• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Dashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlerts
    Company
    AboutQuantisnow PlusContactJobs
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13D/A filed by Entasis Therapeutics Holdings Inc. (Amendment)

    3/15/22 9:00:21 AM ET
    $ETTX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ETTX alert in real time by email
    SC 13D/A 1 tm229285d1_sc13da.htm SC 13D/A

     

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

    SCHEDULE 13D/A
    (Amendment No. 8)*

     

    Under the Securities Exchange Act of 1934

     

    ENTASIS THERAPEUTICS HOLDINGS INC.
    (Name of Issuer)
     
    Common Stock, $0.001 par value
    (Title of Class of Securities)
     
    293614 103
    (CUSIP Number)
     

    Pavel Raifeld

    Chief Executive Officer

    Innoviva, Inc.

    1350 Old Bayshore Highway Suite 400

    Burlingame, CA

    877-202-1097

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
     
    March 15, 2022
    (Date of Event which Requires Filing of this Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box: ☐

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies are to be sent.

     

    *   The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

      

     

     

    CUSIP NO. 04216R 102

    1

    NAME OF REPORTING PERSON

    Innoviva, Inc.

    2

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a) ☐

    (b) ☐

    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    WC

    5 CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
    6

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

    7

    SOLE VOTING POWER

    37,345,794(1)

    8

    SHARED VOTING POWER

    20,000,000(2)

    9

    SOLE DISPOSITIVE POWER

    37,345,794(1)

    10

    SHARED DISPOSITIVE POWER

    20,000,000(2)

    11

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    57,345,794

    12 CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ☐
    13

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    74.93%(3)

    14

    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

    CO

    (1) Includes shares of Common Stock and warrants to purchase Common Stock acquired by INVA on April 22, 2020, June 11, 2020, and September 1, 2020.
       
    (2) Includes shares of Common Stock and warrants to purchase Common Stock acquired by ISO on May 3, 2021 and June 11, 2021.
       
    (3) Based on 47,851,779 shares of Common Stock outstanding as of February 25, 2022, as reported by the Issuer in its Form 10-K filed on March 3, 2022 plus warrants to purchase 28,672,897 shares of Common Stock previously acquired by the Reporting Persons.
             

     - 2 - 

     

     

    CUSIP NO. 04216R 102

    1

    NAME OF REPORTING PERSON

    Innoviva Strategic Opportunities LLC

    2

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a) ☐

    (b) ☐

    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    WC

    5 CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
    6

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

    7

    SOLE VOTING POWER

    0

    8

    SHARED VOTING POWER

    20,000,000(1)

    9

    SOLE DISPOSITIVE POWER

    0

    10

    SHARED DISPOSITIVE POWER

    20,000,000(1)

    11

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    20,000,000

    12 CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ☐
    13

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    34.57%(2)

    14

    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

    OO

    (1) Includes shares of Common Stock and warrants to purchase Common Stock acquired by ISO on May 3, 2021 and June 11, 2021.
       
    (2) Based on 47,851,779 shares of Common Stock outstanding as of February 25, 2022, as reported by the Issuer in its Form 10-K filed on March 3, 2022 plus warrants to purchase 10,000,000 shares of Common Stock previously acquired by the Reporting Persons.
             

     - 3 - 

     

     

    Explanatory Note

     

    This Amendment No. 8 (the “Amendment No. 8”) amends and supplements the initial Statement of Beneficial Ownership on Schedule 13D, as filed with the Securities and Exchange Commission (the “SEC”) on April 23, 2020 and previously amended, (as amended, the “Schedule 13D”) with respect to shares of common stock, $0.001 par value per share (“Common Stock”) of Entasis Therapeutics Holdings Inc., a Delaware corporation (the “Issuer”) and warrants to acquire additional shares of Common Stock of the Issuer. Innoviva, Inc. (“INVA”) and Innoviva Strategic Opportunities LLC (“ISO”) are together referred to herein as the “Reporting Persons”. Except as specifically amended and supplemented by this Amendment No. 8, the Schedule 13D remains in full force and effect.

     

    Item 4. Purpose of Transaction

     

    Item 4 in Schedule 13D is hereby supplemented as follows:

     

    On March 15, 2022 INVA revised its non-binding offer to acquire the Issuer to increase the purchase thereunder to $2.00 per share in cash. All other terms of the offer remain unchanged. The foregoing description of the revised Proposal is qualified in its entirety by reference to the full text of the communication from INVA to the Issuer, a copy of which is attached hereto as Exhibit 16 and is incorporated herein by reference.

