, with Descartes-08-treated participants observed to have a 5.5-point reduction in MG-ADL at Month 4 Durable responses observed through Month 12 in Phase 2b trial Safety profile consistent with previously reported data and continues to support outpatient administration Company to host conference call and webcast with key opinion leader today at 7:30 a.m. ET FREDERICK, Md., Dec. 03, 2024 (GLOB

    12/3/24 6:00:00 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Cartesian Therapeutics to Present Updated Data from Phase 2b Trial of Descartes-08 in Patients with Myasthenia Gravis at the 2nd Annual Cell Therapy for Autoimmune Disease Summit

    FREDERICK, Md., Nov. 21, 2024 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ:RNAC) (the "Company"), a clinical-stage biotechnology company pioneering mRNA cell therapy for autoimmune diseases, today announced that updated efficacy and safety data from the Phase 2b trial of Descartes-08 in patients with generalized myasthenia gravis will be presented at the 2nd Annual Cell Therapy for Autoimmune Disease Summit, being held December 2-4, 2024 in Philadelphia. Details of the presentation are as follows: Title: Perspectives on Bringing Cell Therapies to the Autoimmune Space: From Concept to ClinicSession Name: Diving into Challenges & Successes in the Autoimmune Space to Direct Futu

    11/21/24 7:00:00 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
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    Cartesian Therapeutics Announces Positive Topline Results from Phase 2b Trial of Descartes-08 in Patients with Myasthenia Gravis

    Trial met primary endpoint with statistical significance, with 71% of myasthenia gravis patients treated with Descartes-08 observed to have a clinically meaningful improvement in MGC score at Month 3 compared to 25% for placebo Deep and durable responses up to at least six months observed in patients treated with Descartes-08 Safety profile continues to support outpatient administration Company expects to hold End-of-Phase 2 meeting with the FDA by year-end Company to host conference call today at 8:00 a.m. ET GAITHERSBURG, Md., July 02, 2024 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ:RNAC) ("Cartesian" or the "Company"), a clinical-stage biotechnology company pioneerin

    7/2/24 6:30:00 AM ET
    $RNAC
    Biotechnology: Pharmaceutical Preparations
    Health Care