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    SEC Form SC 13D/A filed by Crinetics Pharmaceuticals Inc. (Amendment)

    3/1/24 8:05:26 PM ET
    $CRNX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $CRNX alert in real time by email
    SC 13D/A 1 d798461dsc13da.htm SC 13D/A SC 13D/A

     

     

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D/A

    Under the Securities Exchange Act of 1934

    (Amendment No. 5)*

     

     

    Crinetics Pharmaceuticals, Inc.

    (Name of Issuer)

    Common Stock, $0.001 par value

    (Title of Class of Securities)

    22663K 107

    (CUSIP Number)

    Alexander Rakitin

    Perceptive Advisors LLC

    51 Astor Place, 10th Floor

    New York, NY 10003

    (646) 205-5340

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    May 24, 2023

    (Date of Event Which Requires Filing of this Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

     

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Section 240.13d-7 for other parties to whom copies are to be sent.

     

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 22663K 107

     

     1.    

     Names of Reporting Persons.

     

     Perceptive Advisors LLC

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Delaware

    Number of

    Shares  Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     1,488,703

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     1,488,703

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     1,488,703

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     1.9%

    14.  

     Type of Reporting Person (See Instructions)

     

     IA


    CUSIP No. 22663K 107

     

     1.    

     Names of Reporting Persons.

     

     Joseph Edelman

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     AF

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     United States of America

    Number of

    Shares  Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     1,488,703

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     1,488,703

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     1,488,703

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     1.9%

    14.  

     Type of Reporting Person (See Instructions)

     

     IN


    CUSIP No. 22663K 107

     

     1.    

     Names of Reporting Persons.

     

     Perceptive Life Sciences Master Fund, Ltd.

     2.  

     Check the Appropriate Box if a Member of a Group (See Instructions)

     (a) ☐  (b) ☒

     

     3.  

     SEC Use Only

     

     4.  

     Source of Funds (See Instructions)

     

     WC

     5.  

     Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

     

     ☐

     6.  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares  Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

     

        7.     

     Sole Voting Power

     

     0

        8.   

     Shared Voting Power

     

     1,476,203

        9.   

     Sole Dispositive Power

     

     0

       10.   

     Shared Dispositive Power

     

     1,476,203

    11.    

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     1,476,203

    12.  

     Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

     ☐

    13.  

     Percent of Class Represented by Amount in Row (11)

     

     1.9%

    14.  

     Type of Reporting Person (See Instructions)

     

     CO


    Item 5.

    Interest in Securities of the Issuer

    Item 5 is amended and restated as follows:

     

      (a)

    The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 69,596,202 outstanding shares of Common Stock, as reported by the Company in its Form 10-K filed with the Securities and Exchange Commission on February 28, 2024, and gives effect to (i) the issuance of 8,333,334 shares of Common Stock issued by Company on March 1, 2024 in connection with the closing of a private placement, and (ii) the exercise of the 12,500 warrants awarded to a former employee of Percetive Advisors.

     

      (b)

    The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference. The beneficial ownership reported on this Schedule 13D reflects 1,476,203 shares of Common Stock held by the Master Fund and, for Perceptive Advisors Mr. Edelman, stock options exercisable for 12,500 shares awarded to a former employee of Perceptive Advisors.

     

      (c)

    The transactions set forth in Schedule A to this Amendment No. 5 to Schedule 13D is incorporated by reference into this Item 5(c).

     

      (d)

    No person (other than the Reporting Persons) is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock subject to this Schedule 13D.

     

      (e)

    The Reporting Pesons ceased to be the beneficial owners of more than 5% of the Issuer’s Common Stock on May 24, 2023.


    SIGNATURES

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    Dated: March 1, 2024

     

    PERCEPTIVE ADVISORS LLC
    By:  

    /s/ Joseph Edelman

      Name: Joseph Edelman
      Title: Managing Member

     

    /s/ Joseph Edelman

    JOSEPH EDELMAN

     

    PERCEPTIVE LIFE SCIENCES MASTER FUND, LTD.
    By:   Perceptive Advisors LLC
    By:  

    /s/ Joseph Edelman

      Name: Joseph Edelman
      Title: Managing Member


    Schedule A

    The Master Fund effected the following transactions with respect to the Issuer’s securities during (i) the past 60 days and (ii) the 60-days preceeding the date the Reporting Persons ceased to be beneficial owners of more than 5% of the Issuer’s Common Stock. The Reporting Persons undertake to provide to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges of the prices reported.