     

    Item 7. Material to Be Filed as Exhibits

     

    Exhibit 16 – Revised Proposal to Members of Board of Directors of the Issuer, dated March 15, 2022

     

     - 4 - 

     

     

    SIGNATURES

     

    After reasonable inquiry and to the best of each of the undersigned’s knowledge and belief, each of the undersigned, severally and not jointly, certifies that the information set forth in this statement is true, complete and correct.

     

    Dated: March 15, 2022

     

      INNOVIVA, INC.  
         
      By: /s/ Pavel Raifeld  
      Name: Pavel Raifeld  
      Title: Chief Executive Officer  
         
      INNOVIVA STRATEGIC OPPORTUNITIES LLC  
      By: Innoviva, Inc., its managing member  
         
      By: /s/ Pavel Raifeld  
      Name: Pavel Raifeld  
      Title: Chief Executive Officer  

     

     - 5 - 

     

     

     

    Get the next $ETTX alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $ETTX

    DatePrice TargetRatingAnalyst
    3/8/2022$9.00 → $1.80Outperform → Neutral
    Wedbush
    3/4/2022$6.00 → $1.80Buy → Neutral
    HC Wainwright & Co.
    10/20/2021$5.00 → $7.00Outperform
    BMO Capital
    10/19/2021$5.00 → $6.00Buy
    HC Wainwright & Co.
    More analyst ratings

    $ETTX
    SEC Filings

    See more
    • SEC Form 15-12G filed by Entasis Therapeutics Holdings Inc.

      15-12G - Entasis Therapeutics Holdings Inc. (0001724344) (Filer)

      7/21/22 5:27:48 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form EFFECT filed by Entasis Therapeutics Holdings Inc.

      EFFECT - Entasis Therapeutics Holdings Inc. (0001724344) (Filer)

      7/13/22 12:15:06 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form EFFECT filed by Entasis Therapeutics Holdings Inc.

      EFFECT - Entasis Therapeutics Holdings Inc. (0001724344) (Filer)

      7/13/22 12:15:20 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Entasis Therapeutics Hldg downgraded by Wedbush with a new price target

      Wedbush downgraded Entasis Therapeutics Hldg from Outperform to Neutral and set a new price target of $1.80 from $9.00 previously

      3/8/22 7:04:37 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Entasis Therapeutics Hldg downgraded by HC Wainwright & Co. with a new price target

      HC Wainwright & Co. downgraded Entasis Therapeutics Hldg from Buy to Neutral and set a new price target of $1.80 from $6.00 previously

      3/4/22 7:10:02 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • BMO Capital reiterated coverage on Entasis Therapeutics Hldg with a new price target

      BMO Capital reiterated coverage of Entasis Therapeutics Hldg with a rating of Outperform and set a new price target of $7.00 from $5.00 previously

      10/20/21 7:59:53 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • Entasis Therapeutics, a Wholly Owned Subsidiary of Innoviva, Announces Data on SUL-DUR to be Presented at IDWeek 2022

      WALTHAM, Mass., Oct. 12, 2022 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc., a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, and wholly owned subsidiary of Innoviva, Inc. (NASDAQ:INVA), today announced that six abstracts highlighting sulbactam-durlobactam (SUL-DUR) have been selected for presentation at IDWeek 2022, the annual meeting of the Infectious Disease Society of America taking place October 19-23, 2022 in Washington, D.C. Details of the presentations are as follows: Oral Presentations: Title: Microbiologic and clinical outcome concordance in the global phase 3 ATTACK trial: sulbactam-durlobactam

      10/12/22 8:30:00 AM ET
      $ETTX
      $INVA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Innoviva Announces Expiration of Cash Tender Offer for Shares of Entasis Therapeutics Holdings Inc.

      Innoviva, Inc. (NASDAQ:INVA) ("Innoviva") today announced that its tender offer to purchase any and all issued and outstanding shares of common stock of Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX) ("Entasis") at a price of $2.20 per share, net to the seller in cash, without interest and less required withholding taxes, expired at 5:00 p.m. New York City time on Thursday, July 7, 2022. The depositary for the tender offer has advised that, as of the expiration of the tender offer, a total of 11,671,662 shares of Entasis' common stock were validly tendered and not withdrawn in the tender offer. Such shares of Entasis' common stock, upon excluding those tendered by Manoussos Perros (the "

      7/8/22 8:35:00 AM ET
      $ETTX
      $INVA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Entasis Therapeutics Presents Data on Sulbactam-Durlobactam and ETX0462 at 2022 ASM Microbe Annual Conference

      WALTHAM, Mass., June 09, 2022 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX), a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced multiple presentations at the American Society for Microbiology (ASM) annual Microbe conference, taking place June 9-13, 2022, in Washington, DC. Entasis is presenting data on sulbactam-durlobactam (SUL-DUR), an investigational drug in development for the treatment of infections caused by Acinetobacter baumannii including carbapenem-resistant and multidrug-resistant (MDR) strains, and ETX0462 a novel, first-in-class, diazabicyclooctane with broad spectrum

      6/9/22 8:00:00 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Leadership Updates

    Live Leadership Updates

    See more
    • Entasis Therapeutics Expands Executive Leadership Team with the Appointment of Anna Diaz Triola as Chief Commercial Officer

      – Significant commercial strategy and product launch experience –– ATTACK Phase 3 top-line data readout remains on-track for 2H 2021 – WALTHAM, Mass., July 14, 2021 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel antibacterial products, announced today the appointment of Anna Diaz Triola as Chief Commercial Officer, effective July 19th 2021. Ms. Triola will be responsible for global commercial strategy, including U.S. sales and marketing operations. "With the ATTACK Phase 3 registration clinical trial nearing completion, we are now engaged in preparing for commercialization

      7/14/21 8:00:00 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • SEC Form 4: Innoviva, Inc. bought $42,395,047 worth of shares (19,270,476 units at $2.20)

      4 - Entasis Therapeutics Holdings Inc. (0001724344) (Issuer)

      7/13/22 9:27:34 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4: Wagner Kristie Ann returned 80,500 shares to the company, closing all direct ownership in the company

      4 - Entasis Therapeutics Holdings Inc. (0001724344) (Issuer)

      7/11/22 4:11:00 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4: Triola Anna Diaz returned 125,000 shares to the company, closing all direct ownership in the company

      4 - Entasis Therapeutics Holdings Inc. (0001724344) (Issuer)

      7/11/22 4:10:15 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • SEC Form SC 13D/A filed by Entasis Therapeutics Holdings Inc. (Amendment)

      SC 13D/A - Entasis Therapeutics Holdings Inc. (0001724344) (Subject)

      7/11/22 5:27:19 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13D/A filed by Entasis Therapeutics Holdings Inc. (Amendment)

      SC 13D/A - Entasis Therapeutics Holdings Inc. (0001724344) (Subject)

      5/23/22 8:55:33 PM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13D/A filed by Entasis Therapeutics Holdings Inc. (Amendment)

      SC 13D/A - Entasis Therapeutics Holdings Inc. (0001724344) (Subject)

      3/15/22 9:00:21 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ETTX
    Financials

    Live finance-specific insights

    See more
    • Innoviva Reports First Quarter 2022 Financial Results

      Royalties increased by 5% to $93.5 million in the first quarter of 2022, compared to the same quarter in 2021. Issued $261.0 million convertible senior notes due 2028 and repurchased a portion of the convertible subordinated notes due 2023. Invested $45.0 million into Armata Pharmaceuticals Inc. (NYSE:ARMP) ("Armata"), an anti-infectives leader. Made a non-binding offer to acquire and provided $15.0 million convertible debt financing to Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX) ("Entasis"), an anti-infectives leader. Innoviva, Inc. (NASDAQ:INVA) ("Innoviva" and "the Company") today reported financial results for the first quarter ended March 31, 2022. Gross royalty revenue

      4/27/22 5:11:00 PM ET
      $ARMP
      $ETTX
      $INVA
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
      Biotechnology: Pharmaceutical Preparations
    • Entasis Therapeutics Announces Third Quarter 2021 Financial Results and Provides Business Update

      Sulbactam-durlobactam (SUL-DUR) achieved all primary and secondary endpoints from landmark Phase 3 ATTACK trialRobust dataset builds compelling case for SUL-DUR which if approved, could become the first, uniquely differentiated and life-saving treatment option for patients with Acinetobacter infectionsPreparing for commercialization ahead of NDA submission in mid-2022, under the leadership of newly appointed Chief Commercial Officer Anna Diaz TriolaEntasis' pathogen-directed platform and latest candidate ETX0462 highlighted by seminal publication in the prestigious scientific journal Nature WALTHAM, Mass., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX),

      11/4/21 7:30:00 AM ET
      $ETTX
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Entasis Therapeutics to Report Third Quarter 2021 Results and Host Conference Call November 4, 2021

      WALTHAM, Mass., Oct. 28, 2021 (GLOBE NEWSWIRE) -- Entasis Therapeutics Holdings Inc. (NASDAQ:ETTX), a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced that management will report third quarter 2021 financial results before the market opens on November 4, 2021. The company will host a conference call and webcast at 8:00AM Eastern Time to discuss its results and provide a clinical and corporate update. A question-and-answer session will follow management's prepared remarks. Investors and the general public are invited to listen to a live audio webcast of the conference call, which may be accessed five min

      10/28/21 8:00:00 AM ET
      $ETTX
      Biotechnology: Pharmaceutical Preparations
      Health Care