     

    Security

       Date      Transaction Type    Shares      Price    

    Price Range

    Common Stock

         3/13/2023      Sale      45,076      $ 17.68 (1)    $17.09 - $17.985, inclusive 

    Common Stock

         3/13/2023      Sale      100      $ 18.11     N/A

    Common Stock

         3/14/2023      Sale      29,776      $ 17.80 (1)    $17.42 to $18.22, inclusive

    Common Stock

         3/15/2023      Sale      31,429      $ 17.21 (1)    $16.97 to $17.69, inclusive

    Common Stock

         3/16/2023      Sale      19,116      $ 16.96 (1)    $16.42 to $17.265, inclusive

    Common Stock

         3/17/2023      Sale      9,420      $ 16.96 (1)    $16.84 to $17.13, inclusive

    Common Stock

         3/20/2023      Sale      19,092      $ 16.86 (1)    $16.73 to $17.08, inclusive

    Common Stock

         3/21/2023      Sale      3,300      $ 16.73 (1)    $16.47 to $17.00, inclusive

    Common Stock

         3/27/2023      Sale      23,152      $ 15.78 (1)    $15.56 to $16.16, inclusive

    Common Stock

         3/28/2023      Sale      53,677      $ 15.56 (1)    $15.24 to $15.895, inclusive

    Common Stock

         3/29/2023      Sale      167,668      $ 15.63 (1)    $15.36 to $15.81, inclusive

    Common Stock

         4/14/2023      Sale      37,172      $ 15.78 (1)    $15.74 to $15.96, inclusive

    Common Stock

         5/11/2023      Sale      100,000      $ 22.19 (1)    $22.01 to $22.61, inclusive

    Common Stock

         5/12/2023      Sale      75,169      $ 22.18 (1)    $21.98 to $22.55, inclusive

    Common Stock

         5/15/2023      Sale      85,000      $ 22.51 (1)    $22.19 to $22.78, inclusive

    Common Stock

         5/16/2023      Sale      65,000      $ 22.08 (1)    $21.90 to $22.40, inclusive

    Common Stock

         5/17/2023      Sale      100,000      $ 22.25 (1)    $22.05 to $22.47, inclusive

    Common Stock

         5/18/2023      Sale      30,000      $ 22.13 (1)    $21.74 to $22.36, inclusive

    Common Stock

         5/23/2023      Sale      75,000      $ 22.87 (1)    $22.62 to $23.04, inclusive

    Common Stock

         5/24/2023      Sale      50,000      $ 22.22 (1)    $21.96 to $22.38, inclusive

    Common Stock

         1/30/2024      Sale      45,172      $ 36.8309 (1)    $36.16 to $37.08, inclusive

    Common Stock

         1/31/2024      Sale      41,200      $ 36.7522 (1)    $36.34 to $37.49, inclusive

    Common Stock

         2/1/2024      Sale      39,128      $ 36.8078 (1)    $36.36 to $37.10, inclusive

    Common Stock

         2/13/2024      Sale      87,000      $ 36.00 (1)    $35.87 to $36.30, inclusive

    Common Stock

         2/14/2024      Sale      26,000      $ 36.19 (1)    $35.80 to $36.685, inclusive

    Common Stock

         2/15/2024      Sale      17,000      $ 36.36 (1)    $35.86 to $36.77, inclusive

    Common Stock

         2/28/2024      Purchase      476,191      $ 42.00     N/A

    Common Stock

         2/28/2024      Short Sale      10,832      $ 43.41 (1)    $43.04 to $44.01, inclusive

    Common Stock

         2/28/2024      Short Sale      18,519      $ 44.52 (1)    $44.05 to $45.04, inclusive

    Common Stock

         2/28/2024      Short Sale      20,649      $ 45.51 (1)    $45.05 to $46.00, inclusive

    Common Stock

         2/29/2024      Short Sale      8,023      $ 41.83 (1)    $41.08 to $42.06, inclusive

    Common Stock

         2/29/2024      Short Sale      14,245      $ 42.38 (1)    $42.07 to $43.04, inclusive

    Common Stock

         2/29/2024      Short Sale      2,266      $ 43.81 (1)    $43.185 to $44.12, inclusive

    Common Stock

         2/29/2024      Short Sale      25,466      $ 44.73 (1)    $44.29 to $45.05, inclusive

     

    (1)

    The reported prices are weighted average prices. These shares were sold in multiple transactions within the corresponding price ranges listed in the table above.

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      SAN DIEGO, May 30, 2024 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (NASDAQ:CRNX), today announced the appointment of Robert M. Cuddihy, M.D., as senior vice president of Medical Affairs. Dr. Cuddihy is a board-certified physician in endocrinology, diabetes and metabolism with more than 30 years of experience spanning clinical practice and pharmaceutical industry medical affairs. "Dr. Cuddihy's wealth of knowledge and experience both as a practicing physician in endocrinology and working within the pharmaceutical industry is an invaluable addition to our talented scientific leadership team," said Scott Struthers, Ph.D., founder and chief executive officer of Crinetics. "As we forg

